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| 1 | Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer显示文摘5-methylcytosine (5mC ) 和它的氧化形式 5-hydroxymethylcytosine (5hmC ) 被建议了涉及 tumorigenesis。因为印射方法的广泛地使用的 5mC 的读出,定序的重亚硫酸盐(BS-seq ) ,是 5mC 的和, 5hmC 层次, 5mC/5hmC 模式和这二修正的关系仍然保持糟糕理解。由介绍真实 5mC (BS-seq 由帮助 Tet 的 BS-seq 改正了, TAB-seq ) 并且 5hmC (TAB-seq ) 在单个核苷酸的分辨率同时铺平,我们这里证明与匹配的正常纸巾相比没有在肾肿瘤的 5mC 的全球损失。相反地, 5hmC 全球性被失去在几乎所有肾肿瘤纸巾。在肿瘤纸巾的 5hmC 水平是为肾癌症的一个独立预示的标记,与与更短的全面幸存联系的 5hmC 的底层。而且,我们证明 5hmC 的损失与匹配的正常纸巾相比在肿瘤被连接到 hypermethylation,特别地在基因身体区域。惊人地,基因身体 hypermethylation 显著地与肿瘤相关的基因的 silencing 被联系。IDH1 的 Downregulation 作为在肾癌症位于 5hmC 损失下面的机制被识别。恢复 5hmC 层次稀释了肿瘤房间的侵略能力并且在一个异种皮移植模型压制了肿瘤生长。一起,我们的结果证明 5hmC 的损失在由改变 DNA methylation 模式的肾癌症是一个预示的标记和一个 oncogenic 事件。 | Ke Chen Jing Zhang Zhongqiang Guo Qin Ma Zhengzheng Xu Yuanyuan Zhou Ziying Xu Zhongwu Li Xiongjun- Ye Xuesong Li Bifeng Yuan Yuwen Ke Chuan He Liqun Zhou Jiang Liu WeiminCi | 2016 | Cell Research2016，26，1： | 10 |
| 2 | Graded activation of CRAC channel by binding of different numbers of STIM1 to Orail subunits显示文摘Ca2+ 激活版本的 Ca2+(CRAC ) 隧道毛孔被 STIM1 被 Orai1 和 gated 在细胞内部的 Ca2+ 店弄空以后形成。为了解决分子被要求到多少 STIM1,打开一条 CRAC 隧道,我们与 STIM1 的功能的二双人脚踏车的细胞质的领域熔化了 Orai1 子单元的不同数字(残余 336-485,指定了领域为 S ) 。整个房间的补丁夹钳揭示的这些妄想的分子的记录在四 Orai1 和八个 S 领域的 stoichiometry 最大的到达的那 CRAC 水流。进一步的实验显示二双人脚踏车的 S 领域明确地与一个 Orai1 子单元,和 CRAC 电流的 C 终点交往当更多的 Orai1 子单元能与 S 领域或 STIM1 蛋白质交往,能逐渐地被增加。我们的数据建议一条 CRAC 隧道的那最大的开始要求八个 STIM1 分子,并且支持 CRAC 隧道激活不以一种鈥渁l l-or-none 鈥 ? 方式,但是经历的一个模型经由 STIM1 的不同数字的绑定的分级的进程。 | Zhengzheng Li Lin Liu Yongqiang Deng Wei Ji Wen Du Pingyong Xu Liangyi Chen Tao Xu | 2011 | Cell Research2011，21，2： | 5 |
| 3 | Energy-efficient cognitive access approach to convergence communications显示文摘This article studies the cognitive access in convergence communications.Convergence communications provide upper-layer applications with uniform communication service,converging different lower-layer networks into a uniform access pattern such as all-IP communications.As an import access in convergence communications,the cognitive access provides users with a flexible and dynamic access to networks.In this article,we do not only take into account the spectrum usage of convergence communication networks,but also consider theirs energy efficiency.An energy-efficient access algorithm is proposed to improve network performance and efficiency.Different from the existing cognitive access,we regard energy efficiency as the optimal objective to turn the energy-efficient cognitive access into an optimal problem.The collision avoidance and sleeping mechanisms are used to reduce energy consumption and raise network throughput.The utility function is proposed to maximize networks’energy efficiency and then achieve the energy-efficient cognitive access.Simulation results show that the proposed approach is effective and feasible,which can significantly improve networks’energy efficiency. | XU ZhengZheng QIN WenDa TANG QingYi JIANG DingDe | 2014 | Science China(Information Sciences)2014，57，4： | 4 |
| 4 | An Approximate Approach to End-to-End Traffic in Communication Networks显示文摘 | JIANG Dingde XU Zhengzheng NIU Laisen LIU Jindi | 2012 | Chinese Journal of Electronics2012，21，4： | 4 |
| 5 | Damage Processes of Polypropylene Fiber Reinforced Mortar in Different Fiber Content Revealed by Acoustic Emission Behavior显示文摘The performances of the cement-based materials can be improved by the incorporation of polypropylene fiber, but the damage processes become more complex with different fiber contents at the same time. The acoustic emission(AE) technology can achieve the global monitoring of internal damage in materials. The evolution process of failure mode and damage degree of polypropylene fiber reinforced mortar and concrete were analyzed by measuring the AE energy, RA value, AF value and b value. It was found that the cement matrix cracked on the initial stage, the cracks further developed on the medium stage and the fibers were pulled out on the last stage. The matrix cracked with minor injury cracks, but the fiber broke with serious damage cracks. The cumulative AE energy was proportional to the polypropylene fiber reinforced concrete and mortar's ductility. The damage mode and damage degree can be judged by identifying the damage stage obtained by the analysis of the AF value. | 王岩 CHEN Shijie XU Zhengzheng LIU Shaojun HU Hongxiang | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，1： | 3 |
