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| 1 | Efficient generation of mice carrying homozygous double-floxp alleles using the Cas9-Avidin/Biotin-donor DNA system显示文摘 | Ming Ma Fengfeng Zhuang Xiongbing Hu Bolun Wang Xian-Zi Wen Jia-Fu Ji Jianzhong Jeff Xi | 2017 | Cell Research2017，27，4： | 7 |
| 2 | Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis:a multi-omics study with drug exploration显示文摘Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics,and currently used drugs cannot reverse the disease progress.Worse still,there are still challenges to be addressed to fully decipher the intricated pathogenesis.Thus,specifying the essential mechanisms and targets in silicosis progression then exploring anti-silicosis pharmacuticals are desperately needed.In this work,multi-omics atlas was constructed to depict the pivotal abnormalities of silicosis and develop targeted agents.By utilizing an unbiased and time-resolved analysis of the transcriptome,proteome and phosphoproteome of a silicosis mouse model,we have verified the significant differences in transcript,protein,kinase activity and signaling pathway level during silicosis progression,in which the importance of essential biological processes such as macrophage activation,chemotaxis,immune cell recruitment and chronic inflammation were emphasized.Notably,the phosphorylation of EGFR(p-EGFR)and SYK(pSYK)were identified as potential therapeutic targets in the progression of silicosis.To inhibit and validate these targets,we tested fostamatinib(targeting SYK)and Gefitinib(targeting EGFR),and both drugs effectively ameliorated pulmonary dysfunction and inhibited the progression of inflammation and fibrosis.Overall,our drug discovery with multi-omics approach provides novel and viable therapeutic strategies for the treatment of silicosis. | Mingyao Wang Zhe Zhang Jiangfeng Liu Meiyue Song Tiantian Zhang Yiling Chen Huiyuan Hu Peiran Yang Bolun Li Xiaomin Song Junling Pang Yanjiang Xing Zhujie Cao Wenjun Guo Hao Yang Jing Wang Juntao Yang Chen Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 1 |
| 3 | Manipulation of invisible cloaking in PT-symmetric thermoacoustic dimer显示文摘Making the propagation of sound waves immune to interference from obstacles with high transmission efficiency is a long-term pursuit in acoustic science and engineering.Recent proposal pointed out that perfect transmission through obstacles can be achieved by deploying a bulky gain-loss distribution in parity-time(PT)symmetry.Here we demonstrate a modified methodology to achieve the extraordinary physical property of acoustic cloaking accompanied by perfect transmission at the exceptional points(EPs).Systematically probing reveals two complementary solutions of EPs corresponding to acoustic cloaking,in the system composed of an equivalent medium slab sandwiched by a pair of PT-symmetric admittance metasurfaces.To model the crucial acoustic gains that are not present in nature,we employ actively controlled ultra-thin carbon nanotube dimer films to mimic admittance metasurfaces perfectly via thermoacoustic effect,and manipulate acoustic cloaking over a wide frequency band in experiments.This divergent strategy releases restrictions on the operating frequency,shape and size of the obstacle,which can be applied to acoustic sensing,directional imaging,and other related wave disciplines. | Haixiao Zhang Bolun Hu Wei Xiong Ying Cheng Xiaojun Liu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，12： | 0 |
| 4 | Copper Catalyzed Iodosulfenylation of Styrenes by Dual C--H Oxidative Functionalization显示文摘A new method for the synthesis of β-iodoalkenyl sulfides via copper catalyzed difunctionalization of styrenes isdescribed. The method allows the formation of two chemical bonds, a C--I bond and a C--S bond, in a single reac-tion. Using alkenes in place of alkynes to synthesize fl-iodoalkenyl sulfides is a significant advantage of this meth-odology for both synthetic and medicinal chemistry. | Yurong Liu Bolun Hu Xingguo Zhang | 2017 | Chinese Journal of Chemistry2017，35，3： | 0 |
| 5 | Nanostructured MXene-based materials for boosting hydrogen sorption properties of Mg/MgH_(2)显示文摘Hydrogen holds the advantages of high energy density,great natural abundance and zero emission,making it suitable for large scale and long term energy storage,while its safe and efficient storage is still challenging.Among various solid state hydrogen storage materials,MgH_(2) is promising for industrial applications due to its high gravimetric and volumetric hydrogen densities and the abundance of Mg on earth.However,the practical application of MgH_(2) has been limited by its stable thermodynamics and slow hydrogen desorption kinetics.Nanocatalysis is considered as a promising approach for improving the hydrogen storage performance of MgH_(2) and bringing it closer to the requirements of commercial applications.It is worth mentioning that the recently emerging two-dimensional material,MXene,has showcased exceptional catalytic abilities in modifying the hydrogen storage properties of MgH_(2).Besides,MXene possesses a high surface area,excellent chemical/physical stability,and negatively charged terminating groups,making it an ideal support for the'nanoconfinement'of MgH_(2) or highly active catalysts.Herein,we endeavor to provide a comprehensive overview of recent investigations on MXene-based catalysts and MXene supports for improving the hydrogen sorption properties of Mg/MgH_(2).The mechanisms of hydrogen sorption involved in Mg-MXene based composites are highlighted with special emphases on thermodynamics,kinetics,and catalytic behaviors.The aim of this work is to provide a comprehensive and objective review of researches on the development of high-performance catalysts/supports to improve hydrogen storage performances of Mg/MgH_(2) and to identify the opportunities and challenges for future applications. | Yingyan Zhao Bolun Wang Li Ren Yinghui Li Xi Lin Qiuyu Zhang Zhigang Hu Jianxin Zou | 2024 | Materials Reports(Energy)2024，4，1： | 0 |
| 6 | Urine biomarkers discovery by metabolomics and machine learning for Parkinson’s disease diagnoses显示文摘Parkinson’s disease(PD)is a complex neurological disorder that typically worsens with age.A wide range of pathologies makes PD a very heterogeneous condition,and there are currently no reliable diagnostic tests for this disease.The application of metabolomics to the study of PD has the potential to identify disease biomarkers through the systematic evaluation of metabolites.In this study,urine metabolic profiles of 215 urine samples from 104 PD patients and 111 healthy individuals were assessed based on liquid chromatography-mass spectrometry.The urine metabolic profile was first evaluated with partial leastsquares discriminant analysis,and then we integrated the metabolomic data with ensemble machine learning techniques using the voting strategy to achieve better predictive performance.A combination of 8-metabolite predictive panel performed well with an accuracy of over 90.7%.Compared to control subjects,PD patients had higher levels of 3-methoxytyramine,N-acetyl-l-tyrosine,orotic acid,uric acid,vanillic acid,and xanthine,and lower levels of 3,3-dimethylglutaric acid and imidazolelactic acid in their urine.The multi-metabolite prediction model developed in this study can serve as an initial point for future clinical studies. | Xiaoxiao Wang Xinran Hao Jie Yan Ji Xu Dandan Hu Fenfen Ji Ting Zeng Fuyue Wang Bolun Wang Jiacheng Fang Jing Ji Hemi Luan Yanjun Hong Yanhao Zhang Jinyao Chen Min Li Zhu Yang Doudou Zhang Wenlan Liu Xiaodong Cai Zongwei Cai | 2023 | Chinese Chemical Letters2023，34，10： | 0 |
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