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| 1 | Effect of Sanhuangwuji powder,anti-rheumatic drugs,and ginger-partitioned acupoint stimulation on the treatment of rheumatoid arthritis with peptic ulcer:a randomized controlled study显示文摘OBjECTIVE:To observe the efficacy and safety of oral Sanhuangwuji powder,anti-rheumatic drugs(ARDs),and ginger-partitioned acupoint stimulation at Zusanli(ST 36) on the treatment of rheumatoid arthritis(RA) complicated by peptic ulcer.METHODS:This prospective randomized controlled study included 180 eligible inpatients and outpatients randomly assigned to an ARD treatment(n = 60),ginger-partitioned stimulation(n =60),or combination treatment(n = 60).Patients assigned to the ARD group were given oral celecoxib,methotrexate,and esomeprazole.Patients assigned to theginger-partitioned stimulation group were given ginger-partitioned acupoint stimulation at Zusanli(ST 36) in addition to the ARDs.Patients in the combination treatment group were given oral Sanhuangwuji powder,ginger-partitioned acupoint stimulation at Zusanli(ST 36),and ARDs.All patients were followed up for 2 months to evaluate clinical effects and safety.The study was registered in the World Health Organization database at the General Hospital of Chengdu Military Area Command Chinese People's Liberation Army(ChiCTR-TCC12002824).RESULTS:The combination treatment group had significantly greater improvements in RA symptoms,laboratory outcomes,and gastrointestinal symptom scores,compared with the other groups(P < 0.05).The peptic ulcer healing rate in the combination treatment group was significantly greater than that in the ARD treatment group(x^2 = 16.875,P < 0.05) and the ginger-partitioned stimulation group(x^2 = 6.171,P<0.05).CONCLUSION:Combination treatment with ginger-partitioned acupoint stimulation at Zusanli(ST36),oral Sanhuangwuji powder,and ARDs had a better clinical effect for RA with complicated peptic ulcer,compared with ARD treatmentalone or in combination with ginger-partitioned acupoint stimulation. | Liu Defang Guo Mingyang Hu Yonghe Liu Taihua Yan Jiao Luo Yong Yun Mingdong Yang Min Zhang Jun Guo Linglin | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 9 |
| 2 | Application of in vitro and in vivo models in the study of food allergy显示文摘Food allergy is one of the most important food safety problems that has attracted increasing attention.The food allergy experimental models provide not only the accurate allergen detection and evaluation methods but also the powerful approaches for mechanism investigations.In this paper,we reviewed the common food allergy cell models including mast cell,basophil granulocyte and basophil,as well as the animal models of BALB/c mouse,C3H/HeJ mouse,and BN rat.We also introduced zebrafish,a promising model organism for investigating immunity though lacking direct applications in food allergy to date,and focused on traumatic inflammation,bacterial infection and viral infection models.In addition,we also summarized the clinical diagnostic research methods for food allergy.The elucidation of these topics will help researchers to understand the characteristics and mechanisms of various models and thus select the proper models for particular study,so as to support further investigations of food allergy. | Jianjian Huang Changjun Liu Yanbo Wang Chong Wang Menghua Xie Yi Qian Linglin Fu | 2018 | Food Science and Human Wellness2018，7，4： | 7 |
| 3 | Small RNA transcriptome investigation based on next-generation sequencing technology显示文摘在过去的十年,有学习小 RNA transcriptome 为理解 transcriptional 规定的复杂性是必要的一条成长认识。与增加的产量和减少的费用,下一代的定序技术提供了一个崭新的机会测量小 RNA transcriptome 的程度和复杂性。同时,大量获得的数据和改变的技术平台也为有效数据分析和采矿提出了多重挑战。提供某卓见进小 RNA transcriptome 调查,这评论描述主要小 RNA 班,识别小 RNA 的试验性的方法,和可得到的生物信息学工具和数据库。 | Linglin Zhou Xueying Li Qi Liu Fangqing Zhao Jinyu Wu | 2011 | Journal of Genetics and Genomics2011，38，11： | 5 |
| 4 | In vivo retention of poloxamer-based in situhydrogels for vaginal application in mouse and rat models显示文摘The purpose of this study is to evaluate the in vivo retention capabilities of poloxamer-based in situ hydrogels for vaginal application with nonoxinol-9 as the model drug. Two in situ hydrogel formulations, which contained 18% poloxamer 407 plus 1% poloxamer 188(GEL1, relative hydrophobic)or 6% poloxamer 188(GEL2, relative hydrophilic), were compared with respect to the rheological properties, in vitro hydrogel erosion and drug release. The vaginal retention capabilities of these hydrogel formulations were further determined in two small animal models, including drug quantitation of vaginal rinsing fluid in mice and isotope tracing with99 m Tc in rats. The two formulations exhibited similar phase transition temperatures ranging from 27 to 32 1C. Increasing the content of poloxamer 188 resulted in higher rheological moduli under body temperature, but slightly accelerated hydrogel erosion and drug release. When compared in vivo, GEL1 was eliminated significantly slower in rat vagina than GEL2,while the vaginal retention of these two hydrogel formulations behaved similarly in mice. In conclusion,increases in the hydrophilic content of formulations led to faster hydrogel erosion, drug release andintravaginal elimination. Rats appear to be a better animal model than mice to evaluate the in situ hydrogel for vaginal application. | Yu Liu Fujin Yang Linglin Feng Long Yang Lingyun Chen Gang Wei Weiyue Lu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 5 |
