|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The DNA-binding factor Ctcf critically controls gene expression in macrophages显示文摘巨噬细胞在免疫和动态平衡起一个重要作用。在经由特定的受体的病原体识别之上,他们很快导致煽动性的回答。这个过程紧在 transcriptional 水平被控制。DNA 有约束力的锌手指蛋白质 CCCTC 有约束力的因素(Ctcf ) 是远程的染色质相互作用的一个关键管理者并且协调在抄写因素和基因表达式进程之间的特定的通讯。在这研究, Ctcf 基因被使用转基因的 Cre-LoxP 系统明确地在 myeloid 房间删除。在 myeloid 房间的 Ctcf 基因的有条件的删除在 vivo 导致了温和显型。显著地展出的 Ctcf 缺乏的老鼠减少了主要 histocompatibility 的表示在肝的建筑群(MHC ) 班 II。Ctcf 缺乏的巨噬细胞表明了正常表面显型和吞噬作用能力。在像使用费的受体(TLR ) 之上刺激,他们生产了支持 inflammatory cytokines IL-12 和 IL-6 的正常层次,但是表明了一个强烈损害的能力生产肿瘤坏死因素(TNF ) 和 IL-10,以及表示 IL-10 家庭成员 IL-19, IL-20 和 IL-24。一起拿,我们的数据表明涉及巨噬细胞功能调整的 Ctcf 的一个角色。 | Tatjana Nikolic Dowty Movita Margaretha EH Lambers Claudia Ribeiro de Almeida] Paula Biesta Kim Kreefft Marjolein JW de Bruijn Ingrid Bergen Niels Galjart Andre Boonstra Rudi Hendriks | 2014 | Cellular & Molecular Immunology2014，11，1： | 2 |
| 2 | Disciplines and Theory in the Academic Study of Education: A Comparative Analysis of the Anglo-American and Continental Construction of the Field 显示文摘 | Biesta G | 2011 | Pedagogy Culture and Society2011，，： | 1 |
| 3 | Beyond Presence:Episte mological and Pedagogical Implications of 'Strong' E mergence显示文摘 | OSBERG D BIESTA G J J | 2007 | Interchange:A Quarterly Review of Ed ucation2007，38，1： | 1 |
| 4 | Restoration of TLR3 -aetivated myeloid dendritic cell activity leads to im- proved natural killer cell function in chronic hepatitis B vi- rus infection 显示文摘 | Tjwa ET Van Oord GW Biesta PJ | 2010 | J Viru12010，86，8： | 1 |
| 5 | Lack of IFN-gamma-mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines 显示文摘 | van der Stoep N Biesta P Quinten E | 2002 | Int J Cancer2002，97，4： | 1 |
| 6 | Favorable ef- fect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV 显示文摘 | Vander Molen RG Sprengers D Biesta PJ | 2006 | Hepatology2006，44，4： | 1 |
| 7 | The Emergent Curriculum: Navigating a Complex Course Between Unguided Learning and Planned Enculturation显示文摘 | OSBERG D BIESTA J J | 2008 | Journal of Curriculum Studies2008，，3： | 1 |
| 8 | Dewey in Europe:A Case Study on the International Dimensions of the Turn-of- the-century Educational Reform 显示文摘 | Gert Biesta & Siebren Miedema | 1996 | American Journal of Education1996，105，： | 1 |
| 9 | Hepatitis B virus lacks immune activating capacity, but actively inhib- its plasmacytoid dendritic cell function显示文摘 | Woltman AM Op den Brouw ML Biesta PJ | 2011 | PLoS One2011，6，15： | 1 |
| 10 | Witnessing Deconstruction in Education Why Quasi-Transcendentalism Matters显示文摘 | Biesta G | 2009 | Journal of Philosophy of Education2009，43，40： | 1 |
| 11 | Hepatitis B virus lacks immune activaling capacity, but actively inhibits plasmacytoid dendritic cell function显示文摘 | WOLTMAN AM OP DEN BROUW ML BIESTA PJ | 2011 | PLoS One2011，6，15： | 1 |
| 12 | Hepatitis B virus lacks immune activating capaciity, but ac- tively inhibits plasmacytoid dendritic cell function 显示文摘 | WOLTMAN AM OP den BROUW ML BIESTA P J | 2011 | PLoS One2011，6，15： | 1 |
| 13 | Hepatitis B virus lacks immune activating capacity, but ac- tively inhibits plasmacytoid dendritic cell function 显示文摘 | WOLTMAN AM OP den BROUW ML BIESTA P J | 2011 | PLoS One2011，6，1： | 1 |
| 14 | Favorable effect of adefovir on the number and function of myeloid dendritic cells of patients with chronic HBV显示文摘 | van der Molen RG Sprengers D Biesta PJ | | 0，，04： | 1 |
| 15 | Tumor necrosis factor alpha inhibits the suppressive effect of regulatory T cells on the hepatitis B virus-specific immune response 显示文摘 | STOOP JN WOLTMAN AM BIESTA PJ | 2007 | Hepatology2007，46，3： | 1 |
| 16 | Bridging the gap between educational research and educational practice: The need for critical distance显示文摘 | Gert Biesta | 2007 | Educational Research and Evaluation2007，，3： | 1 |
| 17 | Kupffer cells express a unique combination of phenotypic and functionalcharacteristics compared with splenic and peritoneal mac- rophages 显示文摘 | MOVITA D KREEFFT K BIESTA P | 2012 | J Leukoc Biol2012，92，： | 1 |
| 18 | The E- mergent Curriculum: Navigating a Complex Course between Unguided Learning and Planned Encultura- tion 显示文摘 | DEBORAH OSBERG GERT J J BIESTA | 2008 | Journal of Curriculum Studies2008，，3： | 1 |
| 19 | Favorable effect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV显示文摘 | van der Molen RG Sprengers D Biesta PJ | 2006 | Hepatology2006，44，4： | 1 |
| 20 | Hepatitis B virus suppresses the functional interaction between natural killer cells and plasmacytoid dendritic ceils显示文摘 | Shi CC Tjwa ET Biesta PJ | 2012 | J Viral Hepat2012，19，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员