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| 1 | Comprehensive eco-environmental effects of the shelter-forest ecological engineering along the Tarim Desert Highway显示文摘In this work, we report a comprehensive study about the eco-environmental effects of the shelter forest along the Tarim Desert Highway, including the effects on aeolian environment, soil, micro-climate, biodiversity, and groundwater. The results show that: (1) The movement of windblown sand near the ground surface was affected by the shelter forest. The wind speed and sediment transport rate in the shelter forest decreased by 64%―80% and 87.45%―99.02%, respectively. In addition, there were also significant changes in the sand flux structure, the sand grain size, and the deflation and deposition on the ground surface. (2) Compared to the natural mobile sand, the soil bulk density in the forest area decreased while the total salt content, the total porosity, and the water content increased. In addition, the soil fertility was significantly improved in the forest area, and showed the 'first rapid, then slow' variation pattern. (3) The shelter forest showed positive effects on the micro-climate. Within the 6 m height above the ground, the air temperature in the shelter forest at different heights was lower than that in the mobile sand, while the air humidity was higher, while, the soil temperature was also lower in the shelter forest than mobile sand. (4) The number of soil microbial species increased significantly with the improvement of habitat in the shelterbelt. However, the population of different species was not distributed evenly across the surveyed area. (5) Currently, no significant effects of groundwater-pumping and forest-irrigation water have been found on the groundwater level and its salinity. The variation amplitude of both groundwater level and salinity was at the level of centimeters and 1g/L, respectively. No obvious variation trend has been observed. | LEI JiaQiang LI ShengYu JIN ZhengZhong FAN JingLong WANG HaiFeng FAN DongDong ZHOU HongWei GU Feng QIU YongZhi XU Bo | 2008 | Chinese Science Bulletin2008，53，S2： | 14 |
| 2 | Classification and regionalization of the forming environment of windblown sand disasters along the Tarim Desert Highway显示文摘Through the systematic field survey and observations, the factor quantification as well as setting the criteria, the sand disaster-forming environment along the Tarim Desert Highway can be divided into four grades by the classification and regionalization based on fuzzy mathematics. The length of the regions with significant sand disaster accounted for 37.1% of the total highway length. Particularly, the area along the Tarim Desert Highway, based on the sand disaster-forming environment classification as well as the difference in the five basic landform units along the highway, combined with the difference of wind regime, can be divided into five regions, in which the length of the regions suffering severe sand damage occupied 64.3% of the total highway length. In addition, the index of disaster formation grade along the highway decreased from north to south, showing a repeated spatial pattern in small length scales. | LEI JiaQiang LI ShengYu FAN DongDong ZHOU HongWei GU Feng QIU YongZhi XU Bo LIU Shang DU WenYi YAN ZengHui WANG YongChang | 2008 | Chinese Science Bulletin2008，53，S2： | 11 |
| 3 | Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons显示文摘Lgr5+intestinal stem cells(ISCs)reside within specialized niches at the crypt base and harbor self-renewal and differentiation capacities.ISCs in the crypt base are sustained by their surrounding niche for precise modulation of self-renewal and differentiation.However,how intestinal cells in the crypt niche and microbiota in enteric cavity coordinately regulate ISC stemness remains unclear.Here,we show that ISCs are regulated by microbiota and niche enteric serotonergic neurons.The gut microbiota metabolite valeric acid promotes Tph2 expression in enteric serotonergic neurons via blocking the recruitment of the NuRD complex onto Tph2 promoter.5-hydroxytryptamine(5-HT)in turn activates PGE2 production in a PGE2+macrophage subset through its receptors HTR2A/3 A;and PGE2 via binding its receptors EP1/EP4,promotes Wnt/β-catenin signaling in ISCs to promote their self-renewal.Our findings illustrate a complex crosstalk among microbiota,intestinal nerve cells,intestinal immune cells and ISCs,revealing a new layer of ISC regulation by niche cells and microbiota. | Pingping Zhu Tiankun Lu Jiayi Wu Dongdong Fan Benyu Liu Xiaoxiao Zhu Hui Guo Ying Du Feng Liu Yong Tian Zusen Fan | 2022 | Cell Research2022，32，6： | 8 |
