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| 1 | Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons显示文摘Lgr5+intestinal stem cells(ISCs)reside within specialized niches at the crypt base and harbor self-renewal and differentiation capacities.ISCs in the crypt base are sustained by their surrounding niche for precise modulation of self-renewal and differentiation.However,how intestinal cells in the crypt niche and microbiota in enteric cavity coordinately regulate ISC stemness remains unclear.Here,we show that ISCs are regulated by microbiota and niche enteric serotonergic neurons.The gut microbiota metabolite valeric acid promotes Tph2 expression in enteric serotonergic neurons via blocking the recruitment of the NuRD complex onto Tph2 promoter.5-hydroxytryptamine(5-HT)in turn activates PGE2 production in a PGE2+macrophage subset through its receptors HTR2A/3 A;and PGE2 via binding its receptors EP1/EP4,promotes Wnt/β-catenin signaling in ISCs to promote their self-renewal.Our findings illustrate a complex crosstalk among microbiota,intestinal nerve cells,intestinal immune cells and ISCs,revealing a new layer of ISC regulation by niche cells and microbiota. | Pingping Zhu Tiankun Lu Jiayi Wu Dongdong Fan Benyu Liu Xiaoxiao Zhu Hui Guo Ying Du Feng Liu Yong Tian Zusen Fan | 2022 | Cell Research2022，32，6： | 8 |
| 2 | ON NON-ISOTROPIC JACOBI PSEUDOSPECTRAL METHOD显示文摘在这篇论文,非各向同性的 Jacobi 假光谱方法被建议,它的应用斧子考虑了。一些结果在上;多维的 Jacobi 高斯类型插值和相关 Bernstein 杰克森类型不平等斧子建立了,它起一个重要作用在假光谱方法。假光谱方法被用于一二 -- 维的单个问题中间 axisymmetric 上的一个问题领域。建议计划的集中被建立。数字结果表明建议方法的效率。 | Benyu Guo Keji Zhang Department of Mathematics,Shanghai Normal University,Shanghai 200234,China Scientific Computing Key Laboratory of Shanghai Universities Division of Computational Science of E-Institute of Shanghai Universities | 2008 | Journal of Computational Mathematics2008，26，4： | 8 |
| 3 | Atg5 regulates late endosome and lysosome biogenesis显示文摘Autophagy is an evolutionarily conserved lysosome-based degradation process.Atg5 plays a very important role in autophagosome formation.Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent manner.In Atg5 cells,but not in other essential autophagy genes defecting cells,recycling and retrieval of late endosomal components from hybrid organelles are impaired,causing persistent hybrid organelles and defective formation of late endosomes and lysosomes.Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles.Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 cells.Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis. | PENG JunYa ZHANG Ran CUI YiTong LIU HaoDong ZHAO XiaoXin HUANG Lei HU MingXu YUAN XiaoXi MA BenYu MA XiaoWei TAKASHI Ueno MASAAKI Komatsu LIANG XingJie YU Li | 2014 | Science China(Life Sciences)2014，57，1： | 6 |
| 4 | A MONOTONE COMPACT IMPLICIT SCHEME FOR NONLINEAR REACTION-DIFFUSION EQUATIONS显示文摘一个单调协议有在空间和秒顺序的第四顺序的精确性的含蓄的有限差别计划及时为解决非线性的反应散开方程被建议。一个加速的单调为结果的反复的方法分离问题被论述。重复的顺序 monotonically 收敛到分离问题的唯一的答案,并且集中率二次或将近二次,取决于非线性的反应的性质。数字结果说明建议计划的高精确性和重复的快速的集中率。 | Yuanming Wang Department of Mathematics,East China Normal University,Shanghai 200241,China Division of Computational Science,E-Institute of Shanghai Universities,Shanghai Normal Benyu Guo Department of Mathematics,Shanghai Normal University,Shanghai 200234,China Division of Computational Science,E-Institute of Shanghai Universities,Shanghai,China | 2008 | Journal of Computational Mathematics2008，26，2： | 4 |
