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76篇 您的检索式：作者名="Beil M"

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	题名	作者	年代	出处	被引量
1	Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans.	Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier	2018	Bone Research2018，6，1：	5
2	Integration and acceleration of virtual microscopy as the key to successful implementation into the routine diagnostic process显示文摘	Wienert S Beil M Saeger K	2009	Diagn Pathol2009，4，：	1
3	Differential glucocorticold effects on repair mechanisms and NF-kappaB activity in the intestinal epithelium显示文摘	Goke M N Schneider M Beil W	2002	RegulPept2002，105，3：	1
4	An inverse-optimization-based auction mechanism to support a multi- attribute RFQ process显示文摘	Beil D R Wein L M	2003	Management Science2003，49，11：	1
5	A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein显示文摘	Spiess C Beil A Ehrmann M	1999	Cell1999，97，3：	1
6	An inverse-optimization-based auction mechanism to support a multi-attribute RFQ process显示文摘	Beil D R Wein L M	2003	Management Science2003，49，11：	1
7	An inverse-optimization-based auction mechanism to support a multiattribute RFQ process显示文摘	Beil D R Wein L M	2003	Management Science2003，49，11：	1
8	Effects of in- creased bone formation on fracture healing in mice 显示文摘	Beil FT Barvencik F Gebauer M	2011	J Trauma2011，70，4：	1
9	Mechanical evaluation of different techniques for achilles tendon repair显示文摘	Gebauer M Beil FT Beckmann J et al	2007	Arch Orthop Trauma Surg2007，127，9：	1
10	Boote, does the medium matter?:A compari- son of a Web -based tutorial with face-to-face library instruction on education students' self-efficacy levels and learning outcomes 显示文摘	Beile P M David N	2004	Research Strategies2004，20，12：	1
11	An inverse-optimization-based auction mechanism to support a multi-attribute RFQ process显示文摘	Beil D R Wein L M	2003	Management Science2003，49，11：	1
12	Other Duties as Assigned: Emerging Trends in the Academic Library Job Market显示文摘	Beile P M Adams M M	2000	College & Research Libraries2000，，4：	1
13	Leptin inhibits boneformation through a hypothalamic relay:a central control of bone mass显示文摘	Ducy P Amling M Takeda S Priemel M Schilling AF Beil FT Shen J Vinson C Rueger JM Karsenty G		0，，：	1
14	Different modes of NF- kappa B/Rel activation in pancreatic lobules显示文摘	Algul H Tando Y Beil M	2002	Am J Physiol Gastrointest Liver Physiol2002，283，：	1
15	Age and sexrelated changes of humeral head microarchitecture:histomorphometric analysis of 60 human specimens显示文摘	Barvencik F Gebauer M Beil FT	2010	J Orthop Res2010，28，：	1
16	Outcome followingcarotid endarterectomy: lessons learned from a large inter- national vascular registry显示文摘	Menyhei G Bjorck M Beiles B	2011	Eur J Vasc Endovasc Surg2011，41，6：	1
17	An Inverse-optimization-based Auction Mechanism to Support a Multiattribute RFQ Process显示文摘	Beil D R and Wein L M	2003	Management Science2003，49，11：	1
18	Number, fixation properties, dye - binding and protease expression of duodenal mast cells : comparisons between healthy subjects and patients with gastritis or Crohn's disease 显示文摘	Beil WJ Schulz M McEuen AR	1997	Histochem J1997，29，10：	1
19	A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein 显示文摘	Spiess C Beil A Ehrmann M	1999	Cell1999，97，3：	1
20	An inverse-optimization-based auction mechanism to support a multi-attribute RFQ process 显示文摘	Beil D R Wein L M	2003	Man-agement Science2003，49，11：	1

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