|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 大鼠结缔组织生长因子部分cDNA序列的克隆及其mRNA在实验性肝纤维化中的表达显示文摘目的克隆出大鼠结缔组织生长因子(connective tissue growth factor, CTGF)的部分cDNA序列,并观察在实验性肝纤维化大鼠肝脏中 CTGF mRNA的表达改变。方法根据小鼠CTGF mRNA序列设计引物,用 RT-PCR从大鼠肝脏总 RNA中扩增出一段 430 bp的产物,并测定其序列。将 16只雌性 Wistar大鼠随机分为胆管堵塞组(n=8)及假手术组(n=8)。6周后取大鼠肝脏提取总RNA,利用多探针以核酸酶保护分析法测定CTGF及TGFβ_1的mRNA水平。结果克隆出的大鼠CTGF cDNA序列在核酸水平与小鼠的同源性为95%。胆汁性肝硬化大鼠肝脏中 TGF β_1及 CTGF的 IRNA水平分别为假手术组大鼠的 4倍和 7倍。结论在实验性肝纤维化大鼠肝脏中CTGF mRNA的表达水平明显上调。 | 贾继东 Michael Bauer Gabriele Boigk Martin Ruelh Detlef Schuppan 王宝恩 | 2000 | 中华肝脏病杂志2000，8，2： | 22 |
| 2 | Role of the receptor for advanced glycation end products in hepatic fibrosis显示文摘AIM:To study the role of advanced glycation end products(AGE)and their specifi c receptor(RAGE)in the pathogenesis of liver fi brogenesis.METHODS:In vitro RAGE expression and extracellular matrix-related gene expression in both rat and human hepatic stellate cells(HSC)were measured after stimulation with the two RAGE ligands,advanced glycation end product-bovine serum albumin(AGE-BSA)and Nε-(carboxymethyl)lysine(CML)-BSA,or with tumor necrosis factor-α(TNF-α).In vivo RAGE expression was examined in models of hepatic fi brosis induced by bile duct ligation or thioacetamide.The effects of AGE-BSA and CML-BSA on HSC proliferation,signal transduction and profi brogenic gene expression were studied in vitro.RESULTS:In hepatic fibrosis,RAGE expression was enhanced in activated HSC,and also in endothelial cells,inflammatory cells and activated bile duct epithelia.HSC expressed RAGE which was upregulated after stimulation with AGE-BSA,CML-BSA,and TNF-α.RAGE stimulation with AGE-BSA and CML-BSA did not alter HSC proliferation,apoptosis,fibrogenic signal transduction and fibrosis-or fibrolysis-related gene expression,except for marginal upregulation of procollagen α1(Ⅰ)mRNA by AGE-BSA.CONCLUSION:Despite upregulation of RAGE in activated HSC,RAGE stimulation by AGE does not alter their fibrogenic activation.Therefore,RAGE does not contribute directly to hepatic fibrogenesis. | Christina Lohwasser Daniel Neureiter Yury Popov Michael Bauer Detlef Schuppan | 2009 | World Journal of Gastroenterology2009，15，46： | 13 |
| 3 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 4 | 利用飞秒双光子光电子发射研究GaAs(100)的自旋动力学过程显示文摘超短激光技术的发展为研究材料中的超快光动方学过程提供了重要的实验手段,也使得人们能够更为深入地研究电子的自旋动力学行为.GaAs(100)表面由于费米钉扎而会导致能带弯曲,位于该区域的电子及其自旋特性将会明显不同于体相材料中的情况.利用时间分辨和自旋分辨的双光子光电子发射技术研究了p型掺杂GaAs(100)表面的电子极化动力学过程.结果表明,由费米钉扎而引起的能带弯曲明显影响电子的自旋弛豫过程,从实验上观察到了GaAs(100)表面能带弯曲区域的电子自旋翻转时间存在近2个量级的差异(从几纳秒到几十皮秒),基于电子_自旋交换相互作用的BAP机理在自旋弛豫过程中起着主导作用. | 郭立俊 Jan-Peter Wüstenberg Andreyev Oleksiy Michael Bauer Martin Aeschlimann | 2005 | 物理学报2005，54，7： | 7 |
| 5 | ⅩⅧ型胶原mRNA在实验性肝纤维化大鼠肝脏中的表达显示文摘目的了解XⅧ型胶原(collagenXⅧ,CXⅧ)mRNA在实验性肝纤维化中的定量改变。方法以逆行胆管硬化注射加结扎的方法制备大鼠胆管堵塞性肝纤维化模型,以假手术组大鼠为对照组。提取肝脏总RNA,以核酸酶保护分析(RNA酶保护分析)定量测定前胶原α1(XⅧ)mRNA水平,并与α1(Ⅰ)和金属蛋白酶组织抑制因子1(TIMP-1)的mRNA变化相比较。结果与假手术组大鼠相比,胆管堵塞性肝纤维化大鼠肝脏前胶原α1(Ⅰ)及TIMP-1mRNA水平分别升高20倍及4倍;而肝纤维化大鼠肝脏前胶原α1(XⅧ)mRNA水平仅升高到1.8倍。结论肝纤维化时肝脏XⅧ胶原仅轻度升高.这种变化类型可能和XⅧ胶原主要由肝实质细胞表达有关。 | 贾继东 Michael Bauer Garbriele Boigk Martin Ruehl Detlef Schuppan 王宝恩 | 2000 | 中华肝脏病杂志2000，8，5： | 4 |
