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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Remote control of BBB: A tale of exosomes and microRNA显示文摘 | Zhen Zhao Berislav V Zlokovic | 2017 | Cell Research2017，27，7： | 8 |
| 3 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 4 | Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods显示文摘Neutralizing antibodies targeting the receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)block severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into cells via surface-expressed angiotensin-converting enzyme 2(ACE2).We used a surrogate virus neutralization test(sVNT)and SARS-CoV-2 S protein-pseudotyped vesicular stomatitis virus(VSV)vector-based neutralization assay(pVNT)to assess the degree to which serum antibodies from coronavirus disease 2019(COVID-19)convalescent patients interfere with the binding of SARS-CoV-2 S to ACE2.Both tests revealed neutralizing anti-SARS-CoV-2 S antibodies in the sera of ~90% of mildly and 100% of severely affected COVID-19 convalescent patients.Importantly,sVNT and pVNT results correlated strongly with each other and to the levels of anti-SARS-CoV-2 S1 IgG and IgA antibodies.Moreover,levels of neutralizing antibodies correlated with the duration and severity of clinical symptoms but not with patient age.Compared to pVNT,sVNT is less sophisticated and does not require any biosafety labs.Since this assay is also much faster and cheaper,sVNT will not only be important for evaluating the prevalence of neutralizing antibodies in a population but also for identifying promising plasma donors for successful passive antibody therapy. | Berislav Bosnjak Saskia Catherina Stein Stefanie Willenzon Anne Katrin Cordes Wolfram Puppe Gunter Bernhardt Inga Ravens Christiane Ritter Christian R.Schultze-Florey Nina Godecke Jorg Martens Hannah Kleine-Weber Markus Hoffmann Anne Cossmann Mustafa Yilmaz Isabelle Pink Marius M.Hoeper Georg M.N.Behrens Stefan Pohlm ann Rainer Blasczyk Thomas F.Schulz Reinhold Forster | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 5 | Neurovascular mechanisms of Alzheimer’s neurodegeneration显示文摘 | Berislav V. Zlokovic | 2005 | Trends in Neurosciences2005，，4： | 2 |
| 6 | Neurovascular mechanisms of Alzheimer's neurodegen- eration 显示文摘 | Berislav VZ | 2005 | Trends Neurosci2005，28，： | 1 |
| 7 | Insourcing Creativity with Lis- tening Posts in Decentralized Firms 显示文摘 | Oliver Gassmann Berislav Gaso | 2004 | Creativity and Innova- tion Management2004，13，1： | 1 |
| 8 | NK cell dysfunction in severe COVID-19:TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity显示文摘In a recent study published in Nature,Witkowski et al.reported that in patients with severe forms of coronavirus disease 2019(COVID-19)deranged tumor growth factor-beta(TGF-β)secretion counteracts interferon-alpha(IFN-α)-induced activation of NK cells by decreasing expression of transcription factor T-bet.Consequently,NK cells fail to upregulate the adhesion molecule integrin beta-2(-ß2),which impedes their attachment to and killing of SARS-CoV-2 infected cells. | Joana Barros-Martins Reinhold Förster Berislav Bošnjak | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 9 | Neurovascular pathways to neurodegeneration in Alzheimer' s disease and other disorders显示文摘 | Berislav V Zlokovi C | 2011 | Nature Reviews Neu- roscience2011，12，12： | 1 |
| 10 | endovascular restorative neurosurgery:a novel concept for molecular and cellular therapy of the nervous system显示文摘 | ARUN PAUL AMAR BERISLAV V ZLOKOVIC MICHAEL L APUZZO | 2003 | Neurosurgery2003，52，： | 1 |
| 11 | Low-density lipoprotein receptor-related protein-1 :a serial clearance homeostatic mechanism controllingAlzheimer’s amyloid p-peptide elimination from the brain显示文摘 | Berislav V Zlokovic Rashid Deane Abhay P Sagare | 2010 | JNeurochem2010，115，5： | 1 |
| 12 | Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease显示文摘 | Robert D. Bell Berislav V. Zlokovic | 2009 | Acta Neuropathologica2009，，1： | 1 |
| 13 | Neurovascular machenisms of Alzheimer's neurodegeneration显示文摘 | Zlokovic | 2005 | TRENDS in Neurosciences2005，28，： | 1 |
| 14 | Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging显示文摘 | Robert D. Bell Ethan A. Winkler Abhay P. Sagare Itender Singh Barb LaRue Rashid Deane Berislav V. Zlokovic | 2010 | Neuron2010，，3： | 1 |
| 15 | Cerebrovascular effects of apolipoprotein E:implications for Alzheimer disease 显示文摘 | Berislav VZ | 2013 | JAMA Neurol2013，70，4： | 1 |
| 16 | Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease显示文摘 | Deane Rashid Berislav V Zlokovic | 2007 | Curr Alzheimer Res2007，4，2： | 1 |
| 17 | The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders显示文摘 | Berislav V. Zlokovic | 2008 | Neuron2008，，2： | 1 |
| 18 | Clarithromycin suppresses airway hyperresponsiveness and inflammation in mouse models of asthma显示文摘 | Bo?ka Hrva?i? Berislav Bo?njak Martina Bosnar ?eljko Feren?i? Ines Glojnari? Vesna Erakovi? Haber | 2009 | European Journal of Pharmacology2009，，1： | 1 |
| 19 | A Laboratory method for measuring the water resistance of sunsereens 显示文摘 | Berislav Markovic Donna Laura Mark Rerek | 2001 | C & T2001，116，9： | 1 |
| 20 | apoE isoform-specific disruption of amyloid [beta] peptide clearance from mouse brain显示文摘 | Deane Rashid Sagare Abhay Hamm Katie Parisi Margaret Lane Steven Finn Mary Beth Holtzman David M Zlokovic Berislav V | 2008 | Journal of Clinical Investigation2008，，12： | 1 |
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