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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Characteristics of enzymatic hydrolysis of the wheat gluten proteins treated by ultrasound wave显示文摘 | JIN H L WANG J S BIAN K | 2011 | Adv Mater Res2011，344，： | 1 |
| 3 | Comparative study on electrochemical 4-chlorophenol degradation in different diaphragm systems with combined reduction and oxidation properties 显示文摘 | Liu S L Wang H Bian Z Y | 2015 | Water Science and Technology2015，71，1： | 1 |
| 4 | Preparation of Molecularly Imprinted Polymer by Surface Imprinting Technique and Its Performance for Adsorption of Dibenzothiophene显示文摘 | Xu W Z Zhou W Bian L H | 2011 | J Sep Sci2011，34，14： | 1 |
| 5 | Spontaneous organization of inorganic nanoparticles into nanovesicles triggered by UV light显示文摘 | Bian T Shang L Yu H Perez M T Wu L Z Tung C H Nie Z Tang Z Zhang T | 2014 | Advanced Materials2014，26，32： | 1 |
| 6 | Bubble template synthesis of Sn2Nb2O7hollow spheres for enhanced visible-light-driven photocatalytic hydrogen production显示文摘 | Zhou C Zhao Y Bian T Shang L Yu H Wu L Z Tung C H Zhang T | 2013 | Chemical Communications2013，49，84： | 1 |
| 7 | Facile synthesis of hierarchical ZnIn2S4submicrospheres composed of ultrathin mesoporousnanosheets as a highly efficient visible-light-driven photocatalyst for H2production显示文摘 | Shang L Zhou C Bian T Yu H Wu L Z Tung C H Zhang T | 2013 | Journal of Materials Chemistry A2013，1，14： | 1 |
| 8 | A three-year experiment confirms continuous immobilization of cadmium and lead in contaminatedpaddy field with biochar amendment显示文摘 | Bian R Joseph S Cui L Pan G Li L Liu X Zhang A Rutlidge H Wong S Chia C Marjo C Gong B Munroe P Donne S | 2014 | Journal of Hazardous Materials2014，272，： | 1 |
| 9 | Preparation and character- ization of modified graphite oxide/poly(propylene carbon-ate) composites by solution intercalation 显示文摘 | Bian J Wei X W Lin H L | 2011 | Polymer Deg- radation and Stability2011，96，10： | 1 |
| 10 | Co MParative study on the exfoliated expanded graphite nanosheet-PES composites prepared via different compounding method 显示文摘 | Bian J Wei X W Lin H L | 2012 | Journal of Applied Polymer Science2012，124，5： | 1 |
| 11 | Dynamic localization in mesoscopic metallic rings 显示文摘 | Wang L Bian X F Yang H | 2002 | Phys Lett A2002，302，56： | 1 |
| 12 | Medium-range order structure in Al80Fe20 alloy during rapid solidification 显示文摘 | Wang L Cong H R Bian X F | 2002 | Phys Lett A2002，301，56： | 1 |
| 13 | Fabrication of microwave exfoliated graphite oxide reinforced thermoplastic polyure- thane nanocomposites:effects of filler on morphology, me- chanical, thermal, rheological, and conductive properties 显示文摘 | Bian J Lin H L Wei X W | 2013 | Compoistes:Part A Applied Science and Manufactur- ing2013，47，： | 1 |
| 14 | Processing and assessment of high-performance poly (butylene terephthalate) nanocom- posites reinforced with microwave exfoliated graphite oxide nanosheets 显示文摘 | Bian J Lin H L He F X | 2013 | European Polymer Journal2013，49，6： | 1 |
| 15 | Mesoporousplasmonic Au-loaded Ta2O5 nanocomposites for efficient visible light photocatalysis显示文摘 | Zhou C Shang L Yu H Bian T Wu L Z Tung C H Zhang T | 2014 | Catalysis Today2014，225，： | 1 |
| 16 | Health risk assessment of metals in food crops and related soils amended with biogas slurry in Taihu Basin:Per- spective from field experiment显示文摘 | Bian B Wu H S Lv L | 2015 | Environmental Science and Pollution Research International2015，22，14： | 1 |
| 17 | Contamination and risk assessment of heavy metals in soils irrigated with biogas slurry:A case study of Taihu basin 显示文摘 | Bian B Wu H S Zhou L J | 2015 | Environmental Monitoring and Assessment2015，187，4： | 1 |
| 18 | A study on an electronically controlled liquefied petroleum gas-diesel dual-fuel automobile显示文摘 | Zhang C H Bian Y Z Si L Z | 2005 | Proceedings of the Institution of Mechanical Engineers Part D: Journal of Automobile Engineering2005，219，2： | 1 |
| 19 | Synthesis and luminescence property of rare earth complex nanoparticles dispersed within pores of modified mesoporous silica显示文摘 | Bian L J Xi H A Qian X F | 2002 | Materials Research Bulletin2002，37，： | 1 |
| 20 | Protein expression in a transformed trabecular meshwork cell line:proteome analysis显示文摘 | STEELY H T DILLOW GW BIAN L | 2006 | Mol Vis2006，12，4： | 1 |
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