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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Differential function of intestinal intraepithelial lymphocyte subsets 显示文摘 | Barrett TA Gajewskj D Danielpour EB | 1992 | J Immunol1992，149，4： | 2 |
| 3 | An electrophoretic ink for all-printed reflective electronic displays显示文摘 | Barrett Comiskey Albert J D Hidekazu Yoshizawa | 1998 | Nature1998，394，： | 2 |
| 4 | Lant-hanide triflate and triflide catalyzed atom economic nitration of fluoroarenes显示文摘 | Barrett A G M Braddock C D Ducray R | 2000 | Synlett2000，，1： | 2 |
| 5 | Development of a European herbage growth model(the EU Grazemore project)显示文摘 | Barrett P D Mayne A S | 2004 | Grassland Science in Europe2004，9，： | 1 |
| 6 | An Electrophoretic Ink for All-printed Reflective Electronic Displays显示文摘 | Barrett C Albert J D Yoshizawa H | 1998 | Nature1998，394，16： | 1 |
| 7 | Determination of reducing sugars with 3- Methyl-2-benzothiazohnonehydrazone 显示文摘 | ANTHON G E BARRETT D M | 2002 | Analytical Biochemistry2002，305，： | 1 |
| 8 | 显示文摘 | Stubington J F Barrett D | 1995 | Fuel Processing Technology1995，41，2： | 1 |
| 9 | High-order aberrations in pseudophakia with different intraocular lenses显示文摘 | VILARRODONA L BARRETT G D JOHNSON B | 2004 | J Cataract Refract Surg2004，30，3： | 1 |
| 10 | Bovine congenital erythrocytic protoporphyria in a Limousin calf bred in the UK 显示文摘 | Armstrong S C Jonsson N N Barrett D C | 2002 | Vet Rec2002，19，： | 1 |
| 11 | Modulation of long- term memory for object recognition via HDAC inhibition 显示文摘 | STEFANKO D P BARRETT R M LY A R | 2009 | Proc Nail Acad Sci U S A2009，106，23： | 1 |
| 12 | Activity of softening enzymes during cherry maturation显示文摘 | Barrett D M Gonzalez G | 2004 | Journal of Food Science2004，59，3： | 1 |
| 13 | Database resources of the National Center for Biotechnology Information显示文摘 | Wheeler D L Barrett T Benson D A | 2006 | Nucleic Acids Res2006，34，： | 1 |
| 14 | Qualitative aspects of nasal irrigation use by patients with chronic sinus disease in a muhimethod study显示文摘 | Rabago D Barrett B Marchand L | 2006 | Ann Fam Med2006，4，4： | 1 |
| 15 | Career patterns and job satisfaction of canadian nurses education显示文摘 | Barrett MC Golden berg D Fauxs | 1992 | Journal of Advanced Nursing1992，12，8： | 1 |
| 16 | Identifying spiders through DNA barcodes显示文摘 | Barrett R D H Hebert P D N | 2005 | Canada Journal of Zoology2005，83，3： | 1 |
| 17 | Shotcrete Support Design in Blocky Ground: Towards A Deterministic Approach显示文摘 | Barrett S V L McCreath D R | 1995 | Tunnelling and Underground Space Technology1995，10，1： | 1 |
| 18 | Three-to six-year follow-up of stand-alone BAK cages implanted by a single surgeon 显示文摘 | Button G Gupta M Barrett C Cammack P Benson D | 2005 | Sline J2005，5，： | 1 |
| 19 | Modified method for the deter- mination of pyruvic acid with dinitrophenylhydrazine in the assessment of onion pungency显示文摘 | Anthon G E Barrett D M | 2003 | J Sci Food Agric2003，83，12： | 1 |
| 20 | GrazeGro: a European herbage growth model to predict pasture production in perennial ryegrass swards for decision support 显示文摘 | Barrett P D Laidlaw A S Mayne C S | 2005 | European Journal of Agronomy2005，1，： | 1 |
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