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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 对骨折内固定术后早期感染者保留内固定物的策略显示文摘背景:开放复位内固定术后,在内固定物存在的情况下治疗伤口深部感染极为棘手,关于治疗方案的使用,文献报道甚少。本研究旨在探讨骨折内固定术后6周内发生感染后保留内固定物直至骨性愈合的可能性。方法:通过回顾3个I级创伤中心以往的病历和创伤登记表,共纳入121例新鲜骨折患者,这些患者术中细菌培养均为阳性,内固定术后6周内共123处创口发生感染。统计保留内固定物并获骨折愈合者的比率,评价预测其治疗成败的指标。结果:86例患者(87处骨折;71%)经手术清创、保留内固定物和敏感抗生素治疗获得骨折愈合。治疗失败的有关因素包括开放性骨折(p=0.03)和髓内钉固定(p=0.01)。其他非明显相关但有相关倾向的变量包括吸烟、假单胞菌感染以及累及股骨、胫骨、踝部或足部的骨折。结论:骨折内固定术后深部感染者可通过手术清创、敏感抗生素治疗及保留内固定物成功获得骨折愈合。这些结果可通过基于危险基因、特定菌种和有关的内固定种类对患者进行选择而获得改善。 | Marschall Berkes, MD William T. Obremskey, MD MPH, Brian Scannell, MD J. Kent Ellington, MD Robert A. Hymes, MD Michael Bosse, MD, and the Southeast Fracture Consortium 黄哲元(译) 丁真奇(译) | 2010 | 中华骨科杂志2010，30，9： | 21 |
| 3 | 甘肃玉门火烧沟遗址出土红-黄色混合颜料的再分析显示文摘古代颜料的科学分析一直是考古学研究和艺术史研究的重要内容,分析和确定颜料的矿物成分,对于中国古代科技史研究具有很重要的意义。本工作利用扫描电子显微镜和激光拉曼显微镜对玉门火烧沟遗址出土的红黄色颜料进行了分析,确定了红黄色混合颜料是雄黄、拟雄黄、三氧化二砷、硫磺与石膏的混合物。 | 马清林 Heinz Berke | 2006 | 文物保护与考古科学2006，18，1： | 11 |
| 4 | 山东青州西汉彩绘陶俑紫色颜料研究显示文摘 | 张治国 马清林 Heinz Berke | 2010 | 文物2010，，9： | 9 |
| 5 | Ground response to high horizontal stresses during longwall retreat and its implications for longwall headgate support显示文摘Roof falls in longwall headgate can occur when weak roof and high horizontal stress are present. To prevent roof falls in the headgate under high horizontal stress, it is important to understand the ground response to high horizontal stress in the longwall headgate and the requirements for supplemental roof support. In this study, a longwall headgate under high horizontal stress was instrumented to monitor stress change in the pillars, deformations in the roof, and load in the cable bolts. The conditions in the headgate were monitored for about six months as the longwall face passed by the instrumented site.The roof behavior in the headgate near the face was carefully observed during longwall retreat.Numerical modeling was performed to correlate the modeling results with underground observation and instrumentation data and to quantify the effect of high horizontal stress on roof stability in the longwall headgate. This paper discusses roof support requirements in the longwall headgate under high horizontal stress in regard to the pattern of supplemental cable bolts and the critical locations where additional supplemental support is necessary. | Peter Zhang Dave Gearhart Mark Van Dyke Daniel Su Essie Esterhuizen Berk Tulu | 2019 | International Journal of Mining Science and Technology2019，29，1： | 6 |
| 6 | Ocular disorders in children with spastic subtype of cerebral palsy显示文摘AIM: To document common ocular abnormalities in children with spastic subtype of cerebral palsy (CP) and to find out whether any correlation exists between their occurance and etiologic factors.METHODS: Totally 194 patients with the diagnosis of spastic type CP were enrolled in this retrospective study. Detailed ophthalmic examinations were performed. Demographic data and neuroradiological findings were documented. Kruskal-Wallis, Mann Whitney U, Pearson Chi-square tests and Student's t tests were used in the statistical analysis.RESULTS: The mean age was 64.7±44.2 months on the first ophthalmic examination. Prevalences of diplegia (47.4%) and tetraplegia (36.1%) were found to be higher than the frequency of hemiplegia (16.5% ) in our study population. Etiologic factor was asphyxia in 60.8% of the patients. Abnormal ocular findings were present in 78.9% of the patients. Statistically significant poor vision was detected in tetraplegia group among all the spastic ubtypes of CP (P =0.000). Anisometropia and significant refractive error were found in 14.4% and 70.1% of the patients, respectively. Thirty-six children (18.6% ) had nystagmus and 107 children (55.2% ) had strabismus. Lower gestational age and birth weight were statistically higher in patients with esotropia than exotropia (P=0.009 and P =0.024, respectively). Abnormal morphology of the optic disc was present in 152 eyes (39.2% ). Severe periventricular leukomalacia (PVL) was found in 48 patients and statistically significant poor vision was detected in the presence of PVL (P =0.000).CONCLUSION:Spastic diplegic or tetraplegic CP patients with positive neuroradiological symptoms, younger gestational age and lower birth weight ought to have detailed ophthalmic examinations as early as possible to provide best visual rehabilitation.· | A.Taylan Ozturk A.Tulin Berk Aylin Yaman | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 5 |
| 7 | Cyclophilin A通过调控炎症/免疫反应介导动脉粥样硬化显示文摘 | 廖端芳 庹勤慧 郭琰 Berk B C | 2009 | 中国动脉硬化杂志2009，17，7： | 5 |
