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| 1 | Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma显示文摘 | Andrew D. Rhim Paul E. Oberstein Dafydd H. Thomas Emily T. Mirek Carmine F. Palermo Stephen A. Sastra Erin N. Dekleva Tyler Saunders Claudia P. Becerra Ian W. Tattersall C. Benedikt Westphalen Jan Kitajewski Maite G. Fernandez-Barrena Martin E. Fernandez- | 2014 | Cancer Cell2014，，： | 5 |
| 2 | Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel,flavopiridol,and 5-fluorouracil显示文摘瞄准:有 docetaxel, flavopiridol,或 5 氟尿嘧啶(5-FU ) 的稳固的肿瘤的临床的治疗经常遇到不受欢迎的副作用和药抵抗。在 modulating chemosensitivity 并且更好与 docetaxel, flavopiridol,或 5-FU 评估联合治疗的潜在的角色的目的理解他们怎么可能临床上被使用的这研究。方法:HCT116 结肠癌房间在几不同行政时间表在试管内与 docetaxel, flavopiridol,和 5-FU 被对待,顺序或同时。房间幸存被 MTT 试金测量。caspase-3 的活动被 caspase-3 试金决定,软琼脂殖民地试金被用来在软琼脂测试 HCT116 房间的菌落形成。我们也建立了异种皮移植模型扩大在试管内观察到一个在活体内系统。结果:当人的结肠癌 HCT116 房间为 flavopiridol 为另一 24 h 为 24 h 和 5-FU 跟随的 1 h 与 docetaxel 被对待时,最大的细胞毒性被发现。这顺序的联合治疗不仅与另外的联合治疗相比更强烈禁止肿瘤细胞生长而且显著地在软琼脂减少菌落形成并且扩充 HCT116 细胞的 apoptosis。docetaxel 定序以后由 flavopiridol 跟随了 1 h,以后在异种皮移植模型由 5-FU 跟随了 24 h,也导致了推迟的肿瘤生长和更高的幸存率。结论:当把 docetaxel 与 flavopiridol 和 5-FU 相结合时,这些结果强调一张行政时间表的重要性,提供对它在临床的试用的发展的基本原理解释。 | Jun GUO An-wu ZHOU Yu-cai FW Udit N VERMA Debu TRIPATHY Eugene P FRENKEL Carlos R BECERRA | 2006 | Acta Pharmacologica Sinica2006，27，10： | 4 |
| 3 | Precipitating factors leading to decompensation of chronic heart failure in the elderly patient in South-American community hospital显示文摘心失败的背景恶化显得经常与心脏病的进化有关不直接把因素与猛抛联系了。在那里静止猛抛的比例的分发上的数据的少量因素明确地在老病人。这研究的目的是有希望地检验在我们的社区医院里与心失败在老病人导致住院的猛抛的因素。我们评估需要录取为的老病人的方法患心脏代偿失调心失败。所有病人每天被学习调查者在开始的 24 h 并且仔细考察跟随起来。补偿不全被定义为在与对医疗的增加的需要联系的临床的 NYHA 班上变得更坏(在最小静脉内地利尿剂) 。结果我们包括了 102 个病人(意味着年龄 79 ??? 敹牡? | Alejandro Diaz Cleto Ciocchini Mariano Esperatti Alberto Becerra Sabrina Mainardi Alejandro Farah | 2011 | Journal of Geriatric Cardiology2011，8，1： | 4 |
| 4 | 联合钢厂采用无碳排放的ENERGIRON直接还原方案减少温室气体的排放显示文摘在基于高炉冶炼的联合企业中,始终有一些过剩的焦炉煤气、转炉煤气和高炉炉顶煤气,通常这些煤气用于电厂发电。另一种替代方法是使用这些现有的能源气体生产直接还原铁(DRI),将其作为金属化炉料加入高炉,提高粗钢产量,以减少化石燃料单耗。优化利用主要的化石燃料可以显著降低吨钢CO2排放量。采用传统的BF-BOF流程,即使在优化工艺流程的基础上,吨钢CO2排放量也有1.7~1.8t左右。而用产自天然气、焦炉煤气和高炉炉顶煤气的DRI作为金属化炉料加入高炉或电炉,却可显著降低CO2排放量。 | Pablo E Duarte Jorge Becerra 熊林(译) 张友平(校) | 2012 | 世界钢铁2012，12，3： | 3 |
| 5 | Transference and congruence effects on purchase intentions in online stores of multi-channel retailers: initial evidence from the U.S. and South Korea显示文摘 | Vishag Badrinarayanan Enrique Becerra Chung-Hyun Kim Sreedhar Madhavaram | 2012 | Journal of the Academy of Marketing Science2012，，4： | 2 |
| 6 | IgG Subclasses Against Helicobacter pylori Isolates: An important Tool for Disease Characterization显示文摘 | F. Martínez‐Becerra G. Castillo‐Rojas S. Ponce de León Y. López‐Vidal* | 2012 | Scandinavian Journal of Immunology2012，，1： | 2 |
