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| 1 | 瑞典斯德哥尔摩市社区人群老年痴呆和阿尔茨海默病的危险因素队列研究显示文摘目的探讨老年痴呆和阿尔茨海默病(AD)的危险因素。方法在6年间(1991—1996 年)对斯德哥尔摩市一个社区非痴呆老年人群(n=1301,年龄≥75岁)进行两次随访检查,并按照美国老年精神病协会制订的DSM-Ⅲ-R标准诊断随访期间痴呆和AD新发病例。研究对象在基线调查时对有关因素暴露情况系经问卷调查、临床检查和查阅住院病例登记资料库等方法确定。采用Cox 比例风险模型对资料进行统计分析。结果随访期间共有350例被诊断为痴呆,包括260例AD患者。多因素分析结果显示,痴呆和AD发病的危险因素有年龄大、文化程度低、认知功能损害、体力活动障碍、低舒张压、糖尿病、缺血性心脏病和携带APOEε4基因。脑卒中和心房纤维颤动亦能增加痴呆的危险性,而服用抗高血压药物则可降低痴呆和AD发病的危险性。结论某些人口统计学因素、认知和体力功能障碍、血管性疾病及遗传易感性是老年痴呆和AD的重要危险因素;使用抗高血压药物及控制高血压相关的血管性疾病可能会降低痴呆发病的危险性。 | 仇成轩 Bengt Winblad Laura Fratiglioni | 2005 | 中华流行病学杂志2005，26，11： | 27 |
| 2 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 3 | Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer’s disease: randomised, double-blind, placebo-controlled, first-in-human study显示文摘 | Bengt Winblad Niels Andreasen Lennart Minthon Annette Floesser Georges Imbert Thomas Dumortier R Paul Maguire Kaj Blennow Joens Lundmark Matthias Staufenbiel Jean-Marc Orgogozo Ana Graf | 2012 | Lancet Neurology2012，，7： | 3 |
| 4 | Revised NIA-AA criteria for the diagnosis of Alzheimer’s disease: a step forward but not yet ready for widespread clinical use显示文摘 | Giovanni B. Frisoni Bengt Winblad John T. O’Brien | 2011 | International Psychogeriatrics2011，，8： | 2 |
| 5 | The effect of midlife physical activity on structural brain changes in the elderly显示文摘 | Suvi Rovio Gabriela Spulber Lasse J. Nieminen Eini Niskanen Bengt Winblad Jaakko Tuomilehto Aulikki Nissinen Hilkka Soininen Miia Kivipelto | 2008 | Neurobiology of Aging2008，，11： | 1 |
| 6 | The age-dependent relation of blood pressure to cognitive function and dementia显示文摘 | Chengxuan Qiu Bengt Winblad Laura Fratiglioni | 2005 | Lancet Neurol2005，4，： | 1 |
| 7 | Therapeu- tic Use of Nieergoline显示文摘 | Bengt Winblad Mario Fioravanti Tomas Dolezal | 2008 | Clin Drug Invest2008，28，9： | 1 |
| 8 | The prevalence of functional disability in activities of daily living and instrumental activities of daily living among elderly Beijing Chinese显示文摘 | Zhe Tang Hui-Xin Wang Chen Meng Xiao-Guang Wu Kjerstin Ericsson Bengt Winblad Jin-Jing Pei | 1999 | Archives of Gerontology and Geriatrics1999，，2： | 1 |
| 9 | Alzheimer’s disease: clinical trials and drug development显示文摘 | Francesca Mangialasche Alina Solomon Bengt Winblad Patrizia Mecocci Miia Kivipelto | 2010 | Lancet Neurology2010，，7： | 1 |
| 10 | Resection of Bronchial Chondroma through the Flexible Fiberoptic Bronchoscope显示文摘 | Rune Lundgren Bengt Winblad | 1980 | Endoscopy1980，，02： | 1 |
| 11 | Influence of social network on occurrence of dementia: a community-based longitudinal study显示文摘 | Laura Fratiglioni Hui-Xin Wang Kjerstin Ericsson Margaret Maytan Bengt Winblad | 2000 | The Lancet2000，，9212： | 1 |
| 12 | Pulse Pressure and Risk of Alzheimer Disease in Persons Aged 75 Years and Older: A Community-Based, Longitudinal Study显示文摘 | Chengxuan Qiu Bengt Winblad Matti Viitanen Laura Fratiglioni | 2003 | Stroke: Journal of the American Heart Association2003，，3： | 1 |
| 13 | Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study显示文摘 | Miia Kivipelto Tiia Ngandu Tiina Laatikainen Bengt Winblad Hilkka Soininen Jaakko Tuomilehto | 2006 | Lancet Neurology2006，，9： | 1 |
| 14 | Person-centred care of people with severe Alzheimer’s disease: current status and ways forward显示文摘 | David Edvardsson Bengt Winblad PO Sandman | 2008 | Lancet Neurology2008，，4： | 1 |
| 15 | The prevalence of functional disability in activities of daily living and instrumental activities of daily living among elderly Beijing Chinese显示文摘 | Zhe Tang Hui-Xin Wang Chen Meng Xiao-Guang Wu Kjerstin Ericsson Bengt Winblad Jin-Jing Pei | 1999 | Archives of Gerontology and Geriatrics1999，，2： | 1 |
| 16 | Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology显示文摘 | Masakazu Hashimoto Nenad Bogdanovic Inga Volkmann Mikio Aoki Bengt Winblad Lars O. Tjernberg | 2010 | Acta Neuropathologica2010，，5： | 1 |
| 17 | 老年痴呆疫苗初获成功显示文摘阿兹海默病疫苗CAD106在一期临床试验中表现良好,但尚需进一步的临床试验来证实其疗效。概述:阿兹海默病是一种极为常见的老年神经退行性疾病,或名老年痴呆,全世界有近2700万名患者。根据世界卫生组织的描述,老年痴呆是当下全球流行速度增长最快的疾病。目前,阿兹海默病无药可治,只有一些暂时性缓解症状的方法。 | Bengt Winblad | 2012 | 科技创业2012，，7： | 0 |
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