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| 1 | Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model显示文摘Osteoarthritis(OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor(EGFR) signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus(DMM) to induce OA in two mouse models with reduced EGFR activity, one with genetic modification(EgfrWa5/1mice) and the other one with pharmacological inhibition(gefitinib treatment). Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13(MMP13), the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2a(HIF2a), a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation. | Xianrong Zhang Ji Zhu Fei Liu Yumei Li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto Ling Qin | 2014 | Bone Research2014，2，3： | 9 |
| 2 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 3 | Emerging Frontiers in cartilage and chondrocyte biology显示文摘 | Amanda J. Fosang Frank Beier | 2011 | Best Practice & Research Clinical Rheumatology2011，，6： | 1 |
| 4 | Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth显示文摘 | Shirine E. Usmani Michael A. Pest Gunwoo Kim Sara N. Ohora Ling Qin Frank Beier | 2012 | Bone2012，，1： | 1 |
| 5 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 6 | Mechanical performance of carbon fibre-reinforced composites based on pre forms stitched with innovative low-melting temperature and ma- trix soluble thermoplastic yarns显示文摘 | Uwe Beier Felipe Wolff-Fabris Frank Fischer et aI | 2008 | Composites2008，39，9： | 1 |
| 7 | Identification of immunodominant antigens from Helicobacter pylori and evaluation of their reactivities with sera from patients with different gastroduodenal pathologies 显示文摘 | Kimmel B Bosserhoff A Frank R Gross R Goebel W Beier D | 2000 | Infect Immun2000，68，2： | 1 |
| 8 | Targeting oxidative stress to reduce Osteoarthritis显示文摘 | Blandine Poulet and Frank Beier | 2016 | Arthritis Research&Therapy2016，18，： | 1 |
| 9 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 10 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 11 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 12 | Impacts of Elevated Carbon Dioxide and Temperature on a Boreal Forest Ecosystem (CLIMEX Project)显示文摘 | Nico van Breemen Alan Jenkins Richard F. Wright David J. Beerling Wim J. Arp Frank Berendse Claus Beier Rob Collins Douwe van Dam Lennart Rasmussen Paul S. J. Verburg Mark A. Wills | 1998 | Ecosystems1998，，4： | 1 |
| 13 | Human stanniocalcin-1 or -2 expressed in mice reduces bone size and severely inhibits cranial intramembranous bone growth显示文摘 | Jennifer Johnston Yudith Ramos-Valdes Lee-Anne Stanton Sadia Ladhani Frank Beier Gabriel E. DiMattia | 2010 | Transgenic Research2010，，6： | 1 |
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