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| 1 | Co-encapsulation of curcumin and doxorubicin in albumin nanoparticles blocks the adaptive treatment tolerance of cancer cells显示文摘The adaptive treatment tolerance (ATT) of cancer cells is the main encumbrance to cancer chemotherapy. A potential solution to this problem is to treat cancer cells with multiple drugs using nanoparticles (NPs). In this study, we tested the co-administration of curcumin (Cur) and doxorubicin (Dox) to MCF-7 resistant breast cancer cells to block the ATTand elicit efficient cell killing. Drugs were co-administered to cells both sequentially and simultaneously. Sequential drug co-administration was carried out by pre-treating the cells with albumin nanoparticles (ANPs) loaded w让h Cur (Cur@ANPs) followed by treatment with Dox-loaded ANPs (Dox@ANPs). Simultaneous drug co-administration was carried out by treating the cells with ANPs loaded with both the drugs (Cur/Dox@ANPs). We found that the simultaneous drug co-administration led to a greater intra-cellular accumulation of Dox and cell killing with respect to the sequential drug co-administration. However;the simultaneous drug co-administration led to a lower intracellular accumulation of Cur with respect to the sequential drug co-administration. We showed that this result was due to the aggregation and entrapment of Cur in the lysosomes as soon as it was released from Cur@ANPs, a phenomenon called lysosomotropism. In contrast, the simultaneous release of Dox and Cur from Cur/Dox@ANPs into the lysosomes led to lysosomal pH elevation, which, in turn, avoided Cur aggregation, led to lysosome swelling and drug release in the cytosol, and finally provoked efficient cell killing. Our study shed the light on the molecular processes driving the therapeutic effects of anti-cancer drugs co-administered to cancer cells in different manners. | Seyed Mohammad Motevalli Ahmed Shaker Eltahan Lu Liu Andrea Magrini Nicola Rosato Weisheng Guo Massimo Bottini Xing-Jie Liang | 2019 | Biophysics Reports2019，5，1： | 3 |
| 2 | Results, Outcome Predictors, and Complications after Stapled Transanal Rectal Resection for Obstructed Defecation显示文摘 | Giuseppe Gagliardi M.D. Mario Pescatori M.D. F.R.C.S. E.B.S.Q. Donato F. Altomare M.D. Gian Andrea Binda M.D. Corrado Bottini M.D. Giuseppe Dodi M.D. Vincenzino Filingeri M.D. Giovanni Milito M.D. Marcella Rinaldi M.D. Giovanni Romano M.D. Liana Spazzaf | 2008 | Diseases of the Colon & Rectum2008，，2： | 2 |
| 3 | Effect of erythromycin on gallbladder emptying in diabetic patients with and without autonomic neuropathy and high levels of motilin显示文摘 | Stefano Fiorucci MD Luciano Scionti MD Rachele Bosso MD Antonio Desando MD Paolo Bottini MD Cecilia Marino MD Prof. Antonio Morelli MD | 1992 | Digestive Diseases and Sciences1992，，11： | 2 |
| 4 | Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism显示文摘PTPN22 has been previously found associated with coronary artery disease(CAD). In the present note we have studied the effect of p53 codon 72,acid phosphatse locus 1(ACP1) and adenosine deaminase(ADA) genetic polymorphism on the strength of association between PTPN22 and CAD. We have studied 133 non diabetic subjects with CAD,122 non diabetic cardiovascular patients without CAD and 269 healthy blood donors. Informed written consent was obtained from all subjects and the study was approved by the Ethical Committee. A high significant association between PTPN22 and CAD is observed in carriers of *A allele of ACP1 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to controls and to non diabetic subjects with cardiovascular diseasewithout CAD. A similar pattern is observed in carriers of *Pro allele of p53 codon 72 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other groups. A highly significant association between PTPN22 and CAD is observed in carriers of ADA2 *2 allele with higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other group. There is a high significant correlation between the number of factors that contributes to increase the strength of association between PTPN22 *T and CAD and the proportion of *T carriers in CAD. ACP1,p53 codon 72 and ADA are involved in immune reaction and give an important additive contribution to the strength of association between PTPN22 and CAD. This study stresses the importance of the simultaneous analysis of multiple genes functionally related to a specific disease: the approach may give important hints to understand multifactorial disorders. | Fulvia Gloria-Bottini Patrizia Saccucci Maria Banci Paolo Nardi Mattia Scognamiglio Antonio Pellegrino Egidio Bottini Luigi Chiariello | 2014 | World Journal of Cardiology2014，6，6： | 2 |
| 5 | Role of PTPN22 in type 1 diabetes and other autoimmune diseases显示文摘 | Bottini N Vang T Cucca F | 2006 | Semin Immunol2006，18，4： | 1 |
| 6 | Exogenous Abscisic Acid Increases Carbohydrate Accumulation and Redistribution to the Grains in Wheat Grown Under Field Conditions of Soil Water Restriction显示文摘 | Claudia Travaglia Ana C. Cohen Herminda Reinoso Carlos Castillo Rubén Bottini | 2007 | Journal of Plant Growth Regulation2007，，3： | 1 |
| 7 | Bone-anchored implant in cosmetic finger reconstrnction显示文摘 | Cervelli V Bottini DJ Arpino A | 2008 | Ann Chir Plast Esthct2008，53，4： | 1 |
| 8 | A pilot study of hyperbaric oxygen in the treatment of human stroke显示文摘 | Anderson DC Bottini AG Jagiella WM | 1991 | Stroke1991，22，： | 1 |
| 9 | Urinalysis:comparison between microscopic analysis and a new automated microscopy image-based urine sediment instrument显示文摘 | BOTTINI P V MARTINEZ M H GARLIPP C R | 2014 | Clin Lab2014，60，4： | 1 |
| 10 | Oxiracetam in dementia a double-blind placebo-controlled study 显示文摘 | Bottini G Vallar G Cappa S | 1992 | Acta Neurol& and1992，86，3： | 1 |
| 11 | A strategy for the design and selection of solvents for separation processes显示文摘 | Brignole E A Bottini S Gani R | 1986 | Fluid Phase Equil1986，29，1： | 1 |
| 12 | FulMength sin gle-walled carbon nanotubes decorated with streptavidin conjugated quantum dots as muhivalent intracellular fluore- scent nanoprobes显示文摘 | Bottini M Cerignoli F Dawson M I | 2006 | Biomacromolecules2006，7，8： | 1 |
| 13 | Reconstruction of the nasal dorsum with autologous rib cartilage 显示文摘 | Cervelli Bottini DJ Gentile P | 2006 | Ann Plast Surg2006，56，3： | 1 |
| 14 | Cerebral representa- tions for egocentric space: Functional-anatomical evidence from caloric vestibular stimulation and neck vibration显示文摘 | Bottini G Karnath HO Vallar G | 2001 | Brain2001，124，6： | 1 |
| 15 | Complications after stapled hemorrhoidectomy: can they be prevented?显示文摘 | B. Ravo A. Amato V. Bianco P. Boccasanta C. Bottini A. Carriero G. Milito G. Dodi D. Mascagni S. Orsini R. Pietroletti V. Ripetti G. B. Tagariello | 2002 | Techniques in Coloproctology2002，，2： | 1 |
| 16 | Polarization of the intigrin in oarian carcinomas显示文摘 | Bottini Moiottis Fioruci S | 1993 | Int J Cancer1993，54，： | 1 |
| 17 | The role of the right hemisphere in the in- terpretation of figurative aspects of language:a positron e- mission tomography activation study 显示文摘 | Bottini G Corcoran R Sterzi R Panlesu E Schenone P Scarpa P | 1994 | Brain1994，，6： | 1 |
| 18 | Multi-walled carbon nanotubes induce T lymphocyte apoptosis显示文摘 | Bottini M Bruckner S Nika K | 2006 | Toxicol Lett2006，160，： | 1 |
| 19 | Reassessing the HAROLD model: is the hemispheric asymmetry reduction in older adults a special case of compensatory-related utilisation of neural circuits? 显示文摘 | BERLINGERI M DANELLI L BOTTINI G | 2013 | Exp Brain Res2013，224，3： | 1 |
| 20 | Duality of fibroblast-like synoviocytes in RA: passive responders andimprinted aggressors 显示文摘 | BOTTINI N FIRESTEIN G S | 2013 | Nat Rev Rheumatol2013，9，1： | 1 |
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