| 5 | Triboelectric nanogenerators: Fundamental physics and potential applications显示文摘Based on the conjunction of contact electrification and electrostatic induction,triboelectric nanogenerators(TENGs)can harvest mechanical energy dispersed in our environment.With the characteristics of simple structure,light weight,broad material availability,low cost,and high efficiency even at low operation frequency,TENG can serve as a promising alternative strategy for meeting the needs of distributed energy for the internet of things and network.The major potential applications of TENG can be summarized as four fields containing micro/nano power sources,self-powered sensors,large-scale blue energy,and direct high-voltage power sources.In this paper,the fundamental physics,output performance enhancement,and applications of TENGs are reviewed to timely summarize the development of TENGs and provide a guideline for future research. | Linglin ZHOU Di LIU Jie WANG Zhong Lin WANG | 2020 | Friction2020，8，3： | 5 |
| 6 | HIV Prevention and Health Poverty Alleviation-Liangshan Prefecture,Sichuan Province,China,2017-2020显示文摘BACKGROUND Liangshan,officially the Liangshan Yi Autonomous Prefecture,is an autonomous prefecture occupying much of the southern portion of Sichuan Province.It has been a remote and deeply impoverished area and also has the largest population of ethnic Yi people in China(1).For many years,due to geographical environment conditions,traffic conditions,and other historic restrictions,the human immunodeficiency virus(HIV)epidemic in Liangshan Prefecture has become the focus of HIV prevention and control in China since the first acquired immunodeficiency syndrome(AIDS)case was reported in this area in 1995(2-3). | Zhongfu Liu Xuefeng Tang Yufen Liu Linglin Zhang Yihui Yang Yongli Zheng Weixin Liu Chunnong Jike Hong Mai Heying Fan Gang Yu Mengjie Han George F.Gao | 2021 | China CDC weekly2021，3，48： | 4 |
| 7 | Vessel fusion tracking with a dual-frequency high-frequency surface wave radar and calibrated by an automatic identification system显示文摘High-frequency surface wave radar(HFSWR) and automatic identification system(AIS) are the two most important sensors used for vessel tracking.The HFSWR can be applied to tracking all vessels in a detection area,while the AIS is usually used to verify the information of cooperative vessels.Because of interference from sea clutter,employing single-frequency HFSWR for vessel tracking may obscure vessels located in the blind zones of Bragg peaks.Analyzing changes in the detection frequencies constitutes an effective method for addressing this deficiency.A solution consisting of vessel fusion tracking is proposed using dual-frequency HFSWR data calibrated by the AIS.Since different systematic biases exist between HFSWR frequency measurements and AIS measurements,AIS information is used to estimate and correct the HFSWR systematic biases at each frequency.First,AIS point measurements for cooperative vessels are associated with the HFSWR measurements using a JVC assignment algorithm.From the association results of the cooperative vessels,the systematic biases in the dualfrequency HFSWR data are estimated and corrected.Then,based on the corrected dual-frequency HFSWR data,the vessels are tracked using a dual-frequency fusion joint probabilistic data association(JPDA)-unscented Kalman filter(UKF) algorithm.Experimental results using real-life detection data show that the proposed method is efficient at tracking vessels in real time and can improve the tracking capability and accuracy compared with tracking processes involving single-frequency data. | ZHANG Hui LIU Yongxin JI Yonggang WANG Linglin | 2018 | Acta Oceanologica Sinica2018，37，7： | 3 |
