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| 1 | ABF2, ABF3, and ABF4 Promote ABA-Mediated Chlorophyll Degradation and Leaf Senescence by Transcriptional Activation of Chlorophyll Catabolic Genes and Senescence-Associated Genes in Arabidopsis显示文摘叶绿素(Chl ) 降级是叶老朽的一个不可分的过程,并且 NYE1/SGR1 在多样的工厂种类作为 Chl 分解代谢的一个关键管理者被表明了。在这研究,用屏蔽的酵母一个混血儿,我们识别了三 abscisic 酸(骆驼毛的织物) 应答的元素(ABRE ) 绑定抄写因素, ABF2 (AREB1 ) , ABF3,和 ABF4 (AREB2 ) , NYE1 倡导者的通常认为的有约束力的蛋白质。通过 transactivation 分析, electrophoretic 活动性移动试金,和染色质 immunoprecipitation,我们表明了直接跳到并且在 vitro 并且在 vivo 激活 NYE1 倡导者的那 ABF2, ABF3,和 ABF4。骆驼毛的织物是叶老朽的一个积极管理者,并且外长地适用骆驼毛的织物能加速 Chl 降级。ABF, abf2abf3abf4,以及二骆驼毛的织物感觉迟钝的异种, abi1-1 和 snrk2.2/2.3/2.6 的三倍的异种,在骆驼毛的织物处理以后的展出停留绿色显型,与 NYE1 和 NYE2 表示的减少的正式就职一起。相反, ABF4 的 overexpression 在骆驼毛的织物处理之上加速了 Chl 降级。有趣地, ABF2/3/4 能也激活二 Chl 分解代谢的酶基因, PAO 和 NYC1 的表达式,由对他们的倡导者直接有约束力。另外, abf2abf3abf4 展出了功能的停留绿色显型,和联系老朽的基因(下垂) 例如 SAG29 (SWEET15 ) ,可能被 ABF 直接调整。一起拿,我们的结果在调停作为关键管理者建议那 ABF2, ABF3,和 ABF4 可能的行为被触发骆驼毛的织物的 Chl 降级和叶老朽一般来说在 Arabidopsis。 | Shan Gao Jiong Gao Xiaoyu Zhu Yi Song Zhongpeng Li Guodong Ren Xin Zhou Benke Kuai | 2016 | Molecular Plant2016，9，9： | 27 |
| 2 | Age-Triggered and Dark-Induced Leaf Senescence Require the bHLH Transcription Factors PIF3, 4, and 5显示文摘叶老朽能被很多发展、环境的因素触发并且支持。证据的众多的线在叶老朽的规定建议了 phytochromes 的参与,但是相关发信号小径和生理的机制糟糕被理解。在这研究,我们开始识别了交往 phytochrome 因素(程序信息文件) 叶老朽的 3, 4,和 5 个同样通常认为的调停人。PIF 基因的变化在被触发年龄、导致黑暗的老朽导致了显著地提高的叶长寿,而这些基因的 overexpressions 在 Arabidopsis 加速了被触发年龄、导致黑暗的老朽。一致地,稀释导致黑暗的 transcriptional 改变的 PIF4 的 loss-of-function 把产生与叶绿体恶化和反应的氧种类(ROS ) 联系了。ChIPPCR 和双酶的试金证明 PIF4 能激活叶绿素降级规章的基因 NYE1 并且镇压由到他们的倡导者区域的绑定的叶绿体活动维护者基因 GLK2。最后,导致黑暗的乙烯生合成和导致乙烯的老朽两个都在 pif4 被阻抑,建议在乙烯生合成和发信号的小径的 PIF4 的参与。我们的学习提供证据那 PIF3, 4,和 5 是进轻发信号的机制的卓见在叶老朽的规定包含了的新奇积极老朽调停人和获得。 | Yi Song Chuangwei Yang Shan Gao Wei Zhang Lin Li Benke Kuai | 2014 | Molecular Plant2014，7，12： | 20 |
| 3 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 4 | Reverse Genetic Identification of CRN1 and its Distinctive Role in Chlorophyll Degradation in Arabidopsis显示文摘Recent identification of NYE1/SGR1 brought up a new era for the exploration of the regulatory mechanism of Chlorophyll (Chl) degradation.Cluster analysis of senescence associated genes with putative chloroplast targeting sequences revealed several genes sharing a similar expression pattern with NYE1.Further characterization of available T-DNA insertion lines led to the discovery of a novel stay-green gene CRN1 (Co-regulated with NYE1).Chl breakdown was significantly restrained in crn1-1 under diversified senescence scenarios,which is comparable with that in acd1-20,but much more severe than that in nye11.Notably,various Chl binding proteins,especially trimeric LHCP II,were markedly retained in crn1-1 four days after dark-treatment,possibly due to a lesion in disassociation of protein-pigment complex.Nevertheless,the photochemical efficiency of PSII in crn1-1 declined,even more rapidly,two days after dark-treatment,compared to those in Col-0 and nye1-1.Our results suggest that CRN1 plays a crucial role in Chl degradation,and that loss of its function produces various side-effects,including those on the breakdown of Ch-protein complex and the maintenance of the residual photosynthetic capability during leaf senescence. | Guodong Ren Qian Zhou Shouxin Wu Yufan Zhang Lingang Zhang Jirong Huang Zhenfei Sun Benke Kuai | 2010 | Journal of Integrative Plant Biology2010，52，5： | 8 |