| 7 | Four-quadrant sensorless brushless ECM Drive 显示文摘 | Becerra R C | 1991 | IEEE Applied Power Electron Conf and Exp1991，87，8： | 1 |
| 8 | Perceived Ttustworthiness within the Organ-ization:The Moderating Impact of Community Frequency on Trustorand Trustee Effects显示文摘 | Becerra M Guper A K | 2003 | Organization Science2003，，1： | 1 |
| 9 | Effects of leaf litter and precipitation on germination and seedling survival in Beilschmiedia miersii 显示文摘 | Becerra P I Celis-Diez J L Bustamente R O | 2004 | Applied Vegetation Science2004，7，： | 1 |
| 10 | Evolutionary Multiobjective Optimization in Materials Science and Engineering显示文摘 | Carlos A. Coello Coello Ricardo Landa Becerra | 2009 | Materials and Manufacturing Processes2009，，2： | 1 |
| 11 | Mycorrhizal status of Phlebopus bruchii (Boletaceae) : Does it form ectomycorrhizas with Fagara coco (Rutaceae) ? 显示文摘 | NOUHRA E URCELAY C BECERRA A | 2008 | Symbiosis2008，46，： | 1 |
| 12 | Focus on molecules: pigment epithelium-derived fac tor (PEDF)显示文摘 | Becerra SP | 2006 | Exp Eye Res2006，82，5： | 1 |
| 13 | Lipoprotein Ca ) and other lipoproteins in hypothyroid patients before and after thyroid re?placement therapy显示文摘 | Becerra A Bellido D Luengo A | 2007 | Clinical Nutrition2007，18，5： | 1 |
| 14 | Four-wave mixing in the diamond configuration in an atomic vapor显示文摘 | Willis R T Becerra F E Orozco L A | 2009 | Phys Rev A2009，79，03： | 1 |
| 15 | Trustworthiness,risk,and the transfer of tacit and explicit knowledge between alliance partners显示文摘 | Becerra M Lunnan R Huemer L | 2008 | Journal of Management Studies2008，45，4： | 1 |
| 16 | Cultured differential evolution for constrained optimization显示文摘 | Becerra R L Coello C A C | 2006 | Computation Methods in Applied Mechanics and Engineering2006，195，33343536： | 1 |
| 17 | Bacteriological studies of bile from the gallbladder in patients with carcinoma of the gallbladder, cholelithiasis, common bile duct stones and no gallstones disease显示文摘 | Csendes A Becerra M Burdiles P | 1994 | Eur J surg1994，160，67： | 1 |
| 18 | Adults and nymphs do not smell the same:The different defensive compounds of the giant mesquite bug (Thasus neoca//forn/cus:Coreidae) 显示文摘 | Prudic K L Noge K Becerra J X | 2008 | Journal of Chemical Ecology2008，34，6： | 1 |
| 19 | The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential显示文摘 | Becerra SP Notario V | 2013 | Nat RevCancer2013，13，4： | 1 |
| 20 | Noxious hot and cold stimulation produce common patterns of brain activation in humans: A functional magnetic resonance imaging study显示文摘 | Tracey I Becerra L Chang I | 2000 | Neurosci Lett2000，288，2： | 1 |
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