|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Review:DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis显示文摘Tissue homeostasis requires a carefully-orchestrated balance between cell proliferation, cellular senescence and cell death. Cells proliferate through a cell cycle that is tightly regulated by cyclin-dependent kinase activities. Cellular senescence is a safeguard program limiting the proliferative competence of cells in living organisms. Apoptosis eliminates unwanted cells by the coordinated activity of gene products that regulate and effect cell death. The intimate link between the cell cycle, cellular senes- cence, apoptosis regulation, cancer development and tumor responses to cancer treatment has become eminently apparent. Extensive research on tumor suppressor genes, oncogenes, the cell cycle and apoptosis regulatory genes has revealed how the DNA damage-sensing and -signaling pathways, referred to as the DNA-damage response network, are tied to cell proliferation, cell-cycle arrest, cellular senescence and apoptosis. DNA-damage responses are complex, involving “sensor” proteins that sense the damage, and transmit signals to “transducer” proteins, which, in turn, convey the signals to numerous “effector” proteins implicated in specific cellular pathways, including DNA repair mechanisms, cell-cycle checkpoints, cellular senescence and apoptosis. The Bcl-2 family of proteins stands among the most crucial regulators of apoptosis and performs vital functions in deciding whether a cell will live or die after cancer chemotherapy and irradiation. In addition, several studies have now revealed that members of the Bcl-2 family also interface with the cell cycle, DNA repair/recombination and cellular senescence, effects that are generally distinct from their function in apoptosis. In this review, we report progress in understanding the molecular networks that regulate cell-cycle checkpoints, cellular senescence and apoptosis after DNA damage, and discuss the influence of some Bcl-2 family members on cell-cycle checkpoint regulation. | SCHMITT Estelle PAQUET Claudie BEAUCHEMIN Myriam BERTRAND Richard | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，6： | 17 |
| 2 | Colitis-associated colon cancer:Is it in your genes?显示文摘Colitis-associated colorectal cancer(CA-CRC) is the cause of death in 10%-15% of inflammatory bowel disease(IBD) patients. CA-CRC results from the accumulation of mutations in intestinal epithelial cells and progresses through a well-characterized inflammation to dysplasia to carcinoma sequence. Quantitative estimates of overall CA-CRC risks are highly variable ranging from 2% to 40% depending on IBD severity, duration and location, with IBD duration being the most significant risk factor associated with CA-CRC development. Recently, studies have identified IBD patients with similar patterns of colonic inflammation, but that differ with respect to CA-CRC development, suggesting a role for additional non-inflammatory risk factors in CA-CRC development. One suggestion is that select IBD patients carry polymorphisms in various low penetrance disease susceptibility genes, which predispose them to CA-CRC development, although these loci have proven difficult to identify in human genomewide association studies. Mouse models of CA-CRC have provided a viable alternative for the discovery, validation and study of individual genes in CA-CRC pathology. In this review, we summarize the current CA-CRC literature with a strong focus on genetic predisposition and highlight an emerging role for mouse models in the search for CA-CRC risk alleles. | Lauren Van Der Kraak Philippe Gros Nicole Beauchemin | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 3 | Performance of optical flow techniques显示文摘 | J. L. Barron D. J. Fleet S. S. Beauchemin | 1994 | International Journal of Computer Vision1994，，1： | 3 |
| 4 | Adenocarcinoma: A unique cervical cancer显示文摘 | Lilian T. Gien Marie-Claude Beauchemin Gillian Thomas | 2009 | Gynecologic Oncology2009，，1： | 3 |
| 5 | Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases显示文摘 | Jeremy Dupaul-Chicoine Garabet Yeretssian Karine Doiron Kirk S.B. Bergstrom Christian R. McIntire Philippe M. LeBlanc Charles Meunier Claire Turbide Philippe Gros Nicole Beauchemin Bruce A. Vallance Maya Saleh | 2010 | Immunity2010，，3： | 2 |
| 6 | Increasing the Physically Effective Fiber Content of Dairy Cow Diets May Lower Efficiency of Feed Use 1显示文摘 | W.Z. Yang K.A. Beauchemin | 2006 | Journal of Dairy Science2006，，7： | 2 |
| 7 | Effects of Physically Effective Fiber on Digestion and Milk Production by Dairy Cows Fed Diets Based on Corn Silage *显示文摘 | W.Z. Yang K.A. Beauchemin | 2005 | Journal of Dairy Science2005，，3： | 2 |
| 8 | Performance of optical flow techniques 显示文摘 | Fleet D Beauchemin S | 1994 | International Journal of Computer Vision1994，12，1： | 1 |
| 9 | Increasing the physically effective fiber content of dairy Cow diets may lower efficiency of feed use显示文摘 | Yang W Z Beauchemin K A | 2006 | J Dairy Sci2006，89，7： | 1 |
| 10 | Effeets of an en- zyme feed additive on extent of digestion and milk production of lactating dairy cows 显示文摘 | YANG W Z BEAUCHEMIN K A RODE L M | 1999 | J Dairy Sci1999，82，2： | 1 |
| 11 | Performance of Optical Flow Techniques显示文摘 | J L BARRON D J FLEET S S BEAUCHEMIN | 1994 | International Journal of Computer Vision1994，12，1： | 1 |
| 12 | Performnce of optical flow techniques显示文摘 | BARRON J FLEET D BEAUCHEMIN S | 1994 | International Journal of Computer Vision1994，12，1： | 1 |
| 13 | Synergy Between Ruminal Fibrolytic Enzymes and Enzymes from Trichoderma Longibrachiatum显示文摘 | Margavi D P Beauchemin K A Nsereko V L | 2000 | J Dairy Sci2000，83，： | 1 |
| 14 | Increasing the physically effective fiber content of dairy cow diets may lower efficiency of feed use 显示文摘 | Yang W Z Beauchemin K A | 2006 | J Dairy Sci2006，89，7： | 1 |
| 15 | Effects of crude protein content,degradability and energy concentration of the diet on growth and carcass characteristics of market Iambs fed high concentrate diets 显示文摘 | Beauchemin K A McCeland L A Jones D | 1995 | Can J Anita Sci1995，75，： | 1 |
| 16 | Performance of optical flow techniques显示文摘 | J. L. Barron D. J. Fleet S. S. Beauchemin | 1994 | International Journal of Computer Vision1994，，1： | 1 |
| 17 | Adenocarcinoma:a unique cervical cancer显示文摘 | Gien LT Beauchemin MC Thomas G | | 0，，1： | 1 |
| 18 | Evaluation of a nonstarch polysaccharidase feed enzyme in dairy cow diets显示文摘 | Beauchemin K A Rode L M Maekawa M | 2000 | Journal of Dairy Science2000，83，3： | 1 |
| 19 | Effects of an Enzyme Feed Additive on Extent of Digestion and Milk Production of Lactating Dairy Cows显示文摘 | Yang W Z Beauchemin K A Rode L M | 1999 | J Dairy Sci1999，82，： | 1 |
| 20 | Use of exogenous fibrolytic enzymes to improve feed utilization by ruminants 显示文摘 | BEAUCHEMIN K A COLOMBATTO D MORGA- VI D P | 2003 | Journal of Animal Science2003，81，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员