| 8 | A framework design for the Chinese National Disaster Reduction System of Systems(CNDRSS)显示文摘China is one of the most disaster-prone countries in the world.Currently,the disaster prevention and relief mechanism in China is mainly based on single disaster types and is implemented by different ministries and divisions in single administrative regions.Subsequently,the available resources,including data,services,materials,and human resources,cannot be shared and used effectively.Based on the idea of an observation system of systems and a business system of systems,this paper presents an integrated framework for a Chinese National Disaster Reduction System of Systems(CNDRSS)to address this issue.The CNDRSS framework aims to achieve data sharing and collaboration among different disaster-related ministries/institutions by providing one-stop services for all phases of disaster management and linking together existing and planned disaster-related business systems and observation systems.The key technologies use federated databases and a web service to integrate multiple disaster management systems among different ministries/institutions and a sensor web to integrate airborne,space-borne,and in-situ observations through the web service.These event-driven focused-services connecting the various observations,processing,and mapping processes can meet the requirements for complex disasterchain systems. | Deren Li Linglin Zeng Nengcheng Chen Jie Shan Liangming Liu Yida Fan Wei Li | 2014 | International Journal of Digital Earth2014，7，1： | 3 |
| 9 | Recent Advances in Self-Powered Electrochemical Systems显示文摘Electrochemistry,one of the most important research and production technology,has been widely applicated in various fields.However,the requirement of external power source is a major challenge to its development.To solve this issue,developing selfpowered electrochemical system(SPES)that can work by collecting energy from the environment is highly desired.The invention of triboelectric nanogenerator(TENG),which can transform mechanical energy into electricity,is a promising approach to build SPES by integrating with electrochemistry.In this view,the latest representative achievements of SPES based on TENG are comprehensively reviewed.By harvesting various mechanical energy,five SPESs are built,including electrochemical pollutants treatment,electrochemical synthesis,electrochemical sensor,electrochromic reaction,and anticorrosion system,according to the application domain.Additionally,the perspective for promoting the development of SPES is discussed. | Linglin Zhou Di Liu Li Liu Lixia He Xia Cao Jie Wang Zhong Lin Wang | 2021 | Research2021，，1： | 1 |
| 10 | Effects of Montmorillonite on Pb Accumulation, Oxidative Stress, and DNA Damage in Tilapia (Oreochromis niloticus) Exposed to Dietary Pb显示文摘 | Wei Dai Linglin Fu Huahua Du Huitao Liu Zirong Xu | 2010 | Biological Trace Element Research2010，，1： | 1 |
| 11 | Effects of Rhynchophylline on Learning and Memory of Alzheimer's Disease Zebrafish显示文摘[Objectives]To investigate the effect of rhynchophylline on the behavior of Alzheimer's disease zebrafish induced by aluminum trichloride(AlCl3),to provide theoretical basis for the development and application of rhynchophylline in the field of Alzheimer's disease.[Methods]The video recording was made on zebrafish before training,so as to judge whether zebrafish training was successful or not.After training zebrafish for 7 d,60 zebrafish were randomly divided into 6 groups:blank group,model group,positive group,low-dose rhynchophylline group,medium-dose rhynchophylline group and high-dose rhynchophylline group.The blank group was video-recorded,while the model group,positive group,low-dose group,medium-dose group and high-dose group were exposed to AlCl3 for modelling.After the end,the model group was video-recorded,and the other groups were given drug intervention.Both the positive group and the rhynchophylline group were given drug for 6 d,and finally all the groups were video-recorded.After all the videos were finished,the behavioral analysis was carried out by using the behavioral record analysis software smart3.0,and the conclusion was drawn by analyzing the data.[Results]The data of length of stay of zebrafish in red short arm area of 6 groups were compared and analyzed:there was a significant difference between blank group and model group(P<0.05),and there was a significant difference between model group and positive group,medium-dose group or high-dose group(P<0.05).The percentage of time spent in the red short arm area of 6 groups of zebrafish was compared and analyzed:there was a significant difference between blank group and model group(P<0.05),and there was a significant difference between model group and positive group,medium-dose group or high-dose group(P<0.05).The data of swimming distance of 6 groups of zebrafish in red short arm area were compared and analyzed:there was no significant difference between the blank group and the model group(P>0.05),but there was only significant difference between the model group and the high-dose group(P<0.05).The percentage of swimming distance of zebrafish in the red short arm area of the six groups was compared and analyzed:there was a significant difference between the blank group and the model group(P<0.05),and there were significant differences between model group and positive group,medium-dose group or high-dose group(P<0.05).[Conclusions]Rhynchophylline can improve the behavior of Alzheimer's disease zebrafish. | Kaifei LIU Yao HUANG Guokai GUAN Shimin WU Xunyi LI Linglin CHEN Yifei CHEN | 2021 | Medicinal Plant2021，12，4： | 1 |
