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| 1 | Nanosecond photoelectric effects in all-oxide p-n junction of La_(0.9)Sr_(0.1)MnO_(3)/SrNb_(0.01)Ti_(0.99)O_(3)显示文摘Nanosecond (ns) photoelectric effects have been observed in all-oxide p-n junctions of La0.9Sr0.1MnO3/SrNb0.01Ti0.99O3 for the first time. The rise time was about 23 ns and the full width at half maximum was about 125 ns for the open-circuit photovoltaic pulse when the La0.9Sr0.1MnO3 thin film in the p-n junction was irradiated by a laser of ~20 ns pulse duration and 308 nm wavelength. The photovoltaic sensitivity was 80 mV/mJ for a 308 nm laser pulse. | HUANG Yanhong L(U) Huibin HE Meng ZHAO Kun CHEN Zhenghao CHENG Bolin ZHOU Yueliang JIN Kuijuan DAI Shouyu YANG Guozhen | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，3： | 4 |
| 2 | LPI radar signal detection based on the combination of FFT and segmented autocorrelation plus PAHT显示文摘This paper proposes a desirable method to detect different kinds of low probability of intercept(LPI) radar signals, targeted at the main intra-pulse modulation method of LPI radar signals including the signals of linear frequency modulation, phase code,and frequency code. Firstly, it improves the coherent integration of LPI radar signals by adding the periodicity of the ambiguity function. Then, it develops a frequency domain detection method based on fast Fourier transform(FFT) and segmented autocorrelation function to detect signals without features of linear frequency modulation by virtue of the distribution characteristics of noise signals in the frequency domain. Finally, this paper gives a verification of the performance of the method for different signal-to-noise ratios by conducting simulation experiments, and compares the method with existing ones. Additionally, this method is characterized by the straightforward calculation and high real-time performance, which is conducive to better detecting all kinds of LPI radar signals. | Chengzhi Yang Zhiwei Xiong Yang Guo Bolin Zhang | 2017 | Journal of Systems Engineering and Electronics2017，28，5： | 3 |
| 3 | Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and the corresponding mechanism显示文摘microRNAs (miRNAs ) 在人的 tumorigenesis,肿瘤前进,和转移起了一个关键作用。在一方面, miRNAs 异常地在人的癌症的许多类型被表示;在另一方面, miRNAs 能作为指向许多癌症相关的基因的肿瘤 suppressors 或 oncogenes 工作。这研究试图在前列腺癌症房间线 Du145 在增长,移植,和侵略的生物行为和机制上调查 miRNA-200c (miR-200c ) 的效果。在这研究, Du145 房间是有 miR-200c 的 transfected 模仿或由使用 X-tremeGENE siRNA transfection 试剂的否定控制 miR-NC。miR-200c 的相对表示被 RT-PCR 测量。Du145 房间的增长,迁居,和侵略能力被 CCK8 试金,迁居试金和侵略试金分别地检测。ZEB1, E-cadherin,和 vimentin 的表情被西方的污点观察。结果证明 DU145 房间与使不朽的正常前列腺相比展出了 miR-200c 的高表情上皮的房间 RWPE-1。Du145 房间当时是有 miR-200c 的 transfected 模仿并且比有否定控制的那些 transfected 的增长,移植,和侵略的显示的更低的能力。ZEB1 和 vimentin 的蛋白质层次在 Du145 房间在低程度被表示,它是有 miR-200c 的 transfected 模仿;由对比, E-cadherin 高度被表示。因此, miR-200c 能显著地禁止前列腺癌症房间线 Du145 的增长;同样, miR-200c 能由上皮间充质的转变禁止移植和侵略。 | Runlin Shi Haibing Xiao Tao Yang Lei Chang Yuanfeng Tian Bolin Wu Hua Xu | 2014 | Frontiers of Medicine2014，8，4： | 2 |
| 4 | Influence of uniaxial tensile pre-strain on forming limit curve by using biaxial tensile test显示文摘This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions of cruciform specimen was optimized through applying finite element method for increasing the strain at specimen center.After that,with the recommended specimen size,the cruciform specimen was tested under various stroke ratios to experimentally characterize the limit strains under different pre-strain levels.Subsequently,the biaxial tensile tests were simulated by Abaqus to obtain the limit strains and validate the material models.It can be observed in both experiments and simulations that the pre-strained uniaxial tension followed by plane tension or equi-biaxial tension can improve the formability of sheet metals.Besides,the strain path change affects the trend of first derivative of strain rate difference between neighboring points with respect to time.An early increase occurred and then fell back to the stable value,the steady evolution continued until to a new increase reaching the critical value.The M–K prediction approach was simulated to verify the influence of pre-strain on FLC.It can be found that the early increase peaks of the major strain incremental ratio rose with the amplitude of pre-strain.Finally,the phenomenon of pseudolocalization caused by the strain path change was explained through evolution of stress state inside the groove. | Wennan YUAN Min WAN Xiangdong WU Bolin MA Xu LU Bing YANG | 2020 | Chinese Journal of Aeronautics2020，33，8： | 2 |