| 4 | Application of profile likelihood function to the uncertainty analysis of hydrometeorological extreme inference显示文摘Profile likelihood function is introduced to analyze the uncertainty of hydrometeorological extreme inference and the theory of estimating confidence intervals of the key parameters and quantiles of extreme value distribution by profile likelihood function is described.GEV(generalized extreme value)distribution and GP(generalized Pareto)distribution are used respectively to fit the annual maximum daily flood discharge sample of the Yichang station in the Yangtze River and the daily rainfall sample in10 big cities including Guangzhou.The parameters of the models are estimated by maximum likelihood method and the fitting results are tested by probability plot,quantile plot,return level plot and density plot.The return levels and confidence intervals of flood and rainstorm in different return periods are calculated by profile likelihood function.The results show that the asymmetry of the profile likelihood function curve increases with the return period,which can reflect the effect of the length of sample series and return periods on confidence interval.As an effective tool for estimating confidence interval of the key parameters and quantiles of extreme value distribution,profile likelihood function can lead to a more accurate result and help to analyze the uncertainty of extreme values of hydrometeorology. | LU Fan WANG Hao YAN DengHua ZHANG DongDong XIAO WeiHua | 2013 | Science China(Technological Sciences)2013，56，12： | 8 |
| 5 | Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation显示文摘Nanotechnology-based photothermal therapy has attracted great attention in the past decade. Nevertheless, photothermal therapy has some inherent drawbacks, such as the uneven heat production and limited laser penetration, often leading to insufficient treatment outcomes. Here, we developed a combination strategy to improve cancer therapy. The biomimetic albumin-modified gold nanorods(AuNRs) were prepared with incorporation of paclitaxel(PTX). This therapeutic system was characterized by several features. First, the albumin modification enhanced the biocompatibility and colloidal stability. Second, the surface-coated albumin promoted cellular uptake via the albumin-binding protein pathway. Third, PTX was incorporated via hydrophobic interaction between PTX and the albumin lipophilic domain. Fourth, the system can be used for combined photothermo-chemotherapy for yielding synergistic effects. The antitumor activity of the system was evaluated both in vitro and in vivo using the HCT116 colon cancer cell and tumor model. The combination therapy was found with an enhanced treatment efficiency and no obvious side effect. Most importantly, the thermal effect was also discovered with the ability to modulate the tumor microenvironments and suppress the macrophages polarization towards the M2 pro-tumor phenotype. It could be a mechanism for photothermal immunotherapy. The combination strategy and the system provide a potential method for cancer therapy. | Dongdong Li Meng Zhang Fan Xu Yingzhi Chen Binfan Chen Ya Chang Huihai Zhong Hongyue Jin Yongzhuo Huang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 8 |
