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| 1 | Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model显示文摘Osteoarthritis(OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor(EGFR) signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus(DMM) to induce OA in two mouse models with reduced EGFR activity, one with genetic modification(EgfrWa5/1mice) and the other one with pharmacological inhibition(gefitinib treatment). Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13(MMP13), the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2a(HIF2a), a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation. | Xianrong Zhang Ji Zhu Fei Liu Yumei Li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto Ling Qin | 2014 | Bone Research2014，2，3： | 9 |
| 2 | The expression of glucose regulated protein-94 in colorectal carcinoma cells treated by sodium butyrate显示文摘The expression of glucose regulated protein 94 (GRP94)during the treatment of human colorectal carcinoma cell lineClone A cells with sodium butyrate was studied. Sodium butyrate (SB) can cause functional and morphological effects on Clone A cells including growth arrest at Go/G1 stage and cell differentiation as observed by morphological changes, MTT and flow cytometry assays, as well as reduced Grp94 gene expression as shown by Northern blot and Western blot assays. The possible mechanism of the correlation between Grp94 gene expression and tumor growth inhibition and cell differentiation is briefly discussed. | WU YI DI JIN DAN SONG( Fax: (024)23256087 E-mail: jdsong@sun10.cmu.edu.cn)(Key Laboratory of Cell Biology, Ministry of Public Health of ChinaInstitute of Medical Molecular Biology, China Medical University, 92 Beier Rd. Heping District, Shenyang 110001, | 2000 | Cell Research2000，10，2： | 9 |
| 3 | Integrated System of Solar Cells with Hierarchical NiCo2O4 Battery-Supercapacitor Hybrid Devices for Self-Driving Light-Emitting Diodes显示文摘An integrated system has been provided with a-Si/H solar cells as energy conversion device,NiCo2O4 battery-supercapacitor hybrid(BSH)as energy storage device,and light emitting diodes(LEDs)as energy utilization device.By designing three-dimensional hierarchical NiCo2O4 arrays as faradic electrode,with capacitive electrode of active carbon(AC),BSHs were assembled with energy density of 16.6 Wh kg-1,power density of 7285 W kg-1,long-term stability with 100% retention after 15,000 cycles,and rather low self-discharge.The NiCo2O4//AC BSH was charged to 1.6 V in 1 s by solar cells and acted as reliable sources for powering LEDs.The integrated system is rational for operation,having an overall efficiency of 8.1% with storage efficiency of 74.24%.The integrated system demonstrates a stable solar power conversion,outstanding energy storage behavior,and reliable light emitting.Our study offers a precious strategy to design a self-driven integrated system for highly efficient energy utilization. | Yuliang Yuan Yangdan Lu BeiEr Jia Haichao Tang Lingxiang Chen YuJia Zeng Yang Hou Qinghua Zhang Qinggang He Lei Jiao Jianxing Leng Zhizhen Ye Jianguo Lu | 2019 | Nano-Micro Letters2019，11，3： | 5 |
| 4 | Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway显示文摘 | Yuejuan Zheng Yang Yang Yuhu Li Limin Xu Yi Wang Ziyi Guo Haiyan Song Muyi Yang Beier Luo Aoxiang Zheng Ping Li Yan Zhang Guang Ji Yizhi Yu | 2013 | Cellular & Molecular Immunology2013，10，4： | 4 |
| 5 | Ultraviolet lasing behavior in ZnO optical microcavities显示文摘Zinc oxide(ZnO)optical microcavity modulated UV lasers have been attracting a wide range of research interests.As one of the most important materials in developing high quality microcavity and efficient UV evisible optoelectronic devices due to its wide band gap(3.37 eV)and large exciton binding energy(~60 meV).In this review,we summarized the latest development of ZnO optical cavity based microlasers,mainly including Fabry-Perot mode lasers and whispering gallery mode lasers.The synthesis and optical studies of ZnO optical microcavities with different morphologies were discussed in detail.Finally,we also consider that the research focus in the near future would include new nanotechnology and physical effects,such as nano/micro fabrication,surface plasmon enhancement,and quantum dot coupling,which may result in new and interesting physical phenomena. | Hongxing Dong Beier Zhou Jingzhou Li Jingxin Zhan Long Zhang | 2017 | Journal of Materiomics2017，3，4： | 3 |
| 6 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 7 | Mechanisms and cell signaling in alcoholic liver disease显示文摘 | Juliane I. Beier Craig J. McClain | 2010 | Biological Chemistry2010，，11： | 3 |
| 8 | eDoc Server项目:建设马普学会的机构知识库显示文摘1引言 马普学会是一个多学科的研究机构,该学会制定了一项战略,旨在使Internet成为变革科学和学术交流、增强对所有与自身研究相关的信息资源的获取的重要渠道,eDoc Server(马普学会电子文档服务器)项目即是这一战略决策的一部分。马普学会将开放获取看作是实现上述战略的一个关键的先决条件,因此在2003年10月22目发起召开了“对科学与人文知识的开放获取”柏林会议,并在会议上联合德国和法国所有主要的研究机构和文化遗产继承单位、以及其他国家的部分科研机构和研究人员签署了“柏林宣言”。德国的主要研究机构正式接受开放获取原则是经过马普学会内部的充分讨论、及其与德国其它关键机构充分讨论后的决定。 | Gerhard Beier Theresa Velden 常唯编(译) | 2005 | 图书情报工作动态2005，，12： | 3 |