| 6 | Arsenic and cadmium removal from water by a calcium-modified and starch-stabilized ferromanganese binary oxide显示文摘A new calcium-modified and starch-stabilized ferromanganese binary oxide (Ca-SFMBO)sorbent was fabricated with different Ca concentrations for the adsorption of arsenic (As)and cadmium (Cd) in water.The maximum As(Ⅲ) and Cd(Ⅱ) adsorption capacities of 1%CaSFMBO were 156.25 mg/g and 107.53 mg/g respectively in single-adsorption systems.The adsorption of As and Cd by the Ca-SFMBO sorbent was pH-dependent at values from 1 to 7,with an optimal adsorption pH of 6.In the dual-adsorbate system,the presence of Cd(Ⅱ) at low concentrations enhanced As(Ⅲ) adsorption by 33.3%,while the adsorption of As(Ⅲ) was inhibited with the increase of Cd(Ⅱ) concentration.Moreover,the addition of As(Ⅲ) increased the adsorption capacity for Cd(Ⅱ) up to two-fold.Through analysis by X-ray photoelectron spectroscopy (XPS) and Fourier-transform infrared spectroscopy (FTIR),it was inferred that the mechanism for the co-adsorption of Cd(Ⅱ) and As(Ⅲ) included both competitive and synergistic effects,which resulted from the formation of ternary complexes.The results indicate that the Ca-SFMBO material developed here could be used for the simultaneous removal of As(Ⅲ) and Cd(Ⅱ) from contaminated water. | Huxing Chen Fangnan Xu Zhengzheng Chen Ouyuan Jiang Williamson Gustave Xianjin Tang | 2020 | Journal of Environmental Sciences2020，32，10： | 3 |
| 7 | Joint Bearing Mechanism of Coal Pillar and Backfilling Body in Roadway Backfilling Mining Technology显示文摘In the traditional mining technology,the coal resources trapped beneath surface buildings,railways,and water bodies cannot be mined massively,thereby causing the lower coal recovery and dynamic disasters.In order to solve the aforementioned problems,the roadway backfilling mining technology is developed and the joint bearing mechanism of coal pillar and backfilling body is presented in this paper.The mechanical model of bearing system of coal pillar and backfilling body is established,by analyzing the basic characteristics of overlying strata deformation in roadway backfilling mining technology.According to the Ritz method in energy variation principle,the elastic solution expression of coal pillar deformation is deduced in roadway backfilling mining technology.Based on elastic-viscoelastic correspondence principle,combining with the burgers rheological constitutive model and Laplace transform theory,the viscoelastic solution expression of coal pillar deformation is obtained in roadway backfilling mining technology.By analyzing the compressive mechanical property of backfilling body,the time formula required for coal pillar and backfilling body to play the joint bearing function in roadway backfilling mining technology is obtained.The example analysis indicates that the time is 140 days.The results can be treated as an important basis for theoretical research and process design in roadway backfilling mining technology. | Zhengzheng Cao Ping Xu Zhenhua Li Minxia Zhang Yu Zhao Wenlong Shen | 2018 | Computers, Materials & Continua2018，，2： | 2 |
