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| 1 | Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition,cytotoxicity,inflammation and lung fibrosis显示文摘Environmental exposure and health risk upon engineered nanomaterials are increasingly concerned. The family of mesoporous carbon nanomaterials(MCNs) is a rising star in nanotechnology for multidisciplinary research with versatile applications in electronics,energy and gas storage, and biomedicine. Meanwhile, there is mounting concern on their environmental health risks due to the growing production and usage of MCNs. The lung is the primary site for particle invasion under environmental exposure to nanomaterials. Here, we studied the comprehensive toxicological profile of MCNs in the lung under the scenario of moderate environmental exposure. It was found that at a low concentration of 10 μg/mL MCNs induced biophysical inhibition of natural pulmonary surfactant. Moreover, MCNs at similar concentrations reduced viability of J774 A.1 macrophages and lung epithelial A549 cells.Incubating with nature pulmonary surfactant effectively reduced the cytotoxicity of MCNs.Regarding the pro-inflammatory responses, MCNs activated macrophages in vitro, and stimulated lung inflammation in mice after inhalation exposure, associated with lung fibrosis.Moreover, we found that the size of MCNs played a significant role in regulating cytotoxicity and pro-inflammatory potential of this nanomaterial. In general, larger MCNs induced more pronounced cytotoxic and pro-inflammatory effects than their smaller counterparts. Our results provided valuable information on the toxicological profile and environmental health risks of MCNs, and suggested that fine-tuning the size of MCNs could be a practical precautionary design strategy to increase safety and biocompatibility of this nanomaterial. | Yunan Chen Yi Yang Bolong Xu Shunhao Wang Bin Li Juan Ma Jie Gao Yi Y.Zuo Sijin Liu | 2017 | Journal of Environmental Sciences2017，29，12： | 3 |
| 2 | Series-Type Switched-Inductor Z-Source Inverter显示文摘To solve the disadvantages of the traditional Z-source inverter(ZSI),this paper investigates a series-type switched-inductor Z-source inverter(SSI-ZSI)topology.It not only preserves the advantages of the traditional ZSI,but also improves the voltage gain.On the condition of the same voltage gain,the capacitor voltage stress is reduced,the soft start characteristic can be achieved and the inverter can be immune to the damage of the inrush current.The circuit structure and operating principle are analyzed in detail;the simulation model and the experimental platform are built.The simulation and experimental results verify the rationality and superiority of the circuit topology. | Xupeng Fang Yingying Tian Xiaokang Ding Bolong Ma | 2020 | CES Transactions on Electrical Machines and Systems2020，4，1： | 2 |
| 3 | Interface synergistic effects induced multi-mode luminescence显示文摘Mechanoluminescence(ML)has become the most promising material for broad applications in display and sensing devices,in which ZnS is the most commonly studied one due to its stable and highly repetitive ML performances.In this work,we have successfully prepared the biphase ZnS on a large scale through the facile in-air molten salt protection strategy.The obtained biphase has the best ML properties,which is mainly attributed to the synergistic effects of piezo-photonic,defect,and interface dislocations.DFT calculations have confirmed that the defects activate the local S and Zn sites and reduce the energy barrier for electron transfer.The much stronger X-ray induced luminescence than the commercial scintillator is also reached.The application of ZnS particles in both papers and inks delivers superior performance.Meanwhile,ZnS particles based screen printing ink is able to directly print on paper,plastic and other carriers to form clear marks.These proposed paper and ink hold great potentials in applications of information security and anti-counterfeiting based on the multi-mode luminescence properties.This work provides a new avenue to understand and realize the high-performance multi-mode luminescence,inspiring more future works to extend on other ML materials and boosting their practical applications. | Ronghua Ma Chunfeng Wang Wei Yan Mingzi Sun Jianxiong Zhao Yuantian Zheng Xu Li Longbiao Huang Bing Chen Feng Wang Bolong Huang Dengfeng Peng | 2022 | Nano Research2022，15，5： | 1 |
| 4 | Three-phase Voltage-fed Quasi-Z-Source AC-AC Converter显示文摘The paper proposes a novel three-phase voltage-fed quasi-Z-source ac-ac converter topology to overcome the shortcomings of the traditional three-phase AC-AC chopper.The quantitative relationship between the output voltage and duty-ratio is deduced by investigating the topology and operating principle.It can provide buck-boost function,and the output voltage of the circuit can keep stable in the case of voltage sagging.Simulation is performed using the MATLAB software,and the experimental circuit is built based on the simulation results,the simulation and experimental results verify the correctness and feasibility of the proposed ac-ac converter topology. | Xupeng Fang Guanzhong Gao Lixin Gao Bolong Ma | 2018 | CES Transactions on Electrical Machines and Systems2018，2，3： | 0 |
| 5 | GreenPhos,a universal method for in-depth measurement of plant phosphoproteomes with high quantitative reproducibility显示文摘Protein phosphorylation regulates a variety of important cellular and physiological processes in plants.In-depth profiling of plant phosphoproteomes has been more technically challenging than that of animal phosphoproteomes.This is largely due to the need to improve protein extraction efficiency from plant cells,which have a dense cell wall,and to minimize sample loss resulting from the stringent sample clean-up steps required for the removal of a large amount of biomolecules interfering with phosphopeptide purification and mass spectrometry analysis.To this end,we developed a method with a streamlined workflow for highly efficient purification of phosphopeptides from tissues of various green organisms including Arabidopsis,rice,tomato,and Chlamydomonas reinhardtii,enabling in-depth identification with high quantitative reproducibility of about 11000 phosphosites,the greatest depth achieved so far with single liquid chromatography-mass spectrometry(LC-MS)runs operated in a data-dependent acquisition(DDA)mode.The mainstay features of the method are the minimal sample loss achieved through elimination of sample clean-up before protease digestion and of desalting before phosphopeptide enrichment and hence the dramatic increases of time-and cost-effectiveness.The method,named GreenPhos,combined with single-shot LC-MS,enabled in-depth quantitative identification of Arabidopsis phosphoproteins,including differentially phosphorylated spliceosomal proteins,at multiple time points during salt stress and a number of kinase substrate motifs.GreenPhos is expected to serve as a universal method for purification of plant phosphopeptides,which,if samples are further fractionated and analyzed by multiple LC-MS runs,could enable measurement of plant phosphoproteomes with an unprecedented depth using a given mass spectrometry technology. | Xiaoxiao Duan Yuanya Zhang Xiahe Huang Xiao Ma Hui Gao Yan Wang Zhen Xiao Chengcheng Huang Zhongshu Wang Bolong Li Wenqiang Yang Yingchun Wang | 2024 | Molecular Plant2024，17，1： | 0 |
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