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| 1 | Early Activation of Astrocytes does not Affect Amyloid Plaque Load in an Animal Model of Alzheimer's Disease显示文摘Astrocytes are closely associated with Alzheimer's disease(AD). However, their precise roles in AD pathogenesis remain controversial. One of the reasons behind the different results reported by different groups might be that astrocytes were targeted at different stages of disease progression. In this study, by crossing h APP(human amyloid precursor protein)-J20 mice with a line of GFAP-TK mice, we found that astrocytes were activated specifically at an early stage of AD before the occurrence of amyloid plaques, while microglia were not affected by this crossing. Activation of astrocytes at the age of 3–5 months did not affect the proteolytic processing of hAPP and amyloid plaque loads in the brains of hAPP-J20 mice. Our data suggest that early activation of astrocytes does not affect the deposition of amyloid b in an animal model of AD. | Dongpi Wang Xiaoqin Zhang Mingkai Wang Dongming Zhou Hongyu Pan Qiang Shu Binggui Sun | 2018 | Neuroscience Bulletin2018，34，6： | 3 |
| 2 | The growth mechanism of the aragonitic stalagmite laminae from Yunnan Xianren Cave,SW China revealed by cave monitoring显示文摘 | Duan Wuhui Cai Binggui Tan Ming | 2012 | Boreas2012，41，1： | 1 |
| 3 | Loess record of the aerodynamic environment in the East Asia monsoon area since 60 000 years before present显示文摘 | Qin Xiaoguang Cai Binggui Liu Tungsheng | 2005 | Journal of Geophysical research2005，110，4： | 1 |
| 4 | Tegumental changes in 21- day-old Schistosoma mansoni harboured in mice treated with artemether显示文摘 | Xiao S Binggui S Chollet J | 2000 | Acta Tropica2000，75，3： | 1 |
| 5 | Intra-annual variation of the calcite deposition rate of drip water in Shihua Cave,Beijing,China and its implications for palaeoclimatic reconstructions显示文摘 | Cai Binggui Zhu Jian Ban Fengmei | 2011 | Boreas2011，40，3： | 1 |
| 6 | Strengthening and Toughening of a Heavy Plate Steel for Shipbuilding with Yield Strength of Approximately 690 MPa显示文摘 | Dongsheng Liu Binggui Cheng Yuanyuan Chen | 2013 | Metallurgical and Materials Transactions A2013，，1： | 1 |
| 7 | Applications of stalagmite laminae to paleoclimate reconstructions: Comparison with dendrochronology/climatology显示文摘 | Ming Tan Andy Baker Dominique Genty Claire Smith Jan Esper Binggui Cai | 2006 | Quaternary Science Reviews2006，，17： | 1 |
| 8 | Temporal and spatial variations in the discharge and dissolved organic carbon of drip waters in Beijing Shihua Cave,China显示文摘 | Ban Fengmei Pan Genxiong Zhu Jian Cai Binggui Tan Ming | | 0，，： | 1 |
| 9 | Regions of Applicability of Aubry-Mather Theory for Non-convex Hamiltonian显示文摘Herman constructed an autonomous system of two degrees of freedom which says that in non-convex situations, oscillations do happen and Aubry-Mather Theory cannot apply (see the results due to W. F. Chen in 1992). In this paper, it is shown that although the orbits could visit a region far away from the initial point in phase space, they can only exist in some fixed regions in I = (I1 , I2 ) plane. Moreover, Aubry-Mather Theory can be applied outside the regions. | Min ZHOU Binggui ZHONG | 2011 | Chinese Annals of Mathematics,Series B2011，32，4： | 0 |
| 10 | Diatom Response to Global Warming in Douhu Lake,Southeast China显示文摘A large number of lacustrine sedimentary records indicate that global warming is the main factor leading to significant changes in diatom communities in lakes of the northern hemisphere.However,due to the intensification of human activities since 1850,some scholars have emphasized that the increasing lake trophic level may be the main reason for the changes in diatom communities.The debate is ongoing.In order to avoid falling into the complex relationship between diatom changes and the seasonal cycle that characterizes lakes in mid and high latitudes,we chose a lake located at a low latitude,where the relationship between diatoms and temperature is not indirect but direct.The diatom record spans the past ca.100 years and reveals that the abundance of Aulacoseira granulata increased from 1900 until 1985,replacing the previously dominant Aulacoseira ambigua.These changes are in agreement with the increasing trend in global temperature.Since 1985,the percentages of the small-celled Discostella stelligera and the benthic diatom Navicula heimansioides have increased,while Aulacoseira granulata has decreased.This latest shift is caused by further global warming.We conclude that warming is the main factor leading to changing diatom communities in Douhu Lake. | LI Jingjing WANG Luo CAO Qi Patrick RIOUAL LEI Guoliang CAI Binggui ZHANG Jiaoyang ZOU Yafei YAN Yao WAN Xiaoqiao XIAO Jule | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 0 |
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