4篇
您的检索式：作者名="Barry Doyle"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | GPR56 promotes myoblast fusion through SRE- and NFAT-mediated signaling but is not essential for muscle development in vivo显示文摘 | Wu MP Doyle JR Barry B | 2013 | FEBS J2013，280，23： | 1 |
| 2 | Prognosis in Women With Myocardial Ischemia in the Absence of Obstructive Coronary Disease: Results From the National Institutes of Health–National Heart, Lung, and Blood Institute–Sponsored Women’s Ischemia Syndrome Evaluation (WISE)显示文摘 | B. Delia Johnson Leslee J. Shaw Steven D. Buchthal C. Noel Bairey Merz Hee-Won Kim Katherine N. Scott Mark Doyle Marian B. Olson Carl J. Pepine Jan den Hollander Barry Sharaf William J. Rogers Sunil Mankad John R. Forder Sheryl F. Kelsey Gerald M. Pohost | 2004 | Circulation: Journal of the American Heart Association2004，，24： | 1 |
| 3 | Natural,synthetic and commercially-available biopolymers used to regenerate tendons and ligaments显示文摘Tendon and ligament(TL)injuries affect millions of people annually.Biopolymers play a significant role in TL tissue repair,whether the treatment relies on tissue engineering strategies or using artificial tendon grafts.The biopolymer governs the mechanical properties,biocompatibility,degradation,and fabrication method of the TL scaffold.Many natural,synthetic and hybrid biopolymers have been studied in TL regeneration,often combined with therapeutic agents and minerals to engineer novel scaffold systems.However,most of the advanced biopolymers have not advanced to clinical use yet.Here,we aim to review recent biopolymers and discuss their features for TL tissue engineering.After introducing the properties of the native tissue,we discuss different types of natural,synthetic and hybrid biopolymers used in TL tissue engineering.Then,we review biopolymers used in commercial absorbable and non-absorbable TL grafts.Finally,we explain the challenges and future directions for the development of novel biopolymers in TL regenerative treatment. | Behzad Shiroud Heidari Rui Ruan Ebrahim Vahabli Peilin Chen Elena M.De-Juan-Pardo Minghao Zheng Barry Doyle | 2023 | Bioactive Materials2023，，1： | 0 |
| 4 | Novel hybrid biocomposites for tendon grafts:The addition of silk to polydioxanone and poly(lactide-co-caprolactone)enhances material properties,in vitro and in vivo biocompatibility显示文摘Biopolymers play a critical role as scaffolds used in tendon and ligament(TL)regeneration.Although advanced biopolymer materials have been proposed with optimised mechanical properties,biocompatibility,degradation,and processability,it is still challenging to find the right balance between these properties.Here,we aim to develop novel hybrid biocomposites based on poly(p-dioxanone)(PDO),poly(lactide-co-caprolactone)(LCL)and silk to produce high-performance grafts suitable for TL tissue repair.Biocomposites containing 1-15%of silk were studied through a range of characterisation techniques.We then explored biocompatibility through in vitro and in vivo studies using a mouse model.We found that adding up to 5%silk increases the tensile properties,degradation rate and miscibility between PDO and LCL phases without agglomeration of silk inside the composites.Furthermore,addition of silk increases surface roughness and hydrophilicity.In vitro experiments show that the silk improved attachment of tendon-derived stem cells and proliferation over 72 h,while in vivo studies indicate that the silk can reduce the expression of pro-inflammatory cytokines after six weeks of implantation.Finally,we selected a promising biocomposite and created a prototype TL graft based on extruded fibres.We found that the tensile properties of both individual fibres and braided grafts could be suitable for anterior cruciate ligament(ACL)repair applications. | Behzad Shiroud Heidari Emma Muiños Lopez Emma Harrington Rui Ruan Peilin Chen Seyed Mohammad Davachi Benjamin Allardyce Rangam Rajkhowa Rodney Dilley Froilán Granero-Moltó Elena M.De-Juan-Pardo Minghao Zheng Barry Doyle | 2023 | Bioactive Materials2023，，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员