| 6 | The enhanced permeability and retention effect based nanomedicine at the site of injury显示文摘The enhanced permeability retention(EPR)effect based nanomedicine has been widely used for tumor targeting during the past decades.Here we unexpectedly observed the similar'EPR effect'at the site of iniury.We found that the temporary dilated and leaky blood vessels caused by the potent vasodilator histamine in response to injury allowed the injected nanoparticles to pass through the vasculature and reached the injured tissue.Our finding shows the potential underline mechanism of'EPR effect'at the injured site.By loading with antibiotics,we further demonstrated a new strategy for prevention of infection at the site of injury. | Yingjun Liu Dongdong Sun Qin Fan Qingle Ma Ziliang Dong Weiwei Tao Huiquan Tao Zhuang Liu Chao Wang | 2020 | Nano Research2020，13，2： | 6 |
| 7 | Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo显示文摘The sustained-release properties of the biodegradable nano-drug delivery systems were used to improve the residence time of the chemotherapeutic agent in the body. These drug delivery systems were widely used to deliver chemotherapeutic drugs. The 5-fluorouracil loaded chitosan nanoparticles prepared in this paper have the above advantage. Here, we found that when the mass ratio of 5-fluorouracil and chitosan was 1:1, the maximum drug loading of nanoparticles was 20.13 ± 0.007%, the encapsulation efficiency was 44.28 ± 1.69%, the particle size was 283.9 ± 5.25 nm and the zeta potential was 45.3 ± 3.23 mV. The prepared nanoparticles had both burst-release and sustained-release phases in vitro release studies.In addition, the inhibitory effect of the prepared nanoparticles on gastric cancer SGC-7901 cells was similar to that of 5-fluorouracil injection, and the blank vector had no obvious inhibitory effect on SGC-7901 cells. In the pharmacokinetic study of rats in vivo, we found that AUC(0-t), MRT(0-t) and t1/2 z of nanoparticles were significantly increased in vivo compared with 5-fluorouracil solution, indicating that the prepared nanoparticles can play a role in sustained-release. | Li Sun Yunna Chen Yali Zhou Dongdong Guo Yufan Fan Fangyan Guo Yufeng Zheng Weidong Chen | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 4 |
| 8 | Interfacial Bonding Mechanism and Mechanical Performance of Continuous Fiber Reinforced Composites in Additive Manufacturing显示文摘The additive manufacturing of continuous fiber composites has the advantage of a high-precision and efficient forming process,which can realize the lightweight and integrated manufacturing of complex structures.However,many void defects exist between layers in the printing process of additive manufacturing;consequently,the bonding performance between layers is poor.The bonding neck is considered a key parameter for representing the quality of interfacial bonding.In this study,the formation mechanism of the bonding neck was comprehensively analyzed.First,the influence of the nozzle and basement temperatures on the printing performance and bonding neck size was measured.Second,CT scanning was used to realize the quantitative characterization of bonding neck parameters,and the reason behind the deviation of actual measurements from theoretical calculations was analyzed.When the nozzle temperature increased from 180 to 220℃,CT measurement showed that the bonding neck diameter increased from 0.29 to 0.34 mm,and the cross-sectional porosity reduced from 5.48%to 3.22%.Finally,the fracture mechanism was studied,and the influence of the interfacial bonding quality on the destruction process of the materials was determined.In conclusion,this study can assist in optimizing the process parameters,which improves the precision of the printing parts and performance between the layers. | Congze Fan Zhongde Shan Guisheng Zou Li Zhan Dongdong Yan | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 4 |
