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| 1 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 20 |
| 2 | 2018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI显示文摘East Asians are the most populous race in the world and their health status is an important global issue.Compared with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this observation, treatment strategies in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed. | Yong Huo Young-Hoon Jeong Yanjun Gong Daowen Wang Ben He Jiyan Chen Guosheng Fu Yundai Chen Jianping Li Yi Li Shinya Goto Udaya S.Tantry Paul A.Gurbel Jong-Hwa Ahn Hyo-Soo Kim Myung Ho Jeong Yaling Han Sidney C.Smith Jr. Junbo Ge | 2019 | Science Bulletin2019，64，3： | 12 |
| 3 | 世界各地动脉粥样硬化血栓形成门诊患者心血管危险因素的流行及诊治情况显示文摘背景:动脉粥样硬化血栓形成是导致心血管疾病和死亡的主要原因。至今,尚无国际数据库阐述动脉粥样硬化血栓形成患者动脉硬化危险因素的特征和治疗强度。
目的:确定动脉粥样硬化危险因素的发生及治疗在世界许多国家是否具有可比性。设计、地点及参试者:“降低动脉粥样硬化血栓形成保持健康研究”(Reduction of Atherothrombosis for Continued Health,REACH)搜集了动脉粥样硬化危险因素及治疗情况的数据。从2003年到2004年,44个国家、5473位内科从业医师总共发现67888例年龄≥45岁的动脉病患者(冠心病[coronaryartery disease,CAD],n=40258;脑血管病,n=18843;周围动脉病,n=8273)或≥3个动脉粥样硬化血栓形成危险因素(n=12389)。主要观测指标:动脉粥样硬化危险因素的基线发生率、药物应用情况及危险因素控制程度。结果:全世界动脉粥样硬化血栓形成患者具有相似的危险因素,即高血压(81.8%)、高胆固醇血症(72.4%)以及糖尿病(44.3%)的比例高。超重(39.8%)、肥胖(26.6%)以及病态肥胖(3.6%)的发生率在大部分地区相似,但是以北美最高(超重:37.1%,肥胖:36.5%,病态肥胖:5.8%;与其他地区比较P〈0.001)。患者采用他汀(总共69.4%;范围:从脑血管病的56.4%到CAD的76.2%)、抗血小板治疗(总共78.6%;范围:从≥3个危险因素的53.9%到CAD的85.6%)及其他循证(降低危险)普遍不足。确诊有血管病的患者在吸烟者为数可观(14.4%)。高血压病治疗不足(基线50.0%血压升高)、高血糖诊断不足(4.9%)以及空腹血糖受损(其中36.5%不知已有糖尿病)均很常见。在有症状的动脉粥样硬化血栓形成患者中,15.9%是有症状的多血管疾病患者。
结论:这项当代大型国际数据库研究显示,在世界许多地区典型心血管危险因素的发生是一致且常见的,但是大多治疗不足、控制不得力。 | Deepak L. Bhatt, MD P. Gabriel Steg, MD E. Magnus Ohman, MD Alan T. Hirsch, MD Yasuo Ikeda, MD Jean-Louis Mas, MD Shinya Goto, MD Chlau-Suong Liau, MD, PhD Alain J. Richard, MD, PhD Joachim Roether, MD Peter W. F. Wilson, MD 徐成斌(译) | 2007 | 美国医学会杂志(中文版)2007，26，1： | 5 |
| 4 | Curative ESD for intraepithelial esophageal carcinoma with leiomyoma mimicking submucosal invasive carcinoma显示文摘This case report presents a 65-year-old man who developed early esophageal cancer with leiomyoma treated by endoscopic submucosal dissection(ESD).There have been several reports of co-existing superficial esophageal cancer and leiomyoma treated by endoscopic mucosal resection.However,there is no previous report describing the co-existing lesion treated by ESD.In order to determine treatment strategies for esophageal cancer,accurate endoscopic evaluation of the cancerous depth is essential.In the present case,the combination of endoscopic ultrasonography and narrow-band imaging system with magnifying endoscopy was extremely useful to evaluate the superficial esophageal cancer with leiomyoma,which lead to the appropriate treatment,ESD. | Keiko Niimi Shinya Kodashima Satoshi Ono Osamu Goto Nobutake Yamamichi Mitsuhiro Fujishiro | 2009 | World Journal of Gastrointestinal Endoscopy2009，1，1： | 3 |
| 5 | Adherence to Secondary Prevention Medications and Four-year Outcomes in Outpatients with Atherosclerosis显示文摘 | Dharam J. Kumbhani Ph. Gabriel Steg Christopher P. Cannon Kim A. Eagle Sidney C. Smith Elaine Hoffman Shinya Goto E. Magnus Ohman Deepak L. Bhatt | 2013 | The American Journal of Medicine2013，，： | 1 |
| 6 | Carotid Atherosclerosis and Risk of Subsequent Coronary Event in Outpatients With Atherothrombosis显示文摘 | Gaia Sirimarco Pierre Amarenco Julien Labreuche Pierre-Jean Touboul Mark Alberts Shinya Goto Joachim Rother Jean-Louis Mas Deepak L. Bhatt Philippe Gabriel Steg | 2013 | Stroke2013，，2： | 1 |
| 7 | Risk factor profiles, drug usage, and prevalence of aspirin-associated gastroduodenal injuries among high-risk cardiovascular Japanese patients: the results from the MAGIC study显示文摘 | Naomi Uemura Kentaro Sugano Hideyuki Hiraishi Kazuyuki Shimada Shinya Goto Shinichiro Uchiyama Yasushi Okada Hideki Origasa Yasuo Ikeda | 2014 | Journal of Gastroenterology2014，，： | 1 |
