|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of a clinical pathway on treatment outcome in patients with acute pancreatitis显示文摘AIM:To determine the impact of a clinical pathway(CP) on acute pancreatitis(AP) treatment outcome.METHODS:A retrospective analysis of medical records was performed. We compared the results of AP treatment outcome over two time periods in our centre,before(2006-2007) and after(2010-2012) the implementation of a CP. The CP comprised the following indicators of quality:performance of all laboratory tests on admission(including lipids and carbohydrate deficient transferrin),determination of AP aetiology,abdomen ultrasound(US) within the first 24 h after admission,contrast-enhanced computed tomography of the abdomen in all cases of suspected pancreatic necrosis,appropriately selected and sufficiently used antibiotic therapy(if necessary),pain control,adequate hydration,control of haemodynamic parameters and transfer to the Intensive Care Unit(ICU)(if necessary),endoscopic retrograde cholangiopancreatography(ERCP) in biliary AP,surgical treatment(if necessary),and advice on outpatient follow-up after discharge. A comparison of the length of stay with that in other Slovenian hospitals was also performed.RESULTS:There were 139 patients treated in the three-year period after the introduction of a CP,of which 81(58.3%) were male and 58(41.7%) female. The patients' mean age was 59.6 ± 17.3 years. The most common aetiologies were alcoholism and gallstones(38.8% each),followed by unexplained(11.5%),drug-induced,hypertriglyceridemia,post ERCP(2.9% each) and tumours(2.2%). Antibiotic therapy was prescribed in 72(51.8%) patients. Abdominal US was performed in all patients within the first 24 h after admission. Thirty-two(23.0%) patients were treated in the ICU. Four patients died(2.9%). In comparison to 2006-2007,we found an increased number of alcoholic and biliary AP and an associateddecrease in the number of unexplained aetiology cases. The use of antibiotics also significantly decreased after the implementation of a CP(from 70.3% to 51.8%; P = 0.003). There was no statistically significant difference in mortality(1.8% vs 2.9%). The length of stay was significantly shorter when compared to the Slovenian average(P = 0.018).CONCLUSION:The introduction of a CP has improved the treatment of patients with AP,as assessed by all of the observed parameters. | Miroslav Vujasinovic Jana Makuc Bojan Tepes Apolon Marolt Zdenko Kikec Nace Robac | 2015 | World Journal of Gastroenterology2015，21，30： | 13 |
| 2 | Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases显示文摘BACKGROUND: The well-known functions of bile acids(BAs) are the emulsification and absorption of lipophilic xenobiotics. However, the emerging evidences in the past decade showed that BAs act as signaling molecules that not only autoregulate their own metabolism and enterohepatic recirculation, but also as important regulators of integrative metabolism by activating nuclear and membrane-bound G protein-coupled receptors. The present review was to get insight into the role of maintenance of BA homeostasis and BA signaling pathways in development and management of hepatobiliary and intestinal diseases.DATA SOURCES: Detailed and comprehensive search of PubM ed and Scopus databases was carried out for original and review articles.RESULTS: Disturbances in BA homeostasis contribute to the development of several hepatobiliary and intestinal disorders, such as non-alcoholic fatty liver disease, liver cirrhosis, cholesterol gallstone disease, intestinal diseases and both hepatocellular and colorectal carcinoma.CONCLUSION: Further efforts made in order to advance the understanding of sophisticated BA signaling network may be promising in developing novel therapeutic strategies related not only to hepatobiliary and gastrointestinal but also systemic diseases. | Bojan Stanimirov Karmen Stankov Momir Mikov | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，1： | 11 |
| 3 | Pancreatic exocrine insufficiency, diabetes mellitus and serum nutritional markers after acute pancreatitis显示文摘AIM:To investigate impairment and clinical significance of exocrine and endocrine pancreatic function in patients after acute pancreatitis(AP).METHODS:Patients with AP were invited to participate in the study.Severity of AP was determined by the Atlanta classification and definitions revised in2012.Pancreatic exocrine insufficiency(PEI)was diagnosed by the concentration of fecal elastase-1.An additional work-up,including laboratory testing of serum nutritional markers for determination ofmalnutrition,was offered to all patients with low levels of fecal elastase-1 FE.Hemoglobin A1c or oral glucose tolerance tests were also performed in patients without prior diabetes mellitus,and type 3c diabetes mellitus(T3c DM)was diagnosed according to American Diabetes Association criteria.RESULTS:One hundred patients were included in the study:75%(75/100)of patients had one attack of AP and 25%(25/100)had two or more attacks.The most common etiology was alcohol.Mild,moderately severe and severe AP were present in 67,15 and 18%of patients,respectively.The mean time from attack of AP to inclusion in the study was 2.7 years.PEI was diagnosed in 21%(21/100)of patients and T3c DM in14%(14/100)of patients.In all patients with PEI,at least one serologic nutritional marker was below the lower limit of normal.T3c DM was more frequently present in patients with severe AP(P=0.031),but was also present in some patients with mild and moderately severe AP.PEI was present in all degrees of severity of AP.There were no statistically significantly differences according to gender,etiology and number of AP attacks.CONCLUSION:As exocrine and endocrine pancreatic insufficiency can develop after AP,routine follow-up of patients is necessary,for which serum nutritional panel measurements can be useful. | Miroslav Vujasinovic Bojan Tepes Jana Makuc Sasa Rudolf Jelka Zaletel Tjasa Vidmar Maja Seruga Bostjan Birsa | 2014 | World Journal of Gastroenterology2014，20，48： | 10 |
| 4 | 新型电磁式电压互感器显示文摘介绍了一种新型电磁式电压互感器,阐述了电磁式和电容式电压互感器技术特性的区别。 | 刘玉凤 Boris Bojanic | 2007 | 变压器2007，44，1： | 9 |
| 5 | Modalities of testing Helicobacter pylori in patients with nonmalignant bile duct diseases显示文摘AIM: This paper describes the procedure of detection ofHelicobacter pylori ( H. pylori) in bile specimens in patientssuffering from benign diseases of biliary ducts (lithiasiswith/without nonspecific cholangitis).METHODS: The group of 72 patients entering the studyconsisted of 32 male and 40 female (45 % and 55 %,respectively). Bile was obtained during ERCP in 68 patients,and during cholecystectomy in 4 patients. A fast urease test(FUT) to determine the existence of H. pylori in gastricmucosa was carried out for all the patients during theendoscopic examination. The existence of genetic materialof H. pylori was determined by detection of ure A gene bythe method of nested PCR. The results of this reaction wereshown by electrophoresis on l0 g@ L-1 agarose gel in a bandof 256 bp.RESULTS: The majority of the patients included in our studyhad biliary lithiasis without signs of cholangitis (48 patients,67 %), whereas other patients were complicated bycholangitis (17 patients, 24 %). Seven patients (9 %) hadnormal ERCP, forming thus the control group. In the groupof patients with lithiasis 26 patients (54.2 %) had positivePCR of H. pylori in bile and among the patients withassociated cholangitis positive PCR was detected in 9patients (52.9 % ). Among the seven patients with nornalERCP only one (14 %) had positive PCR of H. pylori. Ahigh percentage of H. pylori infection of gastric mucosawas observed (57 patients, 79 % ) : It was also observed thatits slightly higher positivity was in the patients with distinctbile pathology: 81% FUT positive patients in the group withcholedocholithiasis alone and 76 % in the group withcholedocholithiasis associated with cholangitis. Seventy-onepercent of the patients with regular findings had positive FUT.CONCLUSION: The prevalence of H. pylori infection both inbile and in gastric mucosa in patients with benign diseasesof biliary ducts does not show a statistically significantdifference in relation to the prevalence of the same with thepatients with normal ERCP. The existence of H. pyloriinfection possibly does not play a role in pathogenesis ofbenign biliary diseases. | Milutin Bulajic Bojan Stimec Miroslav Milicevic Matthias Loehr Petra Mueller Ivan Boricic Nada Kovacevic Mirko Bulajic | 2002 | World Journal of Gastroenterology2002，8，2： | 6 |
| 6 | Modified Helicobacter test using a new test meal and a 13C-urea breath test in Helicobacter pylori positive and negative dyspepsia patients on proton pump inhibitors显示文摘AIM To determine the sensitivity and specificity of the ^(13)C-urea breath test(UBT) in patients taking proton pump inhibitors(PPIs), using a new test meal Refex. METHODS One hundred and fourteen consecutive patients with dyspepsia, 53 Helicobacter pylori(H. pylori) positive, 49 H. pylori negative, were included in the study. The patients were then given esomeprazole 40 mg for 29 consecutive days, and the ^(13)C-UBT with the new test meal was performed the next morning. RESULTS The sensitivity of the ^(13)C-UBT with a cut off 2.5‰ was92.45%(95%CI: 81.79%-97.91%) by per-protocol(PP) analysis and 78.13 %(95%CI: 66.03%-87.49%) by intention-to-treat(ITT) analysis. The specificity of the ^(13)C-UBT test was 96.00 % in the ITT population(95%CI: 86.29%-99.51%) and 97.96% in the PP population(95%CI: 89.15%-99.95%).CONCLUSION The new test meal based ^(13)C-UBT is highly accurate in patients on PPIs and can be used in those unable to stop their PPI treatment. | Bojan Tepes Peter Malfertheiner Joachim Labenz Sitke Aygen | 2017 | World Journal of Gastroenterology2017，23，32： | 5 |
| 7 | EUS diagnosis of ectopic opening of the common bile duct in the duodenal bulb: A case report显示文摘Among the various congenital anomalies of the biliary system,an ectopic opening of the common bile duct (CBD) in the duodenal bulb is extremely rare. ERCP is essential for diagnosing the anomaly. A 55-year-old male was admitted to hospital for severe right upper quadrant abdominal pain,followed by fever, chills, elevated body temperature and mild icterus. The diagnosis of ectopic opening of CBD in the duodenal bulb was established on endoscopic ultraso-nography (EUS),which clearly demonstrated dilated CBD, with multiple stones and air in the lumen, draining into the bulb. A normal pancreatic duct, which did not drain into the bulb, was also observed. This finding was confirmed on ERCP and surgery.As far as we know, this is the first case of this anomaly diagnosed by EUS. Ectopic opening of the CBD in the duodenal bulb is not an incidental finding, but a pathologic condition which can be associated with clinical entities such as recurrent or intractable duodenal ulcer, recurrent biliary pain,choledocholithiasis or acute cholangitis. Endoscopic ultrasonography features allow preoperative diagnosis of this anomaly and can replace ERCP as a first diagnostic tool in such clinical circumstances. Embryology of the anomalies of the extrahepatic biliary tree has been also reviewed. | Miodrag Krstic Bojan Stimec Radmilo Krstic Milenko Ugljesic Srbislav Knezevic Ivan Jovanovic | 2005 | World Journal of Gastroenterology2005，11，32： | 4 |
| 8 | 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions显示文摘 | Glenn N. Levine Eric R. Bates James C. Blankenship Steven R. Bailey John A. Bittl Bojan Cercek Charles E. Chambers Stephen G. Ellis Robert A. Guyton Steven M. Hollenberg Umesh N. Khot Richard A. Lange Laura Mauri Roxana Mehran Issam D. Moussa Debabrata Mu | 2011 | Circulation2011，，23： | 3 |
| 9 | An Application of the Shark Skin Denticle Geometry for Windbreak Fence Design and Fabrication显示文摘在开、城市的区域的防风林篱笆能被用来有效地减少风速度。在这份报纸,我们检验防风林篱笆的几何形状怎么能最佳地减轻风速度。我们基于鲨鱼皮肤小齿几何学的一个仿生的参量的模型为防风林篱笆设计建议一条途径,它改进风速度的减小在附近并且在防风林篱笆后面。生产模型被用来在篱笆面板的参数由变化估计改进几何形状,由鲨鱼皮肤小齿启发了。篱笆表面用鲨鱼皮肤启发了,这比扁平、弄皱的表面更好执行的分析显示的计算液体动力学(CFD ) 的结果。考虑表面的复杂几何学由鲨鱼皮肤小齿启发了,我们用多孔塑料泡沫(EPS ) 建议一个制造过程材料,与一个热电线的工具使用一只工业机器人手臂创造。为鲨鱼皮肤小齿面板创造 EPS 模子允许在最后的设计要过去常的更富有的变化材料,带两个到更高的效率和一个更吸引人的图案。 | Ivana Bajsanski Vesna Stojakovic Bojan Tepavcevic Marko Jovanovic Dejan Mitov | 2017 | Journal of Bionic Engineering2017，14，3： | 3 |
| 10 | Current practice variations in the management of anterior cruciate ligament injuries in Croatia显示文摘AIM: To investigate current preferences and opinions on the diagnosis, treatment and rehabilitation of patients with anterior cruciate ligament(ACL) injury in Croatia. METHODS: The survey was conducted using a questionnaire which was sent by e-mail to all 189 members of the Croatian Orthopaedic and Traumatology Association. Only respondents who had performed at least one ACL reconstruction during 2011 were asked to fill out the questionnaire. RESULTS: Thirty nine surgeons responded to the survey. Nearly all participants(95%) used semitendinosus/gracilis tendon autograft for reconstruction and only 5% used bone-patellar tendon-bone autograft. No other graft type had been used. The accessory anteromedial portal was preferred over the transtibial approach(67% vs 33%). Suspensory fixation was the most common graft fixation method(62%) for the femoral side, followed by the cross-pin(33%) and bioabsorbable interference screw(5%). Almost all respondents(97%) used a bioabsorbable interference screw for tibial side graft fixation. CONCLUSION: The results show that ACL reconstruction surgery in Croatia is in step with the recommendations from latest world literature. | Alan Mahnik Silvija Mahnik Damjan Dimnjakovic Stjepan Curic Tomislav Smoljanovic Ivan Bojanic | 2013 | World Journal of Orthopedics2013，4，4： | 3 |
| 11 | GAJA:3D CAD methodology for developing a parametric system for the automatic(re)modeling of the cutting components of compound washer dies显示文摘For the designing of cutting-dies is a complex and experience-based process,it is poorly supported by conventional 3D CAD software.Thus,the majority of design activities,including the(re)modeling of those cutting die-components that are directly responsible for performing shaping operations on a sheet-metal stamping part,traditionally still need to be carried-out repetitively,separately,and manually by the designer.To eliminate some of these drawbacks and upgrade the capabilities of conventional 3D CAD software,this paper proposes a new methodology for the development of a parametric system capable of automatically performing a(re)modeling process of compound washer dies' cutting-components.The presented methodology integrates CATIA V5 built-in modules,including Part Design,Assembly Design and Knowledge Advisor,publication mechanism,and compound cutting die-design knowledge.The system developed by this methodology represents an 'intelligent' assembly template composed of two modules GAJA1 and GAJA2,respectively.GAJA1 is responsible for the direct input of the die-design problem regarding the shape,dimensions and material of the stamping part,its extraction in the form of geometric features,and the transferring of relevant design parameters and features to the module GAJA2.GAJA2 interprets the current values for the input parameters and automatically performs the modeling process of cutting die-components,using die-design knowledge and the company's internal design and manufacturing standards.Experimental results show that this system significantly shortens the modeling-time for cutting the die-components,improves the modeling-quality,and enables the training of inexperienced designers. | David POTONIK Bojan DOLAK Miran ULBIN | 2013 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2013，14，5： | 2 |
| 12 | Toxicity assessment of polyethylene microplastics in combination with a mix of emerging pollutants on Physalaemus cuvieri tadpoles显示文摘Studies in recent years have shown that aquatic pollution by microplastics(MPs)can be considered to pose additional stress to amphibian populations.However,our knowledge of how MPs affect amphibians is very rudimentary,and even more limited is our understanding of their effects in combination with other emerging pollutants.Thus,we aimed to evaluate the possible toxicity of polyethylene MPs(PE-MPs)(alone or in combination with a mix of pollutants)on the health of Physalaemus cuvieri tadpoles.After 30 days of exposure,multiple biomarkers were measured,including morphological,biometric,and developmental indices,behavioral parameters,mutagenicity,cytotoxicity,antioxidant and cholinesterase responses,as well as the uptake and accumulation of PE-MPs in animals.Based on the results,there was no significant change in any of the parameters measured in tadpoles exposed to treatments,but induced stress was observed in tadpoles exposed to PE-MPs combined with themixture of pollutants,reflecting significant changes in physiological and biochemical responses.Through principal component analysis(PCA)and integrated biomarker response(IBR)assessment,effects induced by pollutants in each test group were distinguished,confirming that the exposure of P.cuvieri tadpoles to the PE-MPs in combination with a mix of emerging pollutants induces an enhanced stress response,although the uptake and accumulation of PE-MPs in these animalswas reduced.Thus,our study provides newinsight into the danger to amphibians of MPs coexisting with other pollutants in aquatic environments. | Amanda Pereira da Costa Araújo Thiarlen Marinho da Luz Mohamed Ahmed Ibrahim Ahmed Mir Mohammad Ali Md.Mostafizur Rahman Bojan Nataraj Daniela de Melo e Silva DamiàBarceló Guilherme Malafaia | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 13 | 新型高压油浸组合互感器的研制与运用显示文摘文章阐述了几种组合互感器的特点,介绍了组合互感器的误差特性。较详细地介绍了由1台倒立式电流互感器和1台具有开放式铁心的电磁式电压互感器组合而成的新型高压组合互感器(VAU型)的基本特征及主要性能,测量结果表明,VAU型组合互感器误差特性好,瓷套管上电场强度沿高度分布均匀,体积小,占空间少,制造成本低,而且还可防铁磁谐振,现在的最高设备电压已达550kV。 | 刘玉凤 Boris Bojanic | 2008 | 电力设备2008，9，3： | 2 |
| 14 | Targeting the Wnt Signaling Pathway in Liver Fibrosis for Drug Options:An Update显示文摘morbidity and mortality for healthcare systems worldwide.It imparts an enormous economic burden to societies,making continuous research and informational updates about its pathogenesis and treatment crucial.This review′s focus is on the current knowledge about the Wnt signaling path-way,serving as an important pathway in liver fibrosis development and activation of hepatic stellate cells(HSCs).Two types of Wnt pathways are distinguished,namely the ß-catenin-dependent canonical and non-canonical Ca^(2+) or planar cell polarity(PCP)-dependent pathway.The dynamic balance of physiologically healthy liver and hepatocytes is disturbed by repeated liver injuries.Activation of theß-catenin Wnt pathway prevents the regeneration of hepatocytes by the replacement of extracellular matrix(ECM),leading to the appearance of scar tissue and the formation of regenerated nodular hepatocytes,lacking the original function of healthy hepatocytes.Therefore,liver function is reduced due to the severely advanced disease.Selective inhibition ofß-catenin inhibits inflammatory processes(since chemokines and pro-inflammatory cytokines are produced during Wnt activation),reduces growth of activated HSCs and reduces collagen synthesis and angiogenesis,thereby reducing the progression of liver fibrosis in vivo.While the canonical Wnt pathway is usually inactive in a physiologically healthy liver,it shows activity during cell regeneration or renewal and in certain pathophysiological conditions,such as liver diseases and cancer.Targeted blocking of some of the basic components of the Wnt path-way is a therapeutic approach.These include the frizzled transmembrane receptor(Fz)receptors using the secreted frizzled-related protein family(sFRP),Fz-coreceptors low-density LRP 5/6 through dickkopf-related protein 1(DKK1)or niclosamide,glycogen kinase-3 beta(GSK-3β)using SB-216763,cyclic-AMP response element-binding protein(CBP)using PRI-724 and ICG-001,the lymphoid enhancer binding factor(LEF)/T cell-specific transcription factor(TCF)system as well as Wnt inhibitory factor 1(WIF1)and miR-17-5p using pinostilbene hydrate(PSH).Significant progress has been made in inhibiting Wnt and thus stopping the progression of liver fibrosis by diminishing key components for its action.Comprehending the role of the Wnt signaling pathway in liver fibrosis may lead to discovery of novel targets in liver fibrosis therapeutic strategies’development. | Kristina Duspara Kristina Bojanic Josipa Ivanusic Pejic Lucija Kuna Tea Omanovic Kolaric Vjera Nincevic Robert Smolic Aleksandar Vcev Marija Glasnovic Ines Bilic Curcic Martina Smolic | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 15 | Peripheral blood hematopoietic stem cell collection显示文摘 | Bojanic I Mazic S Cepulic BG | 2009 | Lijec Vjesn2009，131，1112： | 1 |
| 16 | Parameters affecting the growth and hydrogen production of the green alga Chlamydomonas reinhardtil显示文摘 | Bojan T Fessehaye W Z Geoffrey C M | 2011 | Intemafional Journal of Hydrogen Energy2011，36，13： | 1 |
| 17 | Six-year outcomes of anterior lumbar interbody arthrodesis with use of interbody fusion cages and recombinant human bone morphogenetic protein-2显示文摘 | Smoljanovic T Siric F Bojanic I | | 0，，05： | 1 |
| 18 | Dispersive kinetic model for the non-isothermal reduction of nickel oxide by hydrogen显示文摘 | Borivoj Adna?evi? Bojan Jankovi? | 2008 | Physica B: Physics of Condensed Matter2008，，21： | 1 |
| 19 | Modelling soil behaviour in uniaxial strain conditions by neural networks显示文摘 | GORAN Turk JANKO Logar Bojan Majes | 2001 | Advances in Engineering Software2001，32，1011： | 1 |
| 20 | A class of L^1-convergence显示文摘 | Bojanic R Stanojevic C V | 1982 | Traps Amer Math Soc1982，269，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员