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| 1 | Does urodynamics predict voiding after benign prostatic hyperplasia surgery in patients with detrusor underactivity?显示文摘Objective:We sought to determine if urodynamic study(UDS)predicted voiding outcomes in men with detrusor underactivity(DU)and benign prostatic enlargement(BPE)who underwent photovaporization of the prostate(PVP).Methods:Between September 2010 and July 2015,106 male patients with BPE and DU were identified.All patients underwent PVP.Urinary retention was noted by the preoperative necessity for an indwelling or intermittent catheter.Data collection included comorbidities,quality of life(QoL)scores,prostate volume,prostate-specific antigen(PSA),UDS and perioperative outcomes.UDS parameters included volume at first desire to void,volume at first urge to void,volume of severe urge,volume at capacity,compliance,detrusor contractions,maximum urinary flow rate(Qmax),and postvoid residual(PVR).Results:A total of 106 men were included in this analysis,who had urinary retention with a Foley catheter or clean intermittent catheterization(CIC)at the time of surgery.At baseline we found patients who voided had a detrusor pressure at Qmax(Pdet@Qmax)of 10.05±6.45 cmH2O compared to 16.78±12.17 cmH2O in those who did not void(p=0.071).Postoperatively,96(90.6%,mean age 76.9±26.2 years)of patients voided successfully while 10(9.4%,mean age 80.52±9.61 years)of patients remained in urinary retention.Mean baseline Qmax was 4.895±5.452 mL/s and 2.900±3.356 mL/s(p=0.087)in those who voided and did not respectively.PVR was 319.23±330.62 mL in those who voided and 276.88263.27 mL(p=0.344)in those who did not void.No UDS parameter predicted who would void postoperatively or improvements in QoL.Conclusions:The patients with DU and BPE might be able to successfully void after undergoing PVP regardless of UDS findings.All men who voided had improved international prostate symptom score and QoL scores compared to baseline and these parameters were durable up to 12 months. | Dominique Thomas Kevin C.Zorn Nadir Zaidi Stephanie Ashley Chen Yiye Zhang Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，3： | 8 |
| 2 | The role of photovaporization of the prostate in small volume benign prostatic hyperplasia and review of the literature显示文摘Objective:Our objective was to characterize the safety and efficacy of the 180 W XPS-GreenLight laser in men with lower urinary tract symptoms secondary to a small volume benign prostatic hyperplasia(BPH).Methods:A retrospective analysis was performed for all patients who underwent 180 W XPSlaser photoselective vaporization of the prostate(PVP)vaporization of the prostate between 2012 and 2016 at two-tertiary medical centers.Data collection included baseline comorbidities,disease-specific quality of life scores,maximum urinary flow rate(Qmax),postvoid residual(PVR),complications,prostate volume and prostate-specific antigen(PSA).The secondary endpoints were the incidence of intraoperative and postoperative adverse events.Complications were stratified using the Clavien-Dindo grading system up to 90 days after surgery.Results:Mean age of men was 67.8 years old,with a mean body mass index of 29.7 kg/m2.Mean prostate volume as measured by transrectal ultrasound was 29 mL.Anticoagulation use was 47%and urinary retention with catheter at time of surgery was 17%.Mean hospital stay and catheter time were 0.5 days.Median follow-up time was 6 months with the longest duration of follow-up being 22.5 months(interquartile range,3-22.5 months).The International Prostate Symptom Score improved from 22.8±7.0 at baseline to 10.7±7.4(p<0.01)and 6.3±4.4(p<0.01)at 1 and 6 months,respectively.The Qmax improved from 7.70±4.46 mL/s at baseline to 17.25±9.30 mL/s(p<0.01)and 19.14±7.19 mL/s(p<0.001)at 1 and 6 months,respectively,while the PVR improved from 216.0±271.0 mL preoperatively to 32.8±45.3 mL(p<0.01)and 26.2±46.0 mL(p<0.01)at 1 and 6 months,respectively.The PSA dropped from 1.97±1.76 ng/mL preoperatively to 0.71±0.61 ng/mL(p<0.01)and 0.74±0.63 ng/mL at 1 and 6 months,respectively.No patient had a bladder neck contracture postoperatively and no capsular perforations were noted intraoperatively.Conclusion:The 180 W GreenLight XPS system is safe and effective for men with small volume BPH.PVP produced improvements in symptomatic and clinical parameters without any safety concern.It represents a safe surgical option in this under studied population. | Dominique Thomas Kevin C.Zorn Malek Meskawi Ramy Goueli Pierre-Alain Hueber Lesa Deonarine Vincent Misrai Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，4： | 6 |
