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| 1 | microRNAs and ceRNAs: RNA networks in pathogenesis of cancer显示文摘microRNAs (miRNAs) are a class of endogenous, single-stranded non-coding RNAs of 2023 nucleotides in length, functioning as negative regulators of gene expression at the post-transcriptional level. The dysregulation of miRNAs has been demonstrated to play critical roles in tumorigenesis, either through inhibiting tumor suppressor genes or activating oncogenes inappropriately. Besides their promising clinical applications in cancer diagnosis and treatment, recent studies have uncovered that miRNAs could act as a regulatory language, through which messenger RNAs, transcribed pseudogenes, and long noncoding RNAs crosstalk with each other and form a novel regulatory network. RNA transcripts involved in this network have been termed as competing endogenous RNAs (ceRNAs), since they influence each other's level by competing for the same pool of miRNAs through miRNA response elements (MREs) on their target transcripts. The discovery of miRNA-ceRNA network not only provides the possibility of an additional level of post-transcriptional regulation, but also dictates a reassessment of the existing regulatory pathways involved in cancer initiation and progression. | Xiangqian Su Jiadi Xing Zaozao Wang Lei Chen Ming Cui Beihai Jiang | 2013 | Chinese Journal of Cancer Research2013，25，2： | 13 |
| 2 | Biodegradation of geosmin in drinking water by novel bacteria isolated from biologically active carbon显示文摘Three strains of Gram-negative bacteria capable of removing geosmin from drinking water were isolated from biologically active carbon and identified to be Chryseobacterium sp., Sinorhizobium sp. and Stenotrophomonas sp. based on physio-biochemistry analysis and 16S rRNA gene sequence analysis. Removal efficiencies of 2 mg/L geosmin in mineral salts medium were 84.0%, 80.2% and 74.4% for Chryseobacterium sp., Sinorhizobium sp. and Stenotrophomonas sp., respectively, while removal efficiencies of 560 ng/L geosmin in filter influent were 84.8%, 82.3% and 82.5%, respectively. The biodegradation of geosmin was determined to be a pseudo first-order reaction, with rate constants at 2 mg/L and 560 ng/L being 0.097 and 0.086 day 1 , 0.089 and 0.084 day 1 , 0.074 and 0.098 day 1 for the above mentioned degraders, respectively. The biomass of culture in the presence of geosmin was much higher than that in the absence of geosmin. | Beihai Zhou Rongfang Yuan Chunhong Shi Liying Yu Junnong Gu Chunlei Zhang | 2011 | Journal of Environmental Sciences2011，23，5： | 9 |
| 3 | Biodegradation of 2-methylisoborneol by bacteria enriched from biological activated carbon显示文摘在喝水的最普通的味道和气味混合物(TOC ) 之一是不能被常规水处理乐意地移开的 2-methylisoborneol (2-MIB ) 。为降级的 2-MIB 的四细菌的紧张从一个生物的激活的碳过滤器的表面被孤立,并且作为小球菌 spp 被描绘,黄质菌属 spp, Brevibacterium spp。并且 Pseudomonas spp。基于 16S rRNA 分析。有 515 ng 的起始的集中的 2-MIB 的移动效率 ??? ????????????????????????????????? 漠 ? 桴 ? 瑳敲杮桴 ? | Rongfang YUAN Beihai ZHOU Chunhong SHI Liying YU Chunlei ZHANG Junnong GU | 2012 | Frontiers of Environmental Science & Engineering2012，6，5： | 6 |
| 4 | An Analysis of the Meaning of Generics | Mao Yi, Ph.D. of Philosophy received from the University of Texas at Austin, Master of Computer Sciences gained at UT-Austin. Zhou Beihai, Professor of Logic in the Department of Philosophy at Peking University, | 2003 | Social Sciences in China2003，24，3： | 4 |
| 5 | Blind signal separation of underdetermined mixtures based on clustering algorithms on planes显示文摘Based on clustering method on planes, blind signal separation (BSS) of underdetermined mixtures with three observed signals is discussed. The condition of sufficient sparsity of the source signals is not necessary when clustering method on planes is used. In other words, it needs not that only one source signal plays the main role among others at one time. The proposed method uses normal line clustering of planes first. Then, the mixing matrix can be identified via deciding the intersection lines of the planes. This method is an effective implement of the new theory presented by Georgiev. Simulations illustrate accuracy and restoring capability of the method to estimate the mixing matrix. | Xie Shengli Tan Beihai Fu Yuli | 2007 | Progress in Natural Science:Materials International2007，17，6： | 2 |
