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| 1 | Fractal desulfurization kinetics of high-sulfur coal显示文摘The pore structure characteristics of high-sulfur coal from Wansheng in Chongqing have been studied by a nitrogen adsorption method (BET). The effects of grinding and pre-treating with nitric acid on the inorganic sulfur content of coal have been investigated. Organic sulfur in coal pretreated with nitric acid was desulfurized by using propylene-glycol-KOH (PG-KOH). Fractal kinetic properties of these two desulfurization procedures were investigated by using fractal geometric theory. The results show that both the specific surface area and pore volume increased with the decrease in particle diameter. The microspore surface of coal had fractal characteristics; the fractal dimension was 2.48. The sulfur content decreased with the decrease in particle diameter by grinding. After pretreatment with nitric acid, the desulfurization ratio (DFR) of inorganic sulfur increased to over 99% and the DFR of total sulfur to over 70%. The desulfurization procedure of inorganic sulfur had fractal kinetic characteristics; its reactive fractal dimension was 2.94. The organic sulfur desulfurization procedure by PG-KOH was also tallied with fractal kinetic properties; the reactive fractal dimension was 2.57. The effect of temperature on the desulfurization ratio of organic sulfur can be described with an Arrhenius empirical equation. The rate constant, pre-exponential factor and the activation energy of the reaction increased with the decrease in particle diameter. | Xu Longjun Peng Tiefeng Zhang Dingyue Zhang Fukaia | 2012 | International Journal of Mining Science and Technology2012，22，1： | 7 |
| 2 | Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients显示文摘In late December 2019,the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),was identified in Wuhan,China,and the ensuing pandemic has led to more than 50 million infected individuals and more than one million deaths by November 10,2020(http://gffzze7c39cdc9e894ca6spf0xu0cwuk5566cv.ffgz.tsg.suse.edu.cn/).Pathologic investigations of autopsy tissue have focused primarily on the lung,heart,and kidney,whereas morphologic data on testis injury and the effects of SARS-CoV-2 infection on spermatogenesis are limited.Although two groups did not detect SARS-CoV-2 in the semen or testes of recovered COVID-19 patients,1,2 another group confirmed SARS-CoV-2 in the semen of patients.3 Therefore,it is currently unknown whether SARS-CoV-2 infection impacts spermatogenesis and male fertility.In the present study,we evaluated the effects of SARS-CoV-2 infection on spermatogenesis by examining the pathophysiology and molecular features of testes obtained from five male COVID-19 patients at autopsy. | Xixiang Ma Chuhuai Guan Rong Chen Yunyun Wang Shenglei Feng Rongshuai Wang Guoqiang Qu Sijia Zhao Fengli Wang Xiaoli Wang Dingyu Zhang Liang Liu Aihua Liao Shuiqiao Yuan | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 3 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 4 | Recovery of the free field in noisy environment by using the spherical wave superposition method显示文摘To remove the scattering effect of the disturbing sound on the target source when implementing nearfield acoustic holography in a non-free field,a free field recovery technique based on the spherical wave superposition method is proposed.In the method,the sound field separation technique based on the spherical wave superposition method is first used to separate the incoming and outgoing fields,and a further step for separating the radiated and scattered fields is performed by utilizing the surface admittance of the target source as the boundary conc1ition.The technique makes it possible to correctly identify noise sources in a non-free sound feld.The basic principle of the technique is described firstly,a method for choosing the optimal number of spherical wave expansion terms is given,and two numerical simulations are used to demonstrate the validity of this technique.It is shown that,for the lower frequency,the scattering effect can be neglected,and the radiated field of the target source can be obtained by the sound field separation technique,however,as the increasing of the frequcncy,the scattering effcct cannot be neglected,and the frec field recovery technique has to be used to obtain the radiated field of the target source. | BI Chuanxing HU Dingyu XU Liang ZHANG Yongbin | 2014 | Chinese Journal of Acoustics2014，33，1： | 5 |