| 3 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 4 | Disparities in the Use of Sacral Neuromodulation among Medicare Beneficiaries显示文摘 | Melissa A. Laudano Stephan Seklehner Jaspreet Sandhu W. Stuart Reynolds Kelly A. Garrett Jeffrey W. Milsom Alexis E. Te Steven A. Kaplan Bilal Chughtai Richard K. Lee | 2015 | The Journal of Urology2015，，： | 1 |
| 5 | Photoselective laser va-porization of the prostate(PVP)for treatment of BPH:the firstmulti-center prospective trial显示文摘 | Alexis E Te Terrance RM Barry SS | 2003 | J Urol2003，169，： | 1 |
| 6 | Transurethral electrovaporization of the prostate:a novel method for treating men with benign prostate hyperplasia显示文摘 | Kaplan SA Alexis TE | 1995 | Urology1995，45，4： | 1 |
| 7 | Photoselective vaporization of the prostate for the treatment of benign prostatic hyperplasia:12-month results from the first united states multicenter prospective trial显示文摘 | Alexis E TE Terrence R Malloy | 2004 | The Journa of Urology2004，172，： | 1 |
| 8 | Photoselective vaporization of the prostate for the treatment of benign prostatic hyperplasia:12-month results from the first United States multicenter prospective trial显示文摘 | Alexis TE Malloy T Stein BS | 2004 | J Urol2004，172，4： | 1 |
| 9 | Photoselective laser vaporization of the prostate(PVP)for treatment of (BPH):the first Multi-center prospective trial显示文摘 | ALEXIS E TE TERRANCE R M Barry SS | 2003 | Urol2003，169，： | 1 |
| 10 | Differential Diagnosis of Prostatism: a 12-year Retrospective Analysis of Symptoms, Urodynamics and Satisfaction with Therapy显示文摘 | Steven A. Kaplan David L. Bowers Alexis E. Te Carl A. Olsson | 1996 | The Journal of Urology1996，，4： | 1 |
| 11 | Urodynamic predictors of outcomes with photoselective laser vaporization prostatectomy in patients with benign prostatic hyperplasia and preoperative retention显示文摘 | Mara A. Monoski Ricardo R. Gonzalez Jaspreet S. Sandhu Balaji Reddy Alexis E. Te | 2006 | Urology2006，，2： | 1 |
| 12 | Outcomes and Complications After 532 nm Laser Prostatectomy in Anticoagulated Patients With Benign Prostatic Hyperplasia显示文摘 | Doreen E. Chung James S. Wysock Richard K. Lee Scott R. Melamed Steven A. Kaplan Alexis E. Te | 2011 | The Journal of Urology2011，，3： | 1 |
| 13 | 新一代绿激光高性能系统(HPS)的产生和治疗方法显示文摘 | Alexis E Te Rev Urol 陈智敏(译) | 2007 | 临床泌尿外科杂志2007，22，6： | 1 |
| 14 | Transurethral electrovaporization of the prostate:a novel method for treating men with benign prostate hyperplasia显示文摘 | Kaplan SA Alexis TE | 1995 | Urology1995，45，4： | 1 |
| 15 | Transurethral electrovaporization of the prostate: A novel method for treating men with benign prostatic hyperplasia显示文摘 | Steven A. Kaplan Alexis E. Te | 1995 | Urology1995，，4： | 1 |
| 16 | Contemporary review of the 532 nm laser for treatment of benign prostatic hyperplasia显示文摘Benign prostatic hyperplasia(BPH)is a condition that occurs increasingly with age.The established gold standard treatment for BPH has been the electrocautery-based transurethral resection of the prostate(TURP).TURP,however,is associated with several complications and side effects.Therefore,there is an increasing interest in a number of emerging minimally invasive therapies as alterative treatment options.Laser therapy using the Greenlight laser is a promising alternative to the traditional TURP.Selective absorption by hemoglobin allows rapid,hemostatic vaporization of prostate tissue.Additional advantages include avoidance or minimization of complications such as intraoperative fluid absorption,and bleeding,retrograde ejaculation,impotence,and incontinence,as well as its use in treating high volume BPH.We review the use of the Greenlight laser in the treatment of BPH,when comparing complications and advantages in relation to TURP. | Bilal Chughtai Leanna Laor Claire Dunphy Alexis Te | 2015 | Asian Journal of Urology2015，2，2： | 0 |
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