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| 1 | Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth显示文摘Bone morphogenetic proteins(Bmp) are well-known to induce bone formation following chondrogenesis,but the direct role of Bmp signaling in the osteoblast lineage is not completely understood. We have recently shown that deletion of the receptor Bmpr1 a in the osteoblast lineage with Dmp1-Cre reduces osteoblast activity in general but stimulates proliferation of preosteoblasts specifically in the cancellous bone region,resulting in diminished periosteal bone growth juxtaposed with excessive cancellous bone formation.Because expression of sclerostin(SOST), a secreted Wnt antagonist, is notably reduced in the Bmpr1 adeficient osteocytes, we have genetically tested the hypothesis that increased Wnt signaling might mediate the increase in cancellous bone formation in response to Bmpr1 a deletion. Forced expression of human SOST from a Dmp1 promoter fragment partially rescues preosteoblast hyperproliferation and cancellous bone overgrowth in the Bmpr1 a mutant mice, demonstrating functional interaction between Bmp and Wnt signaling in the cancellous bone compartment. To test whether increased Wnt signaling can compensate for the defect in periosteal growth caused by Bmpr1 a deletion, we have generated compound mutants harboring a hyperactive mutation(A214 V) in the Wnt receptor Lrp5. However, the mutant Lrp5 does not restore periosteal bone growth in the Bmpr1 a-deficient mice. Thus, Bmp signaling restricts cancellous bone accrual partly through induction of SOST that limits preosteoblast proliferation, but promotes periosteal bone growth apparently independently of Wnt activation. | Guangxu He Yu Shi Joohyun Lim Teresita Bellido Jiangdong Ni Fanxin Long | 2017 | Bone Research2017，5，3： | 3 |
| 2 | A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis显示文摘Cell source is the key to decellularized matrix(DM)strategy.This study compared 3 cell types,osteocytes with/without dominant active Wnt/β-catenin signaling(daCO and WTO)and bone marrow stromal cells(BMSCs)for their DMs in bone repair.Decellularization removes all organelles and>95%DNA,and retained>74%collagen and>71%GAG,maintains the integrity of cell basement membrane with dense boundaries showing oval and honeycomb structure in osteocytic DM and smooth but irregular shape in the BMSC-DM.DM produced higher cell survival rate(90%)and higher proliferative activity.In vitro,daCO-DM induces more and longer stress fibers in BMSCs,conducive to cell adhesion,spreading,and osteogenic differentiation.8-wk after implantation of the critical-sized parietal bone defect model,daCO-DM formed tight structures,composed of a large number of densely-arranged type-I collagen under polarized light microscope,which is similar to and integrated with host bone.BV/TV(>54%)was 1.5,2.9,and 3.5 times of WTO-DM,BMSC-DM,and none-DM groups,and N.Ob/T.Ar(3.2×10^(2)/mm^(2))was 1.7,2.9,and 3.3 times.At 4-wk,daCO-DM induced osteoclastogenesis,2.3 times higher than WTO-DM;but BMSC-DM or none-DM didn't.daCO-DM increased the expression of RANKL and MCSF,Vegfa and Angpt1,and Ngf in BMSCs,which contributes to osteoclastogenesis,angiogenesis,and neurogenesis,respectively.daCO-DM promoted H-type vessel formation and nerve markersβ3-tubulin and NeuN expression.Conclusion:daCO-DM produces metabolic and neurovascularized organoid bone to accelerate the repair of bone defects.These features are expected to achieve the effect of autologous bone transplantation,suitable for transformation application. | Xiaofang Wang Yufei Ma Jie Chen Yujiao Liu Guangliang Liu Pengtao Wang Bo Wang Makoto M.Taketo Teresita Bellido Xiaolin Tu | 2023 | Bioactive Materials2023，，3： | 2 |
