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| 1 | Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action显示文摘AIM: To evaluate the protective activity of allylpyrocatechol (APC), the major antioxidant constituent of Piper betel, against the indomethacin-induced stomach ulceration in the rat model and correlates with its antioxidative and mucin protecting properties. METHODS: Male Sprague-Dawley rats were divided into five groups. Normal control rats (group Ⅰ) were given the vehicle oral dose of gum acacia in distilled water (1 mL per rat); ulcerated control and treated rats (groups Ⅱ-Ⅴ) were given a single dose of indomethacin (30 mg/kg body wt.); group Ⅱ rats were sacrificed 4 h after indomethacin administration; groups Ⅲ-Ⅴ rats were given the vehicle (1 mL per rat) or APC (2 mg/kg body wt.) or misoprostol (1.43 μg/kg body wt.) once daily by oral intubation for 7 d starting from 4 h after the indomethacin administration. After 7 d, the stomach tissues were excised for histological examination and biochemical analysis. RESULTS: Treatment with APC (2 mg/kg body wt per day) and misoprostol (1.43 μg/kg body wt per day) for 7 d could effectively heal the stomach ulceration as revealed from the ulcer index and histopathological studies. Compared to the zero day ulcerated group, treatment with APC and misoprostol reduced the ulcer index by 93.4% and 85.4% respectively (P < 0.05). Both APC and misoprostol accelerated ulcer healing observed in natural recovery (P < 0.05), their respective healing capacities not being significantly different. The healing capacities of APC and misoprostol could be attributed to their antioxidant activity as well as the ability to enhancethe mucin content of the gastric tissues. Compared to the ulcerated untreated rats, those treated with APC and misoprostol showed near normal MDA levels, while the protein levels were 86% and 78% of the normal value respectively (P < 0.05). Likewise, both APC and misoprostol increased the SOD, catalase, and mucin levels significantly (P < 0.05), the effect of APC being better. CONCLUSION: APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties. | S Bhattacharya D Banerjee AK Bauri S Chattopadhyay SK Bandyopadhyay | 2007 | World Journal of Gastroenterology2007，13，27： | 4 |
| 2 | Synthesis,Phase Stability and Conduction Behavior of Rare Earth and Transition Elements Doped Barium Cerates显示文摘 | Babu A S Bauri R | 2014 | International Journal of Hydrogen Energy2014，39，14： | 1 |
| 3 | Effect of Equal Channel Angular Pressing (ECAP) on Microstructure and Properties of Al-SiCp Composites 显示文摘 | Ramu G Bauri R | 2009 | Materials and Design2009，30，： | 1 |
| 4 | Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulcera- tion : a mechanistic exploration显示文摘 | Banerjee D Maity B Bauri AK et d | 2007 | J Pharm Pharmaco12007，59，11： | 1 |
| 5 | Effect of friction stir processing on mi- crostructure and mechanical properties of aluminium 显示文摘 | Yadav D Bauri R | 2012 | Materials Science and Engineering A2012，539，： | 1 |
| 6 | Gastroprotice properities of Myristica malabarica aganinst indometacin-induced stomach ulceration:a mechanisic exploration显示文摘 | BANERJEE D MAITY B BAURI A K | 2014 | J Pharm Pharmacol2014，59，： | 1 |
| 7 | Spectroscopic and theoretical insights on supramolecular complexation of C60 and C70 with a designed bisporphyrin 显示文摘 | MUKHERJEE S BAURI A K BHATTACHARYA S | 2010 | Spectrochim Acta Part A: Mol & Biomol Spectroscopy2010，77，1： | 1 |
| 8 | Processing and properties of Al-Li-SiCp compo sites显示文摘 | Ranjit Bauri Surappa M K | 2007 | Sci Techn Adv Mater2007，8，： | 1 |
| 9 | Gastroprotective properties of Myristica malabarica against indometacin- induced stomach ulceration: a mechanistic exploration显示文摘 | Banerjee D Maity B Bauri AK | 2007 | Journal of Pharmacy and Pharmacology2007，59，11： | 1 |
| 10 | Effect of equal channel angular pressing (ECAP) on microstructure and properties of Al–SiC p composites显示文摘 | G. Ramu Ranjit Bauri | 2009 | Materials and Design2009，，9： | 1 |
| 11 | Gene walking by PCR amplification of short fragments from Taq DNA polymerase modified PI Plasmid DNA and TA cloning显示文摘 | Baury B Masson D Lustenberger P | 1999 | Biotechniques1999，27，6： | 1 |
| 12 | Damping behavior of Al-Li-SiCp composites processed by stir casting technique 显示文摘 | BAURI R SURAPPA M K | 2005 | Metallurgical and Materials Transactions A2005，36，3： | 1 |
| 13 | Effect of equal channel angular pressing (ECAP) on microstructure and properties of Al-SiCp composites 显示文摘 | RAMU G BAURI R | 2009 | Materials and Design2009，30，9： | 1 |
| 14 | Overexpression of the CD155 gene in human colorectal Carcinoma 显示文摘 | Masson D Jarry A Baury B | 2001 | Gut2001，49，2： | 1 |
| 15 | Effect of equal channel angular pressing (ECAP) on microstructure and properties of Al-SiCp composites 显示文摘 | RAMU G BAURI R | 2009 | Materials and Design2009，30，： | 1 |
| 16 | Effect of friction stir processing (FSP) on microstructure and properties of Al-TiC in situ composite 显示文摘 | BAURI R YADAV D SUHAS G | 2011 | Materials Science and Engineering A2011，528，： | 1 |
| 17 | Processing, microstructure and me chanical properties of nickel particles embedded aluminium matrix composite显示文摘 | YADAV D BAURI R | 2011 | Materials Science and Engineering: A2011，528，3： | 1 |
| 18 | Damping behavior of AI-Li-SiCp com- posites processed by stir casting technique显示文摘 | BAURI R SURAPPA M K | 2005 | Metallurgical and Materials Transactions2005，36，3： | 1 |
| 19 | Emblica officinalis:A possible preventor of radiation and NSAID induced gastric damage显示文摘 | Bhattacharya S Chatterjee S Bauri AK | 2004 | Indian J Radiat Res2004，1，1： | 1 |
| 20 | Optimization of process parameters for friction stir processing (FSP) of Al-TiC in situ composite 显示文摘 | BAURI R | 2014 | Bulletin of Materials Science2014，37，： | 1 |
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