| 6 | Effect of metal ion-doping on characteristics and photocatalytic activity of Ti02 nanotubes for removal of humic acid from water显示文摘 | Rongfang YUAN | 2015 | Frontiers of Environmental Science & Engineering2015，9，5： | 2 |
| 7 | Optimal Groundwater Development in Coastal Aquifers Near Beihai, China显示文摘Groundwater resources occur in a multi aquifer system in the alluvial coastal plain near Beihai, China. The aquifers receive recharge from precipitation, canal and reservoir infiltration, and discharge through subterranean drainage into the sea and through artificial pumping. A quasi three dimensional finite element model has been used to simulate the spatial and temporal distribution of groundwater levels in the aquifers. Various input parameters were considered in the simulation model. A linear optimization model has been developed for groundwater development within the coastal aquifers. The objective function of the model is to maximize the total groundwater pumpage from the confined aquifer. The control of sea water intrusion is examined by the restriction of the water levels at points along the coast and of the pumping rates in coastal management cells. The response matrix used in the optimization model was generated from the simulation model by forecasting drawdown produced by pumping at a unit impulse discharge. Groundwater development can be primarily optimized by the alteration of the pumping rates of the existing wells. | Zhou Xun Chen Mingyou Wan Li Department of Water Resources and Environmental Engineering, China University of Geosciences, Beijing 100083, China Wang Juping Ning Xuesheng Beihai Institute of Hydrogeology, Engineering Geology and Mineral Resour | 2000 | Journal of Earth Science2000，19，3： | 2 |
| 8 | Source number estimation and separation algorithms of underdetermined blind separation显示文摘Recently,sparse component analysis (SCA) has become a hot spot in BSS re-search. Instead of independent component analysis (ICA),SCA can be used to solve underdetermined mixture efficiently. Two-step approach (TSA) is one of the typical methods to solve SCA based BSS problems. It estimates the mixing matrix before the separation of the sources. K-means clustering is often used to estimate the mixing matrix. It relies on the prior knowledge of the source number strongly. However,the estimation of the source number is an obstacle. In this paper,a fuzzy clustering method is proposed to estimate the source number and mixing matrix simultaneously. After that,the sources are recovered by the shortest path method (SPM). Simulations show the availability and robustness of the proposed method. | YANG ZuYuan TAN BeiHai ZHOU GuoXu ZHANG JinLong | 2008 | Science in China(Series F)2008，51，10： | 2 |
| 9 | Genetic algorithms on documents clustering 显示文摘 | ZHONG Sheng LIN Zhiwei ZHANG Beihai | 2008 | Journal of Computational Information Systems2008，4，3： | 1 |
| 10 | A novel peptide isolated from a phage display peptide library with trastuzumab can mimic antigen epitope of HER-2显示文摘 | Jiang Beihai Liu Wenbin Qu Hong | 2005 | J Biol Chem2005，280，6： | 1 |
| 11 | Clinical Pathologic Study on Effect of Qianggan Capsule (强肝胶囊) in Treating Patients of Chronic Hepatitis B with Liver Cirrhosis显示文摘Objective: To explore the clinical therapeutic effect of Qianggan Capsule (QGC) in treating chronic hepatitis B with liver fibrosis from the pathological aspect. Methods: Sixty three patients of chronic hepatitis B with liver fibrosis were randomly divided into the treated group (n=45) and the control group (n=18). Both groups were treated with general liver protective drugs, such as Glucurone and vitamins B complex for 6 months. To the treated group, QGC was used additionally. The levels of serum alanine transaminase and liver fibrosis indexes including hyaluronic acid (HA), collagen type Ⅳ (C Ⅳ) and laminin (LN) as well as the pathological examination of liver biopsy were observed before and after treatment. Results: The liver cirrhosis indexes, HA, C Ⅳ and LN, were improved significantly in the treated group after treatment, P <0.05. The liver function improvement rate in the treated group and the control group was 90.3% and 66.7% respectively, comparison of the two groups showed insignificant difference, P >0.05. Pathological examination showed that the effective rate of treatment on liver inflammatory necrosis activity grade in the treated group was 57.8% and that on liver fibrosis stage was 75.6%, which were significantly improved as compared with those before treatment ( P <0.05 and P <0.01), while in the control group, no significant improvement was found after treatment ( P >0.05). Conclusion: QGC has marked effects in reversing liver fibrosis and alleviating hepatic inflammatory necrosis in patients of chronic hepatitis B with liver fibrosis, and could lower the serum liver fibrosis related indexes effectively. | YANG Liuming(杨柳明) ZHAO Yanlong(赵延龙) WU Zhirong(吴志荣) CHEN Dufang(陈杜芳) CHEN Zhuoying(岑卓英) XU Kecheng(徐克成) ZUO Jiansheng(左建生) WEI Beihai(危北海) ZHANG Wandai(张万岱) | 2002 | Chinese Journal of Integrative Medicine2002，8，2： | 1 |
