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| 1 | Driving gene-engineered T cell immunotherapy of cancer显示文摘妄想的抗原受体(汽车) 设计基因的 T 房间治疗保持潜力与终末期癌在病人的生活有有意义的差别。为十年,癌症治疗基于生物物理的参数,与到 debulk 的外科的切除术,由放射和化疗列在后面指向很快成长的肿瘤房间,当时主要 sparing 静止正常纸巾。一突破与 allogeneic 骨头髓发生了与白血病为病人移植,它提供了一有时药品治疗。为稳固的肿瘤的采纳房间治疗的地与发现被建立渗入肿瘤的淋巴细胞能与变形黑瘤被扩展并且使用到对待和甚至痊愈病人。肿瘤特定的 T 房间受体(TCR ) 被识别并且设计了进耐心的外部血淋巴细胞,它也被发现治疗肿瘤。然而,这些被耐心的 HLA 限制限制。紧随来汽车的产生,把抗体的优美识别与一个 T 房间的受动器功能相结合。为与先进 B 房间恶意的多重表格对待病人的指向 CD19 的汽车的来临取得了大成功,与多达 95% 反应率。然而,到稳固的肿瘤的适用的汽车治疗刚开始了,但是已经,某些因素被弄明白:肿瘤目标具有最大的重要性让临床医生不做伤害;并且稳固的肿瘤与 hematologic 相比对汽车治疗不同地作出回应。这里,我们考察临床的设计基因的 T 房间免疫疗法,它的成功,挑战,和未来的状态。 | Laura A Johnson Carl H June | 2017 | Cell Research2017，27，1： | 37 |
| 2 | Late Cretaceous biota and the Cretaceous-Paleogene(K--Pg)Boundary in Jiayin of Heilongjiang,China显示文摘An international cooperative study of the Late Cretaceous biota and non-marine strata including the Cretaceous-Paleogene(K--Pg) boundary in Jiayin near the Heilongjiang River,China during 2002-2010,is summarized in this paper. The strata includes the Upper Cretaceous Yong'ancun-,Taipinglinchang-,Yuliang-zi-,and Furao formations,and the Paleocence Wuyun Formation consisting of Baoshantou Member and a Coalbearing Member. Seven palynological assemblages from Santonian to Paleocene are recognized,which is used for definition of the K--Pg boundary. Through the palynological analysis of three drilled boreholes (XHY-2005,2006,2008) in Xiaoheyan of western Jiayin,the K--Pg boundary is defined within 20. 00-20. 05 m in the borehole XHY-2006 (as a standard boundary) which is just between the top of Furao Formation (late Maasterichtian) and the base of Baishantou Member (early Danian) . These new research results are supported by paleo- magnetic,geochemical and other analyses,also. On the other hand,the presence of eight taxa of Maasterichtian dinosaurs (mostly hadrosaurids) have been recognized by the authors; and two mega-plant assemblages from the Yong'ancun Fm (Santonian) to Taipinglinchang Fm (Campanian) are confirmed. These research a-chievements indicate that the Upper Cretaceous-Paleocene in Jiayin can be well correlated to the strata in the neighboring Zeya-Bureja basin,Russia. The K--Pg boundary definited in Jiayin is the first well documented non-marine K--Pg boundary in China. Also the related paleoclimate,paleoenvironment and the mass extinctions in this area during the Cretaceous-Paleocene transition are also discussed. | Sun G. Akhmetiev M. Markevich V. Ashraf A. R. Bugdaeva E. Godefroit P. Bolotsky Yu. Dong Z. M. Golovneva L. Yang H. X. Sun C. L. Sun Y. W. Quan C. Kodrul T. Kezina T. Johnson K. Nishida H Dilcher D. L. Harding I. Chen Y. J. | 2011 | Global Geology2011，14，3： | 9 |
| 3 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 4 | Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study显示文摘 | JT Moller P Cluitmans LS Rasmussen P Houx H Rasmussen J Canet P Rabbitt J Jolles K Larsen CD Hanning O Langeron T Johnson PM Lauven PA Kristensen A Biedler H van Beem O Fraidakis JH Silverstein JEW Beneken JS Gravenstein | 1998 | The Lancet . 1998 (9106)1998，，9106： | 2 |