| 9 | Thermoelectric properties of silicon and recycled silicon sawing waste显示文摘Large-scale-applicable thermoelectric materials should be both self-sustaining,in order to survive longterm duty cycles,and nonpolluting.Among all classes of known thermoelectric materials,these criteria reduce the available candidate pool,leaving silicon as one of the remaining options.Here we first review the thermoelectric properties of various silicon-related materials with respect to their morphologies and microstructures.We then report the thermoelectric properties of silicon sawing wastes recycled from silicon wafer manufacturing.We obtain a high power factor of~32 mWcm1 K2 at 1273 K with 6%phosphorus substitution in the Si crystal,a value comparable to that of phosphorus-doped silicongermanium alloys.Our work suggests the large-scale thermoelectric applicability of recycled silicon that would otherwise contribute to the millions of tons of industrial waste produced by the semiconductor industry. | Ran He Wieland Heyn Felix Thiel Nicolas Perez Christine Damm Darius Pohl Bernd Rellinghaus Christian Reimann Maximilian Beier Jochen Friedrich Hangtian Zhu Zhifeng Ren Kornelius Nielsch Gabi Schierning | 2019 | Journal of Materiomics2019，5，1： | 2 |
| 10 | Development of An Enzyme-Linked Immunosorbent Assay for Determination of the Furaltadone Etabolite,3-Amino-5-Morpholinomethyl-2-Oxazolidinone(AMOZ) in Animal Tissues显示文摘Objective To determine 3-amino-5-morpholinomethyl-2-oxazolidinone(AMOZ) residues released from protein bound AMOZ in animal tissues.Methods Polyclonal and monoclonal antibodies were produced in this study.A rapid,sensitive,and specific competitive direct enzyme-linked immunosorbent assay(cdELISA) was developed.Results Rabbit polyclonal antibodies were used in the optimized cdELISA method,and exhibited negligible cross-reactivity with other compounds structurally related to AMOZ.The IC50of the polyclonal antibody was 0.16 ng/mL.The method limit of detection in four different types of animal and fish tissues was less than 0.06 μg/kg.Recoveries ranged from 80% to 120% for fortified samples with the coefficient of variation values less than 15%.The results of the cdELISA method were in good agreement with the results from an established liquid chromatography-tandem mass spectrometry confirmatory method used for AMOZ residues.Conclusion The cdELISA method developed in the present study is a convenient practical tool for screening large numbers of animal and fish tissue samples for the the detection of released protein bound AMOZ residues. | LUO Peng Jie JIANG Wen Xiao BEIER Ross C. SHEN Jian Zhong JIANG Hai Yang MIAO Hong ZHAO Yun Feng CHEN Xia WU Yong Ning | 2012 | Biomedical and Environmental Sciences2012，25，4： | 2 |
| 11 | Feature- based image metamorphosis 显示文摘 | BEIER T NEELY S | 1992 | Computer Graphics1992，26，2： | 2 |
| 12 | Feature-based Image Metamorphosis显示文摘 | T Beier S Neely | | Computer Graph0，26，： | 2 |
| 13 | Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure显示文摘 | Britta Vogel Andreas Keller Karen S. Frese Petra Leidinger Farbod Sedaghat-Hamedani Elham Kayvanpour Wanda Kloos Christina Backe Ann Thanaraj Thomas Brefort Markus Beier Stefan Hardt Eckart Meese Hugo A. Katus Benjamin Meder | 2013 | European Heart Journal2013，，： | 2 |
| 14 | 陆地生态系统的恢复——模拟全球变化所引起的酸性输入减少和海盐输入增加的影响显示文摘到2010年《哥德堡议定书》正式实施时,欧洲自20世纪70年代末以来已减少的酸化硫和氮释放量将进一步减少。这里我们论述了通过使用应用于3个大型'清洁两'实验(即分别在挪威里斯达尔谢伊阿[Risdalsheia],瑞典耶德松[G(?)rdsj(?)n]以及丹麦克洛斯特海泽[Klosterhede]的所谓'屋顶实验')的酸化模型MAGIC讨论恢复酸化陆地生态糸统的结果。《哥德堡议定书》的实施将启动通过重建盐基饱和恢复上述3处土壤的进程。恢复率较低,在今后30年中,盐基饱和增加不足5%。气候引发的风暴严重性的加剧将增加海盐输入生态糸统的量。这将为土壤提供额外的碱阳离子,并使恢复速度翻一番,同时还将随着沉积的碱阳离子与存储在土壤中的酸性交换导致高海盐输入之后的强酸性脉动。因此,酸化集水区土壤和径流的进一步恢复将取决于酸沉积下降的数量和速率,在近岸系统的情况下,还取决于海盐输入事件的频率和强度。 | Claus Beier Filip Moldan Richard F.Wright 林宝法 | 2003 | AMBIO-人类环境杂志2003，32，4： | 2 |
| 15 | Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation,hypertrophy,and apoptosis显示文摘 | BEIER F | 2005 | J Bone Miner Res2005，20，6： | 1 |
| 16 | Sputum matrix metalloproteinase - 9, tiss inhibitor of metalloproteinase - 1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects 显示文摘 | Beeh KM Beier J Kornmanno O | 2003 | Respir Med2003，97，： | 1 |
| 17 | ICOS is an inducible T-cell costimulator structurally and functionally related to CD28 显示文摘 | Hutloff A Dittrich AU Beier KC | 1999 | Nature1999，397，6716： | 1 |
| 18 | p38 MAPK signaling during routine preimplantation development 显示文摘 | Natale D R Paliga A J Beier F | 2004 | Dev Biol2004，268，1： | 1 |
| 19 | Borehole thermal resistance from line-source model of in-situ tests显示文摘 | Beier R A Smith M D | 2002 | ASHRAE Transactions2002，108，2： | 1 |
| 20 | Parental-specific methylat- ion of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis 显示文摘 | Chaillet J R Vogt T F Beier D R | 1991 | Cell1991，66，1： | 1 |
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