| 9 | Surfactant-Encapsulated Polyoxometalate Complex as a Cathode Interlayer for Nonfullerene Polymer Solar Cells显示文摘An alcohol-soluble,environmentally friendly,and low-cost surfactant-encapsulated polyoxometalate complex[(C8H17)4N]4[SiW_(12)O40](TOASiW_(12))as a cathode interlayer(CIL)has exhibited excellent universality for various active layers and cathodes in nonfullerene polymer solar cells(NF-PSCs).In particular,incorporating TOASiW_(12) as the CIL enhanced power conversion efficiencies(PCEs)of the PM6:Y6-based NF-PSCs with Al or Ag cathode to 16.14%and 15.89%,respectively,and the PCEs of PM6:BTP-BO4Cl-based NF-PSCs with Al or Ag cathode to 17.04%and 17.00%,respectively.More importantly,the performances of the devices with TOASiW_(12) were insensitive to the TOASiW_(12) thickness from 3 to 33 nm.Furthermore,the NF-PSCs with TOASiW_(12) exhibited better device stability.Combined characterization of the photocurrent density versus effective voltage,capacitance versus voltage and electron mobility demonstrated that TOASiW_(12) as the CIL effectively promoted exciton dissociation,charge-carrier extraction,built-in potential,charge-carrier density,and electron mobility in the NF-PSCs.These findings suggest that TOASiW_(12) is a promising,competitive CIL for NF-PSCs fabricated by roll-to-roll processing. | Jing Qiu Yue Zhang Yan Liu Huiru Liu Dongdong Xia Fan Yang Chaowei Zhao Weiwei Li Lixin Wu Fenghong Li | 2022 | CCS Chemistry2022，4，3： | 3 |
| 10 | Protective effects of catalpol and rhein in murine experimental autoimmune encephalomyelitis via regulation of T helper (Th)1, Th2,Th17, and regulatory T cell responses显示文摘OBJECTIVE:To examine the effects of catalpol and rhein on pro-and anti-inflammatory responses in C57 BL/6 mice with experimental autoimmune encephalomyelitis(EAE),a model of multiple sclerosis.METHODS:Female C57 BL/6 mice were randomly divided into four groups(n=30):(a)normal salinecontrol,(b)EAE control,(c)EAE+prednisone acetate(PA,6 mg/kg),and(d)EAE+catalpol(40 mg/kg)and rhein(5 mg/kg).EAE was induced by injection of myelin oligodendrocyte glycoprotein 35-55 plus pertussis toxin.Treatments were orally administered daily for 40 d.Disease progression and neurological function were assessed using a semi-quantitative scale of tail and limb paralysis.Brains and spinal cords were collected on Days 6,20,and 40 and assessed for histopathological changes by hematoxylin and eosin staining.Production of interleukin(IL)-2,IL-4,IL-10,and IL-17 A protein was measured by enzyme-linked immunosorbent assay.Expression of the T helper(Th)1-,Th2-,Th17-,and regulatory T cell(Treg)-specific transcription factors T-bet,GATA3,ROR-γt,and Foxp3,respectively,were analyzed by quantitative reverse-transcription polymerase chain reaction and western blot analysis.RESULTS:Combination treatment with catalpol and rhein significantly alleviated the clinical disability and neurological dysfunction of mice with EAE.Catalpol and rhein treatment also reduced the infiltration of pro-inflammatory T cells into pathological lesions;significantly increased the expression of the anti-inflammatory factors GATA3,Foxp3,IL-4,and IL-10;and significantly decreased the expression of the pro-inflammatory factors T-bet,ROR-γt,IL-2,and IL-17 A.CONCLUSION:Catalpol and rhein reduced the neurological disabilities of mice with EAE,at least in part by rebalancing the pro-and anti-inflammatory environment in the brains and spinal cords. | Wei Mingyan Yang Tao Li Qian Zhou Dongdong Du Zongpan Fan Yongping | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 3 |
| 11 | New Way of Predicting Production State by Carbon Isotope Fractionation in the Fuling Shale Gas Field,Southeast Sichuan Basin显示文摘Objective With the discovery of the Fuling shale gas field and the realization of commercial exploitation, the prediction of shale gas well production state has attracted wide attention of scholars at home and abroad. | LUO Houyong LIU Wenhui FAN Ming TAO Cheng WANG Xiaofeng ZHANG Dongdong HAN Yuanhong | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 2 |
| 12 | Effects of hepatocyte growth factor overexpressed bone marrow‐derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts显示文摘 | Shenxu Wang Xing Qin Dongdong Sun Yunfang Wang Xiaoyan Xie Weiwei Fan Yabin Wang Dong Liang Xuetao Pei Feng Cao | 2012 | Cell Biochem Funct2012，，7： | 2 |