| 5 | Intranasal delivery of paeoniflorin nanocrystals for brain targeting显示文摘Paeoniflorin(PA) is an anti-Parkinson Chinese medicine with inferior bioavailability and difficulty in delivery to the brain. This research is to develop an efficacious PA nanocrystal formulation(PA-NCs) that is suitable for intranasal administration to treat Parkinson’s disease(PD). PA-NCs were fabricated through an antisolvent precipitation method using TPGS as the stabilizer. The rod-shaped PA-NCs had particle size of 139.6 ± 1.3 nm and zeta potential of-23.2 ± 0.529 mV. A molecular dynamics simulation indicated that van der Waals forces are the primary drivers of interactions between PA and TPGS. In the ex vivo nasal mucosa permeation assay, the cumulative drug release at 24 h was 87.14% ± 5.34%,which was significantly higher than that of free PA. PA-NCs exhibited substantially improved cellular uptake as well as permeability on Calu-3 cells as compared to PA alone. FRET imaging analysis demonstrated that intact NCs could be internalized into Calu-3 cells.Moreover, PA-NCs conferred desirable protective effect against MPP+-induced SH-SY5Y cellular damage. Pharmacokinetic studies revealed a higher PA concentration in the brain following intranasal delivery of PA-NCs. In summary, the intranasal administration of PANCs is a promising treatment strategy for PD. | Chaoyin Wu Benyue Li Yi Zhang Tingting Chen Chuangrong Chen Wei Jiang Qi Wang Tongkai Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 4 |
| 6 | Petrov-Galerkin Spectral Element Method for Mixed Inhomogeneous Boundary Value Problems on Polygons显示文摘The authors investigate Petrov-Galerkin spectral element method. Some results on Legendre irrational quasi-orthogonal approximations are established, which play important roles in Petrov-Galerkin spectral element method for mixed inhomogeneous boundary value problems of partial differential equations defined on polygons. As examples of applications, spectral element methods for two model problems, with the spectral accuracy in certain Jacobi weighted Sobolev spaces, are proposed. The techniques developed in this paper are also applicable to other higher order methods. | Hongli JIA Benyu GUO | 2010 | Chinese Annals of Mathematics,Series B2010，31，6： | 4 |
| 7 | Anisotropic characteristics of electrical responses of fractured reservoir with multiple sets of fractures显示文摘In fractured reservoirs, the fractures not only provide the storage space for hydrocarbons, but also form the main flow channels which connect the pores of the matrix, so fractures dominate the productivity of reservoirs. However, because of the heterogeneity and randomness of the distribution of fractures, exploration and evaluation of fractured reservoirs is still one of the most diffi cult problems in the oil industry. In recent years, seismic anisotropy has been applied to the assessment of fractured formations, whereas electrical anisotropy which is more intense in fractured formations than seismic anisotropy has not been studied or used so extensively. In this study, fractured reservoir models which considered multiple sets of fractures with smooth and partly closed, rough surfaces were established based on the fractures and pore network, and the vertical and horizontal electrical resistivities were derived as a function of the matrix and fracture porosities according to Ohm's law. By using the anisotropic resistivity equations, variations of the electrical anisotropy of three types of fractured models under the conditions of free pressure and confi ning pressure were analyzed through the variations of the exerted pressure, matrix porosity, fracture aperture and formation water resistivity. The differences of the vertical and horizontal resistivities and the anisotropy between the connected and non-connected fractures were also analyzed. It is known from the simulated results that an increase of the confining pressure causes a decrease of electrical anisotropy because of the elasticity of the closed fractures and the decrease of the fracture aperture. For a fi xed fracture porosity, the higher the matrix porosity, the weaker the electrical anisotropy in the rock formation. | Shen Jinsong Su Benyu Guo Naichuan | 2009 | Petroleum Science2009，6，2： | 3 |