| 5 | NON-YELLOWING2 (NYE2), a Close Paralog of NYE1, Plays a Positive Role in Chlorophyll Degradation in Arabidopsis显示文摘 | Wu, Shouxin Li, Zhongpeng Yang, Lifeng Xie, Zuokun Chen, Junyi Zhang, Wei Liu, Tianqi Gao, Shan Gao, Jiong Zhu, Yihua Xin, Jiwen Ren, Guodong Kuai, Benke | 2016 | Molecular Plant2016，9，4： | 6 |
| 6 | The Mystery of Mendel's Stay-Green: Magnesium Stays Chelated in Chlorophylls显示文摘 | Chen, Junyi Ren, Guodong Kuai, Benke | 2016 | Molecular Plant2016，9，12： | 4 |
| 7 | The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana显示文摘Endogenous salicylic acid(SA) regulates leaf senescence, but the underlying mechanism remains largely unexplored. The exogenous application of SA to living plants is not efficient for inducing leaf senescence. By taking advantage of probenazole(PBZ)-inducedbiosynthesisof endogenous SA, we previously established a chemical inducible leaf senescence system that depends on SA biosynthesis and its core signaling receptor NPR1 in Arabidopsis thaliana. Here,using this system, we identified WRKY46 and WRKY6 as key components of the transcriptional machinery downstream of NPR1 signaling. Upon PBZ treatment, the wrky46 mutant exhibited significantly delayed leaf senescence. We demonstrate that NPR1 is essential for PBZ/SA-induced WRKY46 activation, whereas WRKY46 in turn enhances NPR1 expression. WRKY46 interacts with NPR1 in the nucleus, binding to the W-box of the WRKY6 promoter to induce its expression in response to SA signaling. Dysfunction of WRKY6 abolished PBZ-induced leaf senescence, while overexpression of WRKY6 was sufficient to accelerate leaf senescence even under normal growth conditions, suggesting that WRKY6 may serve as an integration node of multiple leaf senescence signaling pathways. Taken together,these findings reveal that the NPR1-WRKY46-WRKY6 signaling cascade plays a critical role in PBZ/SA-mediated leaf senescence in Arabidopsis. | Dingyu Zhang Zheng Zhu Jiong Gao Xin Zhou Shuai Zhu Xiaoyan Wang Xiaolei Wang Guodong Ren Benke Kuai | 2021 | Journal of Integrative Plant Biology2021，63，5： | 3 |
| 8 | Biomineralization: Biomimetic Synthesis of Materials and Biomimetic Regulation of Organisms显示文摘What is the most favorite and original chemistry developed in your research group?The discovery of ionic oligomers and their crosslinking following a new concept of inorganic ionic polymerization.How do you get into this specific field?Could you please share some experiences with our readers?I got into the field of biomineralization when I was a graduate student.A challenge in biomineralization community is how we can achieve a moldable construction of inorganic materials(biominerals). | Zaiqiang Ma Benke Li Ruikang Tang | 2021 | Chinese Journal of Chemistry2021，39，8： | 2 |