| 13 | Recent advances in molecular fluorescent probes for organic phosphate biomolecules recognition显示文摘Organic phosphate biomolecules(OPBs) are indispensable components of eukaryotes and prokaryotes,such as acting as the fundamental components of cell membranes and important substrates for nucleic acids. They play pivotal roles in various biological processes, such as energy conservation, metabolism,and signal modulation. Due to the difficulty of detection caused by variety OPBs, investigation of their respective physiological effects in organisms has been restrained by the lack of efficient tools. Many small fluorescent probes have been employed for selective detection and monitoring of OPBs in vitro or in vivo due to the advantages of tailored properties, biodegradability and in situ high temporal and spatial resolution imaging. In this review, we summarize the recent advances in fluorescent probes for OPBs,such as nucleotides, NAD(P)H, FAD/FMN and PS. Importantly, we describe their identification mechanisms in detail and discuss the general strategies for these OPBs probe designs, which provide new insights and ideas for the future probe designs. | Wei Li Xiangyang Gong Xiaopeng Fan Shulu Yin Dongdong Su Xiaobing Zhang Lin Yuan | 2019 | Chinese Chemical Letters2019，30，10： | 2 |
| 14 | Jigsaw-like mini-pillar platform for multi-mode biosensing显示文摘The multiple sensing provides booming options to eliminate interference and ensure the accuracy of detection by mutually coupling and validating multiple data sets.Here,we integrate the jigsaw-like multifunctional mini-pillar platform to perform multi-mode(electrochemical,fluorescence,surface-enhanced Raman scattering(SERS)and colorimetric)sensing in individual microdroplets.Each mini-pillar connector can parallelize together by specific concave-convex interface to form integrated jigsaw-like platform for multi-mode sensing,and each specific mini-pillar can be modified into the individual sensing unit to read the prescribed signals.We successfully implemented electrochemical,fluorescence,SERS and colorimetric detection by multiple signals coupling to reduce the false positive analysis.Such platform brings a promising clue of in-situ analysis and point-of-care testing for disease diagnosis and health monitoring. | Yongchao Song Dongdong Wang Zehua Li Lirong Wang Chuan Fan Xuecheng He Tailin Xu Xueji Zhang | 2022 | Chinese Chemical Letters2022，33，8： | 1 |
| 15 | High Per- formanee Silicon Carbon Composite Anode Materials for Lithium Ion Bat- teries显示文摘 | Luo Zhaojun Fan Dongdong Liu Xianlong | 2009 | J Power Sources2009，189，： | 1 |
| 16 | Controlled remote implementation of partially unknown quantum operation显示文摘A protocol for controlled remote implementation of a partially unknown operation on an arbitrary quantum state is proposed. In this protocol, a task can be performed using a GHZ state shared among three distant parties: Alice, Bob and the controller Charlie. This protocol is also generalized to the multi-party control system based on sharing an N-qubit GHZ state. | FAN QiuBo LIU DongDong | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 1 |
| 17 | A generalizable strategy based on the rule of“like dissolves like”to construct porous liquids with low viscosity for CO_(2)capture显示文摘Porous liquids(PLs),an emerging porous material with permanent cavities,have attracted extensive attention in recent years.However,the current construction methods are complicated and resulting PLs possess high viscosity values,which cannot meet the requirements of practical industrial applications.Herein,we demonstrate a generalizable and simple strategy to prepare type III PLs with low viscosity based on the rule of“like dissolves like”.Specifically,the monoglycidyl ether terminated polydimethylsiloxane(denoted by E-PDMS)is attached to the surface of Universitetet i Oslo(UiO)-66-NH_(2)via covalent linkage,constructing the pore generator(UiO-66-NH_(2)-E-PDMS,denoted by P-UiO-66).Then,P-UiO-66 is dispersed into different types and amounts of sterically hindered solvents(PDMS400 