|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 2 | In-hospitalmortality and three-year survival after repaired acute type Aaortic dissection显示文摘 | Aalberts J J Boonstra P W van den Berg M | 2009 | Neth Heart J2009，17，6： | 1 |
| 3 | Non-isletcell tumor induced hypoglycemia in patients With advanced gastrointestinal stromal tumor possibly worsened by imatinih 显示文摘 | HAMBERG P de JONG FA BOONSTRA JG | 2006 | J Clin Oncol2006，24，18： | 1 |
| 4 | Chemical analysis of heat treated softwoods显示文摘 | Michiel J Boonstra P Boke Tjeerdsma | 2006 | Holz als Robund Werkstoff2006，64，3： | 1 |
| 5 | The epidermal growth factor显示文摘 | Boonstra J Rijken P Humbel B | 1995 | Cell Biol Int1995，19，5： | 1 |
| 6 | The ep- idermal growth factor 显示文摘 | BOONSTRA J RIJKEN P HUMBEL B | 1995 | Cell Biology International1995，19，5： | 1 |
| 7 | Spring declines in Microtus pennsylvanicus and the role of steroid hormones 显示文摘 | Boonstra R Boag P T | 1992 | J Anim Ecol1992，62，： | 1 |
| 8 | The epidermal Growth factor 显示文摘 | Rijken P Humbel B | 1995 | Cell Biology International1995，19，5： | 1 |
| 9 | Pressure Drop, Shear Stress,and Activation of Leukocytes during Cardiopulmonary Bypass:a Comparison between Hollow Fiber and Flat Sheet Membrane Oxygenators显示文摘 | Gu Y J Boonstra P W Graaff R | 2000 | Artif organs2000，24，1： | 1 |
| 10 | The epidermal growth factor显示文摘 | Boonstra J Rijken P Humbel B | 1995 | Cell Biol Int1995，19，5： | 1 |
| 11 | Labelling and patient knowledge of dispensed drugs as quality indicators in pri- mary care in Botswana显示文摘 | E Boonstra M Lindbaek E Ngome K Tshukudu P Fugelli | 2003 | Qual Saf Health Care2003，12，： | 1 |
| 12 | Video-assisted minimally inversive coronary operations without cardiopulmonary bypass: A multicenter study 显示文摘 | Benetti F Mariani MA Sani G Boonstra PW Grandjean JG Giomarelli P Toscano M | 1996 | J Thorac Cardiovasc Surg1996，112，： | 1 |
| 13 | Characterisation of thermally modified wood:molecular reasons for wood performance improvement显示文摘 | Tjeerdsma BF Boonstra M Pizzi A Tekely P Militz H | 1998 | Holz Rob-und Werkstoff1998，56，3： | 1 |
| 14 | Current impact of viral hepatitis on liver cancer development: The challenge remains显示文摘Chronic infections due to hepatitis B and hepatitis C viruses are responsible for most cases of hepatocellular carcinoma(HCC)worldwide,and this association is likely to remain during the next decade.Moreover,viral hepatitis-related HCC imposes an important burden on public health in terms of disability-adjusted life years.In order to reduce such a burden,some major challenges must be faced.Universal vaccination against hepatitis B virus,especially in the neonatal period,is probably the most relevant primary preventive measure against the development of HCC.Moreover,considering the large adult population already infected with hepatitis B and C viruses,it is also imperative to identify these individuals to ensure their access to treatment.Both hepatitis B and C currently have highly effective therapies,which are able to diminish the risk of development of liver cancer.Finally,it is essential for individuals at high-risk of HCC to be included in surveillance programs,so that tumors are detected at an early stage.Patients with hepatitis B or C and advanced liver fibrosis or cirrhosis benefit from being followed in a surveillance program.As hepatitis B virus is oncogenic and capable of leading to liver cancer even in individuals with early stages of liver fibrosis,other high-risk groups of patients with hepatitis B are also candidates for surveillance.Considerable effort is required concerning these strategies in order to decrease the incidence and the mortality of viral hepatitis-related HCC. | Ângelo Zambam de Mattos Jose D Debes Andre Boonstra Ju-Dong Yang Domingo C Balderramo Giovana D P Sartori Angelo Alves de Mattos | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 15 | The epidermal growth factor显示文摘 | Boonstra J Rijken P Humbel B | 1995 | Cell Biol Int1995，19，5： | 1 |
| 16 | Validation of a LightCycler-based reverse transeription polymerase chain reaction for the detection of foot-and-mouth disease virus 显示文摘 | Moonen P Boonstra J Van D H R H | 2003 | Virol Methods2003，113，1： | 1 |
| 17 | The epidermal growth factor显示文摘 | BOONSTRA J RIJKEN P HUMBEL B | 1995 | Cell Biol lnt1995，19，5： | 1 |
| 18 | Corticomuscular and bilateral EMG coherence reflect distinct aspects of neural synchronization 显示文摘 | BOONSTRA T W VAN WIJK B C PRAAMSTRA P | 2009 | Neuroscience Letters2009，463，1： | 1 |
| 19 | Non-islet-cell tumor induced hypoglycemia in patients with advanced gastrointestinal stromal tumor possibly worsened by imatinib显示文摘 | Hamberg P de Jong FA Boonstra JG | 2006 | J Clin Oncol2006，24，18： | 1 |
| 20 | The epidermal growth factor 显示文摘 | Boonstra J Rijken P Humbel B | 1995 | Cell Biol Int1995，19，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员