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| 1 | Research on single event transient pulse quenching effect in 90 nm CMOS technology显示文摘Since single event transient pulse quenching can reduce the SET(single event transient) pulsewidths effectively,the charge collected by passive device should be maximized in order to minimize the propagated SET.From the perspective of the layout and circuit design,the SET pulsewidths can be greatly inhibited by minimizing the layout spacing and signal propagation delay,which sheds new light on the radiation-hardened ICs(integrated circuits) design.Studies show that the SET pulsewidths of propagation are not in direct proportion to the LET(linear energy transfer) of incident particles,thus the defining of the LET threshold should be noted when SET/SEU(single event upset) occurs for the radiation-hardened design.The capability of anti-radiation meets the demand when LET is high but some soft errors may occur when LET is low.Therefore,radiation experiments should be focused on evaluating the LET that demonstrates the worst response to the circuit. | QIN JunRui CHEN ShuMing LIU BiWei CHEN JianJun LIANG Bin LIU Zheng | 2011 | Science China(Technological Sciences)2011，54，11： | 14 |
| 2 | The effect of P^+ deep well doping on SET pulse propagation显示文摘The change of P+ deep well doping will affect the charge collection of the active and passive devices in nano-technology,thus affecting the propagated single event transient(SET) pulsewidths in circuits.The propagated SET pulsewidths can be quenched by reducing the doping of P+ deep well in the appropriate range.The study shows that the doping of P+ deep well mainly affects the bipolar amplification component of SET current,and that changing the P+ deep well doping has little effect on NMOS but great effect on PMOS. | QIN JunRui CHEN ShuMing LIU BiWei LIU FanYu CHEN JianJun | 2012 | Science China(Technological Sciences)2012，55，3： | 7 |
| 3 | Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii显示文摘Aconitum carmichaelii is a high-value medicinal herb widely used across China,Japan,and other Asian countries.Aconitine-type diterpene alkaloids(DAs)are the characteristic compounds in Aconitum.Although six transcriptomes,based on short-read next generation sequencing technology,have been reported from the Aconitum species,the terpene synthase(TPS)corresponding to DAs biosynthesis remains unidentified.We apply a combination of Pacbio isoform sequencing and RNA sequencing to provide a comprehensive view of the A.carmichaelii transcriptome.Nineteen TPSs and five alternative splicing isoforms belonging to TPS-b,TPS-c,and TPS-e/f subfamilies were identified.In vitro enzyme reaction analysis functional identified two sesqui-TPSs and twelve di TPSs.Seven of the TPS-c subfamily genes reacted with GGPP to produce the intermediate ent-copalyl diphosphate.Five Ac KSLs separately reacted with ent-CPP to produce ent-kaurene,ent-atiserene,and ent-13-epi-sandaracopimaradie:a new diterpene found in Aconitum.Ac TPSs gene expression in conjunction DAs content analysis in different tissues validated that ent-CPP is the sole precursor to all DAs biosynthesis,with Ac KSL1,Ac KSL2 s and Ac KSL3-1 responsible for C20 atisine and napelline type DAs biosynthesis,respectively.These data clarified the molecular basis for the C20-DAs biosynthetic pathway in A.carmichaelii and pave the way for further exploration of C19-DAs biosynthesis in the Aconitum species. | Liuying Mao Baolong Jin Lingli Chen Mei Tian Rui Ma Biwei Yin Haiyan Zhang Juan Guo Jinfu Tang Tong Chen Changjiangsheng Lai Guanghong Cui Luqi Huang | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 6 |
| 4 | Novel N-hit single event transient mitigation technique via open guard transistor in 65 nm bulk CMOS process显示文摘In this paper,we proposed a new n-channel MOS single event transient(SET) mitigation technique,which is called the open guard transistor(OGT) technique.This hardening scheme is compared with several classical n-channel MOS hardening structures through 3-D TCAD simulations.The results show that this scheme presents about 35% improvements over the unhardened scheme for mitigating the SET pulse,and its upgrade,the 2-fringe scheme,takes on even more than 50% improvements over the unhardened one.This makes significant sense for the semi-conductor device reliability. | HUANG PengCheng CHEN ShuMing CHEN JianJun LIU BiWei | 2013 | Science China(Technological Sciences)2013，56，2： | 5 |