| 8 | Clarification of the Mechanism of Wiper Blade Rubber Squeal Noise Generation显示文摘 | Shinya Goto Hiroshi Takahashi Takio Oya | 2001 | Society of Automotive Engineers of Japan2001，22，1： | 1 |
| 9 | New therapy with monoclonal antibodiesabciximab, chimeric anti-GP Ⅱb/Ⅲa antibody显示文摘 | Goto Shinya | 2002 | Nippon Rinsho2002，60，3： | 1 |
| 10 | Tensile strength and fiber/matrix interfacial properties of 2D- and 3D- carbon/carbon composites 显示文摘 | Hiroshi Hatta Ken Goto Shinya Ikegaki | 2005 | Journal of the European Ce- ramic Society2005，25，4： | 1 |
| 11 | Endoscopic mucosal resection with a ligation device or endoscopic submucosal dissection for rectal carcinoid tumors: An analysis of 24 consecutive cases显示文摘 | Keiko Niimi Osamu Goto Mitsuhiro Fujishiro Shinya Kodashima Satoshi Ono Satoshi Mochizuki Itsuko Asada‐Hirayama Maki Konno‐Shimizu Rie Mikami‐Matsuda Chihiro Minatsuki Nobutake Yamamichi Kazuhiko Koike | 2012 | Digestive Endoscopy2012，，6： | 1 |
| 12 | New therapy with monoclonal antibodies - abciximab,chimeric anti - GPⅡ bⅢa antibody显示文摘 | - Shinya | 2002 | Nippon Rinsho2002，60，3： | 1 |
| 13 | Specific Inhibiting Characteristics of Tetramethylpyrazine, One of the Active Ingredients of the Chinese Herbal Medicine ‘Chuanxiong,’ on Platelet Thrombus Formation Under High Shear Rates显示文摘 | Min Li Shunnosuke Handa Yasuo Ikeda Shinya Goto | 2001 | Thrombosis Research2001，，1： | 1 |
| 14 | Carotid Atherosclerosis and Risk of Subsequent Coronary Event in Outpatients With Atherothrombosis显示文摘 | Gaia Sirimarco Pierre Amarenco Julien Labreuche Pierre-Jean Touboul Mark Alberts Shinya Goto Joachim Rother Jean-Louis Mas Deepak L. Bhatt Philippe Gabriel Steg | 2013 | Stroke2013，，2： | 1 |
| 15 | Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells显示文摘 | Sakiko Arisawa Kumiki Ishida Natsumi Kameyama Jun Ueyama Ai Hattori Yasuaki Tatsumi Hisao Hayashi Motoyoshi Yano Kazuhiko Hayashi Yoshiaki Katano Hidemi Goto Kenji Takagi Shinya Wakusawa | 2008 | Biochemical Pharmacology2008，，5： | 1 |
| 16 | One-Year Atherothrombotic Vascular Events Rates in Outpatients with Recent Non-Cardioembolic Ischemic Stroke: The EVEREST (Effective Vascular Event REduction after STroke) Registry显示文摘 | Norihiro Suzuki Motoki Sato Kiyohiro Houkin Yasuo Terayama Shinichiro Uchiyama Hiroyuki Daida Hiroshi Shigematsu Shinya Goto Kortaro Tanaka Hideki Origasa Susumu Miyamoto Kazuo Minematsu Masayasu Matsumoto Yasushi Okada | 2012 | Journal of Stroke and Cerebrovascular Diseases2012，，4： | 1 |
| 17 | Contrast-enhanced endoscopic ultrasonography in gallbladder diseases显示文摘 | Yoshiki Hirooka Yasuo Naitoh Hidemi Goto Akihiro Ito Shinya Hayakawa Yoshihiro Watanabe Yoshihiro Ishiguro Shinya Kojima Senju Hashimoto Tetsuo Hayakawa | 1998 | Gastrointestinal Endoscopy1998，，4： | 1 |
| 18 | Enhanced Shear-induced von Willebrand Factor Binding to Platelets in Acute Myocardial Infarction显示文摘 | Min Li Shinya Goto Hiroyuki Sakai Jae-Young Kim Noriko Ichikawa Minako Yoshida Yasuo Ikeda Shunnosuke Handa | 2000 | Thrombosis Research2000，，4： | 1 |
| 19 | Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms显示文摘 | Satoshi Ono Mitsuhiro Fujishiro Keiko Niimi Osamu Goto Shinya Kodashima Nobutake Yamamichi Masao Omata | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 20 | A second-look endoscopy after endoscopic submucosal dissection for gastric epithelial neoplasm may be unnecessary: a retrospective analysis of postendoscopic submucosal dissection bleeding显示文摘 | Osamu Goto Mitsuhiro Fujishiro Shinya Kodashima Satoshi Ono Keiko Niimi Kousuke Hirano Nobutake Yamamichi Kazuhiko Koike | 2010 | Gastrointestinal Endoscopy2010，，2： | 1 |
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