| 8 | Control Mechanism of Surface Subsidence and Overburden Movement in Backfilling Mining based on Laminated Plate Theory显示文摘The backfilling mining technology is a type of high-efficiency coal mining technology that is used to address the environmental issues caused by the caving mining technology.In this paper,the mechanical model of symmetrical laminated plate representing the overburden movement caused by the backfilling mining technology is established,and the governing differential equation of the motion of the overburden is derived.The boundary conditions of the mechanical model are put forward,and the analytical solution of the overburden movement and surface subsidence is obtained.The numerical model of the overburden movement and surface subsidence,under mining with backfilling,is established by means of the FLAC3D numerical software,which aims to systematically study the influence of backfilling compactness,mining thickness,and mining depth on the overburden movement and surface subsidence in backfilling mining.When the compactnessηis less than 70%,the overburden movement and surface subsidence is greater,while whenηis greater than 70%,the overburden movement and surface subsidence is reduced significantly.On this basis,the control mechanism of surface subsidence and overburden movement in backfilling mining is obtained.The suitable backfilling compactness is the key to controlling surface subsidence and overburden movement in backfilling mining. | Zhengzheng Cao Feng Du Ping Xu Haixiao Lin Yi Xue Yuejin Zhou | 2017 | Computers, Materials & Continua2017，，3： | 2 |
| 9 | Joint time-frequency sparse estimation of large-scale network traffic 显示文摘 | Jiang Dingde Xu Zhengzheng Chen Zhenhua | 2011 | Computer Networks2011，55，15： | 1 |
| 10 | An approximation method of origin-destination flow traffic from link load counts 显示文摘 | Jiang Dingde Xu Zhengzheng Xu Hongwei | 2011 | Computers and Electrical Engineering2011，37，6： | 1 |
| 11 | The Application of Combina-tion Forecasting Model in Energy Consumption System显示文摘 | Yi Xue Zhengzheng Cao Lei Xu | 2011 | Ener-gy Procedia2011，，5： | 1 |
| 12 | Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ 1–42 in BV-2 cells显示文摘 | Zuohui Zhang Zhengzheng Wu Xiaolei Zhu Xinchen Hui Jie Pan Yun Xu | 2014 | Neuroscience Letters2014，，： | 1 |
| 13 | Event-triggered shared lateral control for safe-maneuver of intelligent vehicles显示文摘With the increasing number of cars,road traffic accidents have caused a lot of losses every year and human factors play an important role in many cases.Applying active safety assistance control or shared control techniques in intelligent vehicles is promising to reduce the number of traffic accidents.In this context,the dynamic optimization of the shared control policy and the smooth transitions of control authority between human drivers and intelligent driving systems are critical issues to be solved.Motivated by this,this paper proposes an event-triggered shared control approach for safe-maneuver of intelligent vehicles with online risk assessment.In the proposed approach,a Bayesian regularized artificial neural network(BRANN)is designed to predict vehicle trajectories and build a quantization function to assess the risk level owing to potential collision events.The shared controller dynamically optimizes the shared control policies between the human and the intelligent driving system via solving a model predictive control(MPC)problem.The predicted driving behaviors in the prediction horizon are pre-computed with a finite-horizon model predictor steering the predicted trajectories contributed by human driving.Moreover,smooth transitions back to human driving mode are realized via adding penalties on the shared control of the intelligent driving system.Three simulation scenarios in the PreScan environment,i.e.,rear-end collision avoidance,lane-keeping and unskilled driving,are studied to test the effectiveness of the proposed approach.The simulation results,including the comparison with a linear quadratic regulator(LQR)-based shared controller,are reported,which show that the proposed approach can timely evaluate dangerous events and realize safe driving in terms of collision avoidance and lane-keeping.Also,the proposed approach outperforms the LQR-based shared controller in terms of smooth transitions. | Yan JIANG Xinglong ZHANG Xin XU Xing ZHOU Zhengzheng DONG | 2021 | Science China(Information Sciences)2021，64，7： | 1 |
