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| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Design, synthesis, and circu- lar dichroism investigation of a peptide--Sandwiched mesoheme 显示文摘 | Benson D R Hart B R Zhu X | 1995 | J Am Chem Soc1995，117，33： | 1 |
| 3 | Propagation and attenuation in the double- strip H guide显示文摘 | R F B Conlon and F A Benson | | Proc IEE0，1966，： | 1 |
| 4 | Biology of Frankia strains, actinomycete symbionts of actinorhizal plants 显示文摘 | Benson D R Silvester W B | 1993 | Microbiological Reviews1993，57，： | 1 |
| 5 | An au- tomated, handheld biosensor for aflatoxin显示文摘 | Carlson M A Bargeron C B Benson R C | 2000 | Biosens Bioeleetron2000，14，1011： | 1 |
| 6 | Biomimetic synthesis of calcium-deficient hydroxyapatite in a natural hydrogel显示文摘 | Hutchens S A Benson R S Evans B R | 2006 | Biomaterials2006，27，26： | 1 |
| 7 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 8 | Classification of the genus Legionella显示文摘 | Fields B S | 1998 | Semin Respir Infect1998，13，2： | 1 |
| 9 | Phage display for target-based antibacterial drug discovery显示文摘 | C HRISTENSEN D J GOTTLIN E B BENSON R E | 2001 | Research Focus2001，6，14： | 1 |
| 10 | Macrophage control of Brucella abortus:role of reactive oxygen intermediates and nitric oxide显示文摘 | Jiang X B Benson R Baldwin C L | 1993 | Cell Immunol1993，151，： | 1 |
| 11 | Metal ureter- al stent for benign and malignant ureteral Obstruction 显示文摘 | Benson A D Taylor E R Schwartz B F | 2011 | JUrol2011，185，6： | 1 |
| 12 | Colorectal cancer surveillance:2005 update of an American society of clinical oncology practice guideline显示文摘 | DESCH CE BENSON A B 3RD SOMERIELD MR | 2005 | J Clin Oncol2005，23，33： | 1 |
| 13 | Estimating primary productivity of forested wetland communities in different hydrologic landscapes显示文摘 | Mitsch W J Taylor J R Benson K B | 1991 | Landscape Ecol1991，5，： | 1 |
| 14 | Design of a low-cost underwater acoustic modem for short - range sensor networking applications 显示文摘 | BENSON B LI Y KASTNER R | 2010 | Oceans2010，19，22： | 1 |
| 15 | Classification of the genus Legionella显示文摘 | Benson R F Fields B S | 1998 | Semin Resp Infect1998，13，2： | 1 |
| 16 | Resistance training improves metabolic health in type 2 diabetes: a systematic review显示文摘 | GORDON B A BENSON A C BIRD S R | 2009 | Diabetes Res Clin Pract2009，83，2： | 1 |
| 17 | Hyperbaric oxygen inhibits stimulus-induced proinflammatory cytokine synthesis by human blood-derived monocyte-macrophages 显示文摘 | Benson R M Minter L M Osborne B A | 2003 | Clin Exp Immunol2003，134，1： | 1 |
| 18 | Legionella and Legionnaires' disease: 25 years of investigation显示文摘 | Fields B S Benson R F Besser R E | 2002 | Clin Microbiol Rev2002，15，3： | 1 |
| 19 | Monitoring of dissolved reactive phosphorus in wastewaters by flow injection analysis, Part 1, Method development and validation显示文摘 | Benson R L Truong Y B Mckelvie I D | 1996 | Water Res1996，30，9： | 1 |
| 20 | Effect of powder size distribution on sintering显示文摘 | Patterson B R Benson L A | 1984 | Progr Powder Metal1984，39，： | 1 |
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