| 5 | RETRACTED ARTICLE:Human H9N2 Avian Influenza Infection:Epidemiological and Clinical Characterization of 16 Cases in China显示文摘The authors are retracting this paper owing to errors in the reported data.The paper claimed that 16 patient cases were infected with H9N2 virus.However,when the authors recently further investigated all the thirteen sera samples,no anti-H9N2 antibodies were found by the haemagglutination inhibition assay.Moreover,re-sequencing of the remaining five throat swabs showed all five samples were H1N1 virus. | Xuan Dong Jiasong Xiong Chaolin Huang Jie Xiang Wenjuan Wu Nanshan Chen Danning Wen Chao Tu Xueli Qiao Liang Kang Zhongzi Yao Dingyu Zhang Quanjiao Chen | 2021 | Virologica Sinica2021，36，3： | 3 |
| 6 | The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana显示文摘Endogenous salicylic acid(SA) regulates leaf senescence, but the underlying mechanism remains largely unexplored. The exogenous application of SA to living plants is not efficient for inducing leaf senescence. By taking advantage of probenazole(PBZ)-inducedbiosynthesisof endogenous SA, we previously established a chemical inducible leaf senescence system that depends on SA biosynthesis and its core signaling receptor NPR1 in Arabidopsis thaliana. Here,using this system, we identified WRKY46 and WRKY6 as key components of the transcriptional machinery downstream of NPR1 signaling. Upon PBZ treatment, the wrky46 mutant exhibited significantly delayed leaf senescence. We demonstrate that NPR1 is essential for PBZ/SA-induced WRKY46 activation, whereas WRKY46 in turn enhances NPR1 expression. WRKY46 interacts with NPR1 in the nucleus, binding to the W-box of the WRKY6 promoter to induce its expression in response to SA signaling. Dysfunction of WRKY6 abolished PBZ-induced leaf senescence, while overexpression of WRKY6 was sufficient to accelerate leaf senescence even under normal growth conditions, suggesting that WRKY6 may serve as an integration node of multiple leaf senescence signaling pathways. Taken together,these findings reveal that the NPR1-WRKY46-WRKY6 signaling cascade plays a critical role in PBZ/SA-mediated leaf senescence in Arabidopsis. | Dingyu Zhang Zheng Zhu Jiong Gao Xin Zhou Shuai Zhu Xiaoyan Wang Xiaolei Wang Guodong Ren Benke Kuai | 2021 | Journal of Integrative Plant Biology2021，63，5： | 3 |
| 7 | COVID-19-associated monocytic encephalitis(CAME):histological and proteomic evidence from autopsy显示文摘Severe neurological symptoms are associated with Coronavirus disease 2019(COVID-19).However,the morphologic features,pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection.In this study,neuropathological damages and infiltrating inflammatory cells were quantitatively evaluated by immunohistochemical staining,ultrastructural examination under electron microscopy,and an image threshold method,in postmortem brains from nine critically ill COVID-19 patients and nine age-matched cadavers of healthy individuals.Differentially expressed proteins were identified by quantitative proteomic assays.Histopathological findings included neurophagocytosis,microglia nodules,satellite phenomena,extensive edema,focal hemorrhage,and infarction,as well as infiltrating mononuclear cells.Immunostaining of COVID-19 brains revealed extensive activation of both microglia and astrocytes,severe damage of the blood-brain barrier(BBB)and various degrees of perivascular infiltration by predominantly CD14+/CD16+/CD141+/CCR7+/CD11c+monocytes and occasionally CD4+/CD8+T lymphocytes.Quantitative proteomic assays combined with bioinformatics analysis identified upregulated proteins predominantly involved in immune responses,autophagy and cellular metabolism in COVID-19 patient brains compared with control brains.Proteins involved in brain development,neuroprotection,and extracellular matrix proteins of the basement membrane were downregulated,potentially caused by the activation of transforming growth factorβreceptor and vascular endothelial growth factor signaling pathways.Thus,our results define histopathological and molecular profiles of COVID-19-associated monocytic encephalitis(CAME)and suggest potential therapeutic targets. | Pei-Pei Zhang Zhi-Cheng He Xiao-Hong Yao Rui Tang Jie Ma Tao Luo Chuhong Zhu Tian-Ran Li Xindong Liu Dingyu Zhang Shuyang Zhang Yi-Fang Ping Ling Leng Xiu-Wu Bian | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 3 |