| 14 | A compressive sensing-based reconstruction approach to network traffic 显示文摘 | NIE Laisen J1ANG Dingde XU Zhengzheng | 2013 | Computers and Electrical Engineering2013，39，5： | 1 |
| 15 | Maximal Lyapunov Exponent and Almost-Sure Stability for Sto-chastic Mathieu-Duffing Systems显示文摘 | Jiaorui Li Wei Xu Zhengzheng Ren Youming Lei | 2005 | Journal of Sound and Vibration2005，，12： | 1 |
| 16 | Non-invasive assessment of intracranial wall shear stress using high-resolution magnetic resonance imaging in combination with computational fluid dynamics technique显示文摘In vivo studies on association between wall shear stress(WSS)and intracranial plaque are deficient.Based on the three-dimensional T1-weighted high-resolution magnetic resonance imaging(3DT1 HR-MRI)data of patients with low-grade stenotic(<50%)atherosclerotic middle cerebral artery(MCA)and subjects with normal MCA,we built a three-dimensional reconstructed WSS model by computational fluid dynamics(CFD)technique.Three-dimensional registration of the CFD model to the HR-MRI was performed with projections based on the resolution and thickness of the images.The relationships between the Wss at each side of the vessel wall and plaque location were analyzed.A total of 94 MCA plaques from 43 patients and 50 normal MCAs were analyzed.In the normal MCAs,WSS was lower at the ventral-inferior wall than at the dorsal-superior wall(proximal segment,p<0.001;middle segment,p<0.001)and lower at the inner wall than at the outer wall of the MCA curve(p<0.001).In atherosclerotic MCAs,similar low Wss regions were observed where plaques developed.The WSS ratio of the ventral-inferior wall to the dorsal-superior wall in atherosclerotic MCAs was lower than that in normal MCAs(p=0.002).The WSS_(inmer-outer)ratio in atherosclerotic MCAs was lower than that in normal MCAs(p=0.002).Low WSS was associated with MCA atherosclerosis formation and occurred mainly at the ventral inferior wall,which was anatomically opposite the orifices of penetrating arteries,and at the inner wall of the MCA curve.Overall,the results were well consistent with the low WSS theory in atherosclerosis formation.The reconstructed WSS model is a promising novel method for assessing an individualized vascular profile once validated by further studies. | Yuwen Chen Jia Liu Mingli Li Yannan Yu Zhengzheng Yan Wenshin Shiu Bokai Wu Zaiheng Cheng Yao Meng Yang Liu Weizhuang Yuan Zongmuyu Zhang Weihai Xu | 2022 | Fundamental Research2022，2，2： | 0 |
| 17 | Self-assembly of polysarcosine amphiphilic polymers-tethered gold nanoparticles for precise photo-controlled synergistic therapy显示文摘Polymer-induced self-assembly of inorganic nanoparticles has emerged as a powerful strategy for fabrication of stimuliresponsive drug delivery nanosystems.Herein,we designed and synthesized a series of lipoic acid-capped polysarcosine-bpolycaprolactone(PSar-b-PCL)block copolymers.The self-assembly of gold nanoparticles drove by these block copolymers was systematically investigated,and the preparation of near-infrared(NIR)light-responsive PSar-decorated gold nanovesicle(PSGV)was optimized.DOX as anticancer drug was efficiently encapsulated within the cavity of PSGV.The PSGV greatly prevented doxorubicin(DOX)from premature leakage.While upon 808 nm laser irradiation,most of loaded DOX was rapidly released,along with the recovery of DOX fluorescence.Impressively,the DOX-loaded PSGV(DOX-PSGV)exhibited much higher cell uptake efficiency when compared to DOX-loaded polyethylene glycol(PEG)-coated gold nanovesicle(DOX-PEGV).Thanks to the synergistic photothermal/chemo therapy,the DOX-PSGV had highly superior antitumor efficacy in established 4T1 tumor model. | Runkai Lv Zhengzheng Qian Xiaopeng Zhao Fei Xiong Yingjie Xu Wenpei Fan Xikuang Yao Wei Huang | 2023 | Nano Research2023，16，4： | 0 |