| 12 | Recent advances in high-performance triboelectric nanogenerators显示文摘The development of the Internet of Things(IoT)and artificial intelligence has accompanied the evolution of energy demand and structure in the new era,and the power sources for billions of distributed electronics and sensors have aroused worldwide interest.As an alternative energy harvesting technology,triboelectric nanogenerators(TENGs)have received remarkable attention and have shown attractive potential applications for use in micro/nano power sources,self-powered sensors,highvoltage power sources,and blue energy due to their advantages of small size,light weight,flexibility,low cost,and high efficiency at low frequency.In this review,we discuss high-performance TENGs from the perspectives of triboelectric charge density,output voltage,energy density,and corresponding quantification methods.Among these topics,the limitations,optimization methods and techniques,and potential directions to challenge these limits are comprehensively discussed and reviewed.Finally,we discuss the emerging challenges,strategies,and opportunities for research and development of highperformance TENGs. | Di Liu Yikui Gao Linglin Zhou Jie Wang Zhong Lin Wang | 2023 | Nano Research2023，16，9： | 1 |
| 13 | Review of ultraviolet ageing mechanisms and anti-ageing methods for asphalt binders显示文摘Asphalt binder is inevitably aged by ultraviolet(UV)light during its service period.UV ageing can significantly decrease the technical properties of asphalt binder.The sensitivity of asphalt to UV ageing and thermal-oxidative ageing differs,such that the UV ageing performance cannot be determined based on the thermal-oxidative ageing performance.Previous researches mainly focused on the chemical composite and technical performance changes of asphalt binder during UV ageing,and the UV light parameters effect on the ageing rate of asphalt binder.However,the theory for characterizing and explaining the development of UV ageing depth does not get too much attentions,and the UV ageing mechanism of asphalt binder is not very clear.Therefore,it cannot guide to develop or select the good methods or anti-UV ageing additives for asphalt binders.This paper focuses on the latest researches of the mechanisms and anti-ageing methods of asphalt binders.With the increase of UV ageing time,the UV ageing of asphalt binder develops gradually from the surface to inner part.There are various methods,such as low-penetration grade asphalt,less air void ratio,UV stabilizers and UV light absorbers,that can improve the UV ageing resistance of asphalt binders.A new theory of sensitive wavelengths of asphalt UV ageing is proposed,which can enrich the basic theory of asphalt UV ageing.Depending on this theory,different wavelengths of UV light have different ageing effects on asphalt binder.The composite anti-UV ageing additives with barrier and specific absorption effects on UV light is proposed,and may have better improvement effect on the anti-UV ageing performance of asphalt binder. | Yuanyuan Li Jianlin Feng Shaopeng Wu Anqi Chen Dongliang Kuang Tao Bai Yangming Gao Jizhe Zhang Linglin Li Liyao Wan Quantao Liu Zongwu Chen Dengjun Gu | 2022 | Journal of Road Engineering2022，2，2： | 1 |
| 14 | Biogenic amines detection in meat and meat products:the mechanisms,applications,and future trends显示文摘Biogenic amine is one of the main categories of hazardous compounds in meat and meat products,making its detection methods vital for the assurance of edible safety.In this sense,many biogenic amine detection techniques such as chromatographic,electrophoretic,and electrochemical methods have been developed,which play an irreplaceable role in ensuring the safety of meat and meat products.Due to the increasing demand for fast and on-site detection techniques,visual detection methods have been gradually developed compared with non-visual methods such as chromatography and electrophoresis.Herein,we comprehensively review the mechanism and the latest progress of these biogenic amine detection methods;besides,we put forward the prospects for the future development of biogenic amine detection techniques,with a view to providing support for the establishment of more accurate and efficient detection,prevention and control strategies of biogenic amines. | Yanan Liu Yongqiang He Huan Li Donghui Jia Linglin Fu Jian Chen Dequan Zhang Yanbo Wang | 2024 | Journal of Future Foods2024，4，1： | 0 |
