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| 1 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 2 | GJB2 mutation spectrum in deaf population in a typical southeastern area of China显示文摘Mutations in GJB2 gene are the most frequently found mutations in patients with nonsyndromic hearing impairment. However, the spectrum and prevalence of mutations in this gene vary among different ethnic groups. In China, 30,000 infants are born with congenital hearing impairment annually. In order to provide appropriate genetic testing and counseling to the families, we investigated the molecular etiology of nonsyndromic deafness in 103 unrelated school children attending Nantong School for the Deaf and Mute in Jiangsu Province, China. The coding exon of the GJB2 gene was PCR amplified and sequenced. Sixty two GJB2 mutant alleles were identified in 35.9% (37/103) of the patients. Twenty five patients carried two pathogenic mutations and 12 patients carried one mutant allele. The 235delC was the most common mutation accounting for 69.4% (43/62) of GJB2 mutant alleles. The GJB2 mutant alleles accounted for 30.1% (62/206) of all chromosomes responsible for nonsyndromic hearing impairment. Testing of the 3 most prevalent deleterious frame shift mutations in this cohort detected 100% of all GJB2 mutant alleles. These results demonstrate that an effective genetic testing of GJB2 gene for patients and families with nonsyndromic hearing impairment is possible. | DAI Pu1*, YOU Yi-wen2*, CUI Jing-hong2*, YU Fei1, HAN Bing 1, KANG Dong-yang1, YUAN Hui-jun1, HAN Dong-yi1, 1. Department of Otolaryngology, PLA General Hospital, Beijing, People’s Republic China, 100853 2. Department of Otolaryngology, Nantong University Affiliated Hospital, Nantong, Jiangsu Province, People’s Republic China, 226001 *Pu Dai, Yiwen You, Jinghong Cui contribute equally to this paper | 2006 | Journal of Otology2006，1，2： | 10 |
| 3 | Ultrasonography in predicting and screening liver cirrhosis in children:A preliminary study显示文摘AIM: To evaluate the value of ultrasonography in predicting and screening liver cirrhosis in children.METHODS: Twenty-eight children with liver cirrhosis of various etiologies were examined by routine ultrasonography.A percutaneous liver biopsy guided by ultrasound was also performed on each patient, and the results of liver biopsy and ultrasonography were compared.RESULTS: When compared with the biopsy results,ultrasonography in combination of clinical and laboratory findings gave accurate diagnoses of children liver cirrhosis.Although ultrasound imaging of children with liver cirrhosis revealed abnormal characteristics, these images were not specific to this disease, thus reinforcing the necessity of ultrasound-guided liver biopsy in the diagnosis of children liver cirrhosis.CONCLUSION: Ultrasonography is reliable in the diagnosis of children liver cirrhosis, and its usefulness should be stressed in the screening and follow-up of high-risk pediatric patients. | Jia-An Zhu Bing Hu, Department of Ultrasound in Medicine, Affiliated Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, China | 2003 | World Journal of Gastroenterology2003，9，10： | 3 |
| 4 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 5 | Morphology and electrochemical activity of Ru-Ti-Sn ternary-oxide electrodes in 1M NaCl solution显示文摘 | Deng T S Bing J H | 1993 | Electrochem Acta1993，38，15： | 2 |
| 6 | Estimating saturated hydraulic conductivity in spatially variable fields using neural network ensembles 显示文摘 | KAMBAN P AMIN E BING C S | 2006 | Soil Science Society of America Journal2006，70，6： | 1 |
| 7 | Structural basis for AMP binding to mammalian AMP-activated protein kinase显示文摘 | Bing X Richard H Peter S | 2007 | Nature2007，449，7161： | 1 |
| 8 | New Condition Assessment Procedure for Asphalt Pavement Layers, Using Failing Weight Deflectometer Deflections 显示文摘 | XU Bing RANJITHAN S R KIM R Y | 2002 | Transportation Research Record2002，1806，： | 1 |
| 9 | Oxidative processes occurring When pulsed high voltage discharges degrade phenol in aqueous solution显示文摘 | Bing Sun Sato Masayuki Clements J S | 2000 | Journal: Environmental science & technology2000，34，3： | 1 |
| 10 | Purification, cloning, and characterization of the CELI nuclease 显示文摘 | Bing Y Xiao W Nagendra S K | 2003 | Biochemistry2003，39，： | 1 |
| 11 | TLR3 and TLR4 ex- pression in healthy and diseased human endometrium 显示文摘 | Allhorn S Bing C Koch AA | 2008 | Reprod Biol Endocrinol2008，6，： | 1 |
| 12 | In the eyes of the beholder: a non-self-report measure of workplace deviance显示文摘 | STEWART S M BING M N DAVISON H K | 2009 | Journal of Applied Psychology2009，94，1： | 1 |
| 13 | Time - resolved photoluminescence study of a ZnO thin film grown on a ( 100) silicon substrate 显示文摘 | Bing Guo Zhizhen Ye Wong K S | 2003 | Journal of Crystal Growth2003，253，： | 1 |
| 14 | Acidic polysaccharide of Panax ginseng regulates the mitochondria/caspase-depend- ent apoptotic pathway in radiation-induced damage to the jejunum in mice 显示文摘 | Bing S J Kim M J Ahn G | 2014 | Acta Histochemica2014，116，3： | 1 |
| 15 | In-line process condition monitoring expert system for injection molding显示文摘 | Felix T s Chan Henry C W Lau Bing Jiang | 2000 | Journal of Materials Processing Technology2000，101，： | 1 |
| 16 | Autopha: Regulation by the Nuclear Factor kappaB Signal Axis in Acute Pancreati- tis显示文摘 | Yang S Bing M Chen F eL al | 2011 | Pancreas2011，41，3： | 1 |
| 17 | Low-k damage re- duction using a modified plasma strip process 显示文摘 | RAJESH M BING J STEVE S | 2010 | Solid-State- Technology2010，53，5： | 1 |
| 18 | In the eyes of the beholder: A non-self-report measure of workplace deviance显示文摘 | Stewart S M Bing M N and Davison H K | 2009 | Journal of Applied Psychology2009，94，1： | 1 |
| 19 | Microbubble dynamics visualized in the intact capillary circulation 显示文摘 | Feinstein S B Shah P M Bing R J | 1984 | J Am Coil Cardiol1984，4，3： | 1 |
| 20 | An au- tomatic process planning system for the quick genera- tion of manufacturing process plans directly from CAD drawings 显示文摘 | Jiang Bing Lau Henry Chan Felix T S | 1999 | Journal of Materials Processing Tech- nology1999，87，123： | 1 |
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