| 5 | A Cost-Effective D-A-D Type Hole-Transport Material Enabling 20% Efficiency Inverted Perovskite Solar Celis显示文摘High-performance,cost-effective hole-transport materials(HTMs)are greatly desired for the commercialization of perovskite solar cells(PVSCs).Herein,two new HTMs,TPA-FO and TPA-PDO,are devised and synthesized,which have a donor-acceptor-donor(D-A-D)type molecule design featuring carbonyl group-functionalized arenes as the acceptor(A)units.The carbonyl group at the central core of HTMs can not only tune frontier molecular orbital(FMO)energy levels and surface wettability,but also can enable efficient surface passivation effects,resulting in reduced recombination loss.When employed as HTMs in inverted PVSCs without using dopant,TPA-FO with one carbonyl group yields a high power conversion efficiency(PCE)of 20.24%,which is among the highest values reported in the inverted PVSCs with dopant-free HTMs.More importantly,the facile one-step synthetic process enables a low cost of 30 USD g^(-1) for TPA-FO,much cheaper than the most studied HTMs used for high-efficiency dopant-free PVSCs.These results demonstrate the potential of D-A-D type molecules with carbonyl group-functionalized arene core in developing the low-cost dopant-free HTMs toward highly efficient PVSCs. | Jiachen Huang Jie Yang Huiliang Sun Kui Feng Qiaogan Liao Bolin Li He Yan Xugang Guo | 2021 | Chinese Journal of Chemistry2021，39，6： | 2 |
| 6 | SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron strain(as Rnown as B.1.1.529)was identified in Botswana and South Africa in early November 2021 and was later defined as a new variant of concern(VOC)by the World Health Organization on November 26,2021.1,2 To date,the con firmed cases of Omicro n have been reported in more than 38 countries,and the number of cases appears to be rapidly in creasing.SARS-CoV-2 Omicron could give rise to the fourth wave of the COVID-19 epidemic spreading around the world,following the D614G,Beta/Gamma,and Delta VOCs. | Xiantao Zhang Shijian Wu Bolin Wu Qirui Yang Achun Chen Yuzhuang Li Yiwen Zhang Ting Pan Hui Zhang Xin He | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 7 | Several miRNAs derived from serum extracellular vesicles are potential biomarkers for early diagnosis and progression of Parkinson’s disease显示文摘Background:Blood-based test for predicting disease progression and early diagnosis of Parkinson’s disease(PD)is an unmet need in the clinic.The profiles of microRNAs(miRNAs)are regarded as potential diagnostic biomarkers for human diseases,whereas miRNAs in the periphery are susceptible to the influence of various components.MiRNAs enriched in serum extracellular vesicles(EVs)have demonstrated disease-specific advantages in diagnosis due to their high abundance,stability and resistance to degradation.This study was aimed to screen differentially expressed EV-derived miRNAs between healthy controls and PD patients to aid in diagnosis of PD.Methods:A total of 31 healthy controls and 72 patients with a diagnosis of PD at different Hoehn and Yahr stages in Tangdu Hospital were included.In total,185 differentially expressed miRNAs were obtained through RNA sequencing of serum EVs as well as edgeR and t-test analyses.Subsequently,the weighted gene co-expression network analysis(WGCNA)was utilized to identify the commonly expressed miRNAs in all stages of PD by constructing connections between modules,and specifically expressed miRNAs in each stage of PD by functional enrichment analysis.After aligning these miRNAs with PD-related miRNAs in Human miRNA Disease Database,the screened miRNAs were further validated by receiver operating characteristic(ROC)curves and quantitative real-time polymerase chain reaction(qRT-PCR)using peripheral blood EVs from 40 more participants.Results:WGCNA showed that 4 miRNAs were commonly associated with all stages of PD and 13 miRNAs were specifically associated with different stages of PD.Of the 17 obtained miRNAs,7 were validated by ROC curve analysis and 7 were verified in 40 more participants by qRT-PCR.Six miRNAs were verified by both methods,which included 2 miRNAs that were commonly expressed in all stages of PD and 4 miRNAs that were specifically expressed in different stages of PD.Conclusions:The 6 serum EV-derived miRNAs,hsa-miR-374a-5p,hsa-miR-374b-5p,hsa-miR-199a-3p,hsa-miR-28-5p,hsa-miR-22-5p and hsa-miR-151a-5p,may potentially be used as biomarkers for PD progression and for early diagnosis of PD in populations. | Shulei He Lu Huang Ci Shao Tiejian Nie Li Xia Bozhou Cui Fangfang Lu Lin Zhu Bolin Chen Qian Yang | 2021 | Translational Neurodegeneration2021，10，3： | 1 |
