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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | PCR-SSCP comparison of 16S rDNA sequence diversity in soil DNA obtained using different isolation and purification methods 显示文摘 | Stach J E M Bathe S Clapp J P | 2001 | FEMS Microbiology Ecology2001，36，： | 2 |
| 4 | Finite element formulation and solution of nonlinear heat transfer显示文摘 | Bathe K J Khoshgoftaar M R | 1979 | Nuclear Engineering and Design1979，51，： | 2 |
| 5 | High blood pressure in acute stroke and subsequent outcome: a systematic review 显示文摘 | Willmot M Leonardi-Bee J Bath PM | 2004 | Hypertension2004，43，1： | 1 |
| 6 | High blood pressure in acute stroke and subsequent outcome: a systematic review显示文摘 | Willmot M Leonardi-Bee J Bath PM | 2004 | Hypertension2004，43，1： | 1 |
| 7 | Finite element free surface seepage analysis without mesh iteration显示文摘 | Bathe K J Khoshgoftaar M R | 1979 | Numerical analytical methods in Geomechanics1979，3，1： | 1 |
| 8 | Serum S - 100 protein,relationship to clinical outcome in acute stroke显示文摘 | Abraha H D Butterworth R J Bath P M | 1997 | Ann Clin Biochem1997，34，4： | 1 |
| 9 | High blood pressure in a-cute stroke and subsequent outcome:a systematic review显示文摘 | Willmot M Leonardi-Bee J Bath PM | 2004 | Hy-pertension2004，43，1： | 1 |
| 10 | High blood pressure in acute stroke and subsequent outcome: a systematic review 显示文摘 | Willmot M Leonardi-Bee J Bath PM | 2004 | Hypertension2004，43，1： | 1 |
| 11 | Genotyping of environmental and clinical Stenotrophomonas maltophilia:emerging disease patterns and challenges for treatment显示文摘 | Adamek M Overhage J Bathe S | 2011 | Expert Rev Anti Infect Ther2011，9，4： | 1 |
| 12 | High blood pressure in acute stroke and subsequent outcome: a systematic review 显示文摘 | Willmot M Leonardi-Bee J Bath PM | 2004 | Hypertension2004，43，1： | 1 |
| 13 | Caloric equivalent of live weight loss of dairy cattle显示文摘 | Th Bath D L Ronning M Meyer J H | 1965 | J Dairy Sci1965，48，： | 1 |
| 14 | High blood pressure in acute stroke and subsequent outcome: a systematic review显示文摘 | Willmot M Leonardi- Bee J Bath PM | 2004 | Hypertension2004，43，1： | 1 |
| 15 | Influence of platelet size on outcome after myocardial infarction 显示文摘 | MARTIN J F BATH P M BURR M L | 1991 | Lancet1991，338，8780： | 1 |
| 16 | High phylogenetic diversity of transconjugants carrying plasmid pJP4 in an activated sludge-derived microbial community 显示文摘 | Bathe S Lebuhn M Ellwart J W | 2004 | FEMS Microbiology Letters2004，235，2： | 1 |
| 17 | Finite element free surface seepage analysis without mesh iteration显示文摘 | Bathe K J Khoshgoftaar M R | 1979 | International Journal for Numerical and Analytical Methods in Geomechanics1979，3，： | 1 |
| 18 | Finite Element for Surface Seepage Analysis Without Mesh Iteration显示文摘 | Bathe K J Khoshgoftan M R | 1979 | International Journal of Numerical Analytical Methods in Geomechanics1979，3，1： | 1 |
| 19 | High blood pressure in acute stroke and subsequent outcome:a systematic review显示文摘 | Willmot M Leonardi-Bee J Bath PM | 2004 | Hypertension2004，43，1： | 1 |
| 20 | Genotyping of environ mental and clinical Stenotrophomonas maltophilia isolates and their pathogenic potential显示文摘 | Adamek M Overhage J Bathe S | | 0，，11： | 1 |
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