| 15 | Comparison of immune responses and intestinal flora in epicutaneously sensitized BALB/c or C57BL/6 mouse models of food allergy显示文摘Cutaneous exposure to food allergens through a disrupted skin barrier is recognized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic disorders.However,the role of different genetic backgrounds of mice on immune responses to food allergens upon epicutaneous sensitization is largely unknown.In this study,two strains of mice,i.e.,the BALB/c and C57BL/6 mice,were epicutaneously sensitized with ovalbumin on atopic dermatitis(AD)-like skin lesions,followed by intragastric challenge to induce IgE-mediated food allergy.Allergic outcomes were measured as clinical signs,specific antibodies and cytokines,and immune cell subpopulations,as well as changes in intestinal barrier function and gut microbiota.Results showed that both strains of mice exhibited typical food-allergic symptoms with a Th2-skewed response.The C57BL/6 mice,rather than the BALB/c mice,were fitter for establishing an epicutaneously sensitized model of food allergy since a stronger Th2-biased response and severer disruptions in the intestinal barrier and gut homeostasis were observed.This study provides knowledge for selecting an appropriate mouse model to study food-allergic responses associated with AD-like skin lesions and highlights the role of genetic variations in the immune mechanism underlying pathogenesis of food allergy. | Gang Yu Yuhao Jiang Shuifeng Zhang Pengpeng Liu Shunyu Wang Huadong Sheng Yanbo Wang Qiaozhi Zhang Linglin Fu | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
| 16 | Colorimetric indicator based on zwitterionic anti-freezing hydrogel and alizarin for visual monitoring of salmon fillets freshness显示文摘Indicating hydrogels have shown the advantages of being fast, sensitive, and real-time in demonstrating the freshness of aquatic products due to their noticeable color change. In this work, an anti-freezing hydrogel embedded with pH-sensitive alizarin was developed as an original colorimetric indicator for monitoring the corruption of aquatic products at low temperatures. The anti-freezing hydrogel was prepared from 2-carboxyethyl acrylate, [2-(methacryloyloxy)ethyl]-trimethylammonium chloride, and 2-hydroxyethyl methacrylate monomers with triethylene glycol dimethacrylate as cross-linking agent. The hydrogel showed excellent anti-freezing capability, which was further incorporated with the pH-sensitive dye alizarin to gain the indicating capability. When applied in the indication of the freshness of salmon under low-temperature storage, it was found that the color changes of the indicator corresponded with the total volatile basic nitrogen contents of salmon, the correlation coefficient of which was 0.959 6. These results indicated the application potential of the hydrogels as freshness indicators during low-temperature storage or cold-chain transportation. | Yanan Liu Huan Li Jian Chen Jiesi Feng Renjie Lian Linglin Fu Yanbo Wang | 2024 | Journal of Future Foods2024，4，2： | 0 |
| 17 | Amygdala neural ensemble mediates mouse social investigation behaviors显示文摘Innate social investigation behaviors are critical for animal survival and are regulated by both neural circuits and neuroendocrine factors.Our understanding of how neuropeptides regulate social interest,however,is incomplete at the current stage.In this study,we identified the expression of secretin(SCT)in a subpopulation of excitatory neurons in the basolateral amygdala.With distinct mole cular and physiological features,BLA^(SCT+)cells projected to the medial prefrontal cortex and were necessary and sufficient for promoting social investigation behaviors,whilst other basolateral amygdala neurons were anxiogenic and antagonized social behaviors.Moreover,the exogenous application of secretin effectively promoted social interest in both healthy and autism spectrum disorder model mice.These results collectively demonstrate a previously unrecognized group of amygdala neurons for mediating social behaviors and suggest promising strategies for social deficits. | Ji-an Wei Qing Han Zhihua Luo Linglin Liu Jing Cui Jiahui Tan Billy KCChow Kwok-Fai So Li Zhang | 2023 | National Science Review2023，10，1： | 0 |
| 18 | MXene Lubricated Tribovoltaic Nanogenerator with High Current Output and Long Lifetime显示文摘Tribovoltaic nanogenerators(TVNGs)have the characteristics of high current density,low matched impedance and continuous output,which is expected to solve the problem of power supply for small electronic devices.However,wear occurrence in friction interface will seriously reduce the performance of TVNGs as well as lifetime.Here,we employ MXene solution as lubricate to improve output current density and lifetime of TVNG simultaneously,where a high value of 754 mA m^(-2)accompanied with a record durability of 90,000 cycles were achieved.By comparing multiple liquid lubricates with different polarity,we show that conductive polar liquid with MXene as additive plays a crucial role in enhancing the electrical output performance and durability of TVNG.Moreover,the universality of MXene solution is well demonstrated in various TVNGs with Cu and P-type Si,and Cu and N-GaAs as material pairs.This work may guide and accelerates the practical application of TVNG in future. | Wenyan Qiao Linglin Zhou Zhihao Zhao Peiyuan Yang Di Liu Xiaoru Liu Jiaqi Liu Dongyang Liu Zhong Lin Wang Jie Wang | 2023 | Nano-Micro Letters2023，15，12： | 0 |