| 8 | Digital medical education empowered by intelligent fabric space显示文摘Medical education plays an important role in promoting the development of global medical science.Nevertheless,the intrinsic gap existing between institutional medical teaching and practical clinical tasks causes low education efficiency and students’weak initiative.Recent developments of sensing fabric and embedded computing,along with the advances in artificial intelligence(AI)and digital twin technology are paving the way for the transformation of medical research towards digitization.In this work,we present an intelligent fabric space based on novel functional fabric materials and digital twin networking enabled by 5G and internet of things(IoT)technologies.In this space,medical students can learn knowledge with collaborative mapping of the digital and real world,cyber-physical interaction and real-time tactile feedback.And the proposed service system will evaluate and feedback students’operational behaviors to improve their experimental skills.We provide four typical applications of intelligent fabric space for medical education,including medical education training,health and behavior tracking,operation playback and reproduction,as well as medical knowledge popularization.The proposed intelligent fabric space has the potential to promote innovative technologies for training cutting-edge medical students by effective and efficient ways. | Min Chen Rui Wang Rui Wang Yingting Zhou Zicheng He Xiaojuan Liu Muyao He Jiaxi Wang Chaolin Huang Huamin Zhou Ping Hong Chong Hou Ning Zhou Dingyu Zhang Guangming Tao | 2022 | National Science Open2022，1，1： | 2 |
| 9 | Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm显示文摘Coronavirus disease 2019(COVID-19)is an unprecedented pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).As of 22 February 2021,the worldwide pandemic has resulted in more than 110 million cases and 2.4 million deaths.1 Clinical investigation of COVID-19 patients has shown that a systemic cytokine storm can occur,especially in severe cases.2 Treatment of the SARS-CoV-2-associated cytokine storm with tocilizumab3 or anakinra4 has been shown to immediately improve the clinical outcome in most severe and critical COVID-19 patients.These data highlight the systemic cytokine storm as an important exacerbating event in severe COVID-19;however,our understanding of the molecular mechanisms involved in the initiation of the SARS-CoV-2-associated cytokine storm is limited.In the present study,we uncovered a reasonable explanation for cytokine storm initiation through the analysis of 13 autopsy samples from severe COVID-19 patients. | Jinghe Zhang Haibo Wu XiaoHong Yao Dingyu Zhang Yonggang Zhou Binqing Fu Wei Wang Heng Li Zhe Wang Ziming Hu Yong Ren Rui Sun Zhigang Tian Xiuwu Bian Haiming Wei | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 10 | A two-stage convective air and vacuum freeze-drying technique for bamboo shoots显示文摘 | Zhang Min Tu Dingyu | 2005 | International Journal of Food Science and Technology2005，40，： | 1 |
| 11 | Reconstruction of the free-field radiation from a vibrating structure based on measurements in a noisy environment显示文摘 | Bi Chuanxing Hu Dingyu Zhang Yongbin | 2013 | Journal of the Acoustical SocietyofAmerica2013，134，4： | 1 |
| 12 | Thermal shock resistance of ultra-high temperature ceramics including the effects of thermal environment and external constraints显示文摘 | Dingyu Li Weiguo Li Wenbo Zhang Daining Fang | 2012 | Materials and Design2012，，： | 1 |
| 13 | A two-stage convective air and vacuum freeze-drying technique for bamboo shoots显示文摘 | XU Yanyang ZHANG Min TU Dingyu | 2005 | International Journal of Food Science and Technology2005，40，： | 1 |
| 14 | Determination of Diosgenin Content in Medicinal Plants with Enzyme-Linked Immunosorbent Assay显示文摘 | Jiaru Li Dingyu Yang Kun Yu Ji He Yingjun Zhang | 2010 | Planta Med2010，，16： | 1 |
| 15 | Longitudinal Characteristics of T Cell Responses in Asymptomatic SARS-CoV-2 Infection显示文摘Dear Editor,SARS-Co V-2 causes a spectrum of illness,ranging from an asymptomatic state to life-threatening multi-organ failure,and imposes a high socioeconomic burden on its sufferers and on society(Chen et al.2020;Pan et al.2020). | Jingyi Yang Ejuan Zhang Maohua Zhong Qingyu Yang Ke Hong Ting Shu Dihan Zhou Jie Xiang Jianbo Xia Xi Zhou Dingyu Zhang Chaolin Huang You Shang Huimin Yan | 2020 | Virologica Sinica2020，35，6： | 1 |
