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您的检索式：作者名="Tayfun Yilmaz"
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| 1 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 2 | Case report: Percutaneous nephrolithotomy for an ectopic kidney with stone disease显示文摘 | Ali Güne? Murat U?ra? U?ur Yilmaz Aliseydi Bozkurt Tayfun Gürpinar | 2002 | International Urology and Nephrology2002，，1： | 1 |
| 3 | Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9显示文摘 | Bulent Yilmaz Ayhan Sucak Sevtap Kilic Orhan Aksakal Yasemin Aksoy Nese Lortlar Necdet Sut Tayfun Gungor | 2010 | American Journal of Obstetrics and Gynecology2010，，4： | 1 |
| 4 | 45,XY,der(13;14)(q10;q10)in an azoospermic man with hypogonadotrophic hypogonadism显示文摘Dear Sir,I am Feride Iffet Sahin in Baskent University Facultyof Medicine,Department of Medical Genetics,Ankara,Turkey.We write to you about a case of 45,XY,der(13;14)(q10;q10) in an azoospermic man as a result of hypo-gonadotrophic hypogonadism.The most frequent form of Robertsonian transloca-tion is between chromosomes 13 and 14 [1].It is re-ported to be a cause of male infertility [2-4].The fre-quency of Robertsonian translocation among infertile menhas been reported to be 1%,which is higher than that ofthe normal newborn population [2,5].The translocatedchromosomes cause inappropriate pairing during malemeiosis and hinder normal sperm production,resultingin oligo-and azoospermia.A 34-year-old male patient was referred to the De-partment of Medical Genetics from the Department ofObstetrics and Gynecology,Baskent University Facultyof Medicine,for chromosome analysis and Y microdeletiontesting because of azoospermia as a result of hypogona-dotropic hypogonadism.During genetic counseling,we learned that the patientwas one of the seven children of a nonconsanguineousmarried couple.The patient's mother had no miscar-riages in her obstetric history.All his married siblings(three sisters and three brothers) had healthy children. | Ozge Ozalp Zerrin Yilmaz Esra Bulgan Kilicdag Filiz Bolat Tayfun Bagis Feride Iffet Sahin | 2006 | Asian Journal of Andrology2006，8，6： | 0 |
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