| 12 | Optimized environmental conditions for petroleum degra- dation of strain B1 by orthogonal test显示文摘 | WU Chunxu ZHANG Hongtao ZHOU Beihai | 2012 | Advanced Materials Research2012，，393395： | 1 |
| 13 | A novel peptide isolated from a phage display peptide library with trastuzumab can mimic antigen epitope of HER-2显示文摘 | Beihai Jiang Wenbin Liu Hong Qu | 2005 | J Biol Chem2005，280，6： | 1 |
| 14 | A novel peptide isolated from a phage display peptide library with trastuzumab can mimic antigen epitope of HER-2显示文摘 | Beihai Jang Wenbin Liu Hong Qu | 2005 | J Biol Chem2005，280，6： | 1 |
| 15 | A peptide fusion protein inhibits angiogenesis and tumor growth by blocking VEGF binding to KDR显示文摘Vascular endothelial growth factor (VEGF) binding to its tyrosine kinase receptors (KDR/FLK1, Flt-1) induces angiogenesis. In search of the peptides blocking VEGF binding to its receptor KDR/FLK1 to inhibit tumor-angiogenesis and growth, we screened a phage display pep-tide library with KDR as target protein, and some candidate peptides were isolated. In this study, we cloned the DNA fragment coding the peptide K237 from the library, into a vector pQE42 to express fusion protein DHFR-K237 in E. coli M15. The affection of fusion protein DHFR-K237 on endothelial cell proliferation and angiogenesis was investigated. In vitro, DHFR-K237 could completely block VEGF binding to KDR and significantly inhibit the VEGF-medi-ated proliferation of the human vascular endothelial cells. In vivo, DHFR-K237 inhibited angiogenesis in chick embryo chorioa- llantoric membrane and tumor growth in nude mice. These results suggest that K237 is an effective antagonist of VEGF binding to KDR, and could be a potential agent | LEI Hetian SHOU Chengchao LIU Xiaoyin HE Luowen WU Jian JIANG Beihai LIU Meisheng YANG Junshan | 2002 | Chinese Science Bulletin2002，47，8： | 1 |
| 16 | Distribution Pattern of Plant Populations of Rhizophora stylosa Community in Yingluo Bay of Guangxi显示文摘This paper deals with the distribution pattern type,aggregative intensity,pattern scaleand dynamics of plant populations of Rhizophora stylosa community in Yingluo Bay of Guangxi.The measured results show that R.stylosa population is an aggregated distribution,while thepopulations of Kandelia candel,Bruguiera gymnorrhiza and Aegiceras corniculatum appear asrandom distribution.The plant population distribution pattern changes,along with the populationdevelopment and the succession of the community. | Liang Shichu Fan Hangqing (Guangxi Mangrove Research Centre,Beihai 536000) | 1993 | 广西科学院学报1993，9，2： | 1 |
| 17 | A Proposal for the International Cooperation of Mangrove Ecosystem Studies in Guangxi of China显示文摘In the present paper,the situations concerning mangroves in Guangxi,China werereviewed with focus on resources,scientific research and natural conservation.The urgentproblems,related to coastal mangroves,were given out as some research projects for theconsiderations of foreign scientists and managers.On this basis,a favourable local study site ofmangrove ecosystem was introduced in detail. | Fan Hangqing (Guangxi Mangrove Research Centre,Beihai 536000) | 1993 | 广西科学院学报1993，9，2： | 1 |
| 18 | Antimicrobial and Thermal-Responsive Layer-by-Layer Assembly Based on Ionic-Modified Guanidine Polymer and PVA显示文摘 | Yuanfeng Pan Huining Xiao Guanglei Zhao Beihai He | 2008 | Polymer Bulletin2008，，5： | 1 |
| 19 | P37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR显示文摘 | Manman Gong Lin Meng Beihai Jiang | 2008 | Mol Cancer Ther2008，7，3： | 1 |
| 20 | P37 from Mycoplasma- hyorhinis promotes cancer cell? invasiveness and metastasis through activation of MMP - 2 and followed by phosphorylation of EGFR显示文摘 | Manman Gong Lin meng Beihai Jiang | 2008 | Mol Cancer Ther2008，7，3： | 1 |
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