2篇
您的检索式：作者名="Bifeng Guo"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer显示文摘5-methylcytosine (5mC ) 和它的氧化形式 5-hydroxymethylcytosine (5hmC ) 被建议了涉及 tumorigenesis。因为印射方法的广泛地使用的 5mC 的读出,定序的重亚硫酸盐(BS-seq ) ,是 5mC 的和, 5hmC 层次, 5mC/5hmC 模式和这二修正的关系仍然保持糟糕理解。由介绍真实 5mC (BS-seq 由帮助 Tet 的 BS-seq 改正了, TAB-seq ) 并且 5hmC (TAB-seq ) 在单个核苷酸的分辨率同时铺平,我们这里证明与匹配的正常纸巾相比没有在肾肿瘤的 5mC 的全球损失。相反地, 5hmC 全球性被失去在几乎所有肾肿瘤纸巾。在肿瘤纸巾的 5hmC 水平是为肾癌症的一个独立预示的标记,与与更短的全面幸存联系的 5hmC 的底层。而且,我们证明 5hmC 的损失与匹配的正常纸巾相比在肿瘤被连接到 hypermethylation,特别地在基因身体区域。惊人地,基因身体 hypermethylation 显著地与肿瘤相关的基因的 silencing 被联系。IDH1 的 Downregulation 作为在肾癌症位于 5hmC 损失下面的机制被识别。恢复 5hmC 层次稀释了肿瘤房间的侵略能力并且在一个异种皮移植模型压制了肿瘤生长。一起,我们的结果证明 5hmC 的损失在由改变 DNA methylation 模式的肾癌症是一个预示的标记和一个 oncogenic 事件。 | Ke Chen Jing Zhang Zhongqiang Guo Qin Ma Zhengzheng Xu Yuanyuan Zhou Ziying Xu Zhongwu Li Xiongjun- Ye Xuesong Li Bifeng Yuan Yuwen Ke Chuan He Liqun Zhou Jiang Liu WeiminCi | 2016 | Cell Research2016，26，1： | 10 |
| 2 | The Astrometric Performance Test of 80 cm Telescope at Yaoan Station and Precise CCD Positions of Apophis显示文摘The 80 cm azimuthal telescope has newly been mounted at Yaoan Station,Purple Mountain Observatory since2018.The astrometric performance of the telescope is tested in the following three aspects.(a)The geometric distortion of its CCD attached.It is stable in both a single epoch and multi epochs.Eight distortion solutions are derived over about one year.The maximum values range from 0.75 to 0.79 pixel and the median values range from 0.14 to 0.16 pixel.(b)The limit magnitude of stars.About 20.5 mag(Gaia-G)stars can be detected with Johnson-V filter exposured in 300 s.The astrometric error of about 20.5 mag stars is estimated at O'.14 using the fitted sigmoidal function.(c)The astrometric accuracy and the precision of stacked fast-moving faint object.24 stacked frames of the potentially hazardous asteroid(99942)Apophis were derived on 2021 April 14 and 15(fainter than18 mag)based on the ephemeris shifts.During data reduction,the newest Gaia EDR3 Catalog and Jet Propulsion Laboratory Horizons ephemeris are referenced as theoretical positions of stars and Apophis,respectively.Our results show that the mean(O-C)s(observed minus computed)of Apophis are-O'.018 and O'.020 in R.A.and decl.,and the dispersions are estimated at O'.094 and O'.085,respectively,which show the consistency of the stacked results by Astrometrica. | Bifeng Guo Qingyu Peng Ying Chen Zhongjie Zheng Yijia Shang Dan Li Xiao Chen | 2022 | Research in Astronomy and Astrophysics2022，22，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员