| 6 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 7 | Impaired Myofibrillar Energetics and Oxidative Injury During Human Atrial Fibrillation显示文摘 | Michael J. Mihm Fushun Yu Cynthia A. Carnes Peter J. Reiser Patrick M. McCarthy David R. Van Wagoner John Anthony Bauer | 2001 | Circulation: Journal of the American Heart Association2001，，2： | 2 |
| 8 | Structure-Function Analysis of Arabidopsis thaliana Histidine Kinase AHK5 Bound to Its Cognate Phosphotransfer Protein AHP1显示文摘多步 phosphorelay (MSP ) 系统在植物和许多优核质定义一条关键信号 transduction 小径。在这个系统,外部刺激首先导致 histidine kinase 的激活,从 kinase (HKRD ) 的接收装置领域由一个 phosphoryl 组的转移列在后面到下游, cytosolic phosphotransfer 蛋白质(HP ) 。为了为这建立特性的决定因素发信号,中继系统,我们解决了植物 HKRD 的第一水晶结构, AHK5RD 在有它的血缘的 HP 之一的建筑群, AHP1。AHP1 经由停靠山脉和一个恐水病的补丁的一张突出的氢契约绑 AHK5RD。这些特征在所有 AHP 蛋白质之中被保存,但是与原核生物的描绘的另外的在结构上和真核细胞的 HP 显著地不同。AHK5RD 绑在 AHP1-3 与的表面电浆子回声实验表演类似, micromolar 亲密关系,与这发信号的建筑群的短暂性质一致。我们结构、功能的数据的关联提供第一卓见在原子水平以及与量的亲密关系数据,在植物管理 MSP 进分子的识别事件。 | Johannes Bauer Kerstin Reiss Manikandan Veerabagu Michael Heunemann Klaus Harter Thilo Stehle | 2013 | Molecular Plant2013，6，3： | 2 |
| 9 | 在美国使用无纺布菌条防治光肩星天牛的前景(英文)显示文摘An invasive long-horned beetle,Anoplophora glabripennis,was first reported in the northeastern and midwestern United States and eastern Canada between 1996 and 2004 and has been given the common name Asian longhorned beetle(ALB).This beetle has also been found in several countries in Europe.ALB is difficult to control because larvae are found within the wood of living trees and the long-lived adults often occur high in tree canopies.This species is native to China and Korea and,because it has been a major tree killer in China,government agencies in the U.S.and Canada are working to eradicate ALB from North America.Our laboratory has been developing a microbial control approach targeting ALB adults,based on the Japanese product Biolisa Kamikiri which is used to control cerambycids in orchards.Entomopathogenic fungi are grown within non-woven fiber bands(= fungal bands)and placed around tree trunks and branches where ALB adults become inoculated when walking across bands.We have conducted bioassays with Beauveria brongniartii,Beauveria bassiana and Metarhizium anisopliae against ALB larvae and adults to identify effective isolates and now focus our efforts on M.anisopliae F52(ARSEF 7711).Caged field trials conducted in China to compare fungal sprays with fungal bands(2000,2001)demonstrated decreased ALB longevity and fitness for both application methods but longer activity of fungi in cages treated with fungal bands compared with sprays.Uncaged field trials(2001,2002)yielded faster ALB adult mortality in fungal-treated plots and decreased fitness.Studies in New York City testing the longevity of activity of fungal bands in the field have documented that bands retain>1×107 conidia·cm-2(the threshold for activity of Biolisa Kamikiri)for over 3 months.In contrast,studies with unformulated conidia sprayed onto tree trunks in New York documented conidial survival of only a few days.Sublethal effects of exposure of adult female ALB to fungal bands have been investigated further in the laboratory.After either newly eclosed or reproductively active females are exposed to fungal bands,few viable larvae are produced before death of the females.When females are exposed to fungal bands and then caged with males,males become infected. | 安.哈耶克 Thomas Dubois Jennifer Lund Michael Smith Leah Bauer | 2007 | 安徽农业大学学报2007，34，2： | 2 |
