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| 1 | Does urodynamics predict voiding after benign prostatic hyperplasia surgery in patients with detrusor underactivity?显示文摘Objective:We sought to determine if urodynamic study(UDS)predicted voiding outcomes in men with detrusor underactivity(DU)and benign prostatic enlargement(BPE)who underwent photovaporization of the prostate(PVP).Methods:Between September 2010 and July 2015,106 male patients with BPE and DU were identified.All patients underwent PVP.Urinary retention was noted by the preoperative necessity for an indwelling or intermittent catheter.Data collection included comorbidities,quality of life(QoL)scores,prostate volume,prostate-specific antigen(PSA),UDS and perioperative outcomes.UDS parameters included volume at first desire to void,volume at first urge to void,volume of severe urge,volume at capacity,compliance,detrusor contractions,maximum urinary flow rate(Qmax),and postvoid residual(PVR).Results:A total of 106 men were included in this analysis,who had urinary retention with a Foley catheter or clean intermittent catheterization(CIC)at the time of surgery.At baseline we found patients who voided had a detrusor pressure at Qmax(Pdet@Qmax)of 10.05±6.45 cmH2O compared to 16.78±12.17 cmH2O in those who did not void(p=0.071).Postoperatively,96(90.6%,mean age 76.9±26.2 years)of patients voided successfully while 10(9.4%,mean age 80.52±9.61 years)of patients remained in urinary retention.Mean baseline Qmax was 4.895±5.452 mL/s and 2.900±3.356 mL/s(p=0.087)in those who voided and did not respectively.PVR was 319.23±330.62 mL in those who voided and 276.88263.27 mL(p=0.344)in those who did not void.No UDS parameter predicted who would void postoperatively or improvements in QoL.Conclusions:The patients with DU and BPE might be able to successfully void after undergoing PVP regardless of UDS findings.All men who voided had improved international prostate symptom score and QoL scores compared to baseline and these parameters were durable up to 12 months. | Dominique Thomas Kevin C.Zorn Nadir Zaidi Stephanie Ashley Chen Yiye Zhang Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，3： | 8 |
| 2 | 睾酮和良性前列腺增生症显示文摘由于医患双方对于男性迟发性腺功能减退症状的警觉,使得近期针对此类患者的睾酮治疗增多。但是考虑到睾酮治疗对前列腺的影响,尤其可能增加前列腺癌发病风险,促进了该方面的研究进展。出乎意料的是大量的回顾性或小样本随机研究提示睾酮治疗或可改善男性下尿路症状。虽然此改善的确切机理仍在争论中,但或许和代谢综合征密切相关。对于临床医生,这些研究的结果虽然让人期待,但是缺乏高等级证据支持。因此在诊断迟发性腺功能减退症或考虑睾酮治疗前,仍需对患者进行包括病史、体检和睾酮测量在内的全面临床检查。睾酮补充治疗可能导致尿潴留和加重下尿路症状,这些产品说明上标注的风险依然存在,应该在用药前向患者解释说明。 | Thomas R Jarvis Bilal Chughtai Steven A Kaplan | 2015 | Asian Journal of Andrology2015，17，2： | 7 |
| 3 | The role of photovaporization of the prostate in small volume benign prostatic hyperplasia and review of the literature显示文摘Objective:Our objective was to characterize the safety and efficacy of the 180 W XPS-GreenLight laser in men with lower urinary tract symptoms secondary to a small volume benign prostatic hyperplasia(BPH).Methods:A retrospective analysis was performed for all patients who underwent 180 W XPSlaser photoselective vaporization of the prostate(PVP)vaporization of the prostate between 2012 and 2016 at two-tertiary medical centers.Data collection included baseline comorbidities,disease-specific quality of life scores,maximum urinary flow rate(Qmax),postvoid residual(PVR),complications,prostate volume and prostate-specific antigen(PSA).The secondary endpoints were the incidence of intraoperative and postoperative adverse events.Complications were stratified using the Clavien-Dindo grading system up to 90 days after surgery.Results:Mean age of men was 67.8 years old,with a mean body mass index of 29.7 kg/m2.Mean prostate volume as measured by transrectal ultrasound was 29 mL.Anticoagulation use was 47%and urinary retention with catheter at time of surgery was 17%.Mean hospital stay and catheter time were 0.5 days.Median follow-up time was 6 months with the longest duration of follow-up being 22.5 months(interquartile range,3-22.5 months).The International Prostate Symptom Score improved from 22.8±7.0 at baseline to 10.7±7.4(p<0.01)and 6.3±4.4(p<0.01)at 1 and 6 months,respectively.The Qmax improved from 7.70±4.46 mL/s at baseline to 17.25±9.30 mL/s(p<0.01)and 19.14±7.19 mL/s(p<0.001)at 1 and 6 months,respectively,while the PVR improved from 216.0±271.0 mL preoperatively to 32.8±45.3 mL(p<0.01)and 26.2±46.0 mL(p<0.01)at 1 and 6 months,respectively.The PSA dropped from 1.97±1.76 ng/mL preoperatively to 0.71±0.61 ng/mL(p<0.01)and 0.74±0.63 ng/mL at 1 and 6 months,respectively.No patient had a bladder neck contracture postoperatively and no capsular perforations were noted intraoperatively.Conclusion:The 180 W GreenLight XPS system is safe and effective for men with small volume BPH.PVP produced improvements in symptomatic and clinical parameters without any safety concern.It represents a safe surgical option in this under studied population. | Dominique Thomas Kevin C.Zorn Malek Meskawi Ramy Goueli Pierre-Alain Hueber Lesa Deonarine Vincent Misrai Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，4： | 6 |
