|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer显示文摘胰腺的癌症是有导致世界范围的高死亡率的一个高变形的潜力的好攻击的恶意。尽管巨噬细胞有潜力杀死肿瘤房间并且对肿瘤得到有免疫力的回答,有证据,联系肿瘤的巨噬细胞(TAM ) 支持肿瘤前进并且压制 T 房间回答。CC-chemokine ligand 20 (CCL20 ) 并且它的唯一的受体 CC-chemokine 受体(CCR6 ) 6 被癌症房间为移植和转移利用并且在癌症的发展和前进起重要作用。最近的研究证明了 CCL20 的表示是在胰腺的癌症的 upregulated;然而, CCL20 的行动的机制尚待充分被阐明。在这研究,包括变形胰腺的癌症织物,在胰腺的癌症织物的 TAM 的 CCL20 的异常表示被检测。CCL20 表示比在胰腺的癌症房间排队的在巨噬细胞是更加更高的,特别地在 interleukin-4-treated (M2 ) 巨噬细胞。用胰腺的癌症房间的 Boyden 房间试金,我们发现 M2 巨噬细胞分泌的 CCL20 支持了胰腺的癌症房间的迁居,上皮间充质的转变,和侵略。RNA 干扰结果证明 CCR6 是为在胰腺的癌症房间的 CCL20 的受体,调停这些房间的增加的侵略性质由 CCL20 支持了。用一个老鼠模型,我们在在 vivo 支持胰腺的癌症生长和肝转移证实了 CCR6/CCL20 的角色。我们的调查结果在胰腺的癌症提供卓见进藏匿巨噬细胞的 CCL20 的重要角色并且含有 CCR6/CCL20 同样潜在的治疗学的目标。 | Bingyan Liu Yiping Jia Jun Ma Shaoqiu Wu Haosheng Jiang Yan Cao Xianjun Sun Xiang Yin Shuo Yan Mingyi Shang Aiwu Mao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 13 |
| 2 | The cloning and preliminarily functional analysis of the human neurotrimin gene显示文摘Proteins of the immunoglobulin superfamily (IgSF) are involved in a variety of spe- cific cell-cell interactions in the developing nervous system. To identify and characterize new members of this protein family in human nervous system, we screen the human fetal brain cDNA library and isolate a full-length cDNA clone which contains a 1032 bp open reading frame en- coding a protein of 344 amino acids. Sequence analysis reveals that it is a glycoprotein com- prised of three C2-1ike immunoglobulin domains and is anchored to the plasma membrane via a post-translationally attached glycosyl-phosphatidylinositol (GPI) moiety. The protein shows high sequence similarity to the rat Ntm (97%), so we term it human neurotrimin (NTM). Northern blot analysis reveals that (HUMAN)NTM has three different transcripts with the length of 3.2 kb, 4.0 kb and 9.0 kb respectively. It has a wider expression pattern than that of (RAT) Ntm. Notably, the expression of NTM in fetal brain is higher than that in mature brain and is stronger in nervous tumors than that in normal brain tissues. We insert an HA epitope tag between the third Ig-like domain of NTM and the site of GPI attachment, then construct it into the eukaryotic expression vector pcDNA3.1+/Zeocin. The pcDNA3.1-HA-NTM is transfected into the Chinese Hamster Ovary (CHO) cells. The results demonstrate that HA-NTM is expressed on the surface of CHO cells and could strengthen the aggregation of CHO-NTM cells. | LIU Jin, LI Guangtao, PENG Xiaozhong, LIU Bingyan, YIN Bin, TAN Xinyu, FAN Ming, FAN Wenhong, QIANG Boqin & YUAN Jiangang National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, National Human Genome North Center, Beijing 100005, China Department of Neuro- biology, Institute of Basic Medical Science, 27 Taiping Road, Beijing 100850, China | 2004 | Science China(Life Sciences)2004，47，2： | 1 |
| 3 | All-polymer solar cells显示文摘Organic solar cells(OSCs)show a promising commercialization prospect with their power conversion efficiencies(PCEs)exceeding 18%[1−6].Among various types of OSCs,all-polymer solar cells(all-PSCs)with a physical blend of p-and n-type polymer as the active layer to harvest solar irradiation attract growing attention due to their unique advantages like excellent morphological stability,and mechanical durability[7]. | Baoqi Wu Bingyan Yin Chunhui Duan Liming Ding | 2021 | Journal of Semiconductors2021，42，8： | 1 |
| 4 | The multi-scale flow behaviors of sisal fiber reinforced composites during resin transfer molding process显示文摘The flow behaviors of the resin during the resin transfer molding(RTM) process of sisal fiber reinforced composites was studied at different scales with the consideration of the unique hierarchical and lumen structures of sisal fibers compared to those of manmade fibers. The work mainly focused on the development of the multi-scale flow models which include the resin flow inside lumens, intra-bundles and inter-bundles. The models not only quantified the lumen flow based on the Hagen-Poiseuille equation,but also ensured the continuity of the velocity and stress on the boundaries between intra-bundle and inter-bundle regions by applying Brinkman equation. Three dedicated experiments were designed and implemented to validate the effectiveness of the proposed models. The absorbed resin mass over the infiltration time obtained from the single sisal fiber and sisal fiber bundle infiltration experiments showed good agreement with the calculated curves. In terms of the RTM process, the dynamic flow front of the resin was perfectly predicted by the proposed model at macro-scale. | YIN Tao LI Yan YUAN BingYan | 2018 | Science China(Technological Sciences)2018，61，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员