| 5 | HIF-1α is required for solid tumor formation and embryonic vascularization显示文摘 | Ryan H E Lo J Johnson R S | 1998 | EMBO J1998，17，11： | 2 |
| 6 | Metabolism of T-2 toxin by blood cell carboxylesterases显示文摘 | Johnson H Odden E Jonsen BA and Fonnum F | 1988 | Biochem Pharmacol1988，27，： | 2 |
| 7 | 紫杉醇局部治疗抑制猪静脉桥新生内膜形成和增厚的实验研究显示文摘目的 :局部药物治疗是一个很好的防治静脉桥病变的策略。本研究用抗细胞增殖药物紫杉醇处理大隐静脉桥后植入猪的颈动脉 ,以观察紫杉醇的抗细胞增殖作用在抑制静脉桥内膜平滑肌细胞增殖、迁移导致内膜形成和增厚的效果。方法 :将 10头猪的 2 0只大隐静脉桥分为两组。治疗组 :将大隐静脉桥 10只置于含有 10 μmol/L浓度的紫杉醇溶液中 (先用该溶液灌洗 )浸泡 1h后植入猪的颈动脉 ,紫杉醇是溶解在 2 5 μl/L的无水酒精中 ,对照组 10只大隐静脉桥置于单纯的酒精中浸泡。 4周后取开放的静脉桥进行组织学分析。结果 :①治疗组静脉桥新生内膜面积 (1 5 9± 0 95 )mm2 ,对照组新生内膜面积高达 (2 43± 1 3 5 )mm2 ,治疗组显著低于对照组 ,两组比较有非常显著的差异 ,P <0 0 1;②治疗组内膜平滑肌细胞密度均值为 (3 681± 193 5 ) /mm2 ,对照组为 (4 60 7± 1993 ) /mm2 ,两组比较有显著性差异 ,P <0 0 5 ;中膜平滑肌细胞密度均值治疗组 (2 13 9± 73 4) /mm2 ,对照组(3 62 9± 3 2 0 7) /mm2 ,两组比较有显著性的差异 ,P <0 0 5。结论 :紫杉醇可显著抑制静脉桥内膜、中膜平滑肌细胞的增殖 ,抑制新生内膜的形成 ,证明紫杉醇可在防治静脉桥闭塞方面发挥独特作用。 | 吴隐雄 Martin H Chamberlain Thomas Johnson Jason L Johnson Andrew C Newby Gianni D Angelin Martin Oberhoff Karl K Karsch | 2003 | 中国循环杂志2003，18，6： | 2 |
| 8 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 9 | Hydration simulation of C3S显示文摘 | JENNINGS H M JOHNSON | 1986 | Am Ceram Soc1986，69，5： | 1 |
| 10 | FDA drug approval summary: erlotinib (tarveva) tablets显示文摘 | COHEN M H JOHNSON J R CHEN Y F | 2005 | Oncologist2005，10，7： | 1 |
| 11 | Synthesis and DNA binding of spiroeyelic model compounds related to the neocarzinostatin chromophore 显示文摘 | Xi Z Jones G B Qabaja G Wright J Johnson F Goldberg I H | 1999 | Org Lett1999，1，9： | 1 |
| 12 | Formation and properties of new Ni-based amorphous alloys with critical casting thickness up to 5 mm显示文摘 | XU D H DUAN G JOHNSON W L | 2004 | Acta Materialia2004，52，： | 1 |
| 13 | RAS is regulated by the let-7 microRNA family显示文摘 | Johnson S M Grosshans H Shingara J | 2005 | Cell2005，120，： | 1 |
| 14 | Ethanol increases carotenoid production in Phaffia rhodozyma 显示文摘 | Gu W L An G H Johnson E A | 1997 | Journal of Industrial Microbiology & Biotechnology1997，19，： | 1 |
| 15 | Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation显示文摘 | Ding H Matthews TA Johnson GV | 2006 | J Biol Chem2006，281，19： | 1 |
| 16 | Artificial insemination of swine : fecundity of boar semen stored in Beltsville TS ( BTS), modified modena (MMOL/L) or MR-A and inseminated on ane,three and four days after collection 显示文摘 | Johnson L A Aalbers J G Grooten H J G | 1998 | Zucht hygiene1998，23，： | 1 |
| 17 | Transient reactiva- tion of CSF in parthenogenetic one-cell mouse embryos 显示文摘 | Incent C Cheek T R Johnson M H | 1992 | J Cell Sci1992，103，2： | 1 |
| 18 | Alignment of the TiAl/Ti3Al Lamellar Microstructure in TiAl Alloys by Directional Solidification显示文摘 | Johnson D R Masuda Y Inui H | 1997 | Materials Science and Engineering1997，，： | 1 |
| 19 | Spectrally arbitrary patterns显示文摘 | Drew J H Johnson C R Olesky D D | 2000 | Linear Algebra Appl2000，308，13： | 1 |
| 20 | TALL-1 is a novel member of the TNF family that is down-regulated by mitogens显示文摘 | Shu H B Hu W H Johnson H | 1999 | J Leukoc Biol1999，65，5： | 1 |
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