| 4 | Commentary on“Solving the benign prostatic hyperplasia puzzle”显示文摘Benign prostatic hyperplasia(BPH)is a common condition affecting over 50% of men as they reach the 5th decade of their life[1].While over half of these patients have symptoms,it is not clear why some of these men do while others do not.The article Solving the benign prostatic hyperplasia puzzle by Keong Tatt Foo[2],delves into the different conundrums urologists face when trying to treat their patients. | Dominique Thomas Bilal Chughtai Steven Kaplan | 2018 | Asian Journal of Urology2018，5，1： | 2 |
| 5 | Disparities in the Use of Sacral Neuromodulation among Medicare Beneficiaries显示文摘 | Melissa A. Laudano Stephan Seklehner Jaspreet Sandhu W. Stuart Reynolds Kelly A. Garrett Jeffrey W. Milsom Alexis E. Te Steven A. Kaplan Bilal Chughtai Richard K. Lee | 2015 | The Journal of Urology2015，，： | 1 |
| 6 | Cost‐analysis comparison of robot‐assisted laparoscopic radical cystectomy (RC) vs open RC显示文摘 | Richard Lee Bilal Chughtai Michael Herman Shahrokh F. Shariat Douglas S. Scherr | 2011 | BJU International2011，，6： | 1 |
| 7 | Contemporary review of the 532 nm laser for treatment of benign prostatic hyperplasia显示文摘Benign prostatic hyperplasia(BPH)is a condition that occurs increasingly with age.The established gold standard treatment for BPH has been the electrocautery-based transurethral resection of the prostate(TURP).TURP,however,is associated with several complications and side effects.Therefore,there is an increasing interest in a number of emerging minimally invasive therapies as alterative treatment options.Laser therapy using the Greenlight laser is a promising alternative to the traditional TURP.Selective absorption by hemoglobin allows rapid,hemostatic vaporization of prostate tissue.Additional advantages include avoidance or minimization of complications such as intraoperative fluid absorption,and bleeding,retrograde ejaculation,impotence,and incontinence,as well as its use in treating high volume BPH.We review the use of the Greenlight laser in the treatment of BPH,when comparing complications and advantages in relation to TURP. | Bilal Chughtai Leanna Laor Claire Dunphy Alexis Te | 2015 | Asian Journal of Urology2015，2，2： | 0 |
| 8 | Author’s Age and Gender Prediction on Hotel Review Using Machine Learning Techniques显示文摘Author’s Profile(AP)may only be displayed as an article,similar to text collection of material,and must differentiate between gender,age,education,occupation,local language,and relative personality traits.In several informationrelated fields,including security,forensics,and marketing,and medicine,AP prediction is a significant issue.For instance,it is important to comprehend who wrote the harassing communication.In essence,from a marketing perspective,businesses will get to know one another through examining items and websites on the internet.Accordingly,they will direct their efforts towards a certain gender or age restriction based on the kind of individuals who comment on their products.Recently many approaches have been presented many techniques to automatically detect user age and gender from the language which is based on text,documents,or comments on social media.The purpose of this research is to classify age(18–24,25–34,35–49,50–64,and 65–70)and gender(male,female)from a PAN 2014 Hotel Reviews dataset of the English language.The usage of six machine learning models is the main emphasis of this work,including the methods of Support Vector Machine(SVM),Random Forest(RF),Naive Bayes(NB),Logistic Regression(LR),Decision Tree(DT)and K-Nearest Neighbors(KNN). | Muhammad Hood Khan Bilal Khan Saifullah Jan Muhammad Imran Chughtai | 2023 | Journal on Big Data2023，5，1： | 0 |
| 9 | Effect of phosphodiesterase inhibitors in the bladder显示文摘Many aging men will experience lower urinary tract symptoms(LUTS).Phosphodiesterase type 5(PDE5)inhibitors have shown promise in treating LUTS in these patients.PDE5 inhibitors mediate their effects through several pathways including cAMP,NO/cGMP,Kchannel modulated pathways,and the L-cysteine/H2S pathway.PDE5 inhibitors exert their effect in muscle cells,nerve fibers,and interstitial cells(ICs).The use of PDE5 inhibitors led to improvement in LUTS.This included urodynamic parameters.PDE5 inhibitors may play a significant role in LUTS due to their effect on the bladder rather than the prostate. | Bilal Chughtai Aizaz Ali Claire Dunphy Steven A.Kaplan | 2015 | Asian Journal of Urology2015，2，1： | 0 |
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