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| 1 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 2 | Cloud point extraction as a procedure of separation and pre-concentration for metal determination using spectroanalytical techniques:A review显示文摘 | Bezerra M D Arruda M A Z Ferreira S L C | 2005 | Applied Spectroscopy Reviews2005，40，4： | 1 |
| 3 | Statistical design- principal component analysis optimization of a multiple response procedure using cloud point extraction and simultaneous determination of metals by ICP OES显示文摘 | BEZERRA M A BRUNS R E FERREIRA S L C | 2009 | Analyfica Chimica Aeta2009，580，2： | 1 |
| 4 | Increase of tospoviral diversity in Brazil with the identification of two new tospoviruses, one from Chrysanthemum and one from Zucchini显示文摘 | Bezerra I C Resende O de Pozzer L | 1999 | Phytopathology1999，89，： | 1 |
| 5 | Cloud point extraction as a procedure of separation and preconcentration for metal determination using spectroanalytical techniques显示文摘 | Bezerra M D Arruda M A Z Ferreira S L C | 2005 | Appl Spectrosc Rev2005，40，4： | 1 |
| 6 | Measurements and numerical simulations of the degree of activity and vegetation cover on parabolic dunes in north-eastern Brazil显示文摘 | Duran O Silva M V N Bezerra L J C | 2008 | Geomorphology2008，102，34： | 1 |
| 7 | Use of Diagnodent for diagnosis of non-cavitated oeclusal dentin caries 显示文摘 | Costa A Paula L Bezerra A | 2008 | J Appl Oral Sci2008，16，1： | 1 |
| 8 | On-line system for preconcentration and determination of metals in vegetables by inductively coupled plasma optical emission spectrometry显示文摘 | BEZERRA M A dos SANTOS W N L LEMOS V A | 2007 | Journal of Hazardous Materials2007，148，12： | 1 |
| 9 | Correlation between valsalva leak point pressure and maximal urethral closure pressure in women with stress urinary incontinence 显示文摘 | Feldner P C Jr Bezerra L R de Castro R A | 2004 | Int Urogynecol J Pelvic Floor Dysfunct2004，15，3： | 1 |
| 10 | Deep root function in soil water dynamics in Cerrado savannas of central Brazil显示文摘 | Oliveira R S Bezerra L Davidson E A | 2005 | Functional Ecology2005，19，4： | 1 |
| 11 | Extraction of amylase from fermentation broth in poly (ethylene glycol) salt aqueous two-phase system 显示文摘 | Bezerra R P Borba F K S L Moreira K A | 2006 | Brazilian Arch Biol Technol2006，49，4： | 1 |
| 12 | SAR, QSAR and docking of anti cancer flavonoids and variants: a review 显示文摘 | Scotti L Bezerra Mendonca Junior F I Magalhaes Moreira D R | 2009 | Curr Top Med Chem2009，12，24： | 1 |
| 13 | Characterization of a tospovirus isolate of iris yellow spot virus associated with a dis ease in onion fields in Brazil显示文摘 | Pozzer L Bezerra I C Kormelink R | 1999 | Plant Disease1999，83，4： | 1 |
| 14 | Cholestatic Liver Disease in Children 显示文摘 | Santos J L Choquette M Bezerra J A | 2010 | Curr Gastroenterol Rep2010，12，1： | 1 |
| 15 | Response surface methodology (RSM) as a tool for optimization in analyt- ical chemistry 显示文摘 | Bezerra M A Santelli R E Escaleira L A | 2008 | Talanta2008，，76： | 1 |
| 16 | Measure ments and numerical simulations of the degree of activity and vegetation cover on parabolic dunes in north-eastern Brazil 显示文摘 | Duran O Silva M V N Bezerra L J C | 2008 | Geomorphologv2008，102，34： | 1 |
| 17 | Measurements and numerical simulations of the degree of activity and vegetation cover on parabolic dunes in north-eastern Brazil显示文摘 | DURAN O SILVA M V N BEZERRA L J C | 2008 | Geomorhpology2008，102，： | 1 |
| 18 | Evaluation of Packing Attributes of Orange Juice on Consumers’ Intention to Purchase by Conjoint Analysis and Consumer Attitudes Expectation显示文摘 | Izabel Lucena Gadioli Lívia de Lacerda de Oliveira Pineli Juliana Da Silva Quintiliano Rodrigues Alinne Bezerra Campos Isadora Queiroz Gerolim Marileusa D. Chiarello | 2013 | J Sens Stud2013，，1： | 1 |
| 19 | Sleep disorders among undergraduate students in Southern Brazil显示文摘 | FALAVIGNA A DE SOUZA BEZERRA M L TELES A R | 2011 | Sleep Breath2011，15，3： | 1 |
| 20 | Deep root function in soil water dynamics in cerrado sa- vannas of central Brazil 显示文摘 | OLIVEIRA R S BEZERRA L DAVIDSON E A | 2005 | Functional Ecology2005，，19： | 1 |
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