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| 1 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 20 |
| 2 | 妊娠期高血压疾病对远期心血管病的影响显示文摘对妇女妊娠期高血压疾病(hypertensive disorder of pregnancy,HDP)史的研究,可能有助于改善动脉粥样硬化性心血管病的风险评估。但是,有HDP既往史的中年无症状妇女在未来患心血管病的风险仍未知。该研究旨在探讨有或无HDP既往史的中年女性心血管病的远期发病率。纳入标准:在前瞻性、观察性英国生物资料库中,纳入40~69岁并至少有一活产的英国妇女,对其中一亚组妇女进行了无创性动脉硬度测量。 | 周卫(译) 叶鹏(摘、审校) Honigberg MC Zekavat SM Aragam K Klarin D Bhatt DL Scott NS Peloso GM Natarajan P | 2020 | 中华高血压杂志2020，28，2： | 6 |
| 3 | Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD^(2) score显示文摘Background Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack(TIA)and role of ABCD^(2) score in identifying high-risk individuals are not studied.Methods We identified 40825 Medicare beneficiaries hospitalised from 2011 to 2014 for a TIA to a Get With The Guidelines(GWTG)-Stroke hospital and classified them using ABCD^(2)s of mortality and rehospitalisation(all-cause,ischaemic stroke,haemorrhagic stroke,myocardial infarction,and gastrointestinal and intracranial haemorrhage)for high-risk versus low-risk groups adjusted for patient and hospital characteristics.Results Of the 40825 patients,35118(86%)were high risk(ABCD^(2)≥4)and 5707(14%)were low risk(ABCD^(2)=0-3).Overall rate of mortality during 1-year follow-up after hospital discharge for the index TIA was 11.7%,44.3% were rehospitalised for any reason and 3.6%were readmitted due to stroke.Patients with ABCD^(2) score≥4 had higher mortality at 1 year than not(adjusted HR 1.18,95%CI 1.07 to 1.30).Adjusted risks for ischaemic stroke,all-cause readmission and mortality/all-cause readmission at 1 year were also significantly higher for patients with ABCD^(2) score≥4 vs 0-3.In contrast,haemorrhagic stroke,myocardial infarction,gastrointestinal bleeding and intracranial haemorrhage risk were not significantly different by ABCD^(2) score.Conclusions This study validates the use of ABCD^(2) score for long-term risk assessment after TIA in patients aged 65 years and older.Attentive efforts for community-based follow-up care after TIA are needed for ongoing prevention in Medicare beneficiaries who were hospitalised for TIA. | Shreyansh Shah Li Liang Durgesh Bhandary Saga Johansson Eric E Smith Deepak L Bhatt Gregg C Fonarow Naeem D Khan Eric Peterson Janet Prvu Bettger | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 4 | Clinical and microbiological aspects of Trichomonas vaginalis显示文摘 | Petrin D Delgaty K Bhatt R | 1998 | Clin Microbiol Rev1998，11，2： | 1 |
| 5 | Clopidogrel with or without omeprazole in coronary artery disease显示文摘 | BHATT D L CRYER B L CONTANT C F | 2010 | N Eng!J Med2010，363，20： | 1 |
| 6 | Early and sustained survival benefit associated with statin therapy at the time of percutaneous coronary intervention显示文摘 | Chan A W Bhatt D L Chew D P | | 0，，： | 1 |
| 7 | Use of intensive lipidlowering therapy in parients hospitalized with acute coronary syndrome:an analysis of 65,396 hospitalizations from 344 hospital participating in Get With The Guidelines(GWTG)显示文摘 | Javed U Deedwania P C Bhatt D L | | 0，，02： | 1 |
| 8 | Synthesis and in vivo antitumor activity of poly (L-glutamic acid) conjugates of 20 (S)-camptothecin显示文摘 | BHATT R VRIES P D TULINSKY J | 2003 | J Med Chem2003，46，1： | 1 |
| 9 | Thin film TiC/TaC thermocouples 显示文摘 | BHATT H D VEDULA R DESU S B | 1999 | Thin Solid Films1999，342，1： | 1 |
| 10 | Regulation of the NF-κB-mediated transcription of inflammatory genes 显示文摘 | BHATT D GHOSH S | 2014 | Front Immunol2014，5，1： | 1 |
| 11 | Types of Information Technology Capabilities and their role in Competitive Advantage: an Empirical Strudy显示文摘 | Ganesh D Bhatt Varun Grover | 2005 | Journal of Management Information System/Fall2005，22，2： | 1 |
| 12 | The clopidogrel in unstable angina to prevent recurrent events(CURE) study: to what extent should the results be generalizable显示文摘 | Gerschutz G P Bhatt D L | 2003 | Am Heart J2003，145，： | 1 |
| 13 | Identification of no-vel splice variants in horn cancer by RNA-Seq analysis in Zebucattle 显示文摘 | Patel A K Bhatt V D 丁Hpathi A K | 2013 | Genomics2013，101，1： | 1 |
| 14 | Solid phase extraction, preconcetraction and sequential separation of U ( VI ), Th ( IV ),La(III) and Ce(III) by Octa-O-met hoxy resorcin arene based Amberlite XAD -4 chelating resin 显示文摘 | Keyur D Bhatt Disha J Vyas Hrishikesh S Gupte | 2014 | World Journal of Analy-tical Chemistry2014，2，： | 1 |
| 15 | Incremental prognostic Value of elerated baseline C-reactive protein among established markers of risk in percutaneous coronary intervention显示文摘 | CHEW D P BHATT D I ROBBINS M A | 2001 | Circulation2001，104，6： | 1 |
| 16 | Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats显示文摘 | Tikoo K Bhatt D K Gaikwad | 2007 | FEBS Lett2007，581，10： | 1 |
| 17 | Clinical and microbiological aspects of Trichomonas vaginalis显示文摘 | Petrin D Delgaty K Bhatt R | 1998 | Clin Microbiol Rev1998，11，： | 1 |
| 18 | Organizing knowledge in the knowledge de- velopment cycle 显示文摘 | Bhatt G D | 2005 | Journal of Knowledge Manage- ment2005，4，1： | 1 |
| 19 | The design and rationale of the saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus-thrombolysis in myocardial infarction ( SAVOR-TIMI ) 53 study 显示文摘 | Scirica B M Bhatt D L Braunwald E | 2011 | Am Heart J2011，162，5： | 1 |
| 20 | Clopidogrel resistance-a clear problem with an unclear solution显示文摘 | BANSILAL S BHATT D L | 2012 | Indian Heart J2012，64，4： | 1 |
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