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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Proteomic identification of Helicobacter pylori-associated gastroduodenal disease: Challenges and opportunities 显示文摘 | Wu M S ChowLP Lin J T biomarkers related to | 2008 | J Gastroenterol Hepatol2008，23，11： | 1 |
| 3 | Biomarkers and surrogate end points: preferred definitions and conceptual framework 显示文摘 | Biomarkers Definitions Working Group | 2001 | Clin Pharmacol Ther2001，69，3： | 1 |
| 4 | Validation and pharmacokinetic-pharmcodynamic modeling显示文摘 | Colburn WA Lee JW Biomarkers | 2003 | Clin pharmcokinet2003，42，： | 1 |
| 5 | Clin Genitourin Cancer显示文摘 | Goodman OB Jr Symanowski JT Loudyi A Circulating tumor cells as a predictive biomarker in patients with hormone-sensitive prostate cancer | 2011 | 9( 1 ) :31-382011，9，1： | 1 |
| 6 | Analytical characteristics of high-sensitivity cardiac troponinassays显示文摘 | Apple FS Collinson PO IFCC Task Force on Clinical Applications of Cardiac Biomarkers | 2012 | Clin Chem2012，58，1： | 1 |
| 7 | Biomarkers and surrogate endpoints: preferred definitions and conceptual framework显示文摘 | Biomarker Definitions Working Group | 2001 | Clin Pharmacol Ther2001，69，3： | 1 |
| 8 | Listijono DR显示文摘 | Current imaging techniques and potential biomarkers inthe diagnosis of acute aortic dissection | 2012 | JRSM Short Rep2012，3，11： | 1 |
| 9 | Interobserver reproducibility of immunohistochemical HER-2/neu assessment in human breast cancer:an update from INQAT round Ⅲ显示文摘 | Italian Network for Quality Assurance of Tumor Biomarkers ( IN- QAT) Group SIAPEC-IAP | 2005 | Int J Biol Markers2005，20，3： | 1 |
| 10 | Inflammatory heart failure显示文摘 | Ueland T Gullestad L Nymo cytokines as biomarkers in S H | 2015 | Clinica Chimica Acta2015，443，： | 1 |
| 11 | Biomarkers and surrogate endpoints: preferred definitions and conceptual framework 显示文摘 | Biomarkers Definitions Working Group | 2001 | Clin Pharmacol Ther2001，69，3： | 1 |
| 12 | Biomarkers and surrogate endpoints : preferred definitions and conceptual framework 显示文摘 | Biomarkers Definitions Working Group | 2001 | Clin Pharmacol Ther2001，69，3： | 1 |
| 13 | Biomarkers and surrogate endpoints:preferred definitions and conceptual framework显示文摘 | Biomarkers Definitions Working Group | | 0，，03： | 1 |
| 14 | Third universal definition of myocardial infarction显示文摘 | Thygesen K Alpert JS Jaffe AS Joint ESC/ACCF/AHA/ WHF Task Force for Universal Definition of Myocardial Infarction Authors/Task Force Members Chairpersons Biomarker Subcommittee ECG Subcommittee Imaging Subcommittee Classification Subcommittee Intervention Subcommittee Trials & Registries Subcommittee Trials & Registries Subcommittee Trials & Registries Subcommittee Trials & Registries Subcommittee ESC Committee for Practice Guidelines (CPG) Document Reviewers | 2012 | J Am Coil Cardiol2012，60，： | 1 |
| 15 | Comassessment of phytoplankton paleoproductivity for the last 160 kyr off Cap Blanc, NW Africa显示文摘 | ZHAO M X MERCER J L parative molecular biomarker EGLINTON G | 2006 | OrgGeochem2006，37，1： | 1 |
| 16 | Mechanistically identi- effect, and susceptibility for silis : a comprehensive review 显示文摘 | Gulumian M Borm P J Vallyathan fled suitable biomarkers of exposure cosis and coal worker's p J Toxicol Environ Health B Crit Rev V | 2006 | 9 (5): 3572006，9，5： | 1 |
| 17 | Biomarkers and surrogate endpoints:preferred definitions and conceptual framework显示文摘 | Biomarkers Working Group | 2001 | Clin Pharmacol Ther2001，69，3： | 1 |
| 18 | Biomarkers and sur- rogate endpoints: preferred definitions and conceptual frame- work显示文摘 | Biomarkers Definitions Working Group | 2001 | Clin Pharmacol Ther2001，69，3： | 1 |
| 19 | Biomarkers andsurrogate endpoints:preferred definitions and conceptual framework显示文摘 | Biomarkers Definition Working Group | | 0，，： | 1 |
| 20 | Non-invasive guide management following renal transplantation: the need for a muhiplatform approach 显示文摘 | Chowdhury P biomarkers to Hernandez-Fuentes MP | 2013 | Curr Opin Organ Transplant2013，18，1： | 1 |
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