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| 1 | The DNA-binding factor Ctcf critically controls gene expression in macrophages显示文摘巨噬细胞在免疫和动态平衡起一个重要作用。在经由特定的受体的病原体识别之上,他们很快导致煽动性的回答。这个过程紧在 transcriptional 水平被控制。DNA 有约束力的锌手指蛋白质 CCCTC 有约束力的因素(Ctcf ) 是远程的染色质相互作用的一个关键管理者并且协调在抄写因素和基因表达式进程之间的特定的通讯。在这研究, Ctcf 基因被使用转基因的 Cre-LoxP 系统明确地在 myeloid 房间删除。在 myeloid 房间的 Ctcf 基因的有条件的删除在 vivo 导致了温和显型。显著地展出的 Ctcf 缺乏的老鼠减少了主要 histocompatibility 的表示在肝的建筑群(MHC ) 班 II。Ctcf 缺乏的巨噬细胞表明了正常表面显型和吞噬作用能力。在像使用费的受体(TLR ) 之上刺激,他们生产了支持 inflammatory cytokines IL-12 和 IL-6 的正常层次,但是表明了一个强烈损害的能力生产肿瘤坏死因素(TNF ) 和 IL-10,以及表示 IL-10 家庭成员 IL-19, IL-20 和 IL-24。一起拿,我们的数据表明涉及巨噬细胞功能调整的 Ctcf 的一个角色。 | Tatjana Nikolic Dowty Movita Margaretha EH Lambers Claudia Ribeiro de Almeida] Paula Biesta Kim Kreefft Marjolein JW de Bruijn Ingrid Bergen Niels Galjart Andre Boonstra Rudi Hendriks | 2014 | Cellular & Molecular Immunology2014，11，1： | 2 |
| 2 | The response to TLR ligation of human CD16 + CD14 ? monocytes is weakly modulated as a consequence of persistent infection with the hepatitis C virus显示文摘 | Cheng Peng Bi-Sheng Liu Robert J. de Knegt Harry L.A. Janssen André Boonstra | 2011 | Molecular Immunology2011，，12： | 2 |
| 3 | Current impact of viral hepatitis on liver cancer development: The challenge remains显示文摘Chronic infections due to hepatitis B and hepatitis C viruses are responsible for most cases of hepatocellular carcinoma(HCC)worldwide,and this association is likely to remain during the next decade.Moreover,viral hepatitis-related HCC imposes an important burden on public health in terms of disability-adjusted life years.In order to reduce such a burden,some major challenges must be faced.Universal vaccination against hepatitis B virus,especially in the neonatal period,is probably the most relevant primary preventive measure against the development of HCC.Moreover,considering the large adult population already infected with hepatitis B and C viruses,it is also imperative to identify these individuals to ensure their access to treatment.Both hepatitis B and C currently have highly effective therapies,which are able to diminish the risk of development of liver cancer.Finally,it is essential for individuals at high-risk of HCC to be included in surveillance programs,so that tumors are detected at an early stage.Patients with hepatitis B or C and advanced liver fibrosis or cirrhosis benefit from being followed in a surveillance program.As hepatitis B virus is oncogenic and capable of leading to liver cancer even in individuals with early stages of liver fibrosis,other high-risk groups of patients with hepatitis B are also candidates for surveillance.Considerable effort is required concerning these strategies in order to decrease the incidence and the mortality of viral hepatitis-related HCC. | Ângelo Zambam de Mattos Jose D Debes Andre Boonstra Ju-Dong Yang Domingo C Balderramo Giovana D P Sartori Angelo Alves de Mattos | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 4 | Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis显示文摘 | Mark A.A. Claassen Robert J. de Knegt Hugo W. Tilanus Harry L.A. Janssen André Boonstra | 2009 | Journal of Hepatology2009，，3： | 1 |
| 5 | Intrahepatic natural killer cell activation, but not function, is associated with HB sAg levels in patients with HB eAg‐negative chronic hepatitis B显示文摘 | Eric T. T. L. Tjwa Roeland Zoutendijk Gertine W. Oord Paula J. Biesta Joanne Verheij Harry L. A. Janssen Andrea M. Woltman Andre Boonstra | | Liver Int0，，3： | 1 |
| 6 | 1 Alpha,25-dihydroxyvitamin d3 has a direct effect on naive CD4 + T cells to enhance the development of Th2 cells显示文摘 | André Boonstra Franck J Barrat Chad Crain | 2001 | J Immunol2001，167，： | 1 |
| 7 | 1a,25-Dihydroxyvitamin D3 Has a Direct Effect on Naive CD4^+ T Cells to Enhance the Development of Th2 Cells显示文摘 | Andre Boonstra Franek J Barrat | 2001 | The Journal of Immunology2001，167，： | 1 |