| 3 | Lipoprotein Ca ) and other lipoproteins in hypothyroid patients before and after thyroid re?placement therapy显示文摘 | Becerra A Bellido D Luengo A | 2007 | Clinical Nutrition2007，18，5： | 1 |
| 4 | Continuous improvement of arterial compliance beyond blood pressure decrease after 5 years of antihypertensive treatment显示文摘 | Bellido CA Iavicoli OR Rusak EJ | 2006 | J Clin Hypertens (Greenwich)2006，8，8： | 1 |
| 5 | Reactivation of hepatitis B in an HIV-infected patient with antibodies against hepatitis B core antigen as the only serological marker显示文摘 | A. J. Chamorro J. L. Casado D. Bellido S. Moreno | 2005 | European Journal of Clinical Microbiology & Infectious Diseases2005，，7： | 1 |
| 6 | Nongenotropic,sex-nonspecific signaling through the estrogen or androgen receptors:dissociation from transcriptional activity显示文摘 | Bellido T Plotkin LI | 2001 | Cell2001，104，5： | 1 |
| 7 | Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT 显示文摘 | Almeida M Han L Bellido T | 2005 | J Biol Chem2005，280，41： | 1 |
| 8 | Oral cephalosporins: current perspectives显示文摘 | Garcia-Rodriguez JA Mufioz Bellido JL Garcia Stnchez JE | 1995 | Int J Antimicrob Agents1995，5，4： | 1 |
| 9 | In- creased density of galanin binding sites in the dorsal raphe in a genetic rat model of depression显示文摘 | Bellido I Diaz-Cabiale Z Jim6nez-Vasquez PA | 2002 | Neurosci Lett2002，317，2： | 1 |
| 10 | Tetraeyclic triterpenes and nerolidol derivatives from Santolina oblongifolia 显示文摘 | Pascual Terasa JD Bellido IS Gonzalez MS | 1986 | Phytochemistry1986，25，1： | 1 |
| 11 | Proteome, salicylic add, and jasmonic acid changes in cucumber plants inoculated with Trichoderma asperellum strain T34 显示文摘 | Segarca G Casanova E Bellido D | 2007 | Proteomics2007，7，21： | 1 |
| 12 | Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines显示文摘 | Jilka RL Weisein RS Bellido T | 1998 | J Bone Miner Res1998，13，5： | 1 |
| 13 | Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone显示文摘 | Jilka RL Weinstein RS Bellido T Roberson P Parfitt AM Mano-lagas SC | | 0，，： | 1 |
| 14 | Indications for and Survival After Liver Retransplantation显示文摘 | C.B. Bellido J.M.A. Martínez L.M.M. Gómez G.S. Artacho J.S. Diez-Canedo L.B. Pulido J.M.P. Acevedo M.á.G. Bravo | 2010 | Transplantation Proceedings2010，，2： | 1 |
| 15 | Effects of a cross-linkingenzyme on the protein composition,mechanical properties,and microstructure of Chinese-style noodles显示文摘 | G G Bellido D W Hatcher | 2011 | FoodChemistry2011，125，： | 1 |
| 16 | Osteoblast pro grammed cell death (apoptosis) : modulation by growth factors and cytokines 显示文摘 | Jilka RL Weinstein RS Bellido T | 1998 | J Bone Miner Res1998，13，5： | 1 |
| 17 | In vitro susceptibility of community-acquired urinary tract pathogens to commonly used antimicrobial agents in Spain:a comparative multicenter study (2002–2004)显示文摘 | GARCIA GARCIA M I MUNOZ BELLIDO J L GARCIA RODRIGUEZ J A | 2007 | J Chemother2007，19，3： | 1 |
| 18 | Non-steroidal anti-inflammatory drugs (NSAIDs) and ovulation: lessons from morphology显示文摘 | Gaytan M Morales C Bellido C | 2006 | Histol Histopathol2006，21，5： | 1 |
| 19 | Flow cytometryanalysis of Leukocytes in induced sputum from asthmaticpatients显示文摘 | Vidal S Bellido Casado J Granel C | 2012 | Immunobiology2012，217，7： | 1 |
| 20 | Salmonella paratyphi B and Salmonella litchfield outbreaks associated with pet turtle exposure in Spain显示文摘 | Lafuente S Bellido JB Moraga FA | 2013 | Enferm Infect Microbiol Clin2013，31，1： | 1 |
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