| 8 | A case study of multi-seam coal mine entry stability analysis with strength reduction method显示文摘In this paper,the advantage of using numerical models with the strength reduction method(SRM) to evaluate entry stability in complex multiple-seam conditions is demonstrated.A coal mine under variable topography from the Central Appalachian region is used as a case study.At this mine,unexpected roof conditions were encountered during development below previously mined panels.Stress mapping and observation of ground conditions were used to quantify the success of entry support systems in three room-and-pillar panels.Numerical model analyses were initially conducted to estimate the stresses induced by the multiple-seam mining at the locations of the affected entries.The SRM was used to quantify the stability factor of the supported roof of the entries at selected locations.The SRM-calculated stability factors were compared with observations made during the site visits,and the results demonstrate that the SRM adequately identifies the unexpected roof conditions in this complex case.It is concluded that the SRM can be used to effectively evaluate the likely success of roof supports and the stability condition of entries in coal mines. | Tulu Ihsan Berk Esterhuizen Gabriel S. Klemetti Ted Murphy Michael M. Sumner James Sloan Michael | 2016 | International Journal of Mining Science and Technology2016，26，2： | 5 |
| 9 | 大堡礁和大峡谷世界遗产区的适应性管理显示文摘关于人类和环境相互关系的传统观念正在迅速改变。那种认为人类与自然是相互隔离的,自然资源是取之不尽用之不竭的,而且认为世界是稳定的、可以预测的并且是平衡的旧观点已经过时了。在动态的社会-生态景观中强调学习和灵活性管理为基础的适应性方法的新的理念框架已经迅速初现端倪。我们以两个典型的世界遗产地区(大堡礁和大峡谷)为案例来研究如何在自然资源管理中通过改善科学和社会两个方面的结合来指导多尺度管理系统的变革从而应对和处理人类越来越占据主导的世界中出现的不确定性、风险和变化。 | Terence P.Hughes Lance H.Gunderson Carl Folke Andrew H.Baird David Bellwood Fikret Berkes Beatrice Crona Ariella Helfgott Heather Leslie Jon Norberg Magnus Nystrm Per Olsson Henrik sterblom Marten Scheffer Heidi Schuttenberg Robert S.Steneck Maria Teng Max Troell Brian Walker James Wilson Boris Worm 丁莉 | 2007 | AMBIO-人类环境杂志2007，36，B11： | 4 |
| 10 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 11 | Costly external finance, corporate investment, and the subprime mortgage credit crisis显示文摘 | Ran Duchin Oguzhan Ozbas Berk A. Sensoy | 2010 | Journal of Financial Economics2010，，3： | 3 |
| 12 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 13 | Remote sensing for agricultural applications显示文摘Agricultural geospatial information is critical for agricultural policy formulation and decision making,land use monitoring,agricultural sustainability,crop acreage and yield estimation,disaster assessment,bioenergy crop inventory,food security policy,environmental assessment,carbon accounting,and other research topics that are of vital importance to agriculture and economy.Remote sensing technology enables | zhengwei yang wu wen-bin liping di berk ustundag | 2017 | Journal of Integrative Agriculture2017，16，2： | 3 |
| 14 | Spatial estimation of wind speed:a new integrative model using inverse distance weighting and power law显示文摘Spatial interpolation(SI)is currently one of the most common ways to estimate wind speed(Ws).However,classic SI models either ignore the complex geography[e.g.inverse distance weighting(IDW)],or demand high computational resources(e.g.cokriging).This study aimed to develop a simple yet effective SI model for estimating Ws in Eastern Thrace of Turkey.This new method,named MIDW(Ws),is a modified IDW through the integration of IDW with wind profile model,power law(PL),representing the influence of land cover and topography on Ws.Terrain features and elevation data of PL were obtained using normalized difference vegetation index(NDVI)and digital elevation model(DEM),respectively.Results showed superior and comparable performance of MIDW(Ws)to standard IDW and ordinary kriging(OK)across all months of year.Compared to ordinary cokriging(OCK)using DEM as covariate,MIDW(Ws)generated better results in the arid–semiarid seasons(around summer).Local complex atmospheric conditions during rainy seasons(around winter)may have affected the performance of incorporating PL with MIDW(Ws).Generally,the proposed MIDW(Ws)is simpler and easier to implement compared to OCK.For landscape-scale projects,its high computational efficiency and relatively robust performance show potential to deal with large volumes of datasets. | Emre Ozelkan Gang Chen Burak Berk Ustundag | 2016 | International Journal of Digital Earth2016，9，8： | 2 |