| 5 | Effect of p-well contact on n-well potential modulation in a 90 nm bulk technology显示文摘The effect of p-well contact on the n-well potential modulation in a 90 nm bulk technology with P+ deep well is studied based on three-dimensional (3-D) TCAD device simulations. Simulation results illustrate that the p-well contact area has a great impact on the n-well potential modulation and the enhancement factor will level out as the p-well contact area increases, and that at the same time the increase of p-well doping concentration can also enhance the n-well potential modulation. However, the effect of p-well contact location on the n-well modulation is not obvious as the p-well contact distance increases. According to our simulation results, it is proposed that the p-well contact area should be cautiously designed to mitigate single event effect (SEE) in the P+ deep well technology. | DU YanKang CHEN ShuMing LIU BiWei LIANG Bin | 2012 | Science China(Technological Sciences)2012，55，4： | 4 |
| 6 | Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers显示文摘Chemotherapy is one of the important methods to treat cancer,and the emergence of multidrug resistance(MDR)is one major cause for the failure of cancer chemotherapy.Almost all anti-tumor drugs develop drug resistance over a period of time of application in cancer patients,reducing their effects on killing cancer cells.Chemoresistance can lead to a rapid recurrence of cancers and ultimately patient death.MDR may be induced by multiple mechanisms,which are associated with a complex process of multiple genes,factors,pathways,and multiple steps,and today the MDR-associated mechanisms are largely unknown.In this paper,from the aspects of protein–protein interactions,alternative splicing(AS)in pre-mRNA,non-coding RNA(ncRNA)mediation,genome mutations,variance in cell functions,and influence from the tumor microenvironment,we summarize the molecular mechanisms associated with MDR in cancers.In the end,prospects for the exploration of antitumor drugs that can reverse MDR are briefly discussed from the angle of drug systems with improved targeting properties,biocompatibility,availability,and other advantages. | Lei Zhang Biwei Ye Zhuo Chen Zhe-Sheng Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 3 |
| 7 | Charge collection of single event effects at Bragg's peak显示文摘Using Geant4 Monte Carlo code and Technology Computer-Aided Design(TCAD) simulation,energy deposition and charge collection of single event effects(SEE) are studied,which are induced by low-energy protons and α particles in small feature size devices.We analyzed charge collection of SEE especially at Bragg's peak and obtained two types of deposited energy distributions of protons and α particles at different incident energies.The two components of the total charge collected are quantified,which are due to drift current of the space charge region and current in the funnel region separately.Results explain the high soft error rate in experiments of low energy proton. | LIU Zheng CHEN ShuMing LIANG Bin LIU BiWei ZHAO ZhenYu | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 2 |
| 8 | Coupled SET pulse injection in a circuit simulator in ultra-deep submicron technology显示文摘 | LIU Biwei CHEN Shuming LIANG Bin | 2008 | Chinese Journal of Semiconductor2008，29，9： | 1 |
| 9 | The effect of re-convergence on SER estimation in combinational circuits 显示文摘 | Liu Biwei Chen Shuming Liang Bin Liu Zheng Zhao Zhenyu | | IEEE Trans Nucl Sci0，56，6： | 1 |
| 10 | Simulation study of N-hit SET variation in differential cascade voltage switch logical circuits显示文摘The advancement in the process leads to more concern about the Single Event(SE) sensitivity of the Differential Cascade Voltage Switch Logic(DCVSL) circuits. The simulation results indicate that the Single Event Transient(SET) generated at the DCVSL gate is much larger than that at the ordinary CMOS gate, and their SET variation is different. Based on charge collection, in this paper, the effective collection time theory is proposed to set forth the SET pulse generated at the DCVSL gate. Through 3D TCAD mixed-mode simulation in 65 nm twin-well bulk CMOS process, the effects on SET variation of device parameters such as well contact size and environment parameters such as voltage are investigated. | HUANG PengCheng CHEN ShuMing CHEN JianJun WU ZhenYu LIANG ZhengFa HU ChunMei LIANG Bin LIU BiWei | 2015 | Science China(Information Sciences)2015，58，2： | 1 |