| 8 | Dislocation reconfiguration during creep deformation of an Al-Cu-Li alloy via electropulsing显示文摘Creep mechanism was well-known to be mainly dominated by the dislocation sliding and climbing during creep deformation. Here we study the creep deformation of an Al-Cu-Li alloy with the assistance of electropulsing and subsequent microstructural observations. We find that creep strain increased drastically under electropulsing and was almost twelve times as much as that of the non-pulsed sample. Microstructural observations confirmed that dislocation reconfiguration happens via electropulsing, namely helical dislocations being opened rapidly. This opened dislocation structure can possess a much higher mobility than the initial helical dislocation, which mostly responsible for the greatly increased creep strain. Our results revealed a new mechanism accountable for the distinctly electroplastic creep deformation. | Chang Zhou Lihua Zhan He Li Chunhui Liu Yongqian Xu Bolin Ma Youliang Yang Minghui Huang | 2022 | Journal of Materials Science & Technology2022，，35： | 1 |
| 9 | HER2/PI-3K/Akt activation leads to a multidmg resistance in human breast adenocarcinoma cells显示文摘 | Christiane K Yang L Bolin L | 2003 | Oncogene2003，22，： | 1 |
| 10 | Primary malignant tumours and malignant transformation of cysts in the retrorectal space:MRI diagnosis and treatment outcomes显示文摘Background:There are no clear guidelines for the diagnosis and treatment of malignant retrorectal tumours.The purpose of this study was to increase preoperative diagnostic knowledge and to describe the outcomes of treatment for these patients.Methods:This retrospective study was conducted on patients who underwent complete retrorectal tumour resection between May 2006 and July 2018,and had confirmed post-operative pathology reports.Demographic and clinical data(including imaging,perioperative,pathological,and prognostic data)were collected and analysed.Results:Malignant lesions were identified in 15(9[60%],female)patients.The median age of the patients was 59 years(range,34–72 years).Primary malignant tumours were identified in seven patients with solid tumours,in which gastrointestinal stromal tumours accounted for 71.4%(five of seven)and the remainder were chordoma or mucinous adenocarcinoma.Malignant transformation of cysts occurred in another eight patients with heterogeneous tumours,while histopathological features were present in 75%(six of eight)of patients with mucinous adenocarcinoma,and the remainder were squamouscell carcinoma or neuroendocrine tumour(Grade 2).The malignant characteristics of the solid portions observed using magnetic resonance imaging(MRI)were as follows:the cyst wall of the tumour was irregularly thickened;the surface was convex or lobed;the solid tumour had no capsule,or the capsule was destroyed;and the surface had a gyrus-like morphology.At a median follow-up time of 52 months(range,13–100 months),the overall recurrence-free survival rate was 40.0%and the survival rate was 46.7%.Conclusion:Some MRI features can be used to distinguish malignant retrorectal tumours from benign retrorectal tumours.The survival rate of patients with malignant retrorectal tumours is poor. | Jing Gong Yumeng Xu Yan Zhang Lichao Qiao Haixia Xu Ping Zhu Bolin Yang | 2022 | Gastroenterology Report2022，10，1： | 1 |
| 11 | Management Strategies for Ecocities of Sustainable Development显示文摘Building ecocities becomes an objective requirement for sustainable development. This article discusses the relationship between sustainable development and sustainable urban development. On the basis of discussing the sigificance of sustainable urban development and that of an eco-city from different perspectives, it suggests several management strategies for developing an eco-city, a desirable sustainable urban model. | Zhao Linan, Yang Bolin, Xu MingzhiManagement School, Xi’an Jiaotong University, Xi’an 710049, China Shandong Institute of Architecture and Engineering, ]inan 250014, China | 2004 | Chinese Journal of Population,Resources and Environment2004，2，1： | 0 |