| 15 | Equivariant analytical mapping of first principles Hamiltonians to accurate and transferable materials models显示文摘We propose a scheme to construct predictive models for Hamiltonian matrices in atomic orbital representation from ab initio data as a function of atomic and bond environments.The scheme goes beyond conventional tight binding descriptions as it represents the ab initio model to full order,rather than in two-centre or three-centre approximations.We achieve this by introducing an extension to the atomic cluster expansion(ACE)descriptor that represents Hamiltonian matrix blocks that transform equivariantly with respect to the full rotation group.The approach produces analytical linear models for the Hamiltonian and overlap matrices.Through an application to aluminium,we demonstrate that it is possible to train models from a handful of structures computed with density functional theory,and apply them to produce accurate predictions for the electronic structure.The model generalises well and is able to predict defects accurately from only bulk training data. | Liwei Zhang Berk Onat Geneviève Dusson Adam McSloy G.Anand Reinhard J.Maurer Christoph Ortner James R.Kermode | 2022 | npj Computational Materials2022，，1： | 2 |
| 16 | Purification and characteriztion of the periplasmic nitrate reductase from Thiosphaera pantotropha 显示文摘 | Berks BC Richardson DJ Robinson C | 1994 | Eur J Biochem1994，220，： | 2 |
| 17 | The napEDABCgene cluster encoding the periplasmic nitrate reductase system of Thiodphaera pantotropha显示文摘 | Berks BC Richardson DJ ReillyA | 1995 | Biochem J1995，309，： | 2 |
| 18 | Laboratory Diagnosis and Nonoperative Management of Biliary Complications in Living Donor Liver Transplant Patients显示文摘 | Mukund Venu Russell D. Brown Rita Lepe Jamie Berkes Scott J. Cotler Enrico Benedetti Giuliano Testa Rama P. Venu | 2007 | Journal of Clinical Gastroenterology2007，，5： | 2 |
| 19 | Using LaModel to analyze coal bumps显示文摘Coal bumps have long been a safety hazard in coal mines, and even after decades of research, the exact mechanics that cause coal bumps are still not well understood. Therefore, coal bumps are still difficult to predict and control. The LaModel program has a long history of being used to effectively analyze displacements and stresses in coal mines, and with the recent addition of energy release and local mine stiffness calculations, the LaModel program now has greatly increased capabilities for evaluating coal bump potential. This paper presents three recent case histories where coal stress, pillar safety factor, energy release rate and local mine stiffness calculations in LaModel were used to evaluate the pillar plan and cut sequencing that were associated with a number of bumps. The first case history is a longwall mine where a simple stress analysis was used to help determine the limiting depth for safely mining in bump-prone ground. The second case history is a room-and-pillar retreat mine where the LaModel analysis is used to help optimize the pillar extraction sequencing in order to minimize the frequent pillar line bumps. The third case history is the Crandall Canyon mine where an initial bump and then a massive pillar collapse/bump which killed 6 miners is extensively back-analyzed. In these case histories, the calculation tools in LaModel are ultimately shown to be very effective for analyzing various aspects of the bump problem, and in the conclusions, a number of critical insights into the practical calculation of mine failure and stability developed as a result of this research are presented. | Keith A.Heasley Ihsan Berk Tulu | 2018 | International Journal of Mining Science and Technology2018，28，5： | 2 |
| 20 | Sustainability policy considerations for ecosystem management in Central and Eastern Europe显示文摘Here I discuss Central and Eastern European(CEE)countries as a region undergoing rapid change,resulting from the collapse of the Soviet Union and admission of some of the states into the European Union.These events brought changes in governance and ecosystem management,triggering impacts on land use and biodiversity.What are some of the policy options toward sustainability in the face of these political,governance,and socioeconomic changes?Some policy considerations for ecosystem management and sustainability include taking a social-ecological systems approach to integrate biophysical subsystems and social subsystems;paying attention to institutions relevant to shared resources(commons)management;and using resilience theory to study change and guidance for governance.Documented experience in CEE seems to indicate shortcomings for both the centralized state management option and the purely market-driven option for ecosystem management.If so,a“smart mix”of state regulations,market incentives,and self-governance using local commons institutions may be the most promising policy option to foster ecosystem stewardship at multiple levels from local to international. | Fikret Berkes | 2016 | Ecosystem Health and Sustainability2016，2，8： | 2 |
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