| 16 | HSCS:a hybrid shared cache scheduling scheme for multiprogrammed workloads显示文摘The traditional dynamic random-access memory (DRAM)storage medium can be integrated on chips via modem emerging 3D-stacking technology to architect a DRAM shared cache in multicore systems.Compared with static random-access memory (SRAM),DRAM is larger but slower.In the existing research,a lot of work has been devoted to improving the workload performance using SRAM and stacked DRAM together in shared cache systems,ranging from SRAM structure improvement to optimizing cache tags and data access.However,little attention has been paid to designing a shared cache scheduling scheme for multiprogrammed workloads with different memory footprints in multicore systems.Motivated by this,we propose a hybrid shared cache scheduling scheme that allows a multicore system to utilize SRAM and 3D-stacked DRAM efficiently, thus achieving better workload performance.This scheduling scheme employs (1)a cache monitor,which is used to collect cache statistics;(2)a cache evaluator,which is used to evaluate the cache information during the process of programs being executed;and (3)a cache switcher,which is used to self-adaptively choose SRAM or DRAM shared cache modules.A cache data migration policy is naturally developed to guarantee that the scheduling scheme works correctly.Extensive experiments are conducted to evaluate the workload performance of our proposed scheme.The experimental resuits showed that our method can improve the multiprogrammed workload performance by up to 25%compared with state-of-the-art methods (including conventional and DRAM cache systems). | Jingyu ZHANG Chentao WU Dingyu YANG Yuanyi CHEN Xiaodong MENG Liting XU Minyi GUO | 2018 | Frontiers of Computer Science2018，12，6： | 1 |
| 17 | Research of Nodes Deployment for Wireless Sensor Network In Determinstic Area显示文摘 | Yunzhou ZHANG Dingyu XUE Chengdong WU | 2009 | Computer Science and Information Technology2009，，： | 1 |
| 18 | Fractional-order TV-L 2 model for image denoising显示文摘 | Dali Chen Shenshen Sun Congrong Zhang YangQuan Chen Dingyu Xue | 2013 | Central European Journal of Physics2013，，10： | 1 |
| 19 | Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population显示文摘 | Shengli Tang Yufeng Yuan Yueming He Dingyu Pan Yongxi Zhang Yuanyuan Liu Quanyan Liu Zhonglin Zhang Zhisu Liu | 2014 | Human Immunology2014，，4： | 1 |
| 20 | Evaluation of gas production from multiple coal seams: A simulation study and economics显示文摘Gas production from multiple coal seams has become common practice in many coal basins around the world. Although gas production rates are typically enhanced, the economic viability of such practice is not well studied. In order to investigate the technical and economic feasibility of multiple coal seams production, reservoir simulation integrated with economics modelling was performed to study the effect of important reservoir properties of the secondary coal seam on production and economic performance using both vertical and horizontal wells. The results demonstrated that multiple seam gas production of using both vertical and horizontal wells have competitive advantage over single layer production under most scenarios. Gas content and permeability of the secondary coal seam are the most important reservoir properties that have impact on the economic feasibility of multiple seam gas production. The comparison of vertical well and horizontal well performance showed that horizontal well is more economically attractive for both single well and gas field. Moreover, wellhead price is the most sensitive to the economic performance, followed by operating costs and government subsidy. Although the results of reservoir simulation combined with economic analysis are subject to assumptions, multiple seam gas production is more likely to maintain profitability compared with single layer production. | Yanting Wu Zhejun Pan Dingyu Zhang Zhaohui Lu Luke D. Connell | 2018 | International Journal of Mining Science and Technology2018，28，3： | 1 |
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