| 18 | Comparison on the Pattern of Han fu and Kimono显示文摘The traditional costumes-Han fu and Kimono,are also the typical representatives of China and Japan.While costume pattern as a kind of traditional culture,is an essential symbol,reflecting ethnic characteristics and playing an important part in costumes.Based on the consultation,analysis and arrangement of literature data,this paper studied on costume patterns of the two countries,carrying out their comparison in the forms,the color and the connotation respectively,and summarizing their own characteristics.It is through the study that we will be able to inherit the traditional patterns and put them into innovation in modern clothing design. | Xu Zhengzheng Jia Jieying | 2013 | China Textile2013，，7： | 0 |
| 19 | Parallel Domain Decomposition-Based Solver for the Simulation of Flow over an Ahmed Reference Model显示文摘The Ahmed model is a standard bluff body used to study the flow behavior around an automobile.An important issue when investigating turbulent flow fields is the large computational load driven by accurate prediction approaches,such as the large eddy simulation model.In this paper,we present a powerful domain decomposition method-based parallel solver to efficiently utilize existing supercomputer resources.The 3D unsteady incompressible Navier–Stokes equations with a subgridscale(SGS)fluid model are discretized on a pure unstructured tetrahedral grid by a stable P_(1-)P_(1-)finite element method in space,while an implicit second-order backward differentiation formula is employed for the time discretization.We then solve the nonlinear algebraic system by means of the Newton–Krylov–Schwarz method by imposing a restricted additive Schwarz(RAS)right preconditioner for the parallel setting.We validate the proposed method toward the comparison of the flow field,including the velocity profiles and flow structures,with experimental investigations,and we show the parallel efficiency and scalability of the solver with up to 8192 processors. | Zhengzheng Yan Rongliang Chen Chao Wang Lei Xu Jingzhi Li | 2023 | Advances in Applied Mathematics and Mechanics2023，15，3： | 0 |
| 20 | Research on Instability Mechanism and Type of Ore Pillar Based on the Fold Catastrophe Theory显示文摘The stability of ore pillar in mine is essential for the safe and efficient mining.Based on the energy evolvement rule in ore pillar and roadway roof system,the roadway roof and ore pillar are treated as energy release body and energy dissipation body,respectively.Therefore,the double-block mechanical model is established with energy dissipation body and energy release body,and the energy mechanism of ore pillar instability is obtained,based on the fold catastrophe mathematical theory.The research result indicates that the dynamic instability of ore pillar is a physical instability problem caused by the strain softening property of ore mass,and the instability type of ore pillar is determined by the stiffness parameter of double-block mechanical system.When the systematical stiffness parameter is greater than or equal to 1,the equilibrium position of double-block mechanical system passes through shaft K-1 or the origin,from branch 1 of unstable equilibrium state to branch 2 of stable equilibrium state by smooth transition,and the ore pillar shows quasi-static fracture.When the systematical stiffness parameter is less than 1,the equilibrium position of double-block system mutates from branch 1 of unstable equilibrium state to branch 2 of stable equilibrium state by jumping transition,and the ore pillar shows dynamic instability.The research result could provide theoretical guidance for the prevention measures of ore pillar instability. | Zhengzheng Cao Feng Du Zhenhua Li Qinting Wang Ping Xu Haixiao Lin | 2017 | Computer Modeling in Engineering & Sciences2017，，3： | 0 |
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