| 9 | Modulation of cell surface GABA B receptors by desensitization,trafficking and regulated degradation显示文摘Inhibitory neurotransmission ensures normal brain function by counteracting and integrating excitatory activity.-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system,and mediates its effects via two classes of receptors:the GABA A and GABA B receptors.GABA A receptors are heteropentameric GABA-gated chloride channels and responsible for fast inhibitory neurotransmission.GABA B receptors are heterodimeric G protein coupled receptors (GPCR) that mediate slow and prolonged inhibitory transmission.The extent of inhibitory neurotransmission is determined by a variety of factors,such as the degree of transmitter release and changes in receptor activity by posttranslational modifications (e.g.,phosphorylation),as well as by the number of receptors present in the plasma membrane available for signal transduction.The level of GABA B receptors at the cell surface critically depends on the residence time at the cell surface and finally the rates of endocytosis and degradation.In this review we focus primarily on recent advances in the understanding of trafficking mechanisms that determine the expression level of GABA B receptors in the plasma membrane,and thereby signaling strength. | Dietmar Benke Khaled Zemoura Patrick J Maier | 2012 | World Journal of Biological Chemistry2012，3，4： | 2 |
| 10 | Sorption of selected cationic and neutral organic molecules on palygorskite and sepiolite显示文摘 | MERMUT A R BENKE M B | 1999 | Clays Clay Miner1999，47，1： | 1 |
| 11 | Occupational exp- osure to pesticides and risk of non-hodgkln' s lymphoma显示文摘 | FRITSCHI L BENKE G HUGHES A M | 2005 | Am J Epidemiol2005，162，9： | 1 |
| 12 | Concept and pattern of invertebrate production in runnig waters显示文摘 | Benke A C | 1993 | Verh Internat Verein Limnol1993，25，： | 1 |
| 13 | Synthesis of perrhenic acid using solvent extraction 显示文摘 | LESZCZYNSKA-SEJDA K BENKE G KROMPIEC S | 2009 | Hydrometallurgy2009，95，3： | 1 |
| 14 | Paraoxonase 192Gln→ Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adults显示文摘 | Voetsch B Benke KS Damasceno BP | 2002 | Stroke2002，33，： | 1 |
| 15 | Space and cognition: the measurement of behavioral functions during a six-day space mission显示文摘 | Koserenko O Watson NV | 1993 | Aviat Space Environ Med1993，64，5： | 1 |
| 16 | Atrial fibrillation-induced atrial contractile dysfunction:a taehycardiomyopathy of a differ- ent sort显示文摘 | Schotten U Greiser M Benke D | 2002 | Cardiovasc Res2002，53，： | 1 |
| 17 | Distribution and production of two crustaceans in a wetland pond显示文摘 | Martien R F Benke A C | 1977 | Am Midl Nat1977，98，： | 1 |
| 18 | In vitro study of ingested coins: leave them or retrieve them 显示文摘 | Rebhandl W Milassin A Brunner L Steffan I Benk T H? rmann M Burtscher J | 2007 | Pediatr Surg2007，42，10： | 1 |
| 19 | Language lateralizationin temporal lobe epilepsy:a comparison between fMRI andthe Wada Test显示文摘 | Benke T Koylu B Visani P | 2006 | Epilepsia2006，47，8： | 1 |
| 20 | Acute conduction aphasia:an analysis of 20 cases显示文摘 | Bartha L Benke T | 2003 | Brain and language2003，85，1： | 1 |
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