| 11 | The effect of re-convergence on SER estimation in combinational cir- cuits显示文摘 | LIU Biwei CHEN Shuming LIANG Bin | 2009 | IEEE Transactions on Nuclear Science2009，56，6： | 1 |
| 12 | The Effect of Re-Convergence on SER Estimation in Combinational Cir-cuits显示文摘 | Liu Biwei Chen Shuming Liang Bin | 2009 | IEEE Transactions on Nuclear Science2009，56，6： | 1 |
| 13 | Simultaneously Enhancing Strength and Toughness for Impact Polypropylene Copolymers by Regulating the Dispersed Phase with High Density Polyethylene显示文摘 | Qiu Biwei Chen Feng Shangguan Yonggang | 2014 | RSC Adv2014，103，58： | 1 |
| 14 | Device-physics-based analytical model for SET pulse in sub-100 nm bulk CMOS Process显示文摘Through revising the process of charge collection for reversed drain-bulk junction,a bias-dependent SPICE model is proposed which includes the bipolar amplification effect that cannot be ignored in PMOS.The model can capture the plateau effect,and produce current and voltage pulse shapes and widths that are consistent with TCAD simulation.Considering the case of connecting load,it is still valid.For combination and sequential logic circuits,the SET pulsewidths and LET upset threshold from SPICE model are consistent with TCAD simulations. | QIN JunRui CHEN ShuMing LIU BiWei LIANG Bin CHEN JianJun | 2012 | Science China(Information Sciences)2012，55，6： | 1 |
| 15 | Unintentional Injury Mortality Among Children Under Five Years--China,2006−2017显示文摘What is already known about this topic?Unintentional injuries among children aged under five years is still a serious public health problem in China.Epidemiological characteristics of under-five unintentional injury are reported in single provinces and cities for China but not nationally based on the Disease Surveillance Points(DSPs)dataset.What is added by this report?Unintentional injury mortality rates for under-five decreased substantially between 2006 and 2017 in China,with the decrease occurring primarily for males and rural children.Children living in rural areas and males had higher unintentional injury mortality rates than children in urban areas and females.The major fatal types of under-five unintentional injury were drowning and road injury.What are the implications for public health practice?Further interventions need to be taken in accordance with the main types of unintentional injuries,especially effective prevention strategies used in other countries or recommended by the World Health Organization(WHO).Even with equal access to injury prevention and control services for different sexes,policy efforts should focus on higher-risk populations,especially children aged under five years who are males or reside in rural areas. | Bo Chen Pengpeng Ye Biwei Tang Siqi Wang Jia Guo Jing Wu | 2020 | China CDC weekly2020，2，10： | 0 |
| 16 | A Meta-analysis of Acupuncture Treatment for Irritable Bowel Syndrome显示文摘To assess the efficacy of acupuncture for treatment of irritable bowel syndrome through meta-analysis of randomized controlled trials in recent 20 years.Online databases,including CNKI,VIP,WANFANG,PubMed,Cochrane Library,Web of Science and Embase were searched for randomized controlled trials(RCTs)of acupuncture for IBS.Retrieval time was from January 1,2000 to January 31,2021.According to Jadad scoring criteria,the bias risk and quality assessment of each RCT included were evaluated by two researchers.RevMan 5.3 software was used for the metaanalysis.Eight RCTs were selected which include a total of 1181 patients.The control group has 425 patients and the experimental group has 756 patients.The result of meta-analysis indicates that the total effective rate for the experimental group was superior to that of the control group[OR=3.29,95%CI[2.16~5.03](P<0.01)],and the funnel plot was basically symmetric.Acupuncture therapy is shown to have a good safety and compliance record.However,the number of high-quality trials is small,and there are some deficiencies in the methodology of clinical research.Acupuncture,as a supplementary therapy for irritable bowel syndrome,has positive clinical significance and prospects for application.The methodology of clinical research needs to be further improved. | Biwei Chen Lili Zhang Shaozong Chen Changzhen Gong | 2021 | Journal of Integrative Medicine(双语)2021，10，2： | 0 |
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