| 19 | Effect of Huanglian Jiedu Decoction on the Behavior of Zebrafish with Alzheimer's Disease显示文摘[Objectives]To study the effect of Huanglian Jiedu Decoction on the behavior of zebrafish with Alzheimer's disease caused by AlCl 3.[Methods]Each portion of Huanglian Jiedu Decoction was prepared according to the proportion of Coptis chinensis∶Phellodendron chinense Rupr.∶Scutellaria baicalensis Georgi∶Gardenia jasminoides Ellis=63 g∶42 g∶42 g∶63 g.After that,each portion of Huanglian Jiedu Decoction was soaked in 6.3 L water for 30 min and boiled twice at 100℃.The extracts were combined twice and filtered,then concentrated to 308 g/L and put into refrigerator for later use.Before training,zebrafishes were put into T-maze to adapt for 2 d,and then behavioral training was carried out for 7 d.After video recording,the behavior of zebrafish was analyzed by Smart 3.0,and qualified zebrafishes were selected for follow-up experiments.Then 60 successfully trained zebrafishes were randomly divided into control group,model group,positive group,low-dose group,medium-dose group and high-dose group of Huanglian Jiedu Decoction.Except for the control group,all the other groups were exposed to 100μg/L AlCl 3 for 7 d.After that,video was recorded,and behavioral analysis was carried out with behavioral record and analysis software Smart 3.0.And then the zebrafishes in the other four groups except the model group were treated with Huperzine A(4μg/L)and Huanglian Jiedu Decoction(154,308,616 mg/L)for 6 d,respectively.After that,it was recorded and the behavior of each group was analyzed.[Results]There was a significant difference in the time spent in the left area and the percentage of time in the left area between the control group and the model group(P<0.001).The time spent in the left area and the percentage of time in the left area in the model group and positive group,low,medium and high dose groups of Huanglian Jiedu Decoction decreased significantly(P<0.05,P<0.01,P<0.001).The swimming distance in the left area and the percentage of swimming distance in the left area in the model group were significantly higher than those in the control group(P<0.001).There was a significant difference in swimming distance between model group and positive group,low,medium and high dose groups of Huanglian Jiedu Decoction(P<0.01,P<0.001).In the percentage of swimming distance in the left area,there was a significant difference between the model group and the low and high dose groups of Huanglian Jiedu Decoction(P<0.01,P<0.001).[Conclusions]Huanglian Jiedu Decoction can improve the behavior of zebrafish with Alzheimer's disease. | Yao HUANG Kaifei LIU Xiaolong CHEN Xuehong HUANG Dianfeng HUANG Ye CHU Jun LU Linglin CHEN Yingyuan QIN Yifei CHEN | 2023 | Medicinal Plant2023，14，1： | 0 |
| 20 | Evaluating the potential of an amelogenin-derived peptide in tertiary dentin formation显示文摘Several novel biomaterials have been developed for dental pulp capping by inducing tertiary dentin formation.The aim of this study was to evaluate the effect of QP5,an amelogenin-based peptide,on the mineralization of dental pulp cells(DPCs)in vitro and in vivo.The cell viability of human DPCs(hDPCs)after treatment with QP5 was determined using the Cell Counting Kit-8(CCK-8).Migration of hDPCs was assessed using scratch assays,and the pro-mineralization effect was determined using alkaline phosphatase(ALP)staining,alizarin red staining and the expression of mineralization-related genes and proteins.The results showed that QP5 had little effect on the cell viability,and significantly enhanced the migration capability of hDPCs.QP5 promoted the formation of mineralized nodules,and upregulated the activity of ALP,the expression of mRNA and proteins of mineralization-related genes.A pulp capping model in rats was generated to investigate the biological effect of QP5.The results of micro-computed tomography and haematoxylin and eosin staining indicated that the formation of tertiary dentin in QP5-capping groups was more prominent than that in the negative control group.These results indicated the potential of QP5 as a pulp therapy agent. | Xiu Peng Sili Han Kun Wang Longjiang Ding Zhenqi Liu Linglin Zhang | 2021 | Regenerative Biomaterials2021，8，2： | 0 |
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