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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Determination of porcine plasma follitropin levels during superovulation treatment in cows显示文摘 | Demoustier M M Beckers J F Zwalmen P V | 1998 | Theriogenology1998，30，2： | 1 |
| 3 | Leiomyosarcoma of the inferlor vena cava:a case report显示文摘 | Bonamigo T P Becker M Faccini F P | 2003 | Vase Enctovascular Surg2003，37，3： | 1 |
| 4 | Summandibular diagnosic and interventional siaendoscopy: new procedure for ductal disorder 显示文摘 | Marchal F Dulguerov P Becker M | 2002 | Ann Otol Rhinol Laryngol2002，111，1： | 1 |
| 5 | The biodegradation of olive and the treatment of lipid-rich wool scouring wastewater under aerobic thermophilic conditions 显示文摘 | BECKER P KOSTE K POPOV M N | 1999 | Water Research1999，33，3： | 1 |
| 6 | Antinutntional factors present in plant-derived alternate fish feed ingredients and their effects in fish显示文摘 | Francis G Harinder P S M Becker K | 2001 | Aquaculture2001，199，： | 1 |
| 7 | Remodeling after myocardial infarction in humans is not associated with interstitial fibrosis of noninfarcted myocardium 显示文摘 | Marijianowski M M Teeling P Becker A E | 1997 | J Am Coll Cardiol1997，30，1： | 1 |
| 8 | Changing patterns of ganglion cell coupling and connexin expression during chick retinal development显示文摘 | Becker LD Bonness V Catsicas M Mobbs P | 2002 | J Neurobiol2002，52，4： | 1 |
| 9 | How to improve the implementation of guidelines on cancer-related thrombosis显示文摘 | Debourdeau P Beckers M Gér6me P | 2011 | Expert Rev Anticancer Ther2011，11，3： | 1 |
| 10 | A mi- crofluidic array with cellular valving for single cell co- culture显示文摘 | FRIMAT J P BECKER M CHIANG Y Y | 2011 | Lab on a Chip2011，11，： | 1 |
| 11 | Burnout, depression, and career satisfaction: Cross--sectional study of obstetrics and gynecology residents显示文摘 | Becker J L Milad M P Ktock S C | 2006 | 195(5) :1444-14492006，195，5： | 1 |
| 12 | Separate effects of ischemia and reperfusion on vascular permeability in ventilated ferret lungs显示文摘 | Becker P M Pearse D B Permutt S etal | 1992 | J Appl Physiol1992，73，6： | 1 |
| 13 | The M,+AXn Phases: Materials Science and Thin-film Processing显示文摘 | P Eklund M Beckers U Jansson | 2010 | Thin Solid Films2010，518，8： | 1 |
| 14 | Imaging of the larynx and hyopharynx显示文摘 | Becker M Burkhardt K Dulguerov P | 2008 | Eur J Radiol2008，66，3： | 1 |
| 15 | Food intake of the brominated flame retardants PBDEs and HBCD in Sweeden显示文摘 | LIND Y AUNE M ATUMA S BECKER W BJERSELIUS R GLYNN A OLA DARNERUD P | 2002 | Organohalog Compd2002，58，： | 1 |
| 16 | Cold-induced putative DEAD box RNA helicases CshA and CshB are essential for cold adaptation and interact with Cold Shock Protein B in Bacillus subtilis显示文摘 | Hunger K Beckering C L Wiegeshoff F Graumann P L Marahiel M A | 2006 | Journal of Bacteriology2006，188，1： | 1 |
| 17 | Evaluation of candidate vaccine approaches for mers-cov显示文摘 | Wang L Shi W Joyce M G Modjarrad K Zhang Y Leung K Lees C R Zhou T Yassine H M KanekiyoM Yang Z Y Chen X Becker M M Freeman M Vogel L Johnson J C Olinger G Todd J P Bagci U Solomon J Mollura D J Hensley L Jahrling P Deni- son M R Rao S S Subbarao K Kwong P D Mascola J R Kong W P Graham B S | 2015 | Nat Commun2015，6，： | 1 |
| 18 | Alterations of intratumoral pharmacokinetics of 5 fluorouracil in head and neck carcinoma during simultaneous radioehemotherapy显示文摘 | Schlemmer HP Becker M Bachert P | 1999 | Cancer Res1999，59，10： | 1 |
| 19 | Cutting edge: TGF-beta induces a regulatory phenotype in CD4^+ CD25^- T cells through Foxp3 induction and down-regulation of Smad 7显示文摘 | Fantini M C Becker C Monteleone G Pallone F Galle P R Neuratb M F | 2004 | J Inmmnol2004，172，51： | 1 |
| 20 | Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3 显示文摘 | De Becker A Van Hummelen P Bakkus M | 2007 | Haematologica2007，92，4： | 1 |
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