| 8 | Legendre rational approximation on the whole line显示文摘The Legendre rational approximation is investigated. Some approximation results are established, which form the mathematical foundation of a new spectral method on the whole line. A model problem is considered. Numerical results show the efficiency of this new approach. | GUO Benyu WANG Zhongqing | 2004 | Science China Mathematics2004，47，z1： | 3 |
| 9 | Some progress in spectral methods显示文摘In this paper,we review some results on the spectral methods.We frst consider the Jacobi spectral method and the generalized Jacobi spectral method for various problems,including degenerated and singular diferential equations.Then we present the generalized Jacobi quasi-orthogonal approximation and its applications to the spectral element methods for high order problems with mixed inhomogeneous boundary conditions.We also discuss the related spectral methods for non-rectangular domains and the irrational spectral methods for unbounded domains.Next,we consider the Hermite spectral method and the generalized Hermite spectral method with their applications.Finally,we consider the Laguerre spectral method and the generalized Laguerre spectral method for many problems defned on unbounded domains.We also present the generalized Laguerre quasi-orthogonal approximation and its applications to certain problems of non-standard type and exterior problems. | GUO BenYu | 2013 | Science China Mathematics2013，56，12： | 3 |
| 10 | Legendre Rational Spectral Method for Nonlinear Klein-Gordon Equation显示文摘A Legendre rational spectral method is proposed for the nonlinear Klein-Gordon equation on the whole line. Its stability and convergence are proved. Numerical results coincides well with the theoretical analysis and demonstrate the e?ciency of this approach. | Zhongqing Wang Benyu Guo | 2006 | Numerical Mathematics A Journal of Chinese Universities(English Series)2006，15，2： | 3 |
| 11 | Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo显示文摘Astaxanthine(AST) has important biological activities including antioxidant and antiinflammatory effects that could alleviate neurological and heart diseases, but its role in the prevention of cisplatin-induced hearing loss(CIHL) is not yet well understood. In our study, a steady interaction between AST and the E3 ligase adapter Kelch-like ECH-associated protein 1, a predominant repressor of nuclear factor erythroid 2-related factor 2(NRF2), was performed and tested via computer molecular docking and dynamics. AST protected against cisplatin-induced ototoxicity via NRF2 mediated pathwayusing quantitative PCR and Western blotting. The levels of reactive oxygen species(ROS) and mitochondrial membrane potential revealed that AST reduced ROS overexpression and mitochondrial dysfunction.Moreover, AST exerted anti-apoptosis effects in mouse cochlear explants using immunofluorescence staining and HEI-OC1 cell lines using quantitative PCR and Western blotting. Finally, AST combined with poloxamer was injected into the middle ear through the tympanum, and the protection against CIHL was evaluated using the acoustic brain stem test and immunofluorescent staining in adult mice. Our results suggest that AST reduced ROS overexpression, mitochondrial dysfunction, and apoptosis via NRF2-mediated pathway in cisplatin-exposed HEI-OC1 cell lines and mouse cochlear explants, finally promoting cell survival. Our study demonstrates that AST is a candidate therapeutic agent for CIHL. | Benyu Nan Zirui Zhao Kanglun Jiang Xi Gu Huawei Li Xinsheng Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 12 | Nanoparticles with Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice显示文摘 | Bo Xiao Hamed Laroui Emilie Viennois Saravanan Ayyadurai Moiz A. Charania Yuchen Zhang Zhan Zhang Mark T. Baker Benyue Zhang Andrew T. Gewirtz Didier Merlin | 2014 | Gastroenterology2014，，： | 2 |
