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| 1 | 高级别胶质瘤放、化疗耐药性可能与microRNAs相关(英文)显示文摘High-grade gliomas(HGGs) are malignant primary brain tumors of glial cell origin.Despite optimal course of treatment,including maximal surgical resection followed by adjuvant chemo-and/or radiotherapy,the prognosis still remains poor.The main reason is the commonly occurring chemo-and radioresistance of these tumors.In recent years,several signaling pathways,especially PI3K/AKT and ATM/CHK2/p53,have been linked to the resistance of gliomas.Moreover,additional studies have shown that these pathways are significantly regulated by microRNAs(miRNAs),short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis,proliferation,cell cycle,invasivity,and angiogenesis.MiRNAs are not only highly deregulated in gliomas,their expression signatures have also been shown to predict prognosis and therapy response.Therefore,they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients.In this review,we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo-and radiotherapy. | Besse A Sana J Fadrus P Slaby O | 2013 | 中华神经外科疾病研究杂志2013，12，2： | 3 |
| 2 | LOs complications des hysterectomies 显示文摘 | Lopes P Besse O Laurent FX | 1994 | Ref Gynecol Obstet1994，17，2： | 1 |
| 3 | Principal components analysis of sampled functions显示文摘 | Besse P Ramsay J O | 1986 | Psychometrika1986，51，： | 1 |
| 4 | The role of the physician in the late diagnosis of primary malignant tumor of the small intestine显示文摘 | Maglinte DD O' connork Bess ette J | 2001 | Am J Gastro enterol2001，86，3： | 1 |
| 5 | Cellular proteins bound to immunodeficiency viruses: implications for Pathogenesis and vaccines 显示文摘 | Larry O Arthur Julian W Bess JR | 1992 | Science1992，，258： | 1 |
| 6 | Estimation of Direction of Arrival Estimation of Multiple Scattered Sources 显示文摘 | GHOGHO M BESS(IN O SWARN A | 2001 | IEEE Trans on Signal Processing2001，49，11： | 1 |
| 7 | The role of the physician in the late diagnosis of primary malignant tumor of the small intestine显示文摘 | Maglinte DD O' connork Bess ette J | 2001 | Am J Gastro enterol2001，86，3： | 1 |
| 8 | Laparoscopically assisted myomectomy:a report of a new technique in 57 cases显示文摘 | Nezhat C Nezhat F Bess O | 1994 | Int J Fertil Menopausal Stud1994，39，1： | 1 |
| 9 | Laparoscopic amputation of a noncommunicating rudimentary horn after a hysteroscopic diagnosis : a case study 显示文摘 | Nezhat F Nezhat C Bess O | 1994 | Surg Laparosc Endosc1994，4，： | 1 |
| 10 | Pain and disability determine treatment modality for older patients with adult scoliosis, while deformity guides treatment for younger patients显示文摘 | Bess S Boachie-Adjei O Burton D | 2009 | Spine (Phila Pa 1976)2009，34，20： | 1 |
| 11 | Pain and disabili- ty determine treatment modality for older patients with a- dult scoliosis, while deformity guides treatment for youn- ger patients显示文摘 | Bess S Boachie-Adjei O Burton D | 2009 | Spine2009，34，20： | 1 |
| 12 | Does recombinant human bone morphogenetie protein-2 (BMP) use in adult spinal deformity (ASD) increase complications and are complications does related A prospective, muhicenter study of 257 consecutive patients 显示文摘 | Bess S Line BG Boaehie-Adjei O | 2012 | Neuro- surgery2012，71，2： | 1 |
| 13 | Laparoscopically assisted myomectomy:areport ofanew teehniquein 57 cases 显示文摘 | Nezhat C Nezhat F Bess O | 1994 | Int J Fertil Menopaus Stud1994，39，1： | 1 |
| 14 | Pain and disability determine treatment modality for older patients with adult scoliosis,while deformity guides treatment for younger patients显示文摘 | Bess S Boachie-Adjei O Burton D | 2009 | Spine2009，34，20： | 1 |
| 15 | Response of soil microbial communities to the herbicide mesotrione: a dose-effect microcosm approach 显示文摘 | CROUZET O BATISSON B BESSE H P | 2010 | Soil Biology & Biochemistry2010，42，： | 1 |
| 16 | Anatomic and functional results of laparoscopic-perineal neovagina construction by sigmoid colpoplasty in women with Rokitansky's syndrome 显示文摘 | Darai E Toullalan O Besse O | 2003 | Hum Reprod2003，18，11： | 1 |
| 17 | Injures associated with the use of a linear stapler during operative laparoscopy:review of diagnosis,management and prevention显示文摘 | Nezhat C Nezhat F Bess O | 1993 | J Gynecol Surg1993，9，3： | 1 |
| 18 | Hospital cost comparison between abdominal,vaginal,and laparoscopy-assisted vaginal hysterectomies显示文摘 | Nezhat C Bess O Admon D | 1994 | Obstet Gynecol1994，83，51： | 1 |
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