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| 1 | 大鼠结缔组织生长因子部分cDNA序列的克隆及其mRNA在实验性肝纤维化中的表达显示文摘目的克隆出大鼠结缔组织生长因子(connective tissue growth factor, CTGF)的部分cDNA序列,并观察在实验性肝纤维化大鼠肝脏中 CTGF mRNA的表达改变。方法根据小鼠CTGF mRNA序列设计引物,用 RT-PCR从大鼠肝脏总 RNA中扩增出一段 430 bp的产物,并测定其序列。将 16只雌性 Wistar大鼠随机分为胆管堵塞组(n=8)及假手术组(n=8)。6周后取大鼠肝脏提取总RNA,利用多探针以核酸酶保护分析法测定CTGF及TGFβ_1的mRNA水平。结果克隆出的大鼠CTGF cDNA序列在核酸水平与小鼠的同源性为95%。胆汁性肝硬化大鼠肝脏中 TGF β_1及 CTGF的 IRNA水平分别为假手术组大鼠的 4倍和 7倍。结论在实验性肝纤维化大鼠肝脏中CTGF mRNA的表达水平明显上调。 | 贾继东 Michael Bauer Gabriele Boigk Martin Ruelh Detlef Schuppan 王宝恩 | 2000 | 中华肝脏病杂志2000，8，2： | 22 |
| 2 | ⅩⅧ型胶原mRNA在实验性肝纤维化大鼠肝脏中的表达显示文摘目的了解XⅧ型胶原(collagenXⅧ,CXⅧ)mRNA在实验性肝纤维化中的定量改变。方法以逆行胆管硬化注射加结扎的方法制备大鼠胆管堵塞性肝纤维化模型,以假手术组大鼠为对照组。提取肝脏总RNA,以核酸酶保护分析(RNA酶保护分析)定量测定前胶原α1(XⅧ)mRNA水平,并与α1(Ⅰ)和金属蛋白酶组织抑制因子1(TIMP-1)的mRNA变化相比较。结果与假手术组大鼠相比,胆管堵塞性肝纤维化大鼠肝脏前胶原α1(Ⅰ)及TIMP-1mRNA水平分别升高20倍及4倍;而肝纤维化大鼠肝脏前胶原α1(XⅧ)mRNA水平仅升高到1.8倍。结论肝纤维化时肝脏XⅧ胶原仅轻度升高.这种变化类型可能和XⅧ胶原主要由肝实质细胞表达有关。 | 贾继东 Michael Bauer Garbriele Boigk Martin Ruehl Detlef Schuppan 王宝恩 | 2000 | 中华肝脏病杂志2000，8，5： | 4 |
| 3 | Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen α 1(I) and TIMP-1显示文摘 | Ji-Dong Jia Michael Bauer Jae Jin Cho Martin Ruehl Stefano Milani Gabriele Boigk Ernst Otto Riecken Detlef Schuppan | 2001 | Journal of Hepatology2001，，： | 1 |
| 4 | Silymarin retards collagen accumulation in early and advanced billiary fibrosis secondary to complete bile duct obliteration in rats显示文摘 | Boigk G Stroedterl Herbsr H et aI | 1997 | Hepatology1997，26，3： | 1 |
| 5 | Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen alphal (Ⅰ) and TIMP-1显示文摘 | Jia JD Bauer M Cho JJ Ruehl M Milani S Boigk G | 2001 | J Hepatol2001，35，： | 1 |
| 6 | Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis显示文摘 | Raetsch C Jia JD Boigk G | 2002 | Gut2002，50，2： | 1 |
| 7 | Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats显示文摘 | Boigk G Stroedter L Herbst H | 1997 | J Hepatol1997，26，： | 1 |
| 8 | Pentoxifylline downregulates profibrogenic cytokines and proeollagen I expression in rat secondary biliary fibrosis显示文摘 | RAETSH C JIA J D BOIGK G | 2002 | Gut2002，50，2： | 1 |
| 9 | Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis显示文摘 | Raetsch C Jia JD Boigk G | | Gut0，，： | 1 |
| 10 | Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats 显示文摘 | Boigk G Stroedlter L Herbst H | 1997 | Hepatology1997，26，3： | 1 |
| 11 | Pentoxifylline downregulates profibrogenic cytokines and procollagen 1 expression in rat secondary biliary fibrosis显示文摘 | Raetsh C Jia J D Boigk G | 2002 | Gut2002，50，2： | 1 |
| 12 | Silymafin retards collagen accumulation in early an d advanced biliary fibrosis secondary to complete bile duct obliter- ation in rats显示文摘 | Boigk G Stroedter L Herbst H | 1997 | J Hepatol1997，26，： | 1 |
| 13 | Carbon and nitrogen isotope data of Upper Carboniferous and Rotliegend natural gases from North Germany and their relationship to the maturity of the organic source material 显示文摘 | $tahl J W Boigk H Wollanke G | 1977 | Adv Org Geochem1977，3，45： | 1 |
| 14 | Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats显示文摘 | Boigk G Stroedter L Herbst H Waldschmidt J Riecken EO Schuppan D | 1997 | Hepatology1997，26，3： | 1 |
| 15 | Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis 显示文摘 | Raetsch C Jia JD Boigk G | 2002 | Gut2002，50，2： | 1 |
| 16 | Pentoxifylline down regulates profibbrogenic cytokines and procollagen Ⅰ expression in rat secondary biliary fibrosis 显示文摘 | Raetsch C Jia J D Boigk G | 2002 | Gut2002，50，3： | 1 |
| 17 | Silymarin retards collagen accumulation in earIv and advanced biliary fibrosis secondary to com pletebileductobliterationinrats显示文摘 | Boigk G Stroedter L Herbst H | 1997 | Hepatolog1997，26，3： | 1 |
| 18 | Silymarin retards collagenaccumulationinearlyandadvancedbiliaryfibrosissecondarytocompletebile duct obliteration in rats显示文摘 | Boigk G Stroedter L Herbst H | 1997 | Hepatology1997，26，64： | 1 |
| 19 | Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats显示文摘 | G Boigk L Stroedter H Herbst J Waldschmidt EO Riecken D Schuppan | 1997 | Hepatology1997，，3： | 1 |
| 20 | Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats 显示文摘 | Boigk G Stroedter L Herbst H | 1997 | Hepatology1997，26，3： | 1 |
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