| 10 | Echocardiographic Speckle-Tracking Based Strain Imaging for Rapid Cardiovascular Phenotyping in Mice显示文摘 | Michael Bauer Susan Cheng Mohit Jain Soeun Ngoy Catherine Theodoropoulos Anna Trujillo Fen-Chiung Lin Ronglih Liao | 2011 | Circulation Research2011，，8： | 1 |
| 11 | Restorative Proctocolectomy for Ulcerative Colitis Complicated by Colorectal Cancer显示文摘 | Stephen R. Gorfine M.D. Michael T. Harris M.D. David S. Bub M.D. Joel J. Bauer M.D | 2004 | Diseases of the Colon & Rectum2004，，8： | 1 |
| 12 | Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen α 1(I) and TIMP-1显示文摘 | Ji-Dong Jia Michael Bauer Jae Jin Cho Martin Ruehl Stefano Milani Gabriele Boigk Ernst Otto Riecken Detlef Schuppan | 2001 | Journal of Hepatology2001，，： | 1 |
| 13 | Application of the CALIOP layer product to evaluate the vertical distribution of aerosols estimated by global models: AeroCom phase I results显示文摘 | Koffi Brigitte Schulz Michael Bréon Francois-Marie Griesfeller Jan Winker David Balkanski Yves Bauer Susanne Berntsen Terje Chin Mian Collins William D. Dentener Frank Diehl Thomas Easter Richard Ghan Steven Ginoux Paul Gong Sunling Horowi | 2012 | EN2012，，1： | 1 |
| 14 | Impact of nosocomial infections on clinical outcome and resource consumption in critically ill patients显示文摘 | Heinz Burgmann J. Michael Hiesmayr Anne Savey Peter Bauer Barbara Metnitz Philipp G. H. Metnitz | 2010 | Intensive Care Medicine2010，，： | 1 |
| 15 | Traditional Chinese medicine research in the post-genomic era: Good practice, priorities, challenges and opportunities显示文摘 | Halil Uzuner Rudolf Bauer Tai-Ping Fan De-an Guo Alberto Dias Hani El-Nezami Thomas Efferth Elizabeth M. Williamson Michael Heinrich Nicola Robinson Peter J. Hylands Bruce M. Hendry Yung-Chi Cheng Qihe Xu | 2012 | Journal of Ethnopharmacology2012，，3： | 1 |
| 16 | Implementation of an evidence-based“ standard operating procedure” and outcome in the septic shock显示文摘 | Andreas kortgen Petra Niederprau michael bauer | 2006 | Crit Care Med2006，34，： | 1 |
| 17 | An Evaluation of the Relative Sensitivities of the Venereal Disease Research Laboratory Test and the Treponema pallidum Particle Agglutination Test Among Patients Diagnosed With Primary Syphilis显示文摘 | LINDA CREEGAN HEIDI M. BAUER MICHAEL C. SAMUEL JEFFREY KLAUSNER SALLY LISKA GAIL BOLAN | 2007 | Sexually Transmitted Diseases2007，，12： | 1 |
| 18 | The impact of portal vein resection on outcomes for hilar cholangiocarcinoma显示文摘 | Mechteld C. de Jong Hugo Marques Bryan M. Clary Todd W. Bauer J. Wallis Marsh Dario Ribero Pietro Majno Ioannis Hatzaras Dustin M. Walters Andrew S. Barbas Raquel Mega Richard D. Schulick Michael A. Choti David A. Geller Eduardo Barroso Gilles Mentha Lore | 2012 | Cancer2012，，19： | 1 |
| 19 | Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension显示文摘 | Berthold Hocher Michael Godes Jan Olivier Joachim Weil Thomas Eschenhagen Torsten Slowinski Hans-H. Neumayer Christian Bauer Martin Paul Yigal M. Pinto | 2002 | Journal of Hypertension2002，，4： | 1 |
| 20 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员