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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Polyamines reduces lipid peroxidation induced by different pro-oxidant agents显示文摘 | Nádia Aléssio Velloso Bellé Gerusa Duarte Dalmolin Graciela Fonini Maribel Antonello Rubin Jo?o Batista Teixeira Rocha | 2004 | Brain Research2004，，2： | 3 |
| 3 | Insulin-mimetic compound hexaquis(benzylammonium) decavanadate is antilipolytic in human fat cells显示文摘AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate(B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids(FFA) and glucose circulating levels.METHODS Adipose tissue(AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents(insulin,benzylamine,vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake assay.RESULTS In all the species studied, B6V10 exhibited a dosedependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but-similarly to benzylamine-without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells. CONCLUSION B6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance. | Christian Carpéné Silvia Garcia-Vicente Marta Serrano Luc Marti ChloéBelles Miriam Royo Jean Galitzky Antonio Zorzano Xavier Testar | 2017 | World Journal of Diabetes2017，8，4： | 2 |
| 4 | Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic esophagitis: A prospective study显示文摘 | Alfredo J. Lucendo ángel Arias Livia C. De Rezende Jose Luis Yagüe-Compadre Teresa Mota-Huertas Sonia González-Castillo Rubén A. Cuesta José M. Tenias Teresa Bellón | 2011 | The Journal of Allergy and Clinical Immunology2011，，： | 2 |
| 5 | The European Cancer Anaemia Survey (ECAS): A large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients显示文摘 | Heinz Ludwig Simon Van Belle Peter Barrett-Lee Gunnar Birgeg?rd Carsten Bokemeyer Pere Gascón Paris Kosmidis Maciej Krzakowski Johan Nortier Patrizia Olmi Maurice Schneider Dirk Schrijvers | 2004 | European Journal of Cancer2004，，15： | 2 |
| 6 | An analysis of the in vitro and in vivo phenotypes of mutants of herpes simplex virus type 1 lacking glycoproteins gG, gE, gIor the putative gJ显示文摘 | Balan P Davis-Poynter N Bell S | 1994 | J Gen Virol1994，75，6： | 1 |
| 7 | A annotated checklist of the mosses of Europe and Macaronesia 显示文摘 | Hill M O Bell N Bruggeman-Nannenga M A | 2006 | Journal of Bryology2006，28，： | 1 |
| 8 | Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle显示文摘 | BELL S P SACK M N PATEL A | 2000 | J Am Coll Cardiol2000，36，7： | 1 |
| 9 | Association of ICUor hospital admission with unintentional discontinuationof medications for chronic diseases显示文摘 | Bell CM Brener SS Gunraj N | 2011 | JAMA2011，306，8： | 1 |
| 10 | Ammonia emissions and their role in acid deposition 显示文摘 | Apsimon H M Kruse M Bell J N B | 1987 | Atmospheric Environment1987，21，： | 1 |
| 11 | Development of a Water Detritiation Facility for JET 显示文摘 | Perevezentsev A N Bell A C | 2002 | Fusion Eng Des2002，6162，： | 1 |
| 12 | Association of ICU or hospital admission with unintentional discontinuation of medications for chronic diseases 显示文摘 | Bell CM Brener SS Gunraj N | 2011 | JAMA2011，306，8： | 1 |
| 13 | Androgens stimulate gonadotropin-II beta-subunit in eel pituitary cells in vitro 显示文摘 | Huang Y S Schmitz M Le Belle N | 1997 | Molecular and Cellular Endocrinology1997，131，2： | 1 |
| 14 | Oral valproic acid for epilepsy--long-term experience in therapy and side effects显示文摘 | Gerstner T Bell N Konig S | 2008 | Expert Opin Pharmacother2008，9，2： | 1 |
| 15 | Hypoxia Imaging in Gliomas With 18F-Fluoromisonidazole PET: Toward Clinical Translation 显示文摘 | Bell C Dowson N Fay M | 2015 | Semin Nucl Med2015，45，2： | 1 |
| 16 | Safety andefficacy of epicardial cryoablation in a canine model显示文摘 | Bell S Hardin N | 2005 | Heart Rhythm2005，2，1： | 1 |
| 17 | Implicit Versus Explicit Nature of Science Instruction: An Explicit Response to Palmquist and Finley 显示文摘 | Bell R L Lederman N G Abd-EI-Khalick F | 1998 | Journal of Research in Science Teaching1998，35，： | 1 |
| 18 | Development and application of molecular marker linkage maps in woody fruit crops显示文摘 | N F Weeden M Hemmatt D M Lawson M Lodhi R L Bell A G Manganaris B I Reischs S K Brown G N Ye | 1994 | Euphytica1994，77，12： | 1 |
| 19 | Use of molecular markers in a breeding program for Corus florida显示文摘 | Trigiano R N Schlarbaum S E Bell L M | 1996 | Proc Southern Nurseryman’s Res Conf1996，41，： | 1 |
| 20 | Hybrid graphene/titania nanocomposite:interface charge transfer,hole doping,and sensitization for visible light response显示文摘 | DU A NG Y H BELL N J | 2011 | J Phys Chem Lett2011，2，： | 1 |
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