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| 1 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 2 | The precise location and nature of the nerves to the male human urethra: histological and immunohistochemical studies with three-di- mensional reconstruction显示文摘 | Karam I Droupy S Abd-Alsamad I Korbage A Uhl JF Benoit G | 2005 | Eur Urol2005，48，： | 1 |
| 3 | Carbohydrate-active enzymes from the zygomycete fungus Rhizopus oryzae:a highly specialized approach to carbohydrate degradation depicted at genome level显示文摘 | Battaglia E Benoit I Brink J | 2011 | BMC Genomics2011，12，17： | 1 |
| 4 | An adaptive accuracy-based a posteriori error estimator 显示文摘 | GROSSE I R KATRAGADDA P BENOIT J | 1992 | Finite Elements in Analysis and Design1992，12，： | 1 |
| 5 | Carbohy- drate-active enzymes from the zygomycete fungus Rhizopus oryzae: a highly specialized approach to car- bohydrate degradation depicted at genome level 显示文摘 | Battaglia E Benoit I van den Brink J | 2011 | BMC Genomics2011，12，： | 1 |
| 6 | Epigenetic inactivation of RASSFA1 in head and neck cancer 显示文摘 | Seung Myung Dong Dang- I Sun Nicole E Benoit | 2003 | Clin Cancer Res2003，9，： | 1 |
| 7 | Decoration of TiO2 nanotube layers with WO3 nanocrystals for high-electrochmmic activity显示文摘 | Benoit A Paramasivam I Nah Y C | 2009 | Electrochemistry Communications2009，11，： | 1 |
| 8 | Further research on the effect of light of different wave lengths on gonad stimulation of the impuberal male duck 显示文摘 | BENOIT J WALTER F X ASSENMACHER I | 1950 | CR Seances Soc Biol Fil1950，144，12： | 1 |
| 9 | Economic performance evaluation method for hydroelectric generating units显示文摘 | Liu Y Ye L Benoit I | | 0，，06： | 1 |
| 10 | White Sponge Nevus-A Rare Autosomal dominant keratinopathy 显示文摘 | Benoit S Schlipf N Hansser I | 2014 | Klin Padiatr2014，4，2： | 1 |
| 11 | γ - synuelein promotes cancer cell survival and inhibits stress and chemotherapy druginduced apoptosis by modulating MAPK pathways显示文摘 | Pan ZhZ Wendy Bruening Benoit I | 2002 | Biological Chemistry2002，277，35： | 1 |
| 12 | Synthesis and characterization of carbon nanotubesTiO2 nanocomposites显示文摘 | Jitianu A Caeciaguerra T Benoit I Delpeux S Béguin F Bonnamy S | | 0，，5： | 1 |
| 13 | Decoration of TiO2 Nanotube Layers with WO3 Nanocrystals for High-Electrochromic Activity 显示文摘 | Benoit A Paramasivam I Nab Y C | 2009 | Electrochem Commun2009，11，4： | 1 |
| 14 | Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease 显示文摘 | Furman M I Benoit S E Barnard M R | 1998 | J Am Coll Cardiol1998，31，2： | 1 |
| 15 | Tectonic setting for the genesis of oceanic plagiogranites: Evidence from a paleo-spreading structure in the Oman ophiolite显示文摘 | Benoit M Ceuleneer G | 1996 | Earth and Planetary Science Letters1996，139，： | 1 |
| 16 | Biotechnological applications and potential of fangal feruloyl esterases based on prevalence , classification and biochemical diversity显示文摘 | Benoit I Danchin E G J Bleiehrodt R J | 2008 | BiotechnologyLetters2008，30，3： | 1 |
| 17 | Biotechnological applica- tions and potential of fungal feruloyl esterases based on prevalence, classifi- cation and biochemical diversity 显示文摘 | Benoit I Danchin E GJ Bleichrodt R J | 2008 | Bioteehnol Lett2008，30，3： | 1 |
| 18 | Preserved adrenal function in fully PCSK9-deficient subject显示文摘 | Cariou B Benoit I Le May C | 2014 | Int J Cardiol2014，176，2： | 1 |
| 19 | A new link between pesticides and Parkin- son's disease 显示文摘 | Benoit I G Virginia M Y | 2000 | Nature Neuroscience2000，3，12： | 1 |
| 20 | Two-dimensional ultrasonic flaw detection based on the wavelet packet transform显示文摘 | Robini M C Magnin I E Benoit H | 1997 | IEEE Trans UFFC1997，44，6： | 1 |
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