| 13 | rtcisE2F promotes the self-renewal and metastasis of liver tumorinitiating cells via N^(6)-methyladenosine-dependent E2F3/E2F6 mRNA stability显示文摘Liver cancer is highly heterogeneous,and the tumor tissue harbors a variety of cell types.Liver tumor initiating cells(TICs)well contribute to tumor heterogeneity and account for tumor initiation and metastasis,but the molecular mechanisms of liver TIC self-renewal are elusive.Here,we identified a functional read-through rt-circRNA,termed rtcisE2F,that is highly expressed in liver cancer and liver TICs.rtcisE2F plays essential roles in the self-renewal and activities of liver TICs.rtcisE2F targets E2F6 and E2F3 mRNAs,attenuates mRNA turnover,and increases E2F6/E2F3 expression.Mechanistically,rtcisE2F functions as a scaffold of N^(6)-methyladenosine(m^(6)A)reader IGF2BP2 and E2F6/E2F3 mRNA.rtcisE2F promotes the association of E2F6/E2F3 mRNAs with IGF2BP2,and inhibits their association with another m^(6)A reader,YTHDF2.IGF2BP2 inhibits E2F6/E2F3 mRNA decay,whereas YTHDF2 promotes E2F6/E2F3 mRNA decay.By switching m^(6)A readers,rtcisE2F enhances E2F6/E2F3 mRNA stability.E2F6 and E2F3 are both required for liver TIC self-renewal and Wnt/β-catenin activation,and inhibition of these pathways is a potential strategy for preventing liver tumorigenesis and metastasis.In conclusion,the rtcisE2F-IGF2BP2/YTHDF2-E2F6/E2F3-Wnt/β-catenin axis drives liver TIC self-renewal and initiates liver tumorigenesis and metastasis,and may provide a strategy to eliminate liver TICs. | Zhenzhen Chen Lan Huang Kaili Wang Lulu Zhang Xiang Zhong Zhongyi Yan Benyu Liu Pingping Zhu | 2022 | Science China(Life Sciences)2022，65，9： | 2 |
| 14 | Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA显示文摘Group 3 innate lymphoid cells(ILC3s)play critical roles in innate immunity and gut homeostasis.However,how ILC3 homeostasis is regulated remains elusive.Here,we identified a novel circular RNA,circZbtb20,that is highly expressed in ILC3s and required for their maintenance and function.CircZbtb20 deletion causes reduced ILC3 numbers,increasing susceptibility to C.rodentium infection.Mechanistically,circZbtb20 enhances the interaction of Alkbh5 with Nr4a1 mRNA,leading to ablation of the m6A modification of Nr4a1 mRNA to promote its stability.Nr4a1 initiates Notch2 signaling activation,which contributes to the maintenance of ILC3 homeostasis.Deletion of Alkbh5 or Nr4a1 also impairs ILC3 homeostasis and increases susceptibilities to bacterial infection.Thus,our findings reveal an important role of circular RNA in the regulation of innate lymphoid cell homeostasis. | Benyu Liu Nian Liu Xiaoxiao Zhu Liuliu Yang Buqing Ye Huimu Li Pingping Zhu Tiankun Lu Yong Tian Zusen Fan | 2021 | Cellular & Molecular Immunology2021，18，6： | 2 |
| 15 | Graph embedding and extensions: a general framework for dimensionality reduction 显示文摘 | Yan Shuicheng Xu Dong Zhang Benyu | 2007 | IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，1： | 1 |
| 16 | Graph embed- ding and extensions:a general framework for dimension- ality reduction显示文摘 | Yan Shuicheng Xu Dong Zhang Benyu | 2007 | lEEE Trans on Pattern Analysis and Machine Intelligence2007，29，1： | 1 |
| 17 | Graph embedding and extensions: a general framework for dimensionality reduction显示文摘 | Yan Shuicheng Xu Dong Zhang Benyu | 2007 | IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，1： | 1 |
| 18 | Chebyshev spectral-finite element method for incompressible fluid flow显示文摘 | Guo Benyu He Songnian | 1996 | Applied Mathematics1996，，4： | 1 |
| 19 | SPECTRAL AND SPECTRAL ELEMENT METHODS FOR HIGH ORDER PROBLEMS WITH MIXED BOUNDARY CONDITIONS显示文摘在这份报纸,我们为高顺序调查数字方法微分方程。我们求婚新光谱、光谱为高度的元素方法与混合不同类的边界条件订问题,并且证明他们的光谱由在 Jacobi 伪直角的近似上使用最近的结果的精确性。数字结果表明建议算法的高精确性,它也甚至为震荡的答案工作很好。[从作者抽象] | Benyu Guo Chao Zhang | 2014 | Journal of Computational Mathematics2014，32，4： | 1 |
| 20 | Graph Embedding and Extensions: A General Framework for Dimensionality Reduction显示文摘 | Yah Shuicheng Xu Dong Zhang Benyu | 2007 | IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，1： | 1 |
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