or PDMS6000),obtaining a series of type III PLs(denoted by P-UiO-66-PLs)with permanent cavities and low viscosities.The gas sorption-desorption test shows that P-UiO-66-PLs have an enormous potential for CO_(2)/N_(2) selective separation.Besides,the porosity of P-UiO-66-PLs and the CO_(2)sorption mechanism are demonstrated by molecular simulation.Furthermore,the generality of the synthesis strategy is confirmed by the successful construction of PLs using two other amino-metal-organic frameworks(MOFs)(MIL-53(Al)-NH_(2)and MIL-88B(Fe)-NH_(2)).Importantly,it’s worth noting that the strategy based on the rule of“like dissolves like”sheds light on the preparation of other types of PLs for task-specific applications. | Yangyang Xin Hailong Ning Dechao Wang(✉) Xiaoqian Li Wendi Fan Xiaoqian Ju Hongni Wang Yichi Zhang Zhiyuan Yang Dongdong Yao Yaping Zheng | 2023 | Nano Research2023，16，7： | 1 |
| 18 | Spatiotemporal variations of carbon flux and nitrogen deposition flux linked with climate change at the centennial scale in China显示文摘The spatial and temporal variations of the vegetation carbon flux in China from 1901 to 2005 were studied using the vegetation net primary production(NPP)values from seven Earth-system models.In addition,the temporal and spatial changes in the nitrogen deposition flux in China were studied using the NHx and NOy fluxes from 1901 to 2005.The relationship between changes in the carbon flux,nitrogen flux and climate was analyzed.The results show that(1)over the past 100 years,NPP in China has shown an upward trend.The average trend coefficient is 0.88 and the NPP distribution trend is generally low in the north and high in the south,with a gradual increase from the northwest to the southeast.Temperature,precipitation and radiation are all conducive to plant growth in the direction of the gradient.The correlation coefficients between the ensemble model mean NPP and temperature,precipitation,longwave radiation and shortwave radiation are 0.88,0.73,0.91 and 0.67,respectively.(2)In the past 100 years,the NHx and NOy fluxes in China have shown an upward trend,with trend coefficients of 0.98 and 0.98,respectively,which pass the 99.9%confidence level of the t-test.NHx and NOy fluxes are also generally low in the north and high in the south,with a gradual increase from the northwest to the southeast in a step-like pattern.(3)The spatial distribution of the correlation coefficients between the NHx and NOy fluxes and air temperature is similar,with only slight differences in values.The spatial distribution of the correlation coefficients between the NHx and NOy fluxes and precipitation is similar in overall pattern,but the pattern is relatively complicated,with a positive-negative-positive-negative-positive pattern occurring across the monsoon region from north to south,and a negative-positive-negative-positive pattern occurring beyond the monsoon region from east to west.(4)The spatial distribution of the correlation coefficients between the NHx and NOy fluxes and NPP shows a generally consistent pattern,but the pattern is relatively uneven.The average distribution of the ensemble model mean is positive correlation in northeast China and southwest China,and alternating positive and negative correlation in other regions. | Dongdong GAO Li DAN Guangzhou FAN Hanqin TIAN Jing PENG Xiujing YANG Fuqiang YANG Yueyue LI | 2020 | Science China Earth Sciences2020，63，5： | 1 |
| 19 | 人早期胚胎染色质开放性图谱及其进化的关联显示文摘文章简介发育的进行需要体内的基因能够按照设定的程序、在特定的时间和特定的地点有序地表达,这个过程称为基因表达的编程。人体设定基因表达程序的一种'编程语言'被称为'染色体开放状态'。早期胚胎发育中'染色体开放性'如何指挥人类胚胎的基因表达并不是很清楚。本研究克服研究材料缺乏的难题. | Lei Gao Keliang Wu Zhenbo Liu Xuelong Yao Shenli Yuan Wenrong Tao Lizhi Yi Guanling Yu Zhenzhen Hou Dongdong Fan Yong Tian 刘见桥 陈子江 刘江 | 2019 | 科学新闻2019，0，2： | 1 |
| 20 | Performance of a multilayered small-diameter vascular scaffold dual-loaded with VEGF and PDGF显示文摘 | Fengxuan Han Xiaoling Jia Dongdong Dai Xiaoling Yang Jin Zhao Yunhui Zhao Yubo Fan Xiaoyan Yuan | 2013 | Biomaterials2013，，30： | 1 |
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