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1篇 您的检索式:作者名="Billy KCChow"
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1Amygdala neural ensemble mediates mouse social investigation behaviors显示文摘Innate social investigation behaviors are critical for animal survival and are regulated by both neural circuits and neuroendocrine factors.Our understanding of how neuropeptides regulate social interest,however,is incomplete at the current stage.In this study,we identified the expression of secretin(SCT)in a subpopulation of excitatory neurons in the basolateral amygdala.With distinct mole cular and physiological features,BLA^(SCT+)cells projected to the medial prefrontal cortex and were necessary and sufficient for promoting social investigation behaviors,whilst other basolateral amygdala neurons were anxiogenic and antagonized social behaviors.Moreover,the exogenous application of secretin effectively promoted social interest in both healthy and autism spectrum disorder model mice.These results collectively demonstrate a previously unrecognized group of amygdala neurons for mediating social behaviors and suggest promising strategies for social deficits.Ji-an Wei Qing Han Zhihua Luo Linglin Liu Jing Cui Jiahui Tan Billy KCChow Kwok-Fai So Li Zhang 2023National Science Review2023,10,1:0
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