| 8 | Re‐evaluation of hepatitis B virus clinical phases by systems biology identifies unappreciated roles for the innate immune response and B cells显示文摘 | Thomas Vanwolleghem Jun Hou Gertine van Oord Arno C. Andeweg A.D.M.E. Osterhaus Suzan D. Pas Harry L.A. Janssen Andre Boonstra | 2015 | Hepatology2015，，1： | 1 |
| 9 | Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis显示文摘 | Mark A.A. Claassen Robert J. de Knegt Hugo W. Tilanus Harry L.A. Janssen André Boonstra | 2009 | Journal of Hepatology2009，，3： | 1 |
| 10 | Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients显示文摘 | Jeroen N. Stoop Mark A.A. Claassen Andrea M. Woltman Rekha S. Binda Ernst J. Kuipers Harry L.A. Janssen Renate G. van der Molen Andre Boonstra | 2008 | Clinical Immunology2008，，3： | 1 |
| 11 | Flexibility of mouse classical and plasmacytoid-derived dendrit-ic cells in directing T helper type 1 and 2 cell development:de-pendency on antigen dose and differential toll-like receptor liga-tion显示文摘 | André Boonstra Carine Asselin-Paturel Michel Gilliet | | 0，，01： | 1 |
| 12 | 1Alpha, 25-dihydroxyvitamin d3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells显示文摘 | Andre Boonstra Barrat FJ Crain C | 2001 | J Immunol2001，167，9： | 1 |
| 13 | Immune mechanisms of vaccine induced protection against chronic hepatitis C virus infection in chimpanzees显示文摘Hepatitis C virus(HCV) infection is characterized by a high propensity for development of life-long viral persistence. An estimated 170 million people suffer from chronic hepatitis caused by HCV. Currently,there is no approved prophylactic HCV vaccine available.With the near disappearance of the most relevant animal model for HCV,the chimpanzee,we review the progression that has been made regarding prophylactic vaccine development against HCV. We describe the results of the individual vaccine evaluation experiments in chimpanzees,in relation to what has been observed in humans. The results of the different studies indicate that partial protection against infection can be achieved,but a clear correlate of protection has thus far not yet been defined. | Babs E Verstrepen André Boonstra Gerrit Koopman | 2015 | World Journal of Hepatology2015，7，1： | 0 |
| 14 | Immune aspects of hepatocellular carcinoma:From immune markers for early detection to immunotherapy显示文摘Hepatocellular carcinoma(HCC)is one of the most prevalent cancers and one of the main causes of cancer-related deaths worldwide.Most HCCs develop in an inflammatory microenvironment,and mounting evidence emphasizes the importance of immune aspects in hepatocarcinogenesis.In normal physiology,both innate and adaptive immune responses are responsible for eliminating malignantly transformed cells,thus preventing the development of liver cancer.However,in the setting of impaired natural killer cells and exhaustion of T cells,HCC can develop.The immunogenic features of HCC have relevant clinical implications.There is a large number of immune markers currently being studied for the early detection of liver cancer,which would be critical in order to improve surveillance programs.Moreover,novel immunotherapies have recently been proven to be effective,and the combination of atezolizumab and bevacizumab is currently the most effective treatment for advanced HCC.It is expected that in the near future different subgroups of patients will benefit from specific immunotherapy.The better we understand the immune aspects of HCC,the greater the benefit to patients through surveillance aiming for early detection of liver cancer,which allows for curative treatments,and,in cases of advanced disease,through the selection of the best possible therapy for each individual. | Ângelo Z Mattos Jose D Debes Andre Boonstra Arndt Vogel Angelo A Mattos | 2021 | World Journal of Gastrointestinal Oncology2021，13，9： | 0 |
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