| 12 | Self-assembled donor-acceptor hole contacts for inverted perovskite solar cells with an efficiency approaching 22%: The impact of anchoring groups显示文摘Self-assembled molecules(SAMs) have shown great potential in replacing bulk charge selective contact layers in high-performance perovskite solar cells(PSCs) due to their low material consumption and simple processing. Herein, we design and synthesize a series of donor-acceptor(D-A) type SAMs(MPA-BTCA, MPA-BT-BA, and MPA-BT-RA, where MPA is 4-methoxy-N-(4-methoxyphenyl)-N-phenylaniline;BT is benzo[c][1,2,5]-thiadiazole;CA is 2-cyanoacrylic acid, BA is benzoic acid, RA is rhodanine-3-propionic acid) with distinct anchoring groups, which show dramatically different properties. MPA-BTCA with CA anchoring groups exhibited stronger dipole moments and formed a homogeneous monolayer on the indium tin oxide(ITO) surface by adopting an upstanding self-assembling mode. However, the MPA-BT-RA molecules tend to aggregate severely in solid state due to the sp~3 hybridization of the carbon atom on the RA group, which is not favorable for achieving a long-range ordered self-assembled layer.Consequently, benefiting from high dipole moment, as well as dense and uniform self-assembled film,the device based on MPA-BT-CA yielded a remarkable power conversion efficiency(PCE) of 21.81%.Encouragingly, an impressive PCE approaching 20% can still be obtained for the MPA-BT-CA-based PSCs as the device area is increased to 0.80 cm^(2). Our work sheds light on the design principles for developing hole selecting SAMs, which will pave a way for realizing highly efficient, flexible, and large-area PSCs. | Qiaogan Liao Yang Wang Zilong Zhang Kun Yang Yongqiang Shi Kui Feng Bolin Li Jiachen Huang Peng Gao Xugang Guo | 2022 | Journal of Energy Chemistry2022，31，5： | 0 |
| 13 | Efficient and Soluble Expression of N Protein of Peste Des Petits Ruminants Virus and Development of Indirect ELISA显示文摘[Objective] The paper was to get effective soluble N protein to establish indirect ELISA method for Peste des petits ruminants( PPR). [Method]Soluble N protein with high expression was obtained from Escherichia coli expression system through codon optimization and optimization of expression conditions,and indirect ELISA detection method based on N protein was further established. [Result]The assay had no cross reaction with other sheep pathogens. The intraand inter-batch variation coefficients were less than 9%,indicating the method had good repeatability. Furthermore,totally 480 clinical serum samples were detected by the assay,and the agreement rate with commercial ELISA kit( IDVET) was 98. 33%. [Conclusion]The study laid a foundation for further development of mature PPRV antibody detection kits. | Sun Yu Zhao Bolin Wang Xiaoying Dong Hao Zhai Xinyan Qu Ping Hu Dongmei Yang Tianyi Shi Hui Song Xiaohui | 2017 | Animal Husbandry and Feed Science2017，9，1： | 0 |
| 14 | Theoretical analysis of persistent fault attack显示文摘Dear editor,Persistent fault attack is a new type of fault attack that was proposed in CHES 2018[1].Its success relies on the so-called persistent fault which persists from one encryption to another and disappears when the target device reboots.The practical attack is illustrated in[1]at both software and hardware levels,however,the corresponding persistent fault analysis(PFA)has not been thoroughly investigated.The contribution of this study focuses on the theoretical analysis of the persistent fault attack.This study also proposes a new and generic method which could put the analysis of previous cases into one nutshell. | Fan ZHANG Guorui XU Bolin YANG Ziyuan LIANG Kui REN | 2020 | Science China(Information Sciences)2020，63，3： | 0 |
| 15 | The Streptococcus agalactiae Ribose Binding Protein B (RbsB) Mediates Quorum Sensing Signal Uptake via Interaction with Autoinducer-2 Signals显示文摘Understanding aquatic pathogen in sediments or aquacultural water is crucial to protect public health from soilborne and waterborne diseases.Quorum sensing(QS)was increasingly reported in biological wastewater treatment processes because of their inherent roles in biofilm development,bacterial aggregation and so on.The widely QS signals was Antoinducer-2(AI-2),primarily involved to allow the possibility of interspecies communication.However,the cellular components that mediate the response of Streptococcus agalactiae to AI-2 have not been fully characterized.Analysis of the complete genome sequence of S.agalactiae indi-cated that its RbsB protein has similarity to Escherichia coli LsrB and Aggregatibacter actinomycetemcomitans RbsB proteins that bind AI-2.We hypothesized that RbsB protein mediates quorum sensing signal uptake via interaction with AI-2.To evaluate the regulatory effect of RbsB on QS system,the recombinant plasmid pGEX-6p-1-RbsB was constructed and RbsB protein was purified with GST-tag.To further elucidate the role of RbsB protein binding to DPD(AI-2 precursor dihydroxypentanedione),the systemati-cally throughput circular dichroism(CD)spectroscopy,isothermal titration calorimetry200(ITC200)and molecular docking methods were employed.The high expression of soluble RbsB protein with molecular weight of 33 kDa was obtained.The thermodynamics results(ΔH<0,ΔS<0,ΔG<0)with ITC determination indicated that the binding process between DPD and RbsB was exothermic and spontaneous,with hydrogen bonds and van der Waals forces as the main binding forces.Obviously,DPD can be more easily combined with RbsB in a dose-dependent manner,suggesting that RbsB was changed in the microenvironment of DPD when the DPD concentration was between 0.8-1.0mmolL−1 and reaching the maximum binding amount.According to molecular docking,3 hydrophobic residues involved in DPD and RbsB protein stable binding were be found,and also hydrogen bonding plays a key role in the formation of the new complex.RbsB efficiently inhibited V.harveyi bioluminescence induced by both S.agalactiae AI-2 and V.harveyi AI-2 in a dose-dependent manner.However,our results suggest that RbsB may play a role in the response of S.agalactiace to AI-2. | FAN Bolin PAN Lixia WANG Zhongliang WANGKAHART Eakapol HUANG Yuchong YANG Dengfeng JIAN Jichang HUANG Yu WANG Bei | 2021 | Journal of Ocean University of China2021，20，5： | 0 |
| 16 | USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID显示文摘Activation-induced cytidine deaminase(AID)initiates class-switch recombination and somatic hypermutation(SHM)in antibody genes.Protein expression and activity are tightly controlled by various mechanisms.However,it remains unknown whether a signal from the extracellular environment directly affects the AID activity in the nucleus where it works.Here,we demonstrated that a deubiquitinase USP10,which specifically stabilizes nuclear AID protein,can translocate into the nucleus after AKT-mediated phosphorylation at its T674 within the NLS domain.Interestingly,the signals from BCR and TLR1/2 synergistically promoted this phosphorylation.The deficiency of USP10 in B cells significantly decreased AID protein levels,subsequently reducing neutralizing antibody production after immunization with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)or human immunodeficiency virus type 1(HIV-1)nanoparticle vaccines.Collectively,we demonstrated that USP10 functions as an integrator for both BCR and TLR signals and directly regulates nuclear AID activity.Its manipulation could be used for the development of vaccines and adjuvants. | Yuewen Luo Xiantao Zhang Ran Chen Rong Li Yang Liu Junsong Zhang Qin liu Meijun Si Jun Liu Bolin Wu Xuemei Wang Shijian Wu Yiwen Zhang Xu Zhang Deyin Guo Xin He Ting Pan Hui Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 17 | Efficient and Soluble Expression of α Protein of Clostridium perfringens and Preparation of Genetic Engineering Subunit Vaccine显示文摘[Objective] The paper was to develop genetic engineering vaccine that can express α exotoxin antigen protein efficiently without destroying its immunogenicity for preventing and controlling the diseases caused by Clostridium perfringens. [Method] Efficiently expressed soluble recombinant α protein was obtained from Escherichia coli expression system by optimizing codon,removing signal peptide,selecting sequences with better hydrophilicity and antigenicity,and optimizing expression conditions. [Result] Mice obtained higher serum antibody level when immunized by α protein,and the immune protection rates against type A,type B,type C and type D C. perfringens were 100%,90%,85% and 90%,respectively. The antibody titer of mice within 7-14 d after the third immunization reached the peak. [Conclusion]The α protein has good immunogenicity,and can be further used to develop genetic engineering subunit vaccines for preventing C. perfringens. | Sun Yu Yang Lin Wang Chuanbin Dong Hao Qu Ping Zhao Bolin Hu Dongmei Yang Tianyi Song Xiaohui | 2017 | Animal